IMP: Integrative Multi-species Prediction

Homo sapiens

22 genes annotated in human

Multi-species View

establishment of cell polarity

GO:0030010

The specification and formation of anisotropic intracellular organization or cell growth patterns.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "establishment of cell polarity"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "establishment of cell polarity" (in gray)

Name	Description	Probability	Func Analog Organism
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	1.000	Worm
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.997	Yeast Worm Fly
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.971
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.962	Worm
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.953	Rat Worm Fly
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.944	Worm
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.896	Fly
YAP1	Yes-associated protein 1	0.873
APC	adenomatous polyposis coli	0.851
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.726
ACTB	actin, beta	0.693	Yeast
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.650	Worm
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.645
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.522	Worm
PRKCZ	protein kinase C, zeta	0.508	Rat
MARK2	MAP/microtubule affinity-regulating kinase 2	0.492
GSK3B	glycogen synthase kinase 3 beta	0.470	Rat Fly
MAPT	microtubule-associated protein tau	0.469
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.442	Fly
KIF23	kinesin family member 23	0.412
RAB11A	RAB11A, member RAS oncogene family	0.400
SFN	stratifin	0.382
ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	0.370
SYK	spleen tyrosine kinase	0.346
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.291	Fly
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.289
VCL	vinculin	0.270
BTRC	beta-transducin repeat containing	0.267
FBXW11	F-box and WD repeat domain containing 11	0.259
FYN	FYN oncogene related to SRC, FGR, YES	0.253	Worm
MYH9	myosin, heavy chain 9, non-muscle	0.251	Mouse
LRRK2	leucine-rich repeat kinase 2	0.207
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.200	Fly
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.199
GPSM2	G-protein signaling modulator 2	0.194	Mouse Fly
EGFR	epidermal growth factor receptor	0.190
AXIN1	axin 1	0.189
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.187	Worm
CCR5	chemokine (C-C motif) receptor 5	0.176
FLNA	filamin A, alpha	0.173
PRKCI	protein kinase C, iota	0.171	Zebrafish Mouse
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.169
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.169	Worm Fly
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.158	Worm Fly
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.157
RACGAP1	Rac GTPase activating protein 1	0.152
NCOA1	nuclear receptor coactivator 1	0.151
VCAM1	vascular cell adhesion molecule 1	0.142
GDA	guanine deaminase	0.136
VIM	vimentin	0.133
IQGAP1	IQ motif containing GTPase activating protein 1	0.130
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.125
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.119
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.111
SH3KBP1	SH3-domain kinase binding protein 1	0.111
CFL1	cofilin 1 (non-muscle)	0.109	Mouse
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	0.109	Mouse
TCF4	transcription factor 4	0.104
PRC1	protein regulator of cytokinesis 1	0.092
CCL4	chemokine (C-C motif) ligand 4	0.091	Human
CNKSR2	connector enhancer of kinase suppressor of Ras 2	0.088
GRB7	growth factor receptor-bound protein 7	0.085
KIF1B	kinesin family member 1B	0.083
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.079
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.079
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.077	Worm
SQSTM1	sequestosome 1	0.076
ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	0.074	Human
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.071
NUP62	nucleoporin 62kDa	0.070
ZBED1	zinc finger, BED-type containing 1	0.069
PKP2	plakophilin 2	0.066
CDCA8	cell division cycle associated 8	0.063
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.062
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.061
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.060
AMOTL1	angiomotin like 1	0.059	Mouse
CCL5	chemokine (C-C motif) ligand 5	0.058	Human
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.058
ZYX	zyxin	0.057
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.056	Fly
BAIAP2	BAI1-associated protein 2	0.056
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.055	Zebrafish
CCL19	chemokine (C-C motif) ligand 19	0.054
BCAR1	breast cancer anti-estrogen resistance 1	0.054
PBK	PDZ binding kinase	0.053
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.053
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.050
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.049
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.049
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.047	Worm Fly
CEP250	centrosomal protein 250kDa	0.046
PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	0.046
IDE	insulin-degrading enzyme	0.044
EZR	ezrin	0.044	Fly
STARD9	StAR-related lipid transfer (START) domain containing 9	0.043
ICAM1	intercellular adhesion molecule 1	0.043
GLIS2	GLIS family zinc finger 2	0.042
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.041
KIF20A	kinesin family member 20A	0.041
ACTN4	actinin, alpha 4	0.040
PFN1	profilin 1	0.040
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.039
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.039	Fly
INCENP	inner centromere protein antigens 135/155kDa	0.039
AMOT	angiomotin	0.039	Mouse
KIF5B	kinesin family member 5B	0.038	Worm
ENO2	enolase 2 (gamma, neuronal)	0.037
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.037
AP2B1	adaptor-related protein complex 2, beta 1 subunit	0.036
RHOA	ras homolog gene family, member A	0.036
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.036	Yeast
NCAPD2	non-SMC condensin I complex, subunit D2	0.034
CRMP1	collapsin response mediator protein 1	0.034
STRADA	STE20-related kinase adaptor alpha	0.033
ARRB1	arrestin, beta 1	0.032
CAPNS1	calpain, small subunit 1	0.032
TUBGCP4	tubulin, gamma complex associated protein 4	0.032
CENPE	centromere protein E, 312kDa	0.032
CENPF	centromere protein F, 350/400kDa (mitosin)	0.032
LIMK1	LIM domain kinase 1	0.032
HJURP	Holliday junction recognition protein	0.032
BIRC5	baculoviral IAP repeat containing 5	0.031
CFL2	cofilin 2 (muscle)	0.031
OPA1	optic atrophy 1 (autosomal dominant)	0.030
MATK	megakaryocyte-associated tyrosine kinase	0.030
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.030
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.029	Zebrafish
RANBP2	RAN binding protein 2	0.029
LRRC41	leucine rich repeat containing 41	0.029
MARK4	MAP/microtubule affinity-regulating kinase 4	0.029	Human Worm
FN1	fibronectin 1	0.028	Zebrafish
JAM2	junctional adhesion molecule 2	0.027
CXCL9	chemokine (C-X-C motif) ligand 9	0.026
LLGL2	lethal giant larvae homolog 2 (Drosophila)	0.025	Fly
CCR7	chemokine (C-C motif) receptor 7	0.025
GRB2	growth factor receptor-bound protein 2	0.024
VAV1	vav 1 guanine nucleotide exchange factor	0.024
UBASH3B	ubiquitin associated and SH3 domain containing B	0.024
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.024	Human
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.024
ERBB2IP	erbb2 interacting protein	0.023	Human
MED15	mediator complex subunit 15	0.023
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.023	Fly
MPP5	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	0.023
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.022
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.022
CDK17	cyclin-dependent kinase 17	0.022
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.022
CCL2	chemokine (C-C motif) ligand 2	0.021	Human
RANBP9	RAN binding protein 9	0.021
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.021
KIF4A	kinesin family member 4A	0.021
INADL	InaD-like (Drosophila)	0.021
TJP2	tight junction protein 2 (zona occludens 2)	0.020
C13orf34	chromosome 13 open reading frame 34	0.020
EHD1	EH-domain containing 1	0.020
MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3	0.020
ADAM17	ADAM metallopeptidase domain 17	0.020
FYCO1	FYVE and coiled-coil domain containing 1	0.020
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.019
PTN	pleiotrophin	0.019
PKP4	plakophilin 4	0.019
LAMA4	laminin, alpha 4	0.019
SPC25	SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.019
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.019
CKAP5	cytoskeleton associated protein 5	0.019
PLK1	polo-like kinase 1	0.019
ESPL1	extra spindle pole bodies homolog 1 (S. cerevisiae)	0.019
CCL13	chemokine (C-C motif) ligand 13	0.018	Human
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.018
UBE2C	ubiquitin-conjugating enzyme E2C	0.018
CTPS	CTP synthase	0.018
NGF	nerve growth factor (beta polypeptide)	0.018
CAPN2	calpain 2, (m/II) large subunit	0.018
KIF11	kinesin family member 11	0.018
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.018
GNG2	guanine nucleotide binding protein (G protein), gamma 2	0.018
PTTG1	pituitary tumor-transforming 1	0.017
CENPA	centromere protein A	0.017
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.017
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.017
CLIP1	CAP-GLY domain containing linker protein 1	0.017
CAPN1	calpain 1, (mu/I) large subunit	0.017
SBNO2	strawberry notch homolog 2 (Drosophila)	0.017
CAPZB	capping protein (actin filament) muscle Z-line, beta	0.017
GCC1	GRIP and coiled-coil domain containing 1	0.017
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.017
STRN3	striatin, calmodulin binding protein 3	0.016
CCL3	chemokine (C-C motif) ligand 3	0.016	Human
HMMR	hyaluronan-mediated motility receptor (RHAMM)	0.016
TMSB4X	thymosin beta 4, X-linked	0.016
ILK	integrin-linked kinase	0.016
CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.016
GTSE1	G-2 and S-phase expressed 1	0.015
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.015
CCNB2	cyclin B2	0.015
SRGN	serglycin	0.015
MYL12B	myosin, light chain 12B, regulatory	0.015	Worm
NUMA1	nuclear mitotic apparatus protein 1	0.015	Mouse
HDAC7	histone deacetylase 7	0.015
KIAA1377	KIAA1377	0.015
TCEA2	transcription elongation factor A (SII), 2	0.015
AP1M1	adaptor-related protein complex 1, mu 1 subunit	0.015
CCL8	chemokine (C-C motif) ligand 8	0.015	Human
DPP4	dipeptidyl-peptidase 4	0.015
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.014
WWC1	WW and C2 domain containing 1	0.014
PTPRS	protein tyrosine phosphatase, receptor type, S	0.014
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.014
USP8	ubiquitin specific peptidase 8	0.014
ENO1	enolase 1, (alpha)	0.014
FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	0.014
NCKAP1	NCK-associated protein 1	0.014
RHOG	ras homolog gene family, member G (rho G)	0.014
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.014
RUNDC3A	RUN domain containing 3A	0.014
AP2M1	adaptor-related protein complex 2, mu 1 subunit	0.014
CXCL13	chemokine (C-X-C motif) ligand 13	0.014
CD44	CD44 molecule (Indian blood group)	0.014
SH3RF3	SH3 domain containing ring finger 3	0.013
ARHGAP5	Rho GTPase activating protein 5	0.013
CYTH1	cytohesin 1	0.013	Mouse
CTNND1	catenin (cadherin-associated protein), delta 1	0.013
DSTN	destrin (actin depolymerizing factor)	0.013
MYL12A	myosin, light chain 12A, regulatory, non-sarcomeric	0.013	Worm
TBC1D10A	TBC1 domain family, member 10A	0.013
KIF14	kinesin family member 14	0.013
SH3RF1	SH3 domain containing ring finger 1	0.013
TSC2	tuberous sclerosis 2	0.013
NAP1L5	nucleosome assembly protein 1-like 5	0.013
DARC	Duffy blood group, chemokine receptor	0.012
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.012
RBX1	ring-box 1, E3 ubiquitin protein ligase	0.012
CDCA3	cell division cycle associated 3	0.012
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.012
PLEC	plectin	0.012
MAP7D1	MAP7 domain containing 1	0.012
EPB41L3	erythrocyte membrane protein band 4.1-like 3	0.012
CIC	capicua homolog (Drosophila)	0.012
MPDZ	multiple PDZ domain protein	0.012
HSPB1	heat shock 27kDa protein 1	0.012
SPC24	SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.012
NTF4	neurotrophin 4	0.012
PLEK	pleckstrin	0.012
CTGF	connective tissue growth factor	0.012
NCF2	neutrophil cytosolic factor 2	0.012
PEF1	penta-EF-hand domain containing 1	0.012
TRIM33	tripartite motif containing 33	0.012
CCDC158	coiled-coil domain containing 158	0.012
PLCG1	phospholipase C, gamma 1	0.012
USP24	ubiquitin specific peptidase 24	0.012
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.011
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.011
WWTR1	WW domain containing transcription regulator 1	0.011
PRKCD	protein kinase C, delta	0.011
TUBB	tubulin, beta	0.011
VHL	von Hippel-Lindau tumor suppressor	0.011
PSRC1	proline/serine-rich coiled-coil 1	0.011
PKM2	pyruvate kinase, muscle	0.011
RALGDS	ral guanine nucleotide dissociation stimulator	0.011
SMAD3	SMAD family member 3	0.011
FURIN	furin (paired basic amino acid cleaving enzyme)	0.011
LAT	linker for activation of T cells	0.011
ACTG1	actin, gamma 1	0.011	Yeast
SPAG9	sperm associated antigen 9	0.011
ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B	0.011
STK10	serine/threonine kinase 10	0.011	Fly
CLIC1	chloride intracellular channel 1	0.011
NF2	neurofibromin 2 (merlin)	0.011
CENPN	centromere protein N	0.011
SNIP1	Smad nuclear interacting protein 1	0.011
CENPI	centromere protein I	0.011
MFAP1	microfibrillar-associated protein 1	0.011
JUP	junction plakoglobin	0.011
AMOTL2	angiomotin like 2	0.011
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.010
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.010
RAB1A	RAB1A, member RAS oncogene family	0.010
STRADB	STE20-related kinase adaptor beta	0.010
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.010
SH3BP2	SH3-domain binding protein 2	0.010
KIF21A	kinesin family member 21A	0.010
F11R	F11 receptor	0.010
KIAA1539	KIAA1539	0.010
FOXM1	forkhead box M1	0.010
XPO1	exportin 1 (CRM1 homolog, yeast)	0.010
PIP5K1C	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	0.010
SSFA2	sperm specific antigen 2	0.010
TFDP1	transcription factor Dp-1	0.010
EIF3F	eukaryotic translation initiation factor 3, subunit F	0.010
GMPS	guanine monphosphate synthetase	0.010
TAGLN2	transgelin 2	0.010
BAD	BCL2-associated agonist of cell death	0.010
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.010
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.010
JAK1	Janus kinase 1	0.010
PRPS1	phosphoribosyl pyrophosphate synthetase 1	0.010