IMP: Integrative Multi-species Prediction

Homo sapiens

35 genes annotated in human

Multi-species View

rna phosphodiester bond hydrolysis

GO:0090501

The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "rna phosphodiester bond hydrolysis"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "rna phosphodiester bond hydrolysis" (in gray)

Name	Description	Probability	Func Analog Organism
EXOSC3	exosome component 3	1.000	Yeast
EXOSC2	exosome component 2	1.000	Yeast
EXOSC4	exosome component 4	0.998	Yeast
EXOSC10	exosome component 10	0.998
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.996
EXOSC7	exosome component 7	0.995	Yeast
TNRC6A	trinucleotide repeat containing 6A	0.992
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.989	Human
DIS3L	DIS3 mitotic control homolog (S. cerevisiae)-like	0.984
CNOT1	CCR4-NOT transcription complex, subunit 1	0.972
CNOT8	CCR4-NOT transcription complex, subunit 8	0.896
EXOSC9	exosome component 9	0.877	Yeast
TNRC6B	trinucleotide repeat containing 6B	0.826
TNRC6C	trinucleotide repeat containing 6C	0.800
PABPC1	poly(A) binding protein, cytoplasmic 1	0.773	Yeast
EXOSC8	exosome component 8	0.684
CNOT6	CCR4-NOT transcription complex, subunit 6	0.667
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.644
UPF1	UPF1 regulator of nonsense transcripts homolog (yeast)	0.626
CNOT2	CCR4-NOT transcription complex, subunit 2	0.622
DIS3	DIS3 mitotic control homolog (S. cerevisiae)	0.574
RPP40	ribonuclease P/MRP 40kDa subunit	0.566
EXOSC1	exosome component 1	0.338	Yeast
BTG1	B-cell translocation gene 1, anti-proliferative	0.326
CNOT6L	CCR4-NOT transcription complex, subunit 6-like	0.316	Human Yeast Mouse
EXOSC5	exosome component 5	0.308	Yeast
UPF2	UPF2 regulator of nonsense transcripts homolog (yeast)	0.303
FTSJ3	FtsJ homolog 3 (E. coli)	0.295
NUP107	nucleoporin 107kDa	0.285
EIF2C4	eukaryotic translation initiation factor 2C, 4	0.265	Human
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.258
PAN3	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	0.249
NOL11	nucleolar protein 11	0.246
CNOT7	CCR4-NOT transcription complex, subunit 7	0.229
TGS1	trimethylguanosine synthase 1	0.228
CNOT3	CCR4-NOT transcription complex, subunit 3	0.216
EIF2C3	eukaryotic translation initiation factor 2C, 3	0.214	Human
PIGW	phosphatidylinositol glycan anchor biosynthesis, class W	0.167
BMS1	BMS1 homolog, ribosome assembly protein (yeast)	0.162
CNOT10	CCR4-NOT transcription complex, subunit 10	0.148
WDR75	WD repeat domain 75	0.136
RUVBL2	RuvB-like 2 (E. coli)	0.131
SMG1	SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)	0.125
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.113
PFAS	phosphoribosylformylglycinamidine synthase	0.113
NUP85	nucleoporin 85kDa	0.112
C10orf2	chromosome 10 open reading frame 2	0.112
CPSF2	cleavage and polyadenylation specific factor 2, 100kDa	0.104
MAK16	MAK16 homolog (S. cerevisiae)	0.104
NAT10	N-acetyltransferase 10 (GCN5-related)	0.103
CSTF2	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa	0.087
MPHOSPH6	M-phase phosphoprotein 6	0.086
DICER1	dicer 1, ribonuclease type III	0.084
LTV1	LTV1 homolog (S. cerevisiae)	0.083
WDR3	WD repeat domain 3	0.081	Yeast
SAC3D1	SAC3 domain containing 1	0.077
PPAN	peter pan homolog (Drosophila)	0.076
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.072
TRIM25	tripartite motif containing 25	0.071
DGCR8	DiGeorge syndrome critical region gene 8	0.070
IPO8	importin 8	0.069
TSNAX	translin-associated factor X	0.069
TARBP2	TAR (HIV-1) RNA binding protein 2	0.065
EIF2S1	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	0.058
TRMT1	TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae)	0.058
EEF1G	eukaryotic translation elongation factor 1 gamma	0.056
KARS	lysyl-tRNA synthetase	0.054
CYLD	cylindromatosis (turban tumor syndrome)	0.054
TERT	telomerase reverse transcriptase	0.053
WDR12	WD repeat domain 12	0.051
EIF5B	eukaryotic translation initiation factor 5B	0.050
SHQ1	SHQ1 homolog (S. cerevisiae)	0.050
NOP2	NOP2 nucleolar protein homolog (yeast)	0.050
POLR2B	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	0.049
NOLC1	nucleolar and coiled-body phosphoprotein 1	0.046
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.046
NOC3L	nucleolar complex associated 3 homolog (S. cerevisiae)	0.044
NOP56	NOP56 ribonucleoprotein homolog (yeast)	0.043
TARDBP	TAR DNA binding protein	0.042
DROSHA	drosha, ribonuclease type III	0.042
DKC1	dyskeratosis congenita 1, dyskerin	0.042
NUFIP1	nuclear fragile X mental retardation protein interacting protein 1	0.041
NUP133	nucleoporin 133kDa	0.040
HEATR1	HEAT repeat containing 1	0.038	Yeast
SSB	Sjogren syndrome antigen B (autoantigen La)	0.038
SENP1	SUMO1/sentrin specific peptidase 1	0.037
SKIV2L2	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	0.036	Yeast
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.035
UPF3B	UPF3 regulator of nonsense transcripts homolog B (yeast)	0.035
ASCC2	activating signal cointegrator 1 complex subunit 2	0.034
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.033
REXO4	REX4, RNA exonuclease 4 homolog (S. cerevisiae)	0.033
PAN2	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	0.033
RPIA	ribose 5-phosphate isomerase A	0.032
NSUN2	NOP2/Sun domain family, member 2	0.031
NOL8	nucleolar protein 8	0.031
SYMPK	symplekin	0.031
TRMT6	tRNA methyltransferase 6 homolog (S. cerevisiae)	0.031
WDR43	WD repeat domain 43	0.031
BYSL	bystin-like	0.031	Yeast
C19orf61	chromosome 19 open reading frame 61	0.030
NUDC	nuclear distribution gene C homolog (A. nidulans)	0.030
CPSF3	cleavage and polyadenylation specific factor 3, 73kDa	0.029	Mouse
CEBPZ	CCAAT/enhancer binding protein (C/EBP), zeta	0.029
URB2	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	0.028
TSR1	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)	0.028
RRP15	ribosomal RNA processing 15 homolog (S. cerevisiae)	0.028
FIP1L1	FIP1 like 1 (S. cerevisiae)	0.027
GMPS	guanine monphosphate synthetase	0.026
CPSF6	cleavage and polyadenylation specific factor 6, 68kDa	0.026
TOMM40	translocase of outer mitochondrial membrane 40 homolog (yeast)	0.025
SLC5A6	solute carrier family 5 (sodium-dependent vitamin transporter), member 6	0.025
NUP160	nucleoporin 160kDa	0.025
NOP14	NOP14 nucleolar protein homolog (yeast)	0.025	Yeast
RBM28	RNA binding motif protein 28	0.025
UTP15	UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)	0.024
BAK1	BCL2-antagonist/killer 1	0.024
NUP205	nucleoporin 205kDa	0.024
PES1	pescadillo homolog 1, containing BRCT domain (zebrafish)	0.024
DNAJC9	DnaJ (Hsp40) homolog, subfamily C, member 9	0.023
CBWD2	COBW domain containing 2	0.023
PDCD11	programmed cell death 11	0.023	Yeast
NAA10	N(alpha)-acetyltransferase 10, NatA catalytic subunit	0.023
IMP4	IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)	0.023
TNPO3	transportin 3	0.023
IMPDH2	IMP (inosine 5'-monophosphate) dehydrogenase 2	0.023
CDK5RAP1	CDK5 regulatory subunit associated protein 1	0.022
NIPA2	non imprinted in Prader-Willi/Angelman syndrome 2	0.021
DENR	density-regulated protein	0.021
RIOK1	RIO kinase 1 (yeast)	0.021
TTC27	tetratricopeptide repeat domain 27	0.021
CSTF3	cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa	0.021
RPS15	ribosomal protein S15	0.020
HAUS7	HAUS augmin-like complex, subunit 7	0.020
TDG	thymine-DNA glycosylase	0.020
CWC27	CWC27 spliceosome-associated protein homolog (S. cerevisiae)	0.020
TMEM161A	transmembrane protein 161A	0.020
NUDT1	nudix (nucleoside diphosphate linked moiety X)-type motif 1	0.019
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.019
URM1	ubiquitin related modifier 1	0.019
USP36	ubiquitin specific peptidase 36	0.018
SEH1L	SEH1-like (S. cerevisiae)	0.018
AHCTF1	AT hook containing transcription factor 1	0.018
TOB1	transducer of ERBB2, 1	0.018
NTHL1	nth endonuclease III-like 1 (E. coli)	0.018
EBNA1BP2	EBNA1 binding protein 2	0.018
LIG1	ligase I, DNA, ATP-dependent	0.018
U2SURP	U2 snRNP-associated SURP domain containing	0.018
EIF3CL	eukaryotic translation initiation factor 3, subunit C-like	0.017
SNRNP25	small nuclear ribonucleoprotein 25kDa (U11/U12)	0.017
RBM12	RNA binding motif protein 12	0.017
NPM3	nucleophosmin/nucleoplasmin 3	0.017	Human
KIAA0947	KIAA0947	0.017
INTS8	integrator complex subunit 8	0.017
ACP1	acid phosphatase 1, soluble	0.017
C17orf71	chromosome 17 open reading frame 71	0.017
DDX46	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	0.017
OASL	2'-5'-oligoadenylate synthetase-like	0.017	Human
LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.017
C3orf26	chromosome 3 open reading frame 26	0.017
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.016
CUX1	cut-like homeobox 1	0.016
DTYMK	deoxythymidylate kinase (thymidylate kinase)	0.016
CUL3	cullin 3	0.016
ANAPC1	anaphase promoting complex subunit 1	0.016
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.016
SAMD9	sterile alpha motif domain containing 9	0.016
WDR36	WD repeat domain 36	0.016
SUGP2	SURP and G patch domain containing 2	0.016
RG9MTD1	RNA (guanine-9-) methyltransferase domain containing 1	0.015
KPNA3	karyopherin alpha 3 (importin alpha 4)	0.015
NOL9	nucleolar protein 9	0.015
C11orf51	chromosome 11 open reading frame 51	0.015
NUBP2	nucleotide binding protein 2 (MinD homolog, E. coli)	0.015
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.015
ARMC6	armadillo repeat containing 6	0.015
MKI67IP	MKI67 (FHA domain) interacting nucleolar phosphoprotein	0.015
PPAT	phosphoribosyl pyrophosphate amidotransferase	0.015
EDC4	enhancer of mRNA decapping 4	0.014
ISG15	ISG15 ubiquitin-like modifier	0.014
SAAL1	serum amyloid A-like 1	0.014
CDK5RAP3	CDK5 regulatory subunit associated protein 3	0.014
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.014
DDX18	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	0.014
C16orf88	chromosome 16 open reading frame 88	0.014
LSM7	LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.014
LARP4	La ribonucleoprotein domain family, member 4	0.014
ACD	adrenocortical dysplasia homolog (mouse)	0.014
BCCIP	BRCA2 and CDKN1A interacting protein	0.014
ATAD3A	ATPase family, AAA domain containing 3A	0.014
DDX49	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49	0.014	Yeast
LCLAT1	lysocardiolipin acyltransferase 1	0.014
SEC23IP	SEC23 interacting protein	0.014
NUDCD1	NudC domain containing 1	0.014
RARS	arginyl-tRNA synthetase	0.014
AHSA2	AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)	0.013
MOCS3	molybdenum cofactor synthesis 3	0.013
PITPNB	phosphatidylinositol transfer protein, beta	0.013
WRN	Werner syndrome, RecQ helicase-like	0.013
DDX47	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47	0.013
ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	0.013
LSG1	large subunit GTPase 1 homolog (S. cerevisiae)	0.013
CSE1L	CSE1 chromosome segregation 1-like (yeast)	0.013
DIEXF	digestive organ expansion factor homolog (zebrafish)	0.013
DHX29	DEAH (Asp-Glu-Ala-His) box polypeptide 29	0.013
PUS7	pseudouridylate synthase 7 homolog (S. cerevisiae)	0.012
MORC2	MORC family CW-type zinc finger 2	0.012
FBXO45	F-box protein 45	0.012
OAS3	2'-5'-oligoadenylate synthetase 3, 100kDa	0.012
UBAP2L	ubiquitin associated protein 2-like	0.012
POLD1	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	0.012
WDR46	WD repeat domain 46	0.012
UTP14A	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)	0.012
TELO2	TEL2, telomere maintenance 2, homolog (S. cerevisiae)	0.012
KIAA0664	KIAA0664	0.012
HSPA14	heat shock 70kDa protein 14	0.012
TRIM37	tripartite motif containing 37	0.012
PPHLN1	periphilin 1	0.011
RRP7A	ribosomal RNA processing 7 homolog A (S. cerevisiae)	0.011
RQCD1	RCD1 required for cell differentiation1 homolog (S. pombe)	0.011
PRMT7	protein arginine methyltransferase 7	0.011
GFM2	G elongation factor, mitochondrial 2	0.011
LETM1	leucine zipper-EF-hand containing transmembrane protein 1	0.011
FAM136A	family with sequence similarity 136, member A	0.011
TRNT1	tRNA nucleotidyl transferase, CCA-adding, 1	0.011
GDI2	GDP dissociation inhibitor 2	0.011
IFI44	interferon-induced protein 44	0.011
ODC1	ornithine decarboxylase 1	0.011
MTG1	mitochondrial GTPase 1 homolog (S. cerevisiae)	0.011
PWP1	PWP1 homolog (S. cerevisiae)	0.011
TSSC1	tumor suppressing subtransferable candidate 1	0.011
BZW2	basic leucine zipper and W2 domains 2	0.011
STRA13	stimulated by retinoic acid 13 homolog (mouse)	0.011
TDGF1	teratocarcinoma-derived growth factor 1	0.011
GTF2E1	general transcription factor IIE, polypeptide 1, alpha 56kDa	0.011
LAS1L	LAS1-like (S. cerevisiae)	0.011
ECD	ecdysoneless homolog (Drosophila)	0.011
RBMX	RNA binding motif protein, X-linked	0.011
BOP1	block of proliferation 1	0.011	Mouse
TMEM160	transmembrane protein 160	0.011
PDAP1	PDGFA associated protein 1	0.011
USP49	ubiquitin specific peptidase 49	0.011
ZC3H8	zinc finger CCCH-type containing 8	0.010
RBM8A	RNA binding motif protein 8A	0.010
INTS2	integrator complex subunit 2	0.010
SARS2	seryl-tRNA synthetase 2, mitochondrial	0.010
NVL	nuclear VCP-like	0.010
ACBD6	acyl-CoA binding domain containing 6	0.010
HERC5	hect domain and RLD 5	0.010
TRMT61A	tRNA methyltransferase 61 homolog A (S. cerevisiae)	0.010
IWS1	IWS1 homolog (S. cerevisiae)	0.010
ANAPC4	anaphase promoting complex subunit 4	0.010
INTS7	integrator complex subunit 7	0.010
IFIH1	interferon induced with helicase C domain 1	0.010	Human
RNASEH2C	ribonuclease H2, subunit C	0.010
C1orf131	chromosome 1 open reading frame 131	0.010
FAM35A	family with sequence similarity 35, member A	0.010