IMP: Integrative Multi-species Prediction

Homo sapiens

37 genes annotated in human

negative regulation of nucleocytoplasmic transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of nucleocytoplasmic transport"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of nucleocytoplasmic transport" (in gray)

Name	Description	Probability	Func Analog Organism
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.655
GSK3B	glycogen synthase kinase 3 beta	0.417
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.342
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.312
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.303
TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	0.298
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.240
AXIN1	axin 1	0.186	Human
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.173
PAX3	paired box 3	0.162
DTX3L	deltex 3-like (Drosophila)	0.158
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.140
PML	promyelocytic leukemia	0.130
CUL1	cullin 1	0.128
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.125
PRDX1	peroxiredoxin 1	0.123
MMS22L	MMS22-like, DNA repair protein	0.112
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.111
PARP14	poly (ADP-ribose) polymerase family, member 14	0.098	Human
CHUK	conserved helix-loop-helix ubiquitous kinase	0.090
SP100	SP100 nuclear antigen	0.089
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.088
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.088
SMAD7	SMAD family member 7	0.087
PARP9	poly (ADP-ribose) polymerase family, member 9	0.077	Human
HIPK2	homeodomain interacting protein kinase 2	0.069
CREBBP	CREB binding protein	0.068
DCAF7	DDB1 and CUL4 associated factor 7	0.067
ZNF420	zinc finger protein 420	0.067
CKAP5	cytoskeleton associated protein 5	0.065
APC	adenomatous polyposis coli	0.062	Human
MAPK1	mitogen-activated protein kinase 1	0.062
HIPK3	homeodomain interacting protein kinase 3	0.061
C3orf15	chromosome 3 open reading frame 15	0.061
PKD1	polycystic kidney disease 1 (autosomal dominant)	0.059	Mouse
IRS1	insulin receptor substrate 1	0.055
YAP1	Yes-associated protein 1	0.055	Human
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.054
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.050
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.050
PRKAR2A	protein kinase, cAMP-dependent, regulatory, type II, alpha	0.049
BCL3	B-cell CLL/lymphoma 3	0.048	Human
RANBP3	RAN binding protein 3	0.047
POU5F1	POU class 5 homeobox 1	0.046
PROX1	prospero homeobox 1	0.046
NXF1	nuclear RNA export factor 1	0.046
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.045
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.044	Human
ERBB2IP	erbb2 interacting protein	0.040
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.040	Human Rat
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.040	Human
FAS	Fas (TNF receptor superfamily, member 6)	0.039
RARA	retinoic acid receptor, alpha	0.039
MAP2K5	mitogen-activated protein kinase kinase 5	0.039
ZNF84	zinc finger protein 84	0.037
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.037	Rat
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.036
SOD1	superoxide dismutase 1, soluble	0.034
SKP1	S-phase kinase-associated protein 1	0.033
PSMC5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.032
AXL	AXL receptor tyrosine kinase	0.032
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.032
DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	0.032
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.031
TEK	TEK tyrosine kinase, endothelial	0.031
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.030	Human
ZNF585A	zinc finger protein 585A	0.029
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.029
SAMD9L	sterile alpha motif domain containing 9-like	0.028
GLI1	GLI family zinc finger 1	0.028
IFIH1	interferon induced with helicase C domain 1	0.027
DYRK4	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	0.027	Human
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.026
NUP98	nucleoporin 98kDa	0.026
E2F3	E2F transcription factor 3	0.026
SHFM1	split hand/foot malformation (ectrodactyly) type 1	0.026
LMO4	LIM domain only 4	0.026
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.026
POU3F2	POU class 3 homeobox 2	0.025
MAPK14	mitogen-activated protein kinase 14	0.025
KPNB1	karyopherin (importin) beta 1	0.025
BTRC	beta-transducin repeat containing	0.024	Fly
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.024
LZTS2	leucine zipper, putative tumor suppressor 2	0.024
ZNF432	zinc finger protein 432	0.024
SNAI1	snail homolog 1 (Drosophila)	0.023	Human
BIRC3	baculoviral IAP repeat containing 3	0.023
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.023
FBXW11	F-box and WD repeat domain containing 11	0.023	Mouse Fly
IRS2	insulin receptor substrate 2	0.022
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.022
BBS10	Bardet-Biedl syndrome 10	0.022
PSMC1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.022
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.022
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.022
DDAH2	dimethylarginine dimethylaminohydrolase 2	0.021
DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.021
FBXW7	F-box and WD repeat domain containing 7	0.021
NUP50	nucleoporin 50kDa	0.020
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.020
PARP12	poly (ADP-ribose) polymerase family, member 12	0.020
APOL6	apolipoprotein L, 6	0.020
STX8	syntaxin 8	0.020
RANBP2	RAN binding protein 2	0.020
PSMC4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.020
PRRC2C	proline-rich coiled-coil 2C	0.019
SCRIB	scribbled homolog (Drosophila)	0.019
AURKB	aurora kinase B	0.019
RICTOR	RPTOR independent companion of MTOR, complex 2	0.019
ZNF227	zinc finger protein 227	0.019
GBP2	guanylate binding protein 2, interferon-inducible	0.019
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.019
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.019
JUB	jub, ajuba homolog (Xenopus laevis)	0.019	Human
ZNF567	zinc finger protein 567	0.019
PSEN2	presenilin 2 (Alzheimer disease 4)	0.019
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.019
VCP	valosin containing protein	0.019
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.018
BABAM1	BRISC and BRCA1 A complex member 1	0.018
ELK1	ELK1, member of ETS oncogene family	0.018
SREBF2	sterol regulatory element binding transcription factor 2	0.018
MAP2K1	mitogen-activated protein kinase kinase 1	0.018
RNF213	ring finger protein 213	0.018
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.018
TUBG1	tubulin, gamma 1	0.018
MED24	mediator complex subunit 24	0.017
PEX26	peroxisomal biogenesis factor 26	0.017
PRKCZ	protein kinase C, zeta	0.017
TUBA1A	tubulin, alpha 1a	0.017
MEF2A	myocyte enhancer factor 2A	0.017
PARN	poly(A)-specific ribonuclease (deadenylation nuclease)	0.016
ZNF260	zinc finger protein 260	0.016
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.016
ZNF12	zinc finger protein 12	0.016
SAMD9	sterile alpha motif domain containing 9	0.016
PHF11	PHD finger protein 11	0.016
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.016
AKT1S1	AKT1 substrate 1 (proline-rich)	0.016
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.015
PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	0.015
BTN3A1	butyrophilin, subfamily 3, member A1	0.015
TJP2	tight junction protein 2 (zona occludens 2)	0.015
SPRED1	sprouty-related, EVH1 domain containing 1	0.015
PPP1R16A	protein phosphatase 1, regulatory (inhibitor) subunit 16A	0.015
CABLES1	Cdk5 and Abl enzyme substrate 1	0.015
HOXA9	homeobox A9	0.015
TRPC1	transient receptor potential cation channel, subfamily C, member 1	0.015
CNN2	calponin 2	0.015
MED1	mediator complex subunit 1	0.015
PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3	0.015
CASP8AP2	caspase 8 associated protein 2	0.015
SIAH1	seven in absentia homolog 1 (Drosophila)	0.015
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.015
NOG	noggin	0.015
LMNA	lamin A/C	0.015
TOP1	topoisomerase (DNA) I	0.015
EEF2K	eukaryotic elongation factor-2 kinase	0.015
UROD	uroporphyrinogen decarboxylase	0.015
PSMD13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.014
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.014
RAE1	RAE1 RNA export 1 homolog (S. pombe)	0.014
TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	0.014
AMOTL2	angiomotin like 2	0.014
SSRP1	structure specific recognition protein 1	0.014
C10orf116	chromosome 10 open reading frame 116	0.014
COPS6	COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)	0.014
C1orf93	chromosome 1 open reading frame 93	0.014
AMOTL1	angiomotin like 1	0.014
GSK3A	glycogen synthase kinase 3 alpha	0.014	Human
ACTN1	actinin, alpha 1	0.014
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.014
TP53BP2	tumor protein p53 binding protein, 2	0.013
CSNK1E	casein kinase 1, epsilon	0.013
TP73	tumor protein p73	0.013
NLRC4	NLR family, CARD domain containing 4	0.013
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.013
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.013
XAF1	XIAP associated factor 1	0.013
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.013
ANGPT2	angiopoietin 2	0.013
NSFL1C	NSFL1 (p97) cofactor (p47)	0.013
GRB10	growth factor receptor-bound protein 10	0.013
C19orf66	chromosome 19 open reading frame 66	0.013
NLRC5	NLR family, CARD domain containing 5	0.013	Human
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.013
NCOA3	nuclear receptor coactivator 3	0.013
AXIN2	axin 2	0.013
PAAF1	proteasomal ATPase-associated factor 1	0.013
LASP1	LIM and SH3 protein 1	0.013
C19orf46	chromosome 19 open reading frame 46	0.013
CALD1	caldesmon 1	0.013
NCOA6	nuclear receptor coactivator 6	0.013
DEPTOR	DEP domain containing MTOR-interacting protein	0.013
FZD5	frizzled homolog 5 (Drosophila)	0.012
MYD88	myeloid differentiation primary response gene (88)	0.012
ZNF571	zinc finger protein 571	0.012
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.012
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.012
MAPK3	mitogen-activated protein kinase 3	0.012
DUSP3	dual specificity phosphatase 3	0.012
QPRT	quinolinate phosphoribosyltransferase	0.012
TNPO1	transportin 1	0.012
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.012
ZNF304	zinc finger protein 304	0.012
ZNF764	zinc finger protein 764	0.012
SENP1	SUMO1/sentrin specific peptidase 1	0.012
FBXO33	F-box protein 33	0.012
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.012
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.012
RXRA	retinoid X receptor, alpha	0.012
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.012
ACACA	acetyl-CoA carboxylase alpha	0.012
SALL2	sal-like 2 (Drosophila)	0.012
CHD4	chromodomain helicase DNA binding protein 4	0.012
FBN3	fibrillin 3	0.012
DHX34	DEAH (Asp-Glu-Ala-His) box polypeptide 34	0.012
PYDC2	pyrin domain containing 2	0.012
MARCKSL1	MARCKS-like 1	0.012
ITGB1BP1	integrin beta 1 binding protein 1	0.012
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.012
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.012
RANBP9	RAN binding protein 9	0.012
CEP350	centrosomal protein 350kDa	0.012
CBX1	chromobox homolog 1	0.011
NDUFA4	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa	0.011
RAI1	retinoic acid induced 1	0.011
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.011
SOX11	SRY (sex determining region Y)-box 11	0.011	Human
TJP1	tight junction protein 1 (zona occludens 1)	0.011
EMD	emerin	0.011
MID1IP1	MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))	0.011
ASF1B	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.011
ALAS1	aminolevulinate, delta-, synthase 1	0.011
TRIM38	tripartite motif containing 38	0.011
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.011
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	0.011
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.011
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.011
PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	0.011
TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	0.011
CETN2	centrin, EF-hand protein, 2	0.011
PLSCR1	phospholipid scramblase 1	0.011
PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.011
ZNF140	zinc finger protein 140	0.011	Human
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.011
APOL3	apolipoprotein L, 3	0.011
TACC1	transforming, acidic coiled-coil containing protein 1	0.011
BRD7	bromodomain containing 7	0.011
LRIF1	ligand dependent nuclear receptor interacting factor 1	0.011
LTBP4	latent transforming growth factor beta binding protein 4	0.010
MARK3	MAP/microtubule affinity-regulating kinase 3	0.010
C5orf55	chromosome 5 open reading frame 55	0.010
FLNB	filamin B, beta	0.010
PSMD9	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	0.010
ZNF569	zinc finger protein 569	0.010
PEA15	phosphoprotein enriched in astrocytes 15	0.010
PSENEN	presenilin enhancer 2 homolog (C. elegans)	0.010
ZNF189	zinc finger protein 189	0.010
SMS	spermine synthase	0.010
ACTN4	actinin, alpha 4	0.010
OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	0.010
DYNLL1	dynein, light chain, LC8-type 1	0.010