IMP
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p38mapk cascade
An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "p38mapk cascade"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| MAPK14 | mitogen-activated protein kinase 14 | 0.992 | Mouse Worm | |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.956 | ||
| NRP1 | neuropilin 1 | 0.952 | ||
| GADD45GIP1 | growth arrest and DNA-damage-inducible, gamma interacting protein 1 | 0.940 | ||
| MAPK1 | mitogen-activated protein kinase 1 | 0.924 | ||
| FLT1 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 0.903 | ||
| MAP2K6 | mitogen-activated protein kinase kinase 6 | 0.731 | Worm | |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.695 | ||
| ZFP36L1 | zinc finger protein 36, C3H type-like 1 | 0.570 | ||
| SNTA1 | syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) | 0.533 | ||
| DUSP1 | dual specificity phosphatase 1 | 0.500 | ||
| MIDN | midnolin | 0.422 | ||
| MAPK3 | mitogen-activated protein kinase 3 | 0.409 | ||
| TRAF7 | TNF receptor-associated factor 7 | 0.394 | ||
| ATF2 | activating transcription factor 2 | 0.390 | ||
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.287 | ||
| LRRK2 | leucine-rich repeat kinase 2 | 0.236 | ||
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.217 | ||
| MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | 0.172 | ||
| MAPKAPK3 | mitogen-activated protein kinase-activated protein kinase 3 | 0.155 | ||
| PDGFB | platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) | 0.152 | Human | |
| VEGFA | vascular endothelial growth factor A | 0.142 | ||
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.112 | ||
| RPS28 | ribosomal protein S28 | 0.105 | ||
| DUSP7 | dual specificity phosphatase 7 | 0.103 | ||
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | 0.098 | ||
| PLCG1 | phospholipase C, gamma 1 | 0.097 | ||
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.081 | ||
| DUSP9 | dual specificity phosphatase 9 | 0.072 | ||
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.064 | ||
| MAP2K3 | mitogen-activated protein kinase kinase 3 | 0.063 | Worm | |
| CSNK1E | casein kinase 1, epsilon | 0.060 | ||
| RANBP3 | RAN binding protein 3 | 0.052 | ||
| PGF | placental growth factor | 0.051 | Human | |
| TAB1 | TGF-beta activated kinase 1/MAP3K7 binding protein 1 | 0.050 | ||
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.049 | ||
| PKN1 | protein kinase N1 | 0.045 | ||
| RPS6KA4 | ribosomal protein S6 kinase, 90kDa, polypeptide 4 | 0.045 | ||
| FSTL1 | follistatin-like 1 | 0.044 | ||
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.042 | ||
| RPS14 | ribosomal protein S14 | 0.041 | ||
| KDR | kinase insert domain receptor (a type III receptor tyrosine kinase) | 0.040 | ||
| ARRB1 | arrestin, beta 1 | 0.035 | ||
| MAP2K4 | mitogen-activated protein kinase kinase 4 | 0.035 | ||
| DUSP16 | dual specificity phosphatase 16 | 0.030 | ||
| COL4A1 | collagen, type IV, alpha 1 | 0.027 | ||
| RPS11 | ribosomal protein S11 | 0.025 | ||
| ARHGAP9 | Rho GTPase activating protein 9 | 0.024 | ||
| SOCS3 | suppressor of cytokine signaling 3 | 0.023 | ||
| EHD1 | EH-domain containing 1 | 0.023 | ||
| DUSP3 | dual specificity phosphatase 3 | 0.021 | ||
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.021 | ||
| MAPK11 | mitogen-activated protein kinase 11 | 0.020 | Worm | |
| PDGFC | platelet derived growth factor C | 0.019 | ||
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.018 | ||
| RB1 | retinoblastoma 1 | 0.018 | ||
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.017 | Human | |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.017 | ||
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.017 | ||
| MAP2K5 | mitogen-activated protein kinase kinase 5 | 0.016 | ||
| ZFYVE9 | zinc finger, FYVE domain containing 9 | 0.016 | ||
| CSRNP1 | cysteine-serine-rich nuclear protein 1 | 0.015 | ||
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.015 | ||
| SPG20 | spastic paraplegia 20 (Troyer syndrome) | 0.014 | ||
| RPS27 | ribosomal protein S27 | 0.014 | ||
| PTPN7 | protein tyrosine phosphatase, non-receptor type 7 | 0.013 | ||
| FLNB | filamin B, beta | 0.012 | ||
| CUL7 | cullin 7 | 0.012 | ||
| CDK9 | cyclin-dependent kinase 9 | 0.011 | ||
| UBE2B | ubiquitin-conjugating enzyme E2B (RAD6 homolog) | 0.011 | ||
| FAM48A | family with sequence similarity 48, member A | 0.010 |