IMP: Integrative Multi-species Prediction

Homo sapiens

76 genes annotated in human

skin development

The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "skin development"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "skin development" (in gray)

Name	Description	Probability	Func Analog Organism
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	1.000	Mouse
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.999	Human
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.998	Human
FHL2	four and a half LIM domains 2	0.987
FN1	fibronectin 1	0.987
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.986
SFN	stratifin	0.971	Mouse
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.960	Mouse
EGFR	epidermal growth factor receptor	0.955
KRT15	keratin 15	0.951	Human
SMAD2	SMAD family member 2	0.950
FLNA	filamin A, alpha	0.945
ITGB4	integrin, beta 4	0.936
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.936	Human
SPINT1	serine peptidase inhibitor, Kunitz type 1	0.931	Zebrafish
KRT5	keratin 5	0.930	Human
KRT6B	keratin 6B	0.927	Human Mouse
PSEN1	presenilin 1	0.923	Mouse
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.913	Human
SUFU	suppressor of fused homolog (Drosophila)	0.910	Mouse
NOTCH1	notch 1	0.909	Mouse
STK3	serine/threonine kinase 3	0.905
AR	androgen receptor	0.905
TRIM29	tripartite motif containing 29	0.892
HDAC1	histone deacetylase 1	0.887	Mouse
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.886
KLK10	kallikrein-related peptidase 10	0.872	Human
KRT17	keratin 17	0.870	Human
COL1A1	collagen, type I, alpha 1	0.867
NOTCH3	notch 3	0.861
NCOR2	nuclear receptor corepressor 2	0.859
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.830
SPRR1A	small proline-rich protein 1A	0.826
KLK7	kallikrein-related peptidase 7	0.810	Human
PKP3	plakophilin 3	0.792
KRT1	keratin 1	0.790	Human
BBS10	Bardet-Biedl syndrome 10	0.769
ANXA1	annexin A1	0.769
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.761
PXN	paxillin	0.728
AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)	0.724	Human
JUP	junction plakoglobin	0.696	Mouse
SP1	Sp1 transcription factor	0.695
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.691
ZNF746	zinc finger protein 746	0.680
TACSTD2	tumor-associated calcium signal transducer 2	0.664
THBS1	thrombospondin 1	0.662
KRT6A	keratin 6A	0.660	Human
LAD1	ladinin 1	0.649
RARA	retinoic acid receptor, alpha	0.649
AKR1C2	aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)	0.637	Human
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.624
NCOR1	nuclear receptor corepressor 1	0.606
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.585
COL5A2	collagen, type V, alpha 2	0.574
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.561
GRB7	growth factor receptor-bound protein 7	0.555
GJB3	gap junction protein, beta 3, 31kDa	0.551	Rat
KRT34	keratin 34	0.541	Human
ZFYVE9	zinc finger, FYVE domain containing 9	0.538
FXYD3	FXYD domain containing ion transport regulator 3	0.535
FGFR1	fibroblast growth factor receptor 1	0.529	Zebrafish Mouse
SPRR1B	small proline-rich protein 1B	0.510
ELF3	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	0.508
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.502
KLK11	kallikrein-related peptidase 11	0.500	Human
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.499
COL5A1	collagen, type V, alpha 1	0.489
RXRA	retinoid X receptor, alpha	0.488
COL4A1	collagen, type IV, alpha 1	0.485
IVL	involucrin	0.483
DSG2	desmoglein 2	0.480
SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	0.455
TP53	tumor protein p53	0.449	Zebrafish
SLURP1	secreted LY6/PLAUR domain containing 1	0.449
ITGB5	integrin, beta 5	0.448	Human
KLK5	kallikrein-related peptidase 5	0.435	Human
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.430	Human Rat
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.424	Mouse Fly
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.413
ENG	endoglin	0.403
SEC23A	Sec23 homolog A (S. cerevisiae)	0.400
DSG3	desmoglein 3	0.382
COL1A2	collagen, type I, alpha 2	0.382
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.379
KRT16	keratin 16	0.372	Human
TMBIM6	transmembrane BAX inhibitor motif containing 6	0.368
KRT19	keratin 19	0.366	Human
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.366
PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	0.360
KLF5	Kruppel-like factor 5 (intestinal)	0.360
EVPL	envoplakin	0.358
NME2	non-metastatic cells 2, protein (NM23B) expressed in	0.352
HR	hairless homolog (mouse)	0.351
FLNB	filamin B, beta	0.349	Mouse
S100A2	S100 calcium binding protein A2	0.345
EP300	E1A binding protein p300	0.340
KRT13	keratin 13	0.339	Human
CD63	CD63 molecule	0.339
C1orf116	chromosome 1 open reading frame 116	0.339
LY6D	lymphocyte antigen 6 complex, locus D	0.332
LYPD3	LY6/PLAUR domain containing 3	0.312
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.309	Fly
MPRIP	myosin phosphatase Rho interacting protein	0.307
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.297	Mouse
FGF1	fibroblast growth factor 1 (acidic)	0.296
ERBB2IP	erbb2 interacting protein	0.294
HOXB5	homeobox B5	0.293	Human
KRT33B	keratin 33B	0.292	Human
NCOA1	nuclear receptor coactivator 1	0.289	Human
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.286
RHOA	ras homolog gene family, member A	0.282	Fly
KLK13	kallikrein-related peptidase 13	0.281	Human
CREB1	cAMP responsive element binding protein 1	0.281
PAX3	paired box 3	0.277
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.277
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.275
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.273
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.264	Worm Fly
TP63	tumor protein p63	0.262	Zebrafish Mouse
S100A10	S100 calcium binding protein A10	0.262
E2F1	E2F transcription factor 1	0.257
GRB10	growth factor receptor-bound protein 10	0.252
COL3A1	collagen, type III, alpha 1	0.249
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.245
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.245
LGALS1	lectin, galactoside-binding, soluble, 1	0.242
SOX10	SRY (sex determining region Y)-box 10	0.236
S100A14	S100 calcium binding protein A14	0.233
PRSS2	protease, serine, 2 (trypsin 2)	0.231
CSNK1E	casein kinase 1, epsilon	0.231	Fly
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.230
SORBS2	sorbin and SH3 domain containing 2	0.230
EPS8	epidermal growth factor receptor pathway substrate 8	0.224	Worm
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.220
DLG1	discs, large homolog 1 (Drosophila)	0.220
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.214
OVOL1	ovo-like 1(Drosophila)	0.212	Human Mouse Fly
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.209
TGM3	transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.209
NCOA6	nuclear receptor coactivator 6	0.208
FGFR3	fibroblast growth factor receptor 3	0.208
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.205
KRT33A	keratin 33A	0.204	Human
LY6G6C	lymphocyte antigen 6 complex, locus G6C	0.203
DSP	desmoplakin	0.200
KRT6C	keratin 6C	0.200	Human
SIRT1	sirtuin 1	0.200
SOX9	SRY (sex determining region Y)-box 9	0.198	Mouse
KRT75	keratin 75	0.198	Human
GSK3B	glycogen synthase kinase 3 beta	0.198
PLEC	plectin	0.196
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.196
PPL	periplakin	0.194
EFNA1	ephrin-A1	0.187
HOXB6	homeobox B6	0.183	Human
RGS2	regulator of G-protein signaling 2, 24kDa	0.181
GJB5	gap junction protein, beta 5, 31.1kDa	0.181
ESR1	estrogen receptor 1	0.180
SERPINB13	serpin peptidase inhibitor, clade B (ovalbumin), member 13	0.177
ADAM9	ADAM metallopeptidase domain 9	0.177
FKBP1A	FK506 binding protein 1A, 12kDa	0.176
ANXA5	annexin A5	0.175	Human
DSG1	desmoglein 1	0.175
ELF5	E74-like factor 5 (ets domain transcription factor)	0.174
FZD10	frizzled homolog 10 (Drosophila)	0.171	Human
SERPINB5	serpin peptidase inhibitor, clade B (ovalbumin), member 5	0.171
ST14	suppression of tumorigenicity 14 (colon carcinoma)	0.171
FST	follistatin	0.170
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.169
FSTL1	follistatin-like 1	0.166	Human
SPRR3	small proline-rich protein 3	0.166	Human
ALOX12B	arachidonate 12-lipoxygenase, 12R type	0.166
COL11A1	collagen, type XI, alpha 1	0.165	Human
EPHX3	epoxide hydrolase 3	0.164
TLN1	talin 1	0.164
JAG1	jagged 1	0.163	Zebrafish Mouse Rat
KRT14	keratin 14	0.163	Human
CALCA	calcitonin-related polypeptide alpha	0.163
TJP1	tight junction protein 1 (zona occludens 1)	0.160
HOXA10	homeobox A10	0.160
SFRP1	secreted frizzled-related protein 1	0.160
POSTN	periostin, osteoblast specific factor	0.158
KRT2	keratin 2	0.157
KRT4	keratin 4	0.156	Human
PRSS8	protease, serine, 8	0.155	Mouse
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.154
KRT31	keratin 31	0.153	Human
PTK2	PTK2 protein tyrosine kinase 2	0.152
RAB25	RAB25, member RAS oncogene family	0.151	Fly
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.149
INADL	InaD-like (Drosophila)	0.149
TGM1	transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)	0.148
ABI2	abl-interactor 2	0.147
CTSB	cathepsin B	0.146
EPHA2	EPH receptor A2	0.146
RB1	retinoblastoma 1	0.146
BMPR1A	bone morphogenetic protein receptor, type IA	0.145
DDR1	discoidin domain receptor tyrosine kinase 1	0.145	Rat
ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	0.145
OCLN	occludin	0.144
HOXA5	homeobox A5	0.144	Human
KRT8	keratin 8	0.143	Human
FHL1	four and a half LIM domains 1	0.142
TGFB2	transforming growth factor, beta 2	0.142
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.140
COL17A1	collagen, type XVII, alpha 1	0.140
EPS8L1	EPS8-like 1	0.139	Worm
S100A7	S100 calcium binding protein A7	0.138
ATF3	activating transcription factor 3	0.138
KLK6	kallikrein-related peptidase 6	0.136	Human
KLK3	kallikrein-related peptidase 3	0.135	Human
AKR1C3	aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)	0.135
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.134
FOXC1	forkhead box C1	0.132
UBA1	ubiquitin-like modifier activating enzyme 1	0.132
PERP	PERP, TP53 apoptosis effector	0.131
ARRB1	arrestin, beta 1	0.130
TM4SF1	transmembrane 4 L six family member 1	0.129
PI3	peptidase inhibitor 3, skin-derived	0.129
APC	adenomatous polyposis coli	0.129	Mouse
KRT32	keratin 32	0.128	Human
PDIA3	protein disulfide isomerase family A, member 3	0.126
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.126
PLOD3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	0.126	Human Mouse
FGFBP1	fibroblast growth factor binding protein 1	0.126
SOX11	SRY (sex determining region Y)-box 11	0.125
PRKCZ	protein kinase C, zeta	0.125
MED25	mediator complex subunit 25	0.124
LAMC2	laminin, gamma 2	0.123
PDZD11	PDZ domain containing 11	0.123
EDAR	ectodysplasin A receptor	0.123
NME4	non-metastatic cells 4, protein expressed in	0.121
CCND1	cyclin D1	0.120
HIPK2	homeodomain interacting protein kinase 2	0.119
ABI1	abl-interactor 1	0.118
BMP4	bone morphogenetic protein 4	0.117
KRT81	keratin 81	0.116	Human
HTT	huntingtin	0.116
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.116
EFNA5	ephrin-A5	0.115
BTRC	beta-transducin repeat containing	0.115
FZD1	frizzled homolog 1 (Drosophila)	0.114	Human
SMAD3	SMAD family member 3	0.113
CTGF	connective tissue growth factor	0.113
EGR1	early growth response 1	0.112
FAT2	FAT tumor suppressor homolog 2 (Drosophila)	0.112
BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	0.111
STK36	serine/threonine kinase 36	0.110
CDSN	corneodesmosin	0.110
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.109
VEGFA	vascular endothelial growth factor A	0.109
DUSP5	dual specificity phosphatase 5	0.109
ALOXE3	arachidonate lipoxygenase 3	0.109	Mouse
PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	0.107	Human
HOXC10	homeobox C10	0.105
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.105
SEMA3F	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.104
HOXB7	homeobox B7	0.104	Human
LOR	loricrin	0.104
DSC3	desmocollin 3	0.104	Human
NCOA2	nuclear receptor coactivator 2	0.103	Human
CALML3	calmodulin-like 3	0.103
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.103
KAT2B	K(lysine) acetyltransferase 2B	0.103
ALDOA	aldolase A, fructose-bisphosphate	0.102
KLK8	kallikrein-related peptidase 8	0.102	Human
HSPG2	heparan sulfate proteoglycan 2	0.102
C3	complement component 3	0.100
WIPF1	WAS/WASL interacting protein family, member 1	0.100
EPN3	epsin 3	0.100
MSX1	msh homeobox 1	0.099
TMPRSS2	transmembrane protease, serine 2	0.099
TNC	tenascin C	0.098
IRF6	interferon regulatory factor 6	0.098	Mouse
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.098
XIAP	X-linked inhibitor of apoptosis	0.096
PPP1R13L	protein phosphatase 1, regulatory (inhibitor) subunit 13 like	0.096
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.096
WNT5A	wingless-type MMTV integration site family, member 5A	0.095
HOXA11	homeobox A11	0.095
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.094
F11R	F11 receptor	0.093
BCAM	basal cell adhesion molecule (Lutheran blood group)	0.092
ADAM12	ADAM metallopeptidase domain 12	0.091	Human
RAP1B	RAP1B, member of RAS oncogene family	0.091	Worm
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.091
LLGL2	lethal giant larvae homolog 2 (Drosophila)	0.091	Zebrafish Fly
IRS1	insulin receptor substrate 1	0.091
BMP7	bone morphogenetic protein 7	0.091
INHBA	inhibin, beta A	0.091
EPHB3	EPH receptor B3	0.090	Human
TAL1	T-cell acute lymphocytic leukemia 1	0.090
BMP2	bone morphogenetic protein 2	0.090	Human
KRT36	keratin 36	0.089	Human Mouse
CRABP2	cellular retinoic acid binding protein 2	0.089
RHOD	ras homolog gene family, member D	0.088
CYP51A1	cytochrome P450, family 51, subfamily A, polypeptide 1	0.088
IER3	immediate early response 3	0.087
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.087
HMGA1	high mobility group AT-hook 1	0.086
PAX9	paired box 9	0.085
WISP1	WNT1 inducible signaling pathway protein 1	0.084
PTPRC	protein tyrosine phosphatase, receptor type, C	0.084
KRT9	keratin 9	0.083
EHF	ets homologous factor	0.083
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.082
SRSF4	serine/arginine-rich splicing factor 4	0.081	Human
FGF18	fibroblast growth factor 18	0.081
COL4A6	collagen, type IV, alpha 6	0.080
TBC1D10A	TBC1 domain family, member 10A	0.080
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.080	Mouse
STRN3	striatin, calmodulin binding protein 3	0.079
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.079
AP1M2	adaptor-related protein complex 1, mu 2 subunit	0.079
TMEM40	transmembrane protein 40	0.078
AXIN1	axin 1	0.078
CLCA2	chloride channel accessory 2	0.078
SERPINB4	serpin peptidase inhibitor, clade B (ovalbumin), member 4	0.077
ITGA6	integrin, alpha 6	0.076
SDC1	syndecan 1	0.076	Worm
COL13A1	collagen, type XIII, alpha 1	0.076
AMOT	angiomotin	0.076
PTHLH	parathyroid hormone-like hormone	0.075
CIB1	calcium and integrin binding 1 (calmyrin)	0.075
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.075
TMPRSS11D	transmembrane protease, serine 11D	0.074
FOXN1	forkhead box N1	0.074	Mouse Rat
CST6	cystatin E/M	0.074
GPR87	G protein-coupled receptor 87	0.074
C2orf54	chromosome 2 open reading frame 54	0.073
GABRP	gamma-aminobutyric acid (GABA) A receptor, pi	0.072
RARG	retinoic acid receptor, gamma	0.072
USH1G	Usher syndrome 1G (autosomal recessive)	0.072
ZNF512B	zinc finger protein 512B	0.072
CREBBP	CREB binding protein	0.071
GPRC5A	G protein-coupled receptor, family C, group 5, member A	0.071
HOXA2	homeobox A2	0.071
CTNND1	catenin (cadherin-associated protein), delta 1	0.071	Mouse
SIX2	SIX homeobox 2	0.071
PKP4	plakophilin 4	0.070
KRT23	keratin 23 (histone deacetylase inducible)	0.070	Human
PLA2G3	phospholipase A2, group III	0.070
HDAC6	histone deacetylase 6	0.070
BNC1	basonuclin 1	0.069
TRA2B	transformer 2 beta homolog (Drosophila)	0.069
CD9	CD9 molecule	0.069
DUOX1	dual oxidase 1	0.069
WNT2	wingless-type MMTV integration site family member 2	0.069	Human
JUB	jub, ajuba homolog (Xenopus laevis)	0.068
IQGAP1	IQ motif containing GTPase activating protein 1	0.067
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.067	Mouse
PKP2	plakophilin 2	0.067
ESRP2	epithelial splicing regulatory protein 2	0.067
PRSS22	protease, serine, 22	0.067
CTBP1	C-terminal binding protein 1	0.066
SRI	sorcin	0.066
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.066
SPINK5	serine peptidase inhibitor, Kazal type 5	0.065
LAMB3	laminin, beta 3	0.065
SNAI1	snail homolog 1 (Drosophila)	0.065	Mouse
WNT4	wingless-type MMTV integration site family, member 4	0.065	Human
HOXC13	homeobox C13	0.064	Mouse
IL1F5	interleukin 1 family, member 5 (delta)	0.064
TWIST1	twist homolog 1 (Drosophila)	0.064
ALS2CL	ALS2 C-terminal like	0.064
CRCT1	cysteine-rich C-terminal 1	0.064
IRX4	iroquois homeobox 4	0.064	Zebrafish
UBQLN4	ubiquilin 4	0.063
RECQL	RecQ protein-like (DNA helicase Q1-like)	0.063
EPPK1	epiplakin 1	0.063
AP2B1	adaptor-related protein complex 2, beta 1 subunit	0.062
AQP5	aquaporin 5	0.062
KRT7	keratin 7	0.062	Human
CLIC4	chloride intracellular channel 4	0.062
FDFT1	farnesyl-diphosphate farnesyltransferase 1	0.062
PDGFC	platelet derived growth factor C	0.062
TP73	tumor protein p73	0.062
INSIG1	insulin induced gene 1	0.062
PADI3	peptidyl arginine deiminase, type III	0.061
HOXA7	homeobox A7	0.061
LRRC17	leucine rich repeat containing 17	0.061
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.061
PGR	progesterone receptor	0.061
FOXF2	forkhead box F2	0.060
ESRP1	epithelial splicing regulatory protein 1	0.060
SMN1	survival of motor neuron 1, telomeric	0.060
SIX6	SIX homeobox 6	0.060
ATP13A2	ATPase type 13A2	0.059
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.059
HOXB3	homeobox B3	0.059
DBN1	drebrin 1	0.059
HOXA3	homeobox A3	0.059
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	0.058
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.058
SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.058
APAF1	apoptotic peptidase activating factor 1	0.058
RASSF7	Ras association (RalGDS/AF-6) domain family (N-terminal) member 7	0.058
RNF39	ring finger protein 39	0.057
CLDN1	claudin 1	0.057
WFDC2	WAP four-disulfide core domain 2	0.057
YY1	YY1 transcription factor	0.057
GLI1	GLI family zinc finger 1	0.057
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.057
HOXD3	homeobox D3	0.057
FBLN1	fibulin 1	0.057	Zebrafish
CLDN3	claudin 3	0.056	Human
PKM2	pyruvate kinase, muscle	0.056
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.056
ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	0.056
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.056
NCK1	NCK adaptor protein 1	0.056
WT1	Wilms tumor 1	0.056
RASSF3	Ras association (RalGDS/AF-6) domain family member 3	0.055
TIMP3	TIMP metallopeptidase inhibitor 3	0.055
ENDOU	endonuclease, polyU-specific	0.055
ROCK1	Rho-associated, coiled-coil containing protein kinase 1	0.055
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.055
ELOVL1	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1	0.055
MAP1S	microtubule-associated protein 1S	0.054
CALD1	caldesmon 1	0.054
MKL1	megakaryoblastic leukemia (translocation) 1	0.054
SCNN1A	sodium channel, nonvoltage-gated 1 alpha	0.054
ATXN1L	ataxin 1-like	0.054
IGF1R	insulin-like growth factor 1 receptor	0.054	Mouse
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.053	Mouse
KRT18	keratin 18	0.053	Human
RHCG	Rh family, C glycoprotein	0.053
NRP1	neuropilin 1	0.053
KLC3	kinesin light chain 3	0.053
ALDH3A1	aldehyde dehydrogenase 3 family, member A1	0.053	Human
HES2	hairy and enhancer of split 2 (Drosophila)	0.053
SPECC1L	sperm antigen with calponin homology and coiled-coil domains 1-like	0.052
C1orf106	chromosome 1 open reading frame 106	0.052
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.052
GFI1B	growth factor independent 1B transcription repressor	0.052
FUT3	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)	0.052
NCF4	neutrophil cytosolic factor 4, 40kDa	0.052
NUAK1	NUAK family, SNF1-like kinase, 1	0.052
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.051
ADAM10	ADAM metallopeptidase domain 10	0.051
DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.051
MYOD1	myogenic differentiation 1	0.051
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.051
TGFA	transforming growth factor, alpha	0.051
CDX2	caudal type homeobox 2	0.051
ENTPD2	ectonucleoside triphosphate diphosphohydrolase 2	0.051
BMP1	bone morphogenetic protein 1	0.050
KRT78	keratin 78	0.050	Human
TCF4	transcription factor 4	0.050
PRSS55	protease, serine, 55	0.050
EPHA1	EPH receptor A1	0.050	Human
SERPINB7	serpin peptidase inhibitor, clade B (ovalbumin), member 7	0.050
PDLIM5	PDZ and LIM domain 5	0.050
UPK2	uroplakin 2	0.049
FGFR2	fibroblast growth factor receptor 2	0.049	Mouse
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.049
MXRA5	matrix-remodelling associated 5	0.049
RIPK4	receptor-interacting serine-threonine kinase 4	0.049
KRT38	keratin 38	0.049	Human
CLDN4	claudin 4	0.049
HES1	hairy and enhancer of split 1, (Drosophila)	0.049	Mouse Worm
WNT1	wingless-type MMTV integration site family, member 1	0.048	Human Fly
ACTN4	actinin, alpha 4	0.048
SYT8	synaptotagmin VIII	0.048
DAXX	death-domain associated protein	0.048
COL10A1	collagen, type X, alpha 1	0.048
CXCL14	chemokine (C-X-C motif) ligand 14	0.048
NCK2	NCK adaptor protein 2	0.048
HOXC11	homeobox C11	0.048
GJA1	gap junction protein, alpha 1, 43kDa	0.047
MAML1	mastermind-like 1 (Drosophila)	0.047
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	0.047
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.047
MYOCD	myocardin	0.047
IGSF3	immunoglobulin superfamily, member 3	0.047
COL6A1	collagen, type VI, alpha 1	0.047
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.047	Mouse
WNT10A	wingless-type MMTV integration site family, member 10A	0.047
RAX	retina and anterior neural fold homeobox	0.047
INHBB	inhibin, beta B	0.046	Human
HTR3A	5-hydroxytryptamine (serotonin) receptor 3A	0.046
EPHA3	EPH receptor A3	0.046	Human
TNRC6A	trinucleotide repeat containing 6A	0.046
PSORS1C2	psoriasis susceptibility 1 candidate 2	0.046
SPINT2	serine peptidase inhibitor, Kunitz type, 2	0.046
IL1F6	interleukin 1 family, member 6 (epsilon)	0.046
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	0.046
BHLHE40	basic helix-loop-helix family, member e40	0.046
PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)	0.046
VGLL1	vestigial like 1 (Drosophila)	0.046
TMEM123	transmembrane protein 123	0.045
NOTCH2	notch 2	0.045
HOXD9	homeobox D9	0.045
CAPN6	calpain 6	0.045
RNF31	ring finger protein 31	0.045
WDR20	WD repeat domain 20	0.045
SOX21	SRY (sex determining region Y)-box 21	0.045	Mouse
SPRR2B	small proline-rich protein 2B	0.045
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.044
WNT11	wingless-type MMTV integration site family, member 11	0.044	Human
LTBP1	latent transforming growth factor beta binding protein 1	0.044
CNKSR1	connector enhancer of kinase suppressor of Ras 1	0.044
TMPRSS4	transmembrane protease, serine 4	0.044
TMSB4X	thymosin beta 4, X-linked	0.044
KLK2	kallikrein-related peptidase 2	0.044	Human
BCR	breakpoint cluster region	0.044
GRAP2	GRB2-related adaptor protein 2	0.043
HOXC6	homeobox C6	0.043	Human
MYO10	myosin X	0.043
STRA6	stimulated by retinoic acid gene 6 homolog (mouse)	0.042
TSG101	tumor susceptibility gene 101	0.042	Mouse
OTP	orthopedia homeobox	0.042
GPR124	G protein-coupled receptor 124	0.042
FZD7	frizzled homolog 7 (Drosophila)	0.042	Human
KLK12	kallikrein-related peptidase 12	0.042	Human
MAPK6	mitogen-activated protein kinase 6	0.042
FERMT2	fermitin family member 2	0.042
MALL	mal, T-cell differentiation protein-like	0.042
SMO	smoothened homolog (Drosophila)	0.041
MUC4	mucin 4, cell surface associated	0.041
TG	thyroglobulin	0.041
SMS	spermine synthase	0.041
RHBG	Rh family, B glycoprotein (gene/pseudogene)	0.041
KRTDAP	keratinocyte differentiation-associated protein	0.041
RCOR1	REST corepressor 1	0.041
PDCD6	programmed cell death 6	0.041
AHR	aryl hydrocarbon receptor	0.041
IL1F9	interleukin 1 family, member 9	0.041
KIAA1217	KIAA1217	0.041
GAST	gastrin	0.041
DIO2	deiodinase, iodothyronine, type II	0.040
IGFBP3	insulin-like growth factor binding protein 3	0.040
TMPRSS11E	transmembrane protease, serine 11E	0.040
PAX1	paired box 1	0.040
SLC39A2	solute carrier family 39 (zinc transporter), member 2	0.040
LEF1	lymphoid enhancer-binding factor 1	0.040	Rat
PAEP	progestagen-associated endometrial protein	0.040
KRT83	keratin 83	0.040	Human
CALML5	calmodulin-like 5	0.039
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.039	Mouse
SH3D19	SH3 domain containing 19	0.039
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.039
EFNB2	ephrin-B2	0.039	Worm
CD151	CD151 molecule (Raph blood group)	0.039
DSC1	desmocollin 1	0.039	Human
DUOX2	dual oxidase 2	0.039
NKX2-1	NK2 homeobox 1	0.039
SOX4	SRY (sex determining region Y)-box 4	0.038
CLDN7	claudin 7	0.038	Human
TNMD	tenomodulin	0.038
SCEL	sciellin	0.038
RUNX2	runt-related transcription factor 2	0.038
WNT7A	wingless-type MMTV integration site family, member 7A	0.038	Human
PGLYRP4	peptidoglycan recognition protein 4	0.038
CXCR5	chemokine (C-X-C motif) receptor 5	0.038
CEP170	centrosomal protein 170kDa	0.038
FNDC3B	fibronectin type III domain containing 3B	0.038
BAIAP2	BAI1-associated protein 2	0.038
ATN1	atrophin 1	0.038
CTNNBIP1	catenin, beta interacting protein 1	0.038
TGFBI	transforming growth factor, beta-induced, 68kDa	0.038
A2ML1	alpha-2-macroglobulin-like 1	0.038
PAX8	paired box 8	0.038
ALOX15B	arachidonate 15-lipoxygenase, type B	0.038	Mouse
FOXO1	forkhead box O1	0.037
EZR	ezrin	0.037
PRDX1	peroxiredoxin 1	0.037
COL2A1	collagen, type II, alpha 1	0.037	Human
STK4	serine/threonine kinase 4	0.037	Mouse
TP53AIP1	tumor protein p53 regulated apoptosis inducing protein 1	0.036
NDP	Norrie disease (pseudoglioma)	0.036
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.036
SFRP4	secreted frizzled-related protein 4	0.036
PCDH7	protocadherin 7	0.036
RGS3	regulator of G-protein signaling 3	0.036
EDN2	endothelin 2	0.036
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.036
RLIM	ring finger protein, LIM domain interacting	0.036
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.036
BGN	biglycan	0.036
AIPL1	aryl hydrocarbon receptor interacting protein-like 1	0.035
ACVR1	activin A receptor, type I	0.035
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.035	Mouse
GSTO1	glutathione S-transferase omega 1	0.035
MPZL2	myelin protein zero-like 2	0.035
SEPT10	septin 10	0.035
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.035
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.035
GPC1	glypican 1	0.035
RYBP	RING1 and YY1 binding protein	0.035
NRP2	neuropilin 2	0.035
PEX26	peroxisomal biogenesis factor 26	0.035
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.035
SLC6A14	solute carrier family 6 (amino acid transporter), member 14	0.035
ARTN	artemin	0.035
PLXDC1	plexin domain containing 1	0.035
CGN	cingulin	0.035
NOV	nephroblastoma overexpressed gene	0.035
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.035
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.035
LTBP2	latent transforming growth factor beta binding protein 2	0.034
CRNN	cornulin	0.034	Human
FKBP4	FK506 binding protein 4, 59kDa	0.034
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.034	Human Zebrafish
OCA2	oculocutaneous albinism II	0.034
PRKCI	protein kinase C, iota	0.034
HOXD10	homeobox D10	0.034
SOX15	SRY (sex determining region Y)-box 15	0.034
S100A3	S100 calcium binding protein A3	0.034
ITGB6	integrin, beta 6	0.034	Human
FZD2	frizzled homolog 2 (Drosophila)	0.034	Human
TIMP2	TIMP metallopeptidase inhibitor 2	0.033
PMEPA1	prostate transmembrane protein, androgen induced 1	0.033
ALDH3B2	aldehyde dehydrogenase 3 family, member B2	0.033	Human
DDIT4	DNA-damage-inducible transcript 4	0.033
POU3F1	POU class 3 homeobox 1	0.033	Mouse
IGFBP2	insulin-like growth factor binding protein 2, 36kDa	0.033
TGM5	transglutaminase 5	0.033	Human
UNC5B	unc-5 homolog B (C. elegans)	0.033
PAX7	paired box 7	0.033
PDGFA	platelet-derived growth factor alpha polypeptide	0.033	Mouse
NTM	neurotrimin	0.033
TGFB3	transforming growth factor, beta 3	0.033
DLX4	distal-less homeobox 4	0.033	Zebrafish
NDRG1	N-myc downstream regulated 1	0.032
TRIP6	thyroid hormone receptor interactor 6	0.032
FDPS	farnesyl diphosphate synthase	0.032
SDF4	stromal cell derived factor 4	0.032
STK38L	serine/threonine kinase 38 like	0.032	Fly
SIX3	SIX homeobox 3	0.032
EPS8L2	EPS8-like 2	0.032	Worm
TMEM30B	transmembrane protein 30B	0.032
NCR2	natural cytotoxicity triggering receptor 2	0.032
FOXO3	forkhead box O3	0.032
HOXB8	homeobox B8	0.032	Human
EFNB1	ephrin-B1	0.032
NPAS1	neuronal PAS domain protein 1	0.032
NID1	nidogen 1	0.032
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.032
PICALM	phosphatidylinositol binding clathrin assembly protein	0.032
SOX1	SRY (sex determining region Y)-box 1	0.032
FRMD5	FERM domain containing 5	0.032
DUSP23	dual specificity phosphatase 23	0.032
SSH3	slingshot homolog 3 (Drosophila)	0.032
FASN	fatty acid synthase	0.032
CWH43	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	0.032
LGALS7B	lectin, galactoside-binding, soluble, 7B	0.032
SLPI	secretory leukocyte peptidase inhibitor	0.031
AP2M1	adaptor-related protein complex 2, mu 1 subunit	0.031
SALL2	sal-like 2 (Drosophila)	0.031
ABCA12	ATP-binding cassette, sub-family A (ABC1), member 12	0.031	Mouse
SEC24A	SEC24 family, member A (S. cerevisiae)	0.031
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.031
RUNX1	runt-related transcription factor 1	0.031	Mouse
SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.031
TEKT4	tektin 4	0.031
GNAS	GNAS complex locus	0.031
KRT76	keratin 76	0.031	Human
KRT12	keratin 12	0.031	Human
KRT35	keratin 35	0.031	Human
KRT85	keratin 85	0.031	Human
LMNA	lamin A/C	0.031
PLS3	plastin 3	0.031	Rat
ADH7	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	0.031
FGF2	fibroblast growth factor 2 (basic)	0.031
SNIP1	Smad nuclear interacting protein 1	0.031
LOX	lysyl oxidase	0.031
HOXA4	homeobox A4	0.031	Human
WWTR1	WW domain containing transcription regulator 1	0.031
ACAN	aggrecan	0.031
AMOTL2	angiomotin like 2	0.031
PITX1	paired-like homeodomain 1	0.031
WNK1	WNK lysine deficient protein kinase 1	0.031
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.030
SC4MOL	sterol-C4-methyl oxidase-like	0.030
NFIL3	nuclear factor, interleukin 3 regulated	0.030
LDLR	low density lipoprotein receptor	0.030
FLG	filaggrin	0.030
TCF7	transcription factor 7 (T-cell specific, HMG-box)	0.030
ANXA3	annexin A3	0.030	Human
SRSF6	serine/arginine-rich splicing factor 6	0.030
DST	dystonin	0.030
U2AF1	U2 small nuclear RNA auxiliary factor 1	0.030
FAM83C	family with sequence similarity 83, member C	0.030
NOP10	NOP10 ribonucleoprotein homolog (yeast)	0.030
PTK7	PTK7 protein tyrosine kinase 7	0.030
DHCR7	7-dehydrocholesterol reductase	0.030
E2F6	E2F transcription factor 6	0.030
GRP	gastrin-releasing peptide	0.030
MUC1	mucin 1, cell surface associated	0.030
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.030
RND3	Rho family GTPase 3	0.030
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.030
PDE4DIP	phosphodiesterase 4D interacting protein	0.030
AP1M1	adaptor-related protein complex 1, mu 1 subunit	0.030
IL1RN	interleukin 1 receptor antagonist	0.030
GRHL2	grainyhead-like 2 (Drosophila)	0.029
LAMA5	laminin, alpha 5	0.029	Mouse
GPR56	G protein-coupled receptor 56	0.029
BNC2	basonuclin 2	0.029
KCNK7	potassium channel, subfamily K, member 7	0.029
CCND2	cyclin D2	0.029
PPIC	peptidylprolyl isomerase C (cyclophilin C)	0.029
CTSA	cathepsin A	0.029
CAV1	caveolin 1, caveolae protein, 22kDa	0.029
VCL	vinculin	0.029
KRT37	keratin 37	0.029	Human
LRRC15	leucine rich repeat containing 15	0.029
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.029
PRDX4	peroxiredoxin 4	0.029
ALOX12	arachidonate 12-lipoxygenase	0.029	Mouse
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.029
CBFB	core-binding factor, beta subunit	0.028
NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.028
ITGB1BP1	integrin beta 1 binding protein 1	0.028
CALR	calreticulin	0.028
CELSR2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.028
PXDN	peroxidasin homolog (Drosophila)	0.028
PCDH1	protocadherin 1	0.028
USP2	ubiquitin specific peptidase 2	0.028
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.028
EPHB6	EPH receptor B6	0.028	Human
MYOG	myogenin (myogenic factor 4)	0.028
ACTN1	actinin, alpha 1	0.028
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.028
VCAM1	vascular cell adhesion molecule 1	0.028
FBLIM1	filamin binding LIM protein 1	0.028
TTC22	tetratricopeptide repeat domain 22	0.028
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.028
ARHGEF16	Rho guanine nucleotide exchange factor (GEF) 16	0.027
RGS12	regulator of G-protein signaling 12	0.027
SYDE1	synapse defective 1, Rho GTPase, homolog 1 (C. elegans)	0.027
TNS4	tensin 4	0.027
MED13	mediator complex subunit 13	0.027
NFE2L1	nuclear factor (erythroid-derived 2)-like 1	0.027
ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b	0.027
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.027
SFRP5	secreted frizzled-related protein 5	0.027
CRLF1	cytokine receptor-like factor 1	0.027
HSF1	heat shock transcription factor 1	0.027
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.027
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.027
BHLHE23	basic helix-loop-helix family, member e23	0.027
SIM2	single-minded homolog 2 (Drosophila)	0.027
FSTL3	follistatin-like 3 (secreted glycoprotein)	0.027	Human
HOXB13	homeobox B13	0.027
FGF4	fibroblast growth factor 4	0.027
WHSC2	Wolf-Hirschhorn syndrome candidate 2	0.027
CD248	CD248 molecule, endosialin	0.027