IMP: Integrative Multi-species Prediction

Homo sapiens

38 genes annotated in human

Multi-species View

membrane protein proteolysis

GO:0033619

The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "membrane protein proteolysis"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "membrane protein proteolysis" (in gray)

Name	Description	Probability	Func Analog Organism
ADAM15	ADAM metallopeptidase domain 15	1.000	Human
SNX9	sorting nexin 9	0.988
FASLG	Fas ligand (TNF superfamily, member 6)	0.987
PSEN1	presenilin 1	0.939
APP	amyloid beta (A4) precursor protein	0.929
NCSTN	nicastrin	0.898
DNM1	dynamin 1	0.880
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.838
SNX33	sorting nexin 33	0.838
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.834
DNM2	dynamin 2	0.814
IL1R1	interleukin 1 receptor, type I	0.769
NCF1	neutrophil cytosolic factor 1	0.760
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.640
TRAF5	TNF receptor-associated factor 5	0.618
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.593
TRAF1	TNF receptor-associated factor 1	0.578
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.536
PACSIN1	protein kinase C and casein kinase substrate in neurons 1	0.470	Human
ABI2	abl-interactor 2	0.448
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.446
TRADD	TNFRSF1A-associated via death domain	0.435
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.387
NCF2	neutrophil cytosolic factor 2	0.327
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.249
GHR	growth hormone receptor	0.219
PSEN2	presenilin 2 (Alzheimer disease 4)	0.216
DLG1	discs, large homolog 1 (Drosophila)	0.214
FLNB	filamin B, beta	0.213
IL22RA2	interleukin 22 receptor, alpha 2	0.211
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.204
UTRN	utrophin	0.191
A2M	alpha-2-macroglobulin	0.190
TRAF2	TNF receptor-associated factor 2	0.187
HP	haptoglobin	0.180
CD63	CD63 molecule	0.170
IL10RA	interleukin 10 receptor, alpha	0.158
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.150
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.150
PSENEN	presenilin enhancer 2 homolog (C. elegans)	0.117
ADAM12	ADAM metallopeptidase domain 12	0.115	Human
CYBA	cytochrome b-245, alpha polypeptide	0.114
IL1RN	interleukin 1 receptor antagonist	0.111	Human
BIRC3	baculoviral IAP repeat containing 3	0.108
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.108	Human
FNBP1	formin binding protein 1	0.102
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.100
SH3D19	SH3 domain containing 19	0.096
PTPN18	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	0.093
BCAR1	breast cancer anti-estrogen resistance 1	0.093
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.091
SNAP23	synaptosomal-associated protein, 23kDa	0.085
APOC1	apolipoprotein C-I	0.083
IL1B	interleukin 1, beta	0.081
FYN	FYN oncogene related to SRC, FGR, YES	0.080
TRAF3	TNF receptor-associated factor 3	0.080
ITK	IL2-inducible T-cell kinase	0.079
CTSA	cathepsin A	0.077
YAP1	Yes-associated protein 1	0.077
IL22RA1	interleukin 22 receptor, alpha 1	0.075
AGTR2	angiotensin II receptor, type 2	0.075
PSAP	prosaposin	0.072
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.072
CD14	CD14 molecule	0.070
IL1R2	interleukin 1 receptor, type II	0.067
HCK	hemopoietic cell kinase	0.066
ANKRD28	ankyrin repeat domain 28	0.065
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.064
SH3PXD2A	SH3 and PX domains 2A	0.064
LAMP1	lysosomal-associated membrane protein 1	0.060
IL1RAP	interleukin 1 receptor accessory protein	0.059
TNF	tumor necrosis factor	0.054
MYL9	myosin, light chain 9, regulatory	0.053
P4HB	prolyl 4-hydroxylase, beta polypeptide	0.048
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.046
RIPK2	receptor-interacting serine-threonine kinase 2	0.046
WASL	Wiskott-Aldrich syndrome-like	0.045
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.045
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.044
PTPRA	protein tyrosine phosphatase, receptor type, A	0.043
TGFBI	transforming growth factor, beta-induced, 68kDa	0.043
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.042
LCAT	lecithin-cholesterol acyltransferase	0.042
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.041
PLAUR	plasminogen activator, urokinase receptor	0.038
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.038
CD44	CD44 molecule (Indian blood group)	0.037
TRPM6	transient receptor potential cation channel, subfamily M, member 6	0.037
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.037
TP73	tumor protein p73	0.036
ADAM9	ADAM metallopeptidase domain 9	0.034
APOC3	apolipoprotein C-III	0.033
MED28	mediator complex subunit 28	0.032
CCL20	chemokine (C-C motif) ligand 20	0.031
IGFBP3	insulin-like growth factor binding protein 3	0.031
IFI30	interferon, gamma-inducible protein 30	0.030
ACTA2	actin, alpha 2, smooth muscle, aorta	0.030
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.029
PKP4	plakophilin 4	0.029
FGA	fibrinogen alpha chain	0.028
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.027
ARRDC3	arrestin domain containing 3	0.027
ITSN1	intersectin 1 (SH3 domain protein)	0.027
PLD3	phospholipase D family, member 3	0.027
HSPA6	heat shock 70kDa protein 6 (HSP70B')	0.026
MAPT	microtubule-associated protein tau	0.025
BTK	Bruton agammaglobulinemia tyrosine kinase	0.025
DDX4	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	0.025
TIMP2	TIMP metallopeptidase inhibitor 2	0.024	Human
IQGAP1	IQ motif containing GTPase activating protein 1	0.024
CCL22	chemokine (C-C motif) ligand 22	0.024
IL13RA1	interleukin 13 receptor, alpha 1	0.024
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.024
TRPM7	transient receptor potential cation channel, subfamily M, member 7	0.024
CCL4	chemokine (C-C motif) ligand 4	0.024
TRAM1	translocation associated membrane protein 1	0.024
CLPTM1	cleft lip and palate associated transmembrane protein 1	0.023
NPC2	Niemann-Pick disease, type C2	0.023
GRN	granulin	0.023
TNKS2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	0.022
SRCIN1	SRC kinase signaling inhibitor 1	0.022
CIB1	calcium and integrin binding 1 (calmyrin)	0.022
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.022
AMPH	amphiphysin	0.022
PLAU	plasminogen activator, urokinase	0.022
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.021
PTPRB	protein tyrosine phosphatase, receptor type, B	0.021
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.021
USP45	ubiquitin specific peptidase 45	0.020
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	0.020
TOM1	target of myb1 (chicken)	0.020
FTL	ferritin, light polypeptide	0.020
CTTN	cortactin	0.020
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.020
CPD	carboxypeptidase D	0.019
C19orf6	chromosome 19 open reading frame 6	0.019
MPDZ	multiple PDZ domain protein	0.019
MYO1E	myosin IE	0.019
SRSF6	serine/arginine-rich splicing factor 6	0.019
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.019
IGF2R	insulin-like growth factor 2 receptor	0.018
DEFB4A	defensin, beta 4A	0.018
FLNA	filamin A, alpha	0.018
ABHD16A	abhydrolase domain containing 16A	0.018
TRAF3IP2	TRAF3 interacting protein 2	0.018
ADAM10	ADAM metallopeptidase domain 10	0.018
TRAF3IP1	TNF receptor-associated factor 3 interacting protein 1	0.018
PLTP	phospholipid transfer protein	0.018
IL10	interleukin 10	0.018
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.018
BCL2A1	BCL2-related protein A1	0.018
TPM4	tropomyosin 4	0.018
BCL2L1	BCL2-like 1	0.017
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.017
ACTN1	actinin, alpha 1	0.017
TMOD3	tropomodulin 3 (ubiquitous)	0.017
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.017
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.017
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.017
VAT1	vesicle amine transport protein 1 homolog (T. californica)	0.017
SH3RF3	SH3 domain containing ring finger 3	0.016
WIPF1	WAS/WASL interacting protein family, member 1	0.016
ADRB2	adrenergic, beta-2-, receptor, surface	0.016	Human
TGOLN2	trans-golgi network protein 2	0.016
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.016
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.016
S100A11	S100 calcium binding protein A11	0.016
DDR2	discoidin domain receptor tyrosine kinase 2	0.016
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.016
HNRNPA3	heterogeneous nuclear ribonucleoprotein A3	0.016
ALB	albumin	0.016
PTPN21	protein tyrosine phosphatase, non-receptor type 21	0.015	Human
PDIA3	protein disulfide isomerase family A, member 3	0.015
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.015
GNS	glucosamine (N-acetyl)-6-sulfatase	0.015
TIFA	TRAF-interacting protein with forkhead-associated domain	0.015
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.015
LNX1	ligand of numb-protein X 1	0.015
ERO1L	ERO1-like (S. cerevisiae)	0.015
CTSB	cathepsin B	0.015
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.015
TXNDC2	thioredoxin domain containing 2 (spermatozoa)	0.015
ADAM17	ADAM metallopeptidase domain 17	0.015
DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.015
SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	0.015
CST3	cystatin C	0.015
NPHP1	nephronophthisis 1 (juvenile)	0.015
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.014
CNR2	cannabinoid receptor 2 (macrophage)	0.014
STX11	syntaxin 11	0.014
FSTL3	follistatin-like 3 (secreted glycoprotein)	0.014
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.014
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.014
APOA2	apolipoprotein A-II	0.014
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.014
CAPG	capping protein (actin filament), gelsolin-like	0.014
MAN2B1	mannosidase, alpha, class 2B, member 1	0.014
ICAM1	intercellular adhesion molecule 1	0.013
ADAM2	ADAM metallopeptidase domain 2	0.013	Human
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.013
CCL11	chemokine (C-C motif) ligand 11	0.013
WWC1	WW and C2 domain containing 1	0.013
MAPK1	mitogen-activated protein kinase 1	0.013
HMOX1	heme oxygenase (decycling) 1	0.013
IL1F5	interleukin 1 family, member 5 (delta)	0.013
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.013
IL1A	interleukin 1, alpha	0.013	Human
IL4	interleukin 4	0.013
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.013
LBP	lipopolysaccharide binding protein	0.013
TANK	TRAF family member-associated NFKB activator	0.013
TMEM173	transmembrane protein 173	0.013
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.013
TCN2	transcobalamin II	0.013
RAD23A	RAD23 homolog A (S. cerevisiae)	0.013
IL2RA	interleukin 2 receptor, alpha	0.013
PBX1	pre-B-cell leukemia homeobox 1	0.013
ZNF512B	zinc finger protein 512B	0.012
ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	0.012
IFNG	interferon, gamma	0.012
CD83	CD83 molecule	0.012
PLEC	plectin	0.012
CXCL5	chemokine (C-X-C motif) ligand 5	0.012
SOS2	son of sevenless homolog 2 (Drosophila)	0.012
PTPRE	protein tyrosine phosphatase, receptor type, E	0.012
RNF17	ring finger protein 17	0.012
TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	0.012	Human
PI3	peptidase inhibitor 3, skin-derived	0.012
ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	0.012
TSHR	thyroid stimulating hormone receptor	0.012
GRB2	growth factor receptor-bound protein 2	0.012
CLIC4	chloride intracellular channel 4	0.012
NRP2	neuropilin 2	0.012
LEP	leptin	0.012
ZFYVE1	zinc finger, FYVE domain containing 1	0.012
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A	0.012	Human
CD68	CD68 molecule	0.012
COL10A1	collagen, type X, alpha 1	0.012
PLOD1	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	0.012
GPX3	glutathione peroxidase 3 (plasma)	0.011
CXCR3	chemokine (C-X-C motif) receptor 3	0.011
IL19	interleukin 19	0.011	Human
GM2A	GM2 ganglioside activator	0.011
FURIN	furin (paired basic amino acid cleaving enzyme)	0.011
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.011
DTX1	deltex homolog 1 (Drosophila)	0.011
GAB2	GRB2-associated binding protein 2	0.011
FTH1	ferritin, heavy polypeptide 1	0.011
CD81	CD81 molecule	0.011
GAA	glucosidase, alpha; acid	0.011
GALNT7	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)	0.011
CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	0.011
TULP2	tubby like protein 2	0.011
CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18	0.011
ADAM18	ADAM metallopeptidase domain 18	0.011	Human
ECSIT	ECSIT homolog (Drosophila)	0.011
TAGLN2	transgelin 2	0.011
CCL1	chemokine (C-C motif) ligand 1	0.011
IFNGR1	interferon gamma receptor 1	0.011
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.011
CXCR6	chemokine (C-X-C motif) receptor 6	0.011
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.011
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.011
GPNMB	glycoprotein (transmembrane) nmb	0.011
PTPN9	protein tyrosine phosphatase, non-receptor type 9	0.011
SCAMP1	secretory carrier membrane protein 1	0.011
ACTN4	actinin, alpha 4	0.011
AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.011
DRD1	dopamine receptor D1	0.011	Human
GFI1B	growth factor independent 1B transcription repressor	0.011
SKAP2	src kinase associated phosphoprotein 2	0.011
KALRN	kalirin, RhoGEF kinase	0.011
KCTD15	potassium channel tetramerisation domain containing 15	0.010
SNCG	synuclein, gamma (breast cancer-specific protein 1)	0.010
ARHGAP9	Rho GTPase activating protein 9	0.010
TREM1	triggering receptor expressed on myeloid cells 1	0.010
ANXA5	annexin A5	0.010
TP53BP2	tumor protein p53 binding protein, 2	0.010
ECM1	extracellular matrix protein 1	0.010
SLAMF7	SLAM family member 7	0.010
COPG2	coatomer protein complex, subunit gamma 2	0.010
FAM63B	family with sequence similarity 63, member B	0.010
IL1F9	interleukin 1 family, member 9	0.010	Human
GYPA	glycophorin A (MNS blood group)	0.010
IRAK2	interleukin-1 receptor-associated kinase 2	0.010
CTSL1	cathepsin L1	0.010
TNIP2	TNFAIP3 interacting protein 2	0.010
GFRA1	GDNF family receptor alpha 1	0.010
SIRPA	signal-regulatory protein alpha	0.010
PPP6R3	protein phosphatase 6, regulatory subunit 3	0.010
GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	0.010
FCGRT	Fc fragment of IgG, receptor, transporter, alpha	0.010
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.010
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.010
AQP9	aquaporin 9	0.010
CCL7	chemokine (C-C motif) ligand 7	0.010
CCR9	chemokine (C-C motif) receptor 9	0.010
EHMT2	euchromatic histone-lysine N-methyltransferase 2	0.010
THBS2	thrombospondin 2	0.010
S100A4	S100 calcium binding protein A4	0.010
SH3GL1	SH3-domain GRB2-like 1	0.010
SOS1	son of sevenless homolog 1 (Drosophila)	0.010