IMP: Integrative Multi-species Prediction

Homo sapiens

3 genes annotated in human

menaquinone metabolic process

The chemical reactions and pathways involving any of the menaquinones, quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "menaquinone metabolic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "menaquinone metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.991
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.901
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.831
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.770	Human
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.557
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.555	Human
NLE1	notchless homolog 1 (Drosophila)	0.418
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.411
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.337
IPO4	importin 4	0.332
C8B	complement component 8, beta polypeptide	0.261
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.255
KNG1	kininogen 1	0.229
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.173
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.134
ADH6	alcohol dehydrogenase 6 (class V)	0.133
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.119
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	0.114
G6PC	glucose-6-phosphatase, catalytic subunit	0.108
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.106
GLYAT	glycine-N-acyltransferase	0.104
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.102	Human
C8A	complement component 8, alpha polypeptide	0.100
HAL	histidine ammonia-lyase	0.097
AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	0.086
FABP1	fatty acid binding protein 1, liver	0.085
NOL6	nucleolar protein family 6 (RNA-associated)	0.085
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.083
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.082
MAT1A	methionine adenosyltransferase I, alpha	0.081
PAH	phenylalanine hydroxylase	0.078
DAO	D-amino-acid oxidase	0.077
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.076
CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18	0.067
C4BPA	complement component 4 binding protein, alpha	0.058
AZGP1	alpha-2-glycoprotein 1, zinc-binding	0.056
RDH16	retinol dehydrogenase 16 (all-trans)	0.053
F9	coagulation factor IX	0.051
OTC	ornithine carbamoyltransferase	0.051
ARG1	arginase, liver	0.049
PLG	plasminogen	0.047
GSTA3	glutathione S-transferase alpha 3	0.046
FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	0.046
HRG	histidine-rich glycoprotein	0.045
BHMT	betaine--homocysteine S-methyltransferase	0.042
DPH2	DPH2 homolog (S. cerevisiae)	0.039
HGD	homogentisate 1,2-dioxygenase	0.039
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.036
EPHX2	epoxide hydrolase 2, cytoplasmic	0.032
FABP2	fatty acid binding protein 2, intestinal	0.032
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.031
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	0.030
AADAC	arylacetamide deacetylase (esterase)	0.030
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.029
F13B	coagulation factor XIII, B polypeptide	0.029
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.029
SLC22A1	solute carrier family 22 (organic cation transporter), member 1	0.028
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.027
GPX2	glutathione peroxidase 2 (gastrointestinal)	0.026
HPD	4-hydroxyphenylpyruvate dioxygenase	0.026
PIP	prolactin-induced protein	0.026
PRLR	prolactin receptor	0.025
HAO2	hydroxyacid oxidase 2 (long chain)	0.025
SCGB2A1	secretoglobin, family 2A, member 1	0.025
DEFB1	defensin, beta 1	0.025
CYP2J2	cytochrome P450, family 2, subfamily J, polypeptide 2	0.024
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.024
DIO1	deiodinase, iodothyronine, type I	0.023
GBA3	glucosidase, beta, acid 3 (cytosolic)	0.022
HNF4A	hepatocyte nuclear factor 4, alpha	0.022
MASP2	mannan-binding lectin serine peptidase 2	0.022
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.021
ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.021
GYS2	glycogen synthase 2 (liver)	0.021
ORM1	orosomucoid 1	0.021
CEACAM8	carcinoembryonic antigen-related cell adhesion molecule 8	0.021
SEC14L2	SEC14-like 2 (S. cerevisiae)	0.021
HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2	0.021
S100A14	S100 calcium binding protein A14	0.020
APOC3	apolipoprotein C-III	0.020
SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1	0.020
FETUB	fetuin B	0.020
FMO4	flavin containing monooxygenase 4	0.019
LIPC	lipase, hepatic	0.019
SLC13A2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	0.019
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.019
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.019
DDX31	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	0.019
LPA	lipoprotein, Lp(a)	0.019
AKR1D1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	0.019
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.019
GRWD1	glutamate-rich WD repeat containing 1	0.018
ADH1A	alcohol dehydrogenase 1A (class I), alpha polypeptide	0.018
CPB2	carboxypeptidase B2 (plasma)	0.018
C9	complement component 9	0.018
ORM2	orosomucoid 2	0.017
CYP4F8	cytochrome P450, family 4, subfamily F, polypeptide 8	0.017	Human
SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	0.017
NAT8	N-acetyltransferase 8 (GCN5-related, putative)	0.017
CRP	C-reactive protein, pentraxin-related	0.016
ALDH3A1	aldehyde dehydrogenase 3 family, member A1	0.016
PRODH	proline dehydrogenase (oxidase) 1	0.016
F5	coagulation factor V (proaccelerin, labile factor)	0.016
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.016
CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	0.016
GSTT1	glutathione S-transferase theta 1	0.015
KRT13	keratin 13	0.015
CCDC86	coiled-coil domain containing 86	0.015
AGXT2	alanine--glyoxylate aminotransferase 2	0.015
NR1H4	nuclear receptor subfamily 1, group H, member 4	0.015
CRISP3	cysteine-rich secretory protein 3	0.015
CYP8B1	cytochrome P450, family 8, subfamily B, polypeptide 1	0.015
LETM1	leucine zipper-EF-hand containing transmembrane protein 1	0.015
SPINK1	serine peptidase inhibitor, Kazal type 1	0.015
PMM2	phosphomannomutase 2	0.015
TM4SF4	transmembrane 4 L six family member 4	0.014
CYP4B1	cytochrome P450, family 4, subfamily B, polypeptide 1	0.014	Human
KHK	ketohexokinase (fructokinase)	0.014
ANGPTL3	angiopoietin-like 3	0.014
IL22RA1	interleukin 22 receptor, alpha 1	0.014
ANXA13	annexin A13	0.014
KLKB1	kallikrein B, plasma (Fletcher factor) 1	0.014
ADRA1A	adrenergic, alpha-1A-, receptor	0.014
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.014
KIAA0664	KIAA0664	0.014
HPX	hemopexin	0.014
BBOX1	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	0.013
PIPOX	pipecolic acid oxidase	0.013
POF1B	premature ovarian failure, 1B	0.013
CDHR5	cadherin-related family member 5	0.013
APOF	apolipoprotein F	0.013
SLC28A1	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	0.013
GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	0.013
C8G	complement component 8, gamma polypeptide	0.013
ALDH1L1	aldehyde dehydrogenase 1 family, member L1	0.013
VTCN1	V-set domain containing T cell activation inhibitor 1	0.012
PKLR	pyruvate kinase, liver and RBC	0.012
CRISP2	cysteine-rich secretory protein 2	0.012
AKR1B10	aldo-keto reductase family 1, member B10 (aldose reductase)	0.012
UGT2B4	UDP glucuronosyltransferase 2 family, polypeptide B4	0.012
SLC5A6	solute carrier family 5 (sodium-dependent vitamin transporter), member 6	0.012
MOSC1	MOCO sulphurase C-terminal domain containing 1	0.011
AQP7	aquaporin 7	0.011
SCNN1A	sodium channel, nonvoltage-gated 1 alpha	0.011
CES1	carboxylesterase 1	0.011
ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	0.011
CLDN8	claudin 8	0.011
ADH4	alcohol dehydrogenase 4 (class II), pi polypeptide	0.011
IL1RL2	interleukin 1 receptor-like 2	0.011
TRMU	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase	0.011
HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2	0.010
CCL16	chemokine (C-C motif) ligand 16	0.010
MSMB	microseminoprotein, beta-	0.010
FMO5	flavin containing monooxygenase 5	0.010
MGAM	maltase-glucoamylase (alpha-glucosidase)	0.010
SLC22A7	solute carrier family 22 (organic anion transporter), member 7	0.010
CPN1	carboxypeptidase N, polypeptide 1	0.010
C4BPB	complement component 4 binding protein, beta	0.010
C14orf105	chromosome 14 open reading frame 105	0.010
TMC5	transmembrane channel-like 5	0.010
SLC26A3	solute carrier family 26, member 3	0.010
SLC38A3	solute carrier family 38, member 3	0.010