Process View
The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "sphingolipid metabolic process"
Name | Description | Probability | Func Analog Organism | |
---|---|---|---|---|
LAMP1 | lysosomal-associated membrane protein 1 | 0.587 | ||
PARD6A | par-6 partitioning defective 6 homolog alpha (C. elegans) | 0.544 | ||
ITCH | itchy E3 ubiquitin protein ligase homolog (mouse) | 0.367 | ||
COTL1 | coactosin-like 1 (Dictyostelium) | 0.302 | ||
CTSA | cathepsin A | 0.288 | ||
TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.275 | ||
SQLE | squalene epoxidase | 0.258 | ||
CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.236 | ||
PARD6B | par-6 partitioning defective 6 homolog beta (C. elegans) | 0.220 | ||
RPTOR | regulatory associated protein of MTOR, complex 1 | 0.185 | ||
NOXA1 | NADPH oxidase activator 1 | 0.165 | ||
PDPK1 | 3-phosphoinositide dependent protein kinase-1 | 0.153 | ||
RTN4 | reticulon 4 | 0.148 | ||
INSR | insulin receptor | 0.128 | ||
CTGF | connective tissue growth factor | 0.125 | ||
RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 0.124 | ||
BCL2L1 | BCL2-like 1 | 0.119 | ||
SURF4 | surfeit 4 | 0.118 | ||
HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.106 | ||
SIGMAR1 | sigma non-opioid intracellular receptor 1 | 0.103 | ||
USP22 | ubiquitin specific peptidase 22 | 0.094 | ||
CASP7 | caspase 7, apoptosis-related cysteine peptidase | 0.093 | ||
DUSP23 | dual specificity phosphatase 23 | 0.087 | ||
ANXA4 | annexin A4 | 0.081 | ||
CCDC115 | coiled-coil domain containing 115 | 0.079 | ||
BAK1 | BCL2-antagonist/killer 1 | 0.078 | ||
LAT | linker for activation of T cells | 0.075 | ||
MFSD5 | major facilitator superfamily domain containing 5 | 0.067 | ||
PRKCB | protein kinase C, beta | 0.066 | ||
RNF144B | ring finger protein 144B | 0.064 | ||
HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.062 | ||
SLC39A1 | solute carrier family 39 (zinc transporter), member 1 | 0.060 | ||
SC5DL | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like | 0.055 | ||
SH3RF1 | SH3 domain containing ring finger 1 | 0.055 | ||
GNS | glucosamine (N-acetyl)-6-sulfatase | 0.053 | ||
IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.053 | ||
RNR2 | l-rRNA | 0.052 | ||
KITLG | KIT ligand | 0.051 | ||
PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | 0.051 | ||
MAPT | microtubule-associated protein tau | 0.049 | ||
LAMP2 | lysosomal-associated membrane protein 2 | 0.048 | ||
ELOVL1 | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 | 0.047 | ||
CCL14 | chemokine (C-C motif) ligand 14 | 0.046 | ||
PICK1 | protein interacting with PRKCA 1 | 0.045 | ||
NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 0.043 | ||
RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.041 | ||
TM9SF1 | transmembrane 9 superfamily member 1 | 0.041 | ||
ARF3 | ADP-ribosylation factor 3 | 0.040 | ||
NUMB | numb homolog (Drosophila) | 0.038 | ||
ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | 0.038 | ||
TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.037 | ||
TMEM173 | transmembrane protein 173 | 0.037 | ||
AKT1S1 | AKT1 substrate 1 (proline-rich) | 0.036 | ||
INSIG1 | insulin induced gene 1 | 0.036 | ||
HEXA | hexosaminidase A (alpha polypeptide) | 0.035 | Mouse | |
DEPTOR | DEP domain containing MTOR-interacting protein | 0.034 | ||
MTOR | mechanistic target of rapamycin (serine/threonine kinase) | 0.033 | Yeast | |
LASS2 | LAG1 homolog, ceramide synthase 2 | 0.032 | Human Yeast Mouse | |
ZHX1 | zinc fingers and homeoboxes 1 | 0.032 | ||
SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.031 | ||
SNX9 | sorting nexin 9 | 0.030 | ||
JAK2 | Janus kinase 2 | 0.030 | ||
NMT2 | N-myristoyltransferase 2 | 0.030 | ||
ALOX12B | arachidonate 12-lipoxygenase, 12R type | 0.030 | ||
PRKCZ | protein kinase C, zeta | 0.030 | Human | |
CDCP1 | CUB domain containing protein 1 | 0.030 | ||
NCF1 | neutrophil cytosolic factor 1 | 0.030 | ||
ATXN1 | ataxin 1 | 0.029 | ||
CD58 | CD58 molecule | 0.029 | ||
CDC37 | cell division cycle 37 homolog (S. cerevisiae) | 0.029 | ||
CTSL1 | cathepsin L1 | 0.029 | ||
RNF13 | ring finger protein 13 | 0.029 | ||
PDK1 | pyruvate dehydrogenase kinase, isozyme 1 | 0.028 | ||
ZNF71 | zinc finger protein 71 | 0.027 | ||
MALT1 | mucosa associated lymphoid tissue lymphoma translocation gene 1 | 0.027 | ||
FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.027 | ||
SOAT1 | sterol O-acyltransferase 1 | 0.026 | ||
ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.026 | ||
BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 0.025 | ||
GLB1 | galactosidase, beta 1 | 0.025 | ||
CARD11 | caspase recruitment domain family, member 11 | 0.025 | ||
MAPKAP1 | mitogen-activated protein kinase associated protein 1 | 0.025 | ||
ENPP5 | ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) | 0.024 | Human | |
CYB561D2 | cytochrome b-561 domain containing 2 | 0.024 | ||
RHOXF2 | Rhox homeobox family, member 2 | 0.023 | ||
KRT5 | keratin 5 | 0.023 | ||
RARA | retinoic acid receptor, alpha | 0.023 | ||
BRF2 | BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like | 0.023 | ||
TMEM165 | transmembrane protein 165 | 0.023 | ||
CPD | carboxypeptidase D | 0.022 | ||
ASXL1 | additional sex combs like 1 (Drosophila) | 0.022 | ||
ATP6V0E1 | ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 | 0.022 | ||
TWF2 | twinfilin, actin-binding protein, homolog 2 (Drosophila) | 0.022 | ||
NSDHL | NAD(P) dependent steroid dehydrogenase-like | 0.022 | ||
NPTN | neuroplastin | 0.022 | ||
PARD6G | par-6 partitioning defective 6 homolog gamma (C. elegans) | 0.022 | ||
C14orf1 | chromosome 14 open reading frame 1 | 0.021 | ||
BAD | BCL2-associated agonist of cell death | 0.021 | ||
MFSD1 | major facilitator superfamily domain containing 1 | 0.021 | ||
GM2A | GM2 ganglioside activator | 0.021 | Mouse | |
ALOXE3 | arachidonate lipoxygenase 3 | 0.021 | ||
DHCR24 | 24-dehydrocholesterol reductase | 0.020 | ||
NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.020 | ||
ENPP4 | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) | 0.020 | Human | |
TM9SF3 | transmembrane 9 superfamily member 3 | 0.020 | ||
SCAMP2 | secretory carrier membrane protein 2 | 0.020 | ||
PPP2R4 | protein phosphatase 2A activator, regulatory subunit 4 | 0.019 | ||
CASP3 | caspase 3, apoptosis-related cysteine peptidase | 0.019 | ||
PPT1 | palmitoyl-protein thioesterase 1 | 0.019 | ||
ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | 0.019 | ||
PSENEN | presenilin enhancer 2 homolog (C. elegans) | 0.019 | ||
RTN3 | reticulon 3 | 0.019 | ||
BCL10 | B-cell CLL/lymphoma 10 | 0.019 | ||
FUCA1 | fucosidase, alpha-L- 1, tissue | 0.019 | ||
TOR1B | torsin family 1, member B (torsin B) | 0.018 | ||
RHEB | Ras homolog enriched in brain | 0.018 | ||
DCTN1 | dynactin 1 | 0.018 | ||
NEU1 | sialidase 1 (lysosomal sialidase) | 0.018 | ||
IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | 0.018 | ||
STK4 | serine/threonine kinase 4 | 0.018 | ||
SH2B1 | SH2B adaptor protein 1 | 0.018 | ||
SOCS6 | suppressor of cytokine signaling 6 | 0.018 | ||
PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 0.018 | ||
ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | 0.018 | ||
CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.017 | ||
DAZAP2 | DAZ associated protein 2 | 0.017 | ||
FKBP1A | FK506 binding protein 1A, 12kDa | 0.017 | ||
SLC35B2 | solute carrier family 35, member B2 | 0.017 | ||
PRR5 | proline rich 5 (renal) | 0.017 | ||
FYN | FYN oncogene related to SRC, FGR, YES | 0.017 | ||
ADAM10 | ADAM metallopeptidase domain 10 | 0.017 | ||
HEXB | hexosaminidase B (beta polypeptide) | 0.017 | Mouse | |
NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.017 | ||
F11R | F11 receptor | 0.016 | ||
NAGA | N-acetylgalactosaminidase, alpha- | 0.016 | ||
TMEM33 | transmembrane protein 33 | 0.016 | ||
PRR13 | proline rich 13 | 0.016 | ||
NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.015 | ||
BCAP31 | B-cell receptor-associated protein 31 | 0.015 | ||
GRB10 | growth factor receptor-bound protein 10 | 0.015 | ||
AMOTL2 | angiomotin like 2 | 0.015 | ||
DHCR7 | 7-dehydrocholesterol reductase | 0.015 | ||
RHEBL1 | Ras homolog enriched in brain like 1 | 0.015 | ||
RNPEP | arginyl aminopeptidase (aminopeptidase B) | 0.015 | ||
UBE2D1 | ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) | 0.015 | ||
PARD3 | par-3 partitioning defective 3 homolog (C. elegans) | 0.015 | ||
CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.015 | ||
ROD1 | ROD1 regulator of differentiation 1 (S. pombe) | 0.015 | ||
ATG7 | ATG7 autophagy related 7 homolog (S. cerevisiae) | 0.015 | ||
SYNGR2 | synaptogyrin 2 | 0.015 | ||
TRIM9 | tripartite motif containing 9 | 0.015 | ||
MAGEA2 | melanoma antigen family A, 2 | 0.015 | ||
PAG1 | phosphoprotein associated with glycosphingolipid microdomains 1 | 0.015 | ||
AUP1 | ancient ubiquitous protein 1 | 0.015 | ||
M6PR | mannose-6-phosphate receptor (cation dependent) | 0.015 | ||
SFN | stratifin | 0.014 | ||
SLC25A1 | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 | 0.014 | ||
CTSB | cathepsin B | 0.014 | ||
PNP | purine nucleoside phosphorylase | 0.014 | ||
TMEM41B | transmembrane protein 41B | 0.014 | ||
SPTLC2 | serine palmitoyltransferase, long chain base subunit 2 | 0.014 | Mouse | |
CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.014 | ||
P2RX4 | purinergic receptor P2X, ligand-gated ion channel, 4 | 0.014 | ||
TMBIM1 | transmembrane BAX inhibitor motif containing 1 | 0.014 | ||
UNC45A | unc-45 homolog A (C. elegans) | 0.014 | ||
RBPMS | RNA binding protein with multiple splicing | 0.014 | ||
IRS2 | insulin receptor substrate 2 | 0.014 | ||
MANBA | mannosidase, beta A, lysosomal | 0.014 | ||
IKBKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 0.014 | ||
CLIC1 | chloride intracellular channel 1 | 0.014 | ||
KIAA0174 | KIAA0174 | 0.014 | ||
DEGS1 | degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) | 0.014 | Mouse | |
LLGL1 | lethal giant larvae homolog 1 (Drosophila) | 0.014 | ||
SLC35B4 | solute carrier family 35, member B4 | 0.014 | ||
NCSTN | nicastrin | 0.014 | ||
IRS1 | insulin receptor substrate 1 | 0.014 | ||
CMTM6 | CKLF-like MARVEL transmembrane domain containing 6 | 0.014 | ||
ORMDL2 | ORM1-like 2 (S. cerevisiae) | 0.014 | ||
LARS | leucyl-tRNA synthetase | 0.014 | ||
IL6ST | interleukin 6 signal transducer (gp130, oncostatin M receptor) | 0.014 | ||
ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.013 | ||
STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.013 | ||
KLF4 | Kruppel-like factor 4 (gut) | 0.013 | ||
AP1S1 | adaptor-related protein complex 1, sigma 1 subunit | 0.013 | ||
STK17A | serine/threonine kinase 17a | 0.013 | ||
POFUT1 | protein O-fucosyltransferase 1 | 0.013 | ||
FUCA2 | fucosidase, alpha-L- 2, plasma | 0.013 | ||
PLOD3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 0.013 | ||
RBM47 | RNA binding motif protein 47 | 0.013 | ||
MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | 0.013 | ||
CBLC | Cas-Br-M (murine) ecotropic retroviral transforming sequence c | 0.013 | ||
NPC1 | Niemann-Pick disease, type C1 | 0.013 | ||
PRKACA | protein kinase, cAMP-dependent, catalytic, alpha | 0.013 | ||
RER1 | RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae) | 0.013 | ||
SWAP70 | SWAP switching B-cell complex 70kDa subunit | 0.013 | ||
AKT3 | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 0.013 | Human | |
GUSB | glucuronidase, beta | 0.013 | ||
PSEN1 | presenilin 1 | 0.012 | ||
SORBS2 | sorbin and SH3 domain containing 2 | 0.012 | ||
SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.012 | ||
YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 0.012 | ||
TUBB6 | tubulin, beta 6 | 0.012 | ||
THEM4 | thioesterase superfamily member 4 | 0.012 | ||
TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.012 | ||
TSC22D1 | TSC22 domain family, member 1 | 0.012 | ||
IFNGR1 | interferon gamma receptor 1 | 0.012 | ||
SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | 0.012 | ||
MAP1LC3A | microtubule-associated protein 1 light chain 3 alpha | 0.012 | ||
FHL2 | four and a half LIM domains 2 | 0.012 | ||
CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.012 | ||
SCPEP1 | serine carboxypeptidase 1 | 0.012 | ||
SPRR2A | small proline-rich protein 2A | 0.012 | ||
SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.012 | ||
ACVR1 | activin A receptor, type I | 0.012 | ||
PRDM8 | PR domain containing 8 | 0.012 | ||
PCDHA4 | protocadherin alpha 4 | 0.012 | ||
CTNS | cystinosis, nephropathic | 0.012 | ||
LPCAT1 | lysophosphatidylcholine acyltransferase 1 | 0.012 | ||
IL13RA1 | interleukin 13 receptor, alpha 1 | 0.012 | ||
SEPT11 | septin 11 | 0.012 | ||
TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.011 | ||
ATXN7L3 | ataxin 7-like 3 | 0.011 | ||
PEBP4 | phosphatidylethanolamine-binding protein 4 | 0.011 | ||
GSK3B | glycogen synthase kinase 3 beta | 0.011 | ||
TMEM50A | transmembrane protein 50A | 0.011 | ||
SESN2 | sestrin 2 | 0.011 | ||
GLA | galactosidase, alpha | 0.011 | Mouse | |
OSTM1 | osteopetrosis associated transmembrane protein 1 | 0.011 | ||
IL10RB | interleukin 10 receptor, beta | 0.011 | ||
CTSC | cathepsin C | 0.011 | ||
DLG1 | discs, large homolog 1 (Drosophila) | 0.011 | ||
CD164 | CD164 molecule, sialomucin | 0.011 | ||
ELOVL6 | ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) | 0.011 | ||
ETS1 | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | 0.011 | ||
YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 0.011 | ||
RHOB | ras homolog gene family, member B | 0.011 | ||
SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.011 | ||
SLC4A2 | solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) | 0.011 | ||
CTSH | cathepsin H | 0.011 | ||
TM9SF4 | transmembrane 9 superfamily protein member 4 | 0.011 | ||
MAP2K3 | mitogen-activated protein kinase kinase 3 | 0.011 | ||
TOR1A | torsin family 1, member A (torsin A) | 0.011 | ||
CREG1 | cellular repressor of E1A-stimulated genes 1 | 0.011 | ||
PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.011 | ||
ANXA5 | annexin A5 | 0.011 | ||
GLT25D1 | glycosyltransferase 25 domain containing 1 | 0.011 | ||
SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.011 | ||
DCTD | dCMP deaminase | 0.011 | ||
SNX18 | sorting nexin 18 | 0.011 | ||
SH2D2A | SH2 domain containing 2A | 0.011 | ||
DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.011 | ||
SCARB2 | scavenger receptor class B, member 2 | 0.011 | ||
C7orf42 | chromosome 7 open reading frame 42 | 0.011 | ||
BID | BH3 interacting domain death agonist | 0.011 | ||
SH2D1A | SH2 domain containing 1A | 0.011 | ||
PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.011 | ||
GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.011 | ||
RETSAT | retinol saturase (all-trans-retinol 13,14-reductase) | 0.011 | ||
SLC31A1 | solute carrier family 31 (copper transporters), member 1 | 0.011 | ||
RRAGD | Ras-related GTP binding D | 0.011 | ||
DTX1 | deltex homolog 1 (Drosophila) | 0.010 | ||
GPR137B | G protein-coupled receptor 137B | 0.010 | ||
PPP2R5A | protein phosphatase 2, regulatory subunit B', alpha | 0.010 | ||
DPYSL2 | dihydropyrimidinase-like 2 | 0.010 | ||
TM9SF2 | transmembrane 9 superfamily member 2 | 0.010 | ||
GANAB | glucosidase, alpha; neutral AB | 0.010 | ||
ZBTB43 | zinc finger and BTB domain containing 43 | 0.010 | ||
VIM | vimentin | 0.010 | ||
RNF149 | ring finger protein 149 | 0.010 | ||
LRRK2 | leucine-rich repeat kinase 2 | 0.010 | ||
FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.010 | ||
TGM1 | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) | 0.010 | ||
MPDU1 | mannose-P-dolichol utilization defect 1 | 0.010 | ||
LIPA | lipase A, lysosomal acid, cholesterol esterase | 0.010 | ||
INO80B | INO80 complex subunit B | 0.010 | ||
ARF5 | ADP-ribosylation factor 5 | 0.010 | ||
KIAA1598 | KIAA1598 | 0.010 | ||
DENND5A | DENN/MADD domain containing 5A | 0.010 | ||
PIGO | phosphatidylinositol glycan anchor biosynthesis, class O | 0.010 | ||
TMBIM4 | transmembrane BAX inhibitor motif containing 4 | 0.010 | ||
PTPLB | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b | 0.010 | ||
PLP2 | proteolipid protein 2 (colonic epithelium-enriched) | 0.010 | ||
C1orf93 | chromosome 1 open reading frame 93 | 0.010 | ||
MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.010 | ||
GNG10 | guanine nucleotide binding protein (G protein), gamma 10 | 0.010 | ||
SGPP1 | sphingosine-1-phosphate phosphatase 1 | 0.010 | ||
ALG2 | asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae) | 0.010 | ||
ALCAM | activated leukocyte cell adhesion molecule | 0.010 | ||
DNASE2 | deoxyribonuclease II, lysosomal | 0.010 | ||
ITM2A | integral membrane protein 2A | 0.010 | ||
SLC25A22 | solute carrier family 25 (mitochondrial carrier: glutamate), member 22 | 0.010 | ||
TPM4 | tropomyosin 4 | 0.010 |