IMP: Integrative Multi-species Prediction

Homo sapiens

31 genes annotated in human

fatty acid oxidation

GO:0019395

The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "fatty acid oxidation"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "fatty acid oxidation" (in gray)

Name	Description	Probability	Func Analog Organism
PEX19	peroxisomal biogenesis factor 19	0.975
HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	0.918	Rat Fly
SCP2	sterol carrier protein 2	0.907
HADH	hydroxyacyl-CoA dehydrogenase	0.826	Rat
DECR1	2,4-dienoyl CoA reductase 1, mitochondrial	0.731
CAT	catalase	0.649
ETFB	electron-transfer-flavoprotein, beta polypeptide	0.645
ECH1	enoyl CoA hydratase 1, peroxisomal	0.585
PEX14	peroxisomal biogenesis factor 14	0.568
ACAA1	acetyl-CoA acyltransferase 1	0.516
HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	0.350	Mouse Fly
CPT2	carnitine palmitoyltransferase 2	0.337
INSR	insulin receptor	0.317
GRB10	growth factor receptor-bound protein 10	0.245
PHYH	phytanoyl-CoA 2-hydroxylase	0.230
TST	thiosulfate sulfurtransferase (rhodanese)	0.229
PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.194
ECI2	enoyl-CoA delta isomerase 2	0.180	Rat
ACADSB	acyl-CoA dehydrogenase, short/branched chain	0.164
NCOR2	nuclear receptor corepressor 2	0.129
ECHS1	enoyl CoA hydratase, short chain, 1, mitochondrial	0.122	Rat
ECI1	enoyl-CoA delta isomerase 1	0.122
ETFDH	electron-transferring-flavoprotein dehydrogenase	0.118
C21orf33	chromosome 21 open reading frame 33	0.112
SETD8	SET domain containing (lysine methyltransferase) 8	0.109
ACAT1	acetyl-CoA acetyltransferase 1	0.106
ACADVL	acyl-CoA dehydrogenase, very long chain	0.102	Mouse Rat
MCCC1	methylcrotonoyl-CoA carboxylase 1 (alpha)	0.094
PXMP2	peroxisomal membrane protein 2, 22kDa	0.090
SQSTM1	sequestosome 1	0.086
NOXA1	NADPH oxidase activator 1	0.083
PEX12	peroxisomal biogenesis factor 12	0.078
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.077
GRHPR	glyoxylate reductase/hydroxypyruvate reductase	0.073
ACAA2	acetyl-CoA acyltransferase 2	0.063	Rat
PEX3	peroxisomal biogenesis factor 3	0.061
MUT	methylmalonyl CoA mutase	0.060
GABARAPL1	GABA(A) receptor-associated protein like 1	0.055
HNF4A	hepatocyte nuclear factor 4, alpha	0.053
AKR7A2	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	0.052
DCXR	dicarbonyl/L-xylulose reductase	0.050
BCKDHB	branched chain keto acid dehydrogenase E1, beta polypeptide	0.050
UQCRC2	ubiquinol-cytochrome c reductase core protein II	0.047
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.045
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.044
NNT	nicotinamide nucleotide transhydrogenase	0.044
RPTOR	regulatory associated protein of MTOR, complex 1	0.044
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.042
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.041
CYB5A	cytochrome b5 type A (microsomal)	0.041
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.040
GATA2	GATA binding protein 2	0.040
SLC25A20	solute carrier family 25 (carnitine/acylcarnitine translocase), member 20	0.038
ALDH6A1	aldehyde dehydrogenase 6 family, member A1	0.037
ALDH3A2	aldehyde dehydrogenase 3 family, member A2	0.037
HSDL2	hydroxysteroid dehydrogenase like 2	0.037
IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	0.037
ADH5	alcohol dehydrogenase 5 (class III), chi polypeptide	0.037
NDUFB5	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa	0.037
NME2	non-metastatic cells 2, protein (NM23B) expressed in	0.035
RARA	retinoic acid receptor, alpha	0.034
HSD17B4	hydroxysteroid (17-beta) dehydrogenase 4	0.034
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.033
HIBCH	3-hydroxyisobutyryl-CoA hydrolase	0.033
SH3RF1	SH3 domain containing ring finger 1	0.033
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.032
MAPT	microtubule-associated protein tau	0.032
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.032
PRKAG1	protein kinase, AMP-activated, gamma 1 non-catalytic subunit	0.031
NCF1	neutrophil cytosolic factor 1	0.031
GBAS	glioblastoma amplified sequence	0.030
HIBADH	3-hydroxyisobutyrate dehydrogenase	0.028
ESRRG	estrogen-related receptor gamma	0.027
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.027
ULK1	unc-51-like kinase 1 (C. elegans)	0.026
SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.026
SLC25A1	solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1	0.025
SUCLG2	succinate-CoA ligase, GDP-forming, beta subunit	0.025
KAT2B	K(lysine) acetyltransferase 2B	0.025
ALDH9A1	aldehyde dehydrogenase 9 family, member A1	0.025
PEX11B	peroxisomal biogenesis factor 11 beta	0.024
CCL14	chemokine (C-C motif) ligand 14	0.024
TCF12	transcription factor 12	0.024
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.023	Human
RUNX1	runt-related transcription factor 1	0.023
PICK1	protein interacting with PRKCA 1	0.023
PRKCZ	protein kinase C, zeta	0.023	Human
CRAT	carnitine O-acetyltransferase	0.022	Human
NBR1	neighbor of BRCA1 gene 1	0.022
SUOX	sulfite oxidase	0.022
BAG3	BCL2-associated athanogene 3	0.022
AKT1S1	AKT1 substrate 1 (proline-rich)	0.022
SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa	0.021
NDUFS2	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	0.021
PGM1	phosphoglucomutase 1	0.021
PHKB	phosphorylase kinase, beta	0.021
IGF1R	insulin-like growth factor 1 receptor	0.021
IDH2	isocitrate dehydrogenase 2 (NADP+), mitochondrial	0.021	Yeast
KRT5	keratin 5	0.020
ACOX1	acyl-CoA oxidase 1, palmitoyl	0.020
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.020
ADH1A	alcohol dehydrogenase 1A (class I), alpha polypeptide	0.019	Human
ACADS	acyl-CoA dehydrogenase, C-2 to C-3 short chain	0.019	Rat
PEBP1	phosphatidylethanolamine binding protein 1	0.018
KEAP1	kelch-like ECH-associated protein 1	0.018
EHHADH	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	0.018
DGAT1	diacylglycerol O-acyltransferase 1	0.018
ACACA	acetyl-CoA carboxylase alpha	0.018
CHD9	chromodomain helicase DNA binding protein 9	0.018
CDCP1	CUB domain containing protein 1	0.018
IMPA2	inositol(myo)-1(or 4)-monophosphatase 2	0.018
DCTN1	dynactin 1	0.017
HRSP12	heat-responsive protein 12	0.017
PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	0.017
PDPK1	3-phosphoinositide dependent protein kinase-1	0.017
PGRMC1	progesterone receptor membrane component 1	0.017
RETSAT	retinol saturase (all-trans-retinol 13,14-reductase)	0.016
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.016
ALDH4A1	aldehyde dehydrogenase 4 family, member A1	0.016
FABP1	fatty acid binding protein 1, liver	0.016	Rat
NME3	non-metastatic cells 3, protein expressed in	0.016
PCCB	propionyl CoA carboxylase, beta polypeptide	0.016
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.016
MPST	mercaptopyruvate sulfurtransferase	0.016
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.015
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.015	Human
PRKCB	protein kinase C, beta	0.015
TAL1	T-cell acute lymphocytic leukemia 1	0.015	Human
C14orf1	chromosome 14 open reading frame 1	0.015
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.015
MLYCD	malonyl-CoA decarboxylase	0.015
GSTZ1	glutathione transferase zeta 1	0.015
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.015
MIPEP	mitochondrial intermediate peptidase	0.015
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.014	Human
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.014
MYOD1	myogenic differentiation 1	0.014
FAH	fumarylacetoacetate hydrolase (fumarylacetoacetase)	0.014
BCKDHA	branched chain keto acid dehydrogenase E1, alpha polypeptide	0.014
MGST2	microsomal glutathione S-transferase 2	0.014
ACO2	aconitase 2, mitochondrial	0.014
EPHX2	epoxide hydrolase 2, cytoplasmic	0.014
ACSM5	acyl-CoA synthetase medium-chain family member 5	0.014
SOS1	son of sevenless homolog 1 (Drosophila)	0.014
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.014
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.013
MAT1A	methionine adenosyltransferase I, alpha	0.013
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.013
SORBS2	sorbin and SH3 domain containing 2	0.013
ANGPTL3	angiopoietin-like 3	0.013
ASL	argininosuccinate lyase	0.013
COQ5	coenzyme Q5 homolog, methyltransferase (S. cerevisiae)	0.013
HOXD12	homeobox D12	0.013
NR1H3	nuclear receptor subfamily 1, group H, member 3	0.013
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.013
PHOX2A	paired-like homeobox 2a	0.013
ACAD8	acyl-CoA dehydrogenase family, member 8	0.013
AUH	AU RNA binding protein/enoyl-CoA hydratase	0.013
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.013
AADAC	arylacetamide deacetylase (esterase)	0.013
PDX1	pancreatic and duodenal homeobox 1	0.013
NIPSNAP1	nipsnap homolog 1 (C. elegans)	0.013
ETFA	electron-transfer-flavoprotein, alpha polypeptide	0.013	Zebrafish
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.013
GSTK1	glutathione S-transferase kappa 1	0.013
RAB4A	RAB4A, member RAS oncogene family	0.013
CYBA	cytochrome b-245, alpha polypeptide	0.012
PPP2R4	protein phosphatase 2A activator, regulatory subunit 4	0.012
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.012
ALAD	aminolevulinate dehydratase	0.012
F8	coagulation factor VIII, procoagulant component	0.012
NCOR1	nuclear receptor corepressor 1	0.012
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.012
AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	0.012
SEPP1	selenoprotein P, plasma, 1	0.012
C8A	complement component 8, alpha polypeptide	0.012
DECR2	2,4-dienoyl CoA reductase 2, peroxisomal	0.012
PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	0.012
FHOD3	formin homology 2 domain containing 3	0.012
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.012
PEX16	peroxisomal biogenesis factor 16	0.011
IVD	isovaleryl-CoA dehydrogenase	0.011
FABP4	fatty acid binding protein 4, adipocyte	0.011
SESN2	sestrin 2	0.011	Mouse
PPARG	peroxisome proliferator-activated receptor gamma	0.011	Rat
PRDX6	peroxiredoxin 6	0.011
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.011
ISOC1	isochorismatase domain containing 1	0.011
TSC22D1	TSC22 domain family, member 1	0.011
STK4	serine/threonine kinase 4	0.011
G6PC	glucose-6-phosphatase, catalytic subunit	0.011
HIPK2	homeodomain interacting protein kinase 2	0.011
C4BPA	complement component 4 binding protein, alpha	0.011
LRBA	LPS-responsive vesicle trafficking, beach and anchor containing	0.011
ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	0.011	Human
PRR5	proline rich 5 (renal)	0.011
ACOT13	acyl-CoA thioesterase 13	0.011
ACSL1	acyl-CoA synthetase long-chain family member 1	0.011
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.011
BRP44	brain protein 44	0.011
NDUFS1	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	0.011
PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	0.011
NUDT6	nudix (nucleoside diphosphate linked moiety X)-type motif 6	0.011
AQP7	aquaporin 7	0.011
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.011
OTC	ornithine carbamoyltransferase	0.011
CBR4	carbonyl reductase 4	0.010
TTPA	tocopherol (alpha) transfer protein	0.010
COQ9	coenzyme Q9 homolog (S. cerevisiae)	0.010
C6	complement component 6	0.010
RICTOR	RPTOR independent companion of MTOR, complex 2	0.010
OXA1L	oxidase (cytochrome c) assembly 1-like	0.010
EIF4EBP1	eukaryotic translation initiation factor 4E binding protein 1	0.010
AZGP1	alpha-2-glycoprotein 1, zinc-binding	0.010
EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	0.010
NDUFV1	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	0.010
BHMT	betaine--homocysteine S-methyltransferase	0.010
BLVRB	biliverdin reductase B (flavin reductase (NADPH))	0.010
ALAS1	aminolevulinate, delta-, synthase 1	0.010
SUCLG1	succinate-CoA ligase, alpha subunit	0.010
LMF2	lipase maturation factor 2	0.010
ECHDC2	enoyl CoA hydratase domain containing 2	0.010
FMO4	flavin containing monooxygenase 4	0.010
KIAA0564	KIAA0564	0.010
BDH2	3-hydroxybutyrate dehydrogenase, type 2	0.010