IMP: Integrative Multi-species Prediction

Homo sapiens

3 genes annotated in human

Multi-species View

positive regulation of blood pressure

GO:0045777

Any process in which the force of blood traveling through the circulatory system is increased.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of blood pressure"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of blood pressure" (in gray)

Name	Description	Probability	Func Analog Organism
TGFB1	transforming growth factor, beta 1	0.968
NCF4	neutrophil cytosolic factor 4, 40kDa	0.954
NCF1	neutrophil cytosolic factor 1	0.935
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.774
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.537
CYBA	cytochrome b-245, alpha polypeptide	0.418
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.376
SDF2L1	stromal cell-derived factor 2-like 1	0.267
HYOU1	hypoxia up-regulated 1	0.250
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.229
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.179
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.175
CRELD2	cysteine-rich with EGF-like domains 2	0.132
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	0.127
PPIB	peptidylprolyl isomerase B (cyclophilin B)	0.110
ARRDC3	arrestin domain containing 3	0.106
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.100
TRIM9	tripartite motif containing 9	0.090
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.079
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.072
DRD2	dopamine receptor D2	0.069
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.067
ARRB1	arrestin, beta 1	0.060
ADORA2A	adenosine A2a receptor	0.054
PDIA4	protein disulfide isomerase family A, member 4	0.054
C19orf10	chromosome 19 open reading frame 10	0.054
TKT	transketolase	0.052
GLIS2	GLIS family zinc finger 2	0.050
DNAJB11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.049
TGFB3	transforming growth factor, beta 3	0.049
PRKCB	protein kinase C, beta	0.044
PRKCA	protein kinase C, alpha	0.041
PRKCD	protein kinase C, delta	0.041
PGD	phosphogluconate dehydrogenase	0.038
SVOP	SV2 related protein homolog (rat)	0.035
PKM2	pyruvate kinase, muscle	0.031
ARRB2	arrestin, beta 2	0.029
CRYZ	crystallin, zeta (quinone reductase)	0.029
CDK2AP2	cyclin-dependent kinase 2 associated protein 2	0.027
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.027
FN1	fibronectin 1	0.027
ACVRL1	activin A receptor type II-like 1	0.026
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.025
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.025
C1QTNF1	C1q and tumor necrosis factor related protein 1	0.025
TGFBR1	transforming growth factor, beta receptor 1	0.024
S100A9	S100 calcium binding protein A9	0.024
P2RX2	purinergic receptor P2X, ligand-gated ion channel, 2	0.023
HSPB1	heat shock 27kDa protein 1	0.023
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	0.023
TMED9	transmembrane emp24 protein transport domain containing 9	0.022
IL6R	interleukin 6 receptor	0.021
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.021
ADAMTS7	ADAM metallopeptidase with thrombospondin type 1 motif, 7	0.020
HPN	hepsin	0.020
GLA	galactosidase, alpha	0.020
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.019
GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	0.019
TALDO1	transaldolase 1	0.019
PDIA6	protein disulfide isomerase family A, member 6	0.019
RAB5C	RAB5C, member RAS oncogene family	0.019
ALDOA	aldolase A, fructose-bisphosphate	0.019
TAC1	tachykinin, precursor 1	0.019
NRP1	neuropilin 1	0.018
FHL2	four and a half LIM domains 2	0.018
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.018
CRYAB	crystallin, alpha B	0.018
ADRA1D	adrenergic, alpha-1D-, receptor	0.018	Mouse
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.018
FKBP11	FK506 binding protein 11, 19 kDa	0.018
PDIA3	protein disulfide isomerase family A, member 3	0.017
BDH2	3-hydroxybutyrate dehydrogenase, type 2	0.017
TSHR	thyroid stimulating hormone receptor	0.017
TAL1	T-cell acute lymphocytic leukemia 1	0.017
ACTB	actin, beta	0.017
HAND1	heart and neural crest derivatives expressed 1	0.017
ESRRB	estrogen-related receptor beta	0.017
RPN1	ribophorin I	0.017
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.016
ALPL	alkaline phosphatase, liver/bone/kidney	0.016
ACAN	aggrecan	0.016
KCNH1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.016
GRK6	G protein-coupled receptor kinase 6	0.016
EMX1	empty spiracles homeobox 1	0.016
ECI2	enoyl-CoA delta isomerase 2	0.016
AVP	arginine vasopressin	0.015
SLC28A1	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	0.015
FETUB	fetuin B	0.015
P2RY1	purinergic receptor P2Y, G-protein coupled, 1	0.015
GJD2	gap junction protein, delta 2, 36kDa	0.015
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.015
SOX1	SRY (sex determining region Y)-box 1	0.015
NOS1	nitric oxide synthase 1 (neuronal)	0.015
NPPC	natriuretic peptide C	0.015
S100A8	S100 calcium binding protein A8	0.015
SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	0.015
SMAD9	SMAD family member 9	0.015
HTR4	5-hydroxytryptamine (serotonin) receptor 4	0.014
WASL	Wiskott-Aldrich syndrome-like	0.014
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.014
PITX3	paired-like homeodomain 3	0.014
GHRHR	growth hormone releasing hormone receptor	0.014
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.014
GFRA4	GDNF family receptor alpha 4	0.014
SMAD7	SMAD family member 7	0.014
FOXB1	forkhead box B1	0.014
ROM1	retinal outer segment membrane protein 1	0.014
SELS	selenoprotein S	0.014
CD63	CD63 molecule	0.014
TULP3	tubby like protein 3	0.014
HOXD12	homeobox D12	0.014
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.014
T	T, brachyury homolog (mouse)	0.014
KCNE1	potassium voltage-gated channel, Isk-related family, member 1	0.014
PAQR6	progestin and adipoQ receptor family member VI	0.014
FSTL1	follistatin-like 1	0.014
CRHBP	corticotropin releasing hormone binding protein	0.014
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.013
GMPPB	GDP-mannose pyrophosphorylase B	0.013
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.013
TACR1	tachykinin receptor 1	0.013	Rat
IQGAP2	IQ motif containing GTPase activating protein 2	0.013
ITGA6	integrin, alpha 6	0.013
CD9	CD9 molecule	0.013
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.013
CRYBB3	crystallin, beta B3	0.013
SLC35B1	solute carrier family 35, member B1	0.013
RHO	rhodopsin	0.013
MBOAT7	membrane bound O-acyltransferase domain containing 7	0.013
PTEN	phosphatase and tensin homolog	0.013
CHRNA4	cholinergic receptor, nicotinic, alpha 4	0.013
ABCC9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	0.013
CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	0.013
ADAMTSL4	ADAMTS-like 4	0.013
PNP	purine nucleoside phosphorylase	0.013
EDNRB	endothelin receptor type B	0.013
ESD	esterase D	0.013
SLC22A1	solute carrier family 22 (organic cation transporter), member 1	0.013
PRODH2	proline dehydrogenase (oxidase) 2	0.013
ADRA2B	adrenergic, alpha-2B-, receptor	0.013
ACRV1	acrosomal vesicle protein 1	0.013
CYB5A	cytochrome b5 type A (microsomal)	0.013
TUB	tubby homolog (mouse)	0.012
HTR6	5-hydroxytryptamine (serotonin) receptor 6	0.012
CEND1	cell cycle exit and neuronal differentiation 1	0.012
SLC22A7	solute carrier family 22 (organic anion transporter), member 7	0.012
EPO	erythropoietin	0.012
HOXD3	homeobox D3	0.012
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.012
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.012
DSCAML1	Down syndrome cell adhesion molecule like 1	0.012
CDC42EP2	CDC42 effector protein (Rho GTPase binding) 2	0.012
ALDH7A1	aldehyde dehydrogenase 7 family, member A1	0.012
HRC	histidine rich calcium binding protein	0.012
SPCS3	signal peptidase complex subunit 3 homolog (S. cerevisiae)	0.012
MAPK10	mitogen-activated protein kinase 10	0.012
ARNT	aryl hydrocarbon receptor nuclear translocator	0.012
MCAM	melanoma cell adhesion molecule	0.012
GALR1	galanin receptor 1	0.012
HS3ST2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	0.012
SEC13	SEC13 homolog (S. cerevisiae)	0.012
NEUROG2	neurogenin 2	0.012
S1PR2	sphingosine-1-phosphate receptor 2	0.012
HSD3B1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	0.012
CRHR1	corticotropin releasing hormone receptor 1	0.012
TRIP10	thyroid hormone receptor interactor 10	0.012
CLEC4M	C-type lectin domain family 4, member M	0.012
CDCP1	CUB domain containing protein 1	0.012
CCL1	chemokine (C-C motif) ligand 1	0.012
GRIK3	glutamate receptor, ionotropic, kainate 3	0.012
SLC6A13	solute carrier family 6 (neurotransmitter transporter, GABA), member 13	0.012
PGM5	phosphoglucomutase 5	0.012
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.012
DECR1	2,4-dienoyl CoA reductase 1, mitochondrial	0.012
NCR2	natural cytotoxicity triggering receptor 2	0.012
INSL3	insulin-like 3 (Leydig cell)	0.012
SLC24A2	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	0.012
GPR6	G protein-coupled receptor 6	0.012
GCGR	glucagon receptor	0.012
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A	0.012
GFRA3	GDNF family receptor alpha 3	0.012
PTPRA	protein tyrosine phosphatase, receptor type, A	0.012
NEUROG3	neurogenin 3	0.012
AQP7	aquaporin 7	0.012
CNNM1	cyclin M1	0.012
FEZF2	FEZ family zinc finger 2	0.012
OR10H1	olfactory receptor, family 10, subfamily H, member 1	0.012
PTPRE	protein tyrosine phosphatase, receptor type, E	0.012
SLC6A7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.012
FOXH1	forkhead box H1	0.012
BCKDHB	branched chain keto acid dehydrogenase E1, beta polypeptide	0.012
VTN	vitronectin	0.011
GFAP	glial fibrillary acidic protein	0.011
NPY	neuropeptide Y	0.011
LAMC3	laminin, gamma 3	0.011
TEF	thyrotrophic embryonic factor	0.011
RGS19	regulator of G-protein signaling 19	0.011
ITGB1BP1	integrin beta 1 binding protein 1	0.011
GNG4	guanine nucleotide binding protein (G protein), gamma 4	0.011
CHRM5	cholinergic receptor, muscarinic 5	0.011
LHCGR	luteinizing hormone/choriogonadotropin receptor	0.011
FGG	fibrinogen gamma chain	0.011
SLC7A2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.011
FOXD3	forkhead box D3	0.011
FKBP2	FK506 binding protein 2, 13kDa	0.011
NECAB2	N-terminal EF-hand calcium binding protein 2	0.011
CLPS	colipase, pancreatic	0.011
GABRQ	gamma-aminobutyric acid (GABA) receptor, theta	0.011
PAX7	paired box 7	0.011
THBS1	thrombospondin 1	0.011
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.011
SLC16A3	solute carrier family 16, member 3 (monocarboxylic acid transporter 4)	0.011
CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.011
SSTR1	somatostatin receptor 1	0.011
GCG	glucagon	0.011
CPB1	carboxypeptidase B1 (tissue)	0.011
PAK7	p21 protein (Cdc42/Rac)-activated kinase 7	0.011
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.011
GRIK4	glutamate receptor, ionotropic, kainate 4	0.011
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.011
GRIN2D	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	0.011
SCN7A	sodium channel, voltage-gated, type VII, alpha	0.011
TBX5	T-box 5	0.011
GPR12	G protein-coupled receptor 12	0.011
ADRB3	adrenergic, beta-3-, receptor	0.011
GLRA1	glycine receptor, alpha 1	0.011
ONECUT2	one cut homeobox 2	0.011
CHN2	chimerin (chimaerin) 2	0.011
AKAP13	A kinase (PRKA) anchor protein 13	0.011
PITPNM3	PITPNM family member 3	0.011
AMELX	amelogenin, X-linked	0.011
CHST4	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4	0.011
REN	renin	0.011
TCF21	transcription factor 21	0.011
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.011
HMOX1	heme oxygenase (decycling) 1	0.011
PIPOX	pipecolic acid oxidase	0.011
SLC13A3	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	0.011
CDH20	cadherin 20, type 2	0.011
GNG13	guanine nucleotide binding protein (G protein), gamma 13	0.011
HSPB6	heat shock protein, alpha-crystallin-related, B6	0.011
UNC119	unc-119 homolog (C. elegans)	0.011
PRL	prolactin	0.011
ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.011
RARRES2	retinoic acid receptor responder (tazarotene induced) 2	0.011
GHSR	growth hormone secretagogue receptor	0.011
SCN4A	sodium channel, voltage-gated, type IV, alpha subunit	0.011
PRLR	prolactin receptor	0.011
PTPN21	protein tyrosine phosphatase, non-receptor type 21	0.011
CORO1B	coronin, actin binding protein, 1B	0.011
AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.011	Mouse Rat
PTPRN	protein tyrosine phosphatase, receptor type, N	0.011
CALR	calreticulin	0.011
ZBTB43	zinc finger and BTB domain containing 43	0.011
SEC61B	Sec61 beta subunit	0.011
SHKBP1	SH3KBP1 binding protein 1	0.011
OSBP2	oxysterol binding protein 2	0.011
MAP3K11	mitogen-activated protein kinase kinase kinase 11	0.011
PROL1	proline rich, lacrimal 1	0.010
PDIA5	protein disulfide isomerase family A, member 5	0.010
ALDH9A1	aldehyde dehydrogenase 9 family, member A1	0.010
HTR1D	5-hydroxytryptamine (serotonin) receptor 1D	0.010
DNM1	dynamin 1	0.010
MT3	metallothionein 3	0.010
INSL4	insulin-like 4 (placenta)	0.010
NQO1	NAD(P)H dehydrogenase, quinone 1	0.010
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.010
INSM1	insulinoma-associated 1	0.010
STOM	stomatin	0.010
PNLIPRP1	pancreatic lipase-related protein 1	0.010
KRT76	keratin 76	0.010
TACR2	tachykinin receptor 2	0.010
KCNQ1	potassium voltage-gated channel, KQT-like subfamily, member 1	0.010
BCAN	brevican	0.010
HADH	hydroxyacyl-CoA dehydrogenase	0.010
AMBP	alpha-1-microglobulin/bikunin precursor	0.010
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.010
GH1	growth hormone 1	0.010
ADRB1	adrenergic, beta-1-, receptor	0.010	Mouse Rat
SGK2	serum/glucocorticoid regulated kinase 2	0.010
SLC26A1	solute carrier family 26 (sulfate transporter), member 1	0.010
DRD1	dopamine receptor D1	0.010
TRHR	thyrotropin-releasing hormone receptor	0.010
NTN1	netrin 1	0.010
OPRM1	opioid receptor, mu 1	0.010
HCRTR1	hypocretin (orexin) receptor 1	0.010
CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	0.010
FSTL4	follistatin-like 4	0.010
SPRR2A	small proline-rich protein 2A	0.010
UPB1	ureidopropionase, beta	0.010
KCNA2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.010
EID1	EP300 interacting inhibitor of differentiation 1	0.010
DNMT3L	DNA (cytosine-5-)-methyltransferase 3-like	0.010
OPRK1	opioid receptor, kappa 1	0.010
PPYR1	pancreatic polypeptide receptor 1	0.010
SLC34A1	solute carrier family 34 (sodium phosphate), member 1	0.010
CALCA	calcitonin-related polypeptide alpha	0.010
BCAR1	breast cancer anti-estrogen resistance 1	0.010
C8B	complement component 8, beta polypeptide	0.010
GNAT2	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	0.010
FGF5	fibroblast growth factor 5	0.010
KCNQ3	potassium voltage-gated channel, KQT-like subfamily, member 3	0.010
HOXB8	homeobox B8	0.010
STMN3	stathmin-like 3	0.010
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.010
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.010
GRM1	glutamate receptor, metabotropic 1	0.010
WNT11	wingless-type MMTV integration site family, member 11	0.010
SAA4	serum amyloid A4, constitutive	0.010
CCIN	calicin	0.010
FGF8	fibroblast growth factor 8 (androgen-induced)	0.010
OMP	olfactory marker protein	0.010
AHSG	alpha-2-HS-glycoprotein	0.010
CKMT2	creatine kinase, mitochondrial 2 (sarcomeric)	0.010
PAPSS1	3'-phosphoadenosine 5'-phosphosulfate synthase 1	0.010