IMP: Integrative Multi-species Prediction

Homo sapiens

4 genes annotated in human

type b pancreatic cell development

The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "type b pancreatic cell development"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "type b pancreatic cell development" (in gray)

Name	Description	Probability	Func Analog Organism
CCND1	cyclin D1	0.994
BMPR1A	bone morphogenetic protein receptor, type IA	0.975
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.972
CDK6	cyclin-dependent kinase 6	0.928
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.913
CDK4	cyclin-dependent kinase 4	0.845	Human
RB1	retinoblastoma 1	0.824
CCND3	cyclin D3	0.824
BMPR1B	bone morphogenetic protein receptor, type IB	0.651
ARNTL	aryl hydrocarbon receptor nuclear translocator-like	0.578	Mouse
CLOCK	clock homolog (mouse)	0.530	Mouse
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.384
CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.351
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.327
NOG	noggin	0.278
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.251
CCND2	cyclin D2	0.195
CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.148
FSTL1	follistatin-like 1	0.135
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.134
ZFYVE9	zinc finger, FYVE domain containing 9	0.109
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.106
RUNX1	runt-related transcription factor 1	0.083
CCNE1	cyclin E1	0.067
CDK2	cyclin-dependent kinase 2	0.058
AHR	aryl hydrocarbon receptor	0.058
BMP2	bone morphogenetic protein 2	0.054	Human
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.052
C1orf93	chromosome 1 open reading frame 93	0.040
CDK14	cyclin-dependent kinase 14	0.039
CDK11B	cyclin-dependent kinase 11B	0.036
HNF1A	HNF1 homeobox A	0.035
FZD1	frizzled homolog 1 (Drosophila)	0.035
CDKN2D	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.035
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.031
HNF4A	hepatocyte nuclear factor 4, alpha	0.029
CDK5	cyclin-dependent kinase 5	0.029
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.026
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	0.026
TRAP1	TNF receptor-associated protein 1	0.025
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.025
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.024
DTNBP1	dystrobrevin binding protein 1	0.024
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.023
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.023
PITX2	paired-like homeodomain 2	0.021
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.020
ZC3HC1	zinc finger, C3HC-type containing 1	0.020
TAL1	T-cell acute lymphocytic leukemia 1	0.019
NPAS2	neuronal PAS domain protein 2	0.018
EPAS1	endothelial PAS domain protein 1	0.018
FOXA2	forkhead box A2	0.017
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.017
HAND1	heart and neural crest derivatives expressed 1	0.016
KAT2B	K(lysine) acetyltransferase 2B	0.016
GJD2	gap junction protein, delta 2, 36kDa	0.016
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.016
PDX1	pancreatic and duodenal homeobox 1	0.015
CCNDBP1	cyclin D-type binding-protein 1	0.015
SNIP1	Smad nuclear interacting protein 1	0.015
NEUROD1	neurogenic differentiation 1	0.015
HOXC8	homeobox C8	0.015
COL2A1	collagen, type II, alpha 1	0.015
TDGF1	teratocarcinoma-derived growth factor 1	0.014
SPRED1	sprouty-related, EVH1 domain containing 1	0.014
TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	0.014
PROX1	prospero homeobox 1	0.014
MPP3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	0.014
SOX2	SRY (sex determining region Y)-box 2	0.014
MYT1	myelin transcription factor 1	0.014
HOXD8	homeobox D8	0.013
SLC22A2	solute carrier family 22 (organic cation transporter), member 2	0.013
FOXF1	forkhead box F1	0.013
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.013
SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.013
TGFB2	transforming growth factor, beta 2	0.013
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.013
FZD10	frizzled homolog 10 (Drosophila)	0.013
ULK2	unc-51-like kinase 2 (C. elegans)	0.013
FOXF2	forkhead box F2	0.013
LECT1	leukocyte cell derived chemotaxin 1	0.013
MAX	MYC associated factor X	0.013
HOXB7	homeobox B7	0.013
CCNA1	cyclin A1	0.013
FOXB1	forkhead box B1	0.013
HES2	hairy and enhancer of split 2 (Drosophila)	0.013
AIMP2	aminoacyl tRNA synthetase complex-interacting multifunctional protein 2	0.012
SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	0.012
USH1C	Usher syndrome 1C (autosomal recessive, severe)	0.012
MLLT3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	0.012
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.012
FGF4	fibroblast growth factor 4	0.012
HOXD10	homeobox D10	0.012
REG3A	regenerating islet-derived 3 alpha	0.012
AMY2A	amylase, alpha 2A (pancreatic)	0.012
KLHL12	kelch-like 12 (Drosophila)	0.012
XPNPEP2	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	0.012
SLC25A5	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5	0.012
MAF1	MAF1 homolog (S. cerevisiae)	0.012
ZIC3	Zic family member 3 (odd-paired homolog, Drosophila)	0.011
SOSTDC1	sclerostin domain containing 1	0.011
NKX3-2	NK3 homeobox 2	0.011
ONECUT1	one cut homeobox 1	0.011
ANXA13	annexin A13	0.011
MAN2A2	mannosidase, alpha, class 2A, member 2	0.011
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.011
NKX2-2	NK2 homeobox 2	0.011	Mouse
NPY5R	neuropeptide Y receptor Y5	0.011
GCKR	glucokinase (hexokinase 4) regulator	0.011
FAM46A	family with sequence similarity 46, member A	0.011
FZD8	frizzled homolog 8 (Drosophila)	0.011
SOX21	SRY (sex determining region Y)-box 21	0.011
POU3F4	POU class 3 homeobox 4	0.011
FEV	FEV (ETS oncogene family)	0.011
DCX	doublecortin	0.011
FGF3	fibroblast growth factor 3	0.011
RARA	retinoic acid receptor, alpha	0.011
OLIG2	oligodendrocyte lineage transcription factor 2	0.011
HS3ST2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	0.011
MNX1	motor neuron and pancreas homeobox 1	0.010
C15orf29	chromosome 15 open reading frame 29	0.010
GADD45G	growth arrest and DNA-damage-inducible, gamma	0.010
ANGPT2	angiopoietin 2	0.010
GPR50	G protein-coupled receptor 50	0.010
PAX6	paired box 6	0.010
INSM1	insulinoma-associated 1	0.010	Mouse
RAB3IL1	RAB3A interacting protein (rabin3)-like 1	0.010
IL1RAPL2	interleukin 1 receptor accessory protein-like 2	0.010
LGALS4	lectin, galactoside-binding, soluble, 4	0.010
SCRT1	scratch homolog 1, zinc finger protein (Drosophila)	0.010
PSORS1C2	psoriasis susceptibility 1 candidate 2	0.010
SIM2	single-minded homolog 2 (Drosophila)	0.010
PRPH2	peripherin 2 (retinal degeneration, slow)	0.010