IMP: Integrative Multi-species Prediction

Homo sapiens

3 genes annotated in human

Multi-species View

negative regulation of cell size

GO:0045792

Any process that reduces cell size.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in humanInclude functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of cell size"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of cell size" (in gray)

Name	Description	Probability	Func Analog Organism
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.978	Mouse Rat
RPTOR	regulatory associated protein of MTOR, complex 1	0.949
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.821
TP53	tumor protein p53	0.790
PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	0.754
RICTOR	RPTOR independent companion of MTOR, complex 2	0.640
LIN9	lin-9 homolog (C. elegans)	0.608
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.435
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.244
RB1	retinoblastoma 1	0.195
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.172
TSC2	tuberous sclerosis 2	0.158	Rat Fly
DEPTOR	DEP domain containing MTOR-interacting protein	0.141
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.139	Fly
BAD	BCL2-associated agonist of cell death	0.138
BRCA1	breast cancer 1, early onset	0.136
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.122	Rat
PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.116
PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	0.114
NLK	nemo-like kinase	0.114
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.111
KIF23	kinesin family member 23	0.107
FOXO3	forkhead box O3	0.101	Fly
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.100
TUBA1B	tubulin, alpha 1b	0.096
LRRK2	leucine-rich repeat kinase 2	0.094
CLSPN	claspin	0.094
ACTB	actin, beta	0.093
ACTG1	actin, gamma 1	0.092
AKT1S1	AKT1 substrate 1 (proline-rich)	0.088
CCNE1	cyclin E1	0.087
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.084
FOXM1	forkhead box M1	0.083
IRS1	insulin receptor substrate 1	0.083
NCOR1	nuclear receptor corepressor 1	0.083
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.083
TNK2	tyrosine kinase, non-receptor, 2	0.081
CDT1	chromatin licensing and DNA replication factor 1	0.074
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.073
AR	androgen receptor	0.068
NCOA2	nuclear receptor coactivator 2	0.067
TUBA1C	tubulin, alpha 1c	0.062
FKBP1A	FK506 binding protein 1A, 12kDa	0.060
HDAC4	histone deacetylase 4	0.057
SORBS1	sorbin and SH3 domain containing 1	0.056
CLTC	clathrin, heavy chain (Hc)	0.055
CREBBP	CREB binding protein	0.052
SORBS2	sorbin and SH3 domain containing 2	0.046
CFL2	cofilin 2 (muscle)	0.044
E2F1	E2F transcription factor 1	0.044
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.042	Fly
RHEB	Ras homolog enriched in brain	0.041
GTSE1	G-2 and S-phase expressed 1	0.041
LARS	leucyl-tRNA synthetase	0.041
CCNB2	cyclin B2	0.040
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.040	Fly
RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	0.040
TIMELESS	timeless homolog (Drosophila)	0.039
CACNA1H	calcium channel, voltage-dependent, T type, alpha 1H subunit	0.038
WEE1	WEE1 homolog (S. pombe)	0.038
IQGAP1	IQ motif containing GTPase activating protein 1	0.037
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.037
BRCA2	breast cancer 2, early onset	0.036
BTRC	beta-transducin repeat containing	0.036
FOXO1	forkhead box O1	0.035	Fly
TRIP10	thyroid hormone receptor interactor 10	0.034
ORC1	origin recognition complex, subunit 1	0.032
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.031
STK38	serine/threonine kinase 38	0.030
KAT2B	K(lysine) acetyltransferase 2B	0.029
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.029
TPD52L1	tumor protein D52-like 1	0.029
LIMK1	LIM domain kinase 1	0.028
DCTN1	dynactin 1	0.028
MAPK12	mitogen-activated protein kinase 12	0.027
RHEBL1	Ras homolog enriched in brain like 1	0.026
HJURP	Holliday junction recognition protein	0.026
MARK2	MAP/microtubule affinity-regulating kinase 2	0.025
PAK3	p21 protein (Cdc42/Rac)-activated kinase 3	0.025
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.025
CAV1	caveolin 1, caveolae protein, 22kDa	0.025
EIF4EBP1	eukaryotic translation initiation factor 4E binding protein 1	0.025
FAM64A	family with sequence similarity 64, member A	0.024
PDPK1	3-phosphoinositide dependent protein kinase-1	0.024
ACACA	acetyl-CoA carboxylase alpha	0.023
SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.023	Fly
ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	0.023
VIM	vimentin	0.022
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.022
GSK3B	glycogen synthase kinase 3 beta	0.022
ESPL1	extra spindle pole bodies homolog 1 (S. cerevisiae)	0.022
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.021
LIN54	lin-54 homolog (C. elegans)	0.021
ZFYVE26	zinc finger, FYVE domain containing 26	0.020
RALGPS2	Ral GEF with PH domain and SH3 binding motif 2	0.020
EZR	ezrin	0.020
SEMA6D	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.020	Fly
H2AFX	H2A histone family, member X	0.020
MKI67	antigen identified by monoclonal antibody Ki-67	0.020
MAP3K11	mitogen-activated protein kinase kinase kinase 11	0.019
KIF2C	kinesin family member 2C	0.019
MAPKAP1	mitogen-activated protein kinase associated protein 1	0.019
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.019
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.019
CDC42EP2	CDC42 effector protein (Rho GTPase binding) 2	0.019
PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	0.018
POLQ	polymerase (DNA directed), theta	0.018
MAPT	microtubule-associated protein tau	0.018
CDCA3	cell division cycle associated 3	0.018
PRKCZ	protein kinase C, zeta	0.018
RAD54L	RAD54-like (S. cerevisiae)	0.017
SIRT1	sirtuin 1	0.017
BAIAP2	BAI1-associated protein 2	0.017
BIRC5	baculoviral IAP repeat containing 5	0.017
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.017
PPP2R4	protein phosphatase 2A activator, regulatory subunit 4	0.017
PLD1	phospholipase D1, phosphatidylcholine-specific	0.016
NEIL3	nei endonuclease VIII-like 3 (E. coli)	0.016
PRKAG1	protein kinase, AMP-activated, gamma 1 non-catalytic subunit	0.016
PLK1	polo-like kinase 1	0.016
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.016
RUNX1	runt-related transcription factor 1	0.016
SH3RF1	SH3 domain containing ring finger 1	0.016
CENPI	centromere protein I	0.015
NCOA1	nuclear receptor coactivator 1	0.015
ERC2	ELKS/RAB6-interacting/CAST family member 2	0.015
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.015
ING1	inhibitor of growth family, member 1	0.015
EPB41L3	erythrocyte membrane protein band 4.1-like 3	0.015
NCKAP1	NCK-associated protein 1	0.015
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.015
PAK4	p21 protein (Cdc42/Rac)-activated kinase 4	0.014	Fly
FAM82A2	family with sequence similarity 82, member A2	0.014
ATAD5	ATPase family, AAA domain containing 5	0.014
FNIP1	folliculin interacting protein 1	0.014
KIF5B	kinesin family member 5B	0.014
NCOA3	nuclear receptor coactivator 3	0.014
ASF1B	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.013
NGFRAP1	nerve growth factor receptor (TNFRSF16) associated protein 1	0.013
ADRB2	adrenergic, beta-2-, receptor, surface	0.013
PPM1E	protein phosphatase, Mg2+/Mn2+ dependent, 1E	0.013
PRR5L	proline rich 5 like	0.013
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.013
ASXL1	additional sex combs like 1 (Drosophila)	0.012
NCOA6	nuclear receptor coactivator 6	0.012
MXD3	MAX dimerization protein 3	0.012
ARHGAP32	Rho GTPase activating protein 32	0.012
PSRC1	proline/serine-rich coiled-coil 1	0.012
EXO1	exonuclease 1	0.012
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.012
DEPDC1B	DEP domain containing 1B	0.012
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.012
KCNK3	potassium channel, subfamily K, member 3	0.012
IQGAP2	IQ motif containing GTPase activating protein 2	0.012
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.012
WASL	Wiskott-Aldrich syndrome-like	0.012
LDLR	low density lipoprotein receptor	0.012
GATAD2A	GATA zinc finger domain containing 2A	0.012
ARRB2	arrestin, beta 2	0.012
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.012
GSG2	germ cell associated 2 (haspin)	0.011
JPH2	junctophilin 2	0.011
RRAGD	Ras-related GTP binding D	0.011
ITSN1	intersectin 1 (SH3 domain protein)	0.011
CAPNS1	calpain, small subunit 1	0.011
KIF4A	kinesin family member 4A	0.011
PRR5	proline rich 5 (renal)	0.011
CRTC2	CREB regulated transcription coactivator 2	0.011
RAB5C	RAB5C, member RAS oncogene family	0.011
KLF13	Kruppel-like factor 13	0.011
CDC42BPA	CDC42 binding protein kinase alpha (DMPK-like)	0.011
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.011
LARP1	La ribonucleoprotein domain family, member 1	0.011
AURKB	aurora kinase B	0.011
SSX2IP	synovial sarcoma, X breakpoint 2 interacting protein	0.011
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	0.011
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.011
CKAP2L	cytoskeleton associated protein 2-like	0.011
FOXO4	forkhead box O4	0.011
SRCAP	Snf2-related CREBBP activator protein	0.011
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.011
RAB11FIP3	RAB11 family interacting protein 3 (class II)	0.011
ARRB1	arrestin, beta 1	0.010
DDIT4	DNA-damage-inducible transcript 4	0.010
MTAP	methylthioadenosine phosphorylase	0.010
PDE6D	phosphodiesterase 6D, cGMP-specific, rod, delta	0.010
FHL2	four and a half LIM domains 2	0.010
KIF20A	kinesin family member 20A	0.010
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.010
RGS3	regulator of G-protein signaling 3	0.010
MAP2K6	mitogen-activated protein kinase kinase 6	0.010
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	0.010
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.010
KLC4	kinesin light chain 4	0.010
MKNK1	MAP kinase interacting serine/threonine kinase 1	0.010
NOVA1	neuro-oncological ventral antigen 1	0.010
CENPA	centromere protein A	0.010
MBNL2	muscleblind-like 2 (Drosophila)	0.010
NEK6	NIMA (never in mitosis gene a)-related kinase 6	0.010
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.010
KLC1	kinesin light chain 1	0.010
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.010
SOCS5	suppressor of cytokine signaling 5	0.010
CAMKK1	calcium/calmodulin-dependent protein kinase kinase 1, alpha	0.010
CBX4	chromobox homolog 4	0.010
PAK7	p21 protein (Cdc42/Rac)-activated kinase 7	0.010	Fly
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	0.010
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.010