IMP: Integrative Multi-species Prediction

Homo sapiens

4 genes annotated in human

cranial nerve development

The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cranial nerve development"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "cranial nerve development" (in gray)

Name	Description	Probability	Func Analog Organism
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	1.000	Zebrafish
EGFR	epidermal growth factor receptor	1.000
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	1.000	Zebrafish Mouse
DTNA	dystrobrevin, alpha	0.996
POU5F1	POU class 5 homeobox 1	0.996
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.995
GRB7	growth factor receptor-bound protein 7	0.992
SUFU	suppressor of fused homolog (Drosophila)	0.987
CHD8	chromodomain helicase DNA binding protein 8	0.978	Human
SPG21	spastic paraplegia 21 (autosomal recessive, Mast syndrome)	0.976
EP300	E1A binding protein p300	0.975
PPARA	peroxisome proliferator-activated receptor alpha	0.959
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.956
CHD7	chromodomain helicase DNA binding protein 7	0.954
PTCH1	patched 1	0.932
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.895
HOXA5	homeobox A5	0.894
STK36	serine/threonine kinase 36	0.849
GATA2	GATA binding protein 2	0.847
GATA4	GATA binding protein 4	0.831
HOXB5	homeobox B5	0.823
SETD8	SET domain containing (lysine methyltransferase) 8	0.805
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.791
SOX2	SRY (sex determining region Y)-box 2	0.788
VEGFA	vascular endothelial growth factor A	0.758
MYOD1	myogenic differentiation 1	0.738
SIX6	SIX homeobox 6	0.723
PTK6	PTK6 protein tyrosine kinase 6	0.717
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.701
INSR	insulin receptor	0.696
HAND2	heart and neural crest derivatives expressed 2	0.661	Human
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.653
KLF4	Kruppel-like factor 4 (gut)	0.648
NGF	nerve growth factor (beta polypeptide)	0.579
AKAP2	A kinase (PRKA) anchor protein 2	0.558
PLCG1	phospholipase C, gamma 1	0.546
TNS3	tensin 3	0.535
HOXB9	homeobox B9	0.534
HOXD12	homeobox D12	0.528
TMSB4X	thymosin beta 4, X-linked	0.505
PDX1	pancreatic and duodenal homeobox 1	0.495
HOXA3	homeobox A3	0.483	Mouse
IER2	immediate early response 2	0.476
PAX6	paired box 6	0.468
ZFYVE9	zinc finger, FYVE domain containing 9	0.467
COL4A3BP	collagen, type IV, alpha 3 (Goodpasture antigen) binding protein	0.466
FGF1	fibroblast growth factor 1 (acidic)	0.464
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.456
HOXA4	homeobox A4	0.447
LPXN	leupaxin	0.444
HDAC6	histone deacetylase 6	0.443
MDFI	MyoD family inhibitor	0.441
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.440
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.415
POU4F2	POU class 4 homeobox 2	0.411
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.400	Mouse
FGB	fibrinogen beta chain	0.392
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.391
NEUROG1	neurogenin 1	0.391	Human Zebrafish
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.383
RUNX1	runt-related transcription factor 1	0.381
HOXD13	homeobox D13	0.363
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.361
SH3BP4	SH3-domain binding protein 4	0.361
HOXD9	homeobox D9	0.340
FEV	FEV (ETS oncogene family)	0.340
HOXA9	homeobox A9	0.338
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.332
SYK	spleen tyrosine kinase	0.331
ALX4	ALX homeobox 4	0.322
HOXA11	homeobox A11	0.321
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.321
HOXB6	homeobox B6	0.298
C11orf73	chromosome 11 open reading frame 73	0.292
FGF2	fibroblast growth factor 2 (basic)	0.288
TUBB3	tubulin, beta 3	0.286
BBS10	Bardet-Biedl syndrome 10	0.284
EPHB1	EPH receptor B1	0.283	Mouse
HOXB3	homeobox B3	0.280	Mouse
PRR13	proline rich 13	0.279
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.276
TAL1	T-cell acute lymphocytic leukemia 1	0.273	Human
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.265
CYLD	cylindromatosis (turban tumor syndrome)	0.257
DTNB	dystrobrevin, beta	0.243
HOXB4	homeobox B4	0.239
POU4F3	POU class 4 homeobox 3	0.238	Mouse
KCTD1	potassium channel tetramerisation domain containing 1	0.236
HOXD11	homeobox D11	0.235
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.233
BARX1	BARX homeobox 1	0.228
HOXC11	homeobox C11	0.220
PITX2	paired-like homeodomain 2	0.218
TMEM30B	transmembrane protein 30B	0.217
EYA2	eyes absent homolog 2 (Drosophila)	0.213
NRP2	neuropilin 2	0.205	Mouse
FRS2	fibroblast growth factor receptor substrate 2	0.200
CABLES1	Cdk5 and Abl enzyme substrate 1	0.197
JUN	jun proto-oncogene	0.196
ECEL1	endothelin converting enzyme-like 1	0.194
FOSL2	FOS-like antigen 2	0.192
GAB2	GRB2-associated binding protein 2	0.190
PYY	peptide YY	0.189
TBX5	T-box 5	0.188	Zebrafish
DUSP23	dual specificity phosphatase 23	0.188
NPAS1	neuronal PAS domain protein 1	0.186
CDX2	caudal type homeobox 2	0.186
EYA1	eyes absent homolog 1 (Drosophila)	0.185
C1orf31	chromosome 1 open reading frame 31	0.182
HNF1B	HNF1 homeobox B	0.182
HOXA6	homeobox A6	0.181
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.180
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.176
OTP	orthopedia homeobox	0.176
HOXA13	homeobox A13	0.175
LMO2	LIM domain only 2 (rhombotin-like 1)	0.174
PHOX2A	paired-like homeobox 2a	0.174	Mouse
HMGA2	high mobility group AT-hook 2	0.174
FOXF2	forkhead box F2	0.169
MNX1	motor neuron and pancreas homeobox 1	0.168
HOXD3	homeobox D3	0.167	Mouse
QPRT	quinolinate phosphoribosyltransferase	0.165
HOXB13	homeobox B13	0.165
LHX5	LIM homeobox 5	0.165
NKX2-1	NK2 homeobox 1	0.164
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.164
MYT1	myelin transcription factor 1	0.163
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.161
ATP5C1	ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1	0.161
HOXD10	homeobox D10	0.160
MSX1	msh homeobox 1	0.160
NCOR1	nuclear receptor corepressor 1	0.159
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.155
SOX11	SRY (sex determining region Y)-box 11	0.154
IGF1R	insulin-like growth factor 1 receptor	0.153
CWC15	CWC15 spliceosome-associated protein homolog (S. cerevisiae)	0.153
HOXC8	homeobox C8	0.153
DAB1	disabled homolog 1 (Drosophila)	0.150
HOXA10	homeobox A10	0.149
GAB1	GRB2-associated binding protein 1	0.148
SNTB1	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	0.148
COL2A1	collagen, type II, alpha 1	0.148
SIX3	SIX homeobox 3	0.145
LMO1	LIM domain only 1 (rhombotin 1)	0.144
NKX6-1	NK6 homeobox 1	0.143
PEX26	peroxisomal biogenesis factor 26	0.143
FOXA2	forkhead box A2	0.141
VAV3	vav 3 guanine nucleotide exchange factor	0.141
DLX4	distal-less homeobox 4	0.140	Zebrafish Fly
FOXG1	forkhead box G1	0.138
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.138
FBXW12	F-box and WD repeat domain containing 12	0.138
RUNX2	runt-related transcription factor 2	0.138
FGF3	fibroblast growth factor 3	0.137
DDR2	discoidin domain receptor tyrosine kinase 2	0.136
SHOX2	short stature homeobox 2	0.136
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.135
GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	0.135
ARID1A	AT rich interactive domain 1A (SWI-like)	0.134
HNF4A	hepatocyte nuclear factor 4, alpha	0.134
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.133	Mouse
BMP4	bone morphogenetic protein 4	0.132
BNC1	basonuclin 1	0.132
HOXC13	homeobox C13	0.129
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.127
HOXB8	homeobox B8	0.127
MLL4	myeloid/lymphoid or mixed-lineage leukemia 4	0.123
CCND3	cyclin D3	0.122
TLX2	T-cell leukemia homeobox 2	0.121
DLX2	distal-less homeobox 2	0.120
TCF12	transcription factor 12	0.119
SIM2	single-minded homolog 2 (Drosophila)	0.119
ALAS1	aminolevulinate, delta-, synthase 1	0.118
ZNF764	zinc finger protein 764	0.118
ALX3	ALX homeobox 3	0.117
FGD1	FYVE, RhoGEF and PH domain containing 1	0.117
TUBB2A	tubulin, beta 2A	0.117
GLI1	GLI family zinc finger 1	0.116	Zebrafish
PAX2	paired box 2	0.116	Mouse
ZIC2	Zic family member 2 (odd-paired homolog, Drosophila)	0.115
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.114
SH3BP2	SH3-domain binding protein 2	0.114
RET	ret proto-oncogene	0.113
POU4F1	POU class 4 homeobox 1	0.113	Mouse
ZMYND8	zinc finger, MYND-type containing 8	0.113
BBS1	Bardet-Biedl syndrome 1	0.113
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.112
DUSP1	dual specificity phosphatase 1	0.112
AMN	amnionless homolog (mouse)	0.112
CBX2	chromobox homolog 2	0.112
ZNF611	zinc finger protein 611	0.112
FOXE3	forkhead box E3	0.111
SIX2	SIX homeobox 2	0.111
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.110
VAX1	ventral anterior homeobox 1	0.110	Zebrafish
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.110
TLX1	T-cell leukemia homeobox 1	0.110
FOXL1	forkhead box L1	0.109
ESPN	espin	0.108
TBX1	T-box 1	0.106
ARX	aristaless related homeobox	0.106
NCOR2	nuclear receptor corepressor 2	0.105
NGFR	nerve growth factor receptor	0.103
NKX3-2	NK3 homeobox 2	0.103
HOXA2	homeobox A2	0.102	Human
GLIS3	GLIS family zinc finger 3	0.101
TACR1	tachykinin receptor 1	0.099
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.099
TP73	tumor protein p73	0.098
FOXB1	forkhead box B1	0.097
LHX2	LIM homeobox 2	0.096	Zebrafish
EFNB2	ephrin-B2	0.096
FOXA1	forkhead box A1	0.095
LBX1	ladybird homeobox 1	0.092
A1BG	alpha-1-B glycoprotein	0.092
LRRK2	leucine-rich repeat kinase 2	0.092
WNT1	wingless-type MMTV integration site family, member 1	0.091
PRDM13	PR domain containing 13	0.091
SFRP5	secreted frizzled-related protein 5	0.091
ACP5	acid phosphatase 5, tartrate resistant	0.090
DLL3	delta-like 3 (Drosophila)	0.089
HOXC5	homeobox C5	0.088
GCM2	glial cells missing homolog 2 (Drosophila)	0.088
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.088
NEUROD1	neurogenic differentiation 1	0.088	Human
PAX7	paired box 7	0.087
FGFR1	fibroblast growth factor receptor 1	0.087	Zebrafish
SIX1	SIX homeobox 1	0.087	Mouse
BHLHE23	basic helix-loop-helix family, member e23	0.086
FOXD3	forkhead box D3	0.086	Zebrafish
MPP3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	0.085
DMRT1	doublesex and mab-3 related transcription factor 1	0.085
NHLH2	nescient helix loop helix 2	0.085	Human
NXPH4	neurexophilin 4	0.084
WNT6	wingless-type MMTV integration site family, member 6	0.084
ZIC3	Zic family member 3 (odd-paired homolog, Drosophila)	0.084
HOXD4	homeobox D4	0.083
ZNF160	zinc finger protein 160	0.083
VSX2	visual system homeobox 2	0.083
SLC9A3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.083
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.082
HOXD1	homeobox D1	0.082	Human
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.081
FOXL2	forkhead box L2	0.080
GSC2	goosecoid homeobox 2	0.079
CSNK1E	casein kinase 1, epsilon	0.079
ZNF721	zinc finger protein 721	0.079
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.079
C1QL1	complement component 1, q subcomponent-like 1	0.079
POU3F2	POU class 3 homeobox 2	0.078
GDF7	growth differentiation factor 7	0.078
EN1	engrailed homeobox 1	0.078
HMX1	H6 family homeobox 1	0.078
GJD2	gap junction protein, delta 2, 36kDa	0.077
BNC2	basonuclin 2	0.077
HES2	hairy and enhancer of split 2 (Drosophila)	0.076
CYP26C1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.076
LAT	linker for activation of T cells	0.075
NRG1	neuregulin 1	0.075
FOXD2	forkhead box D2	0.074
CHIC2	cysteine-rich hydrophobic domain 2	0.074
GPR161	G protein-coupled receptor 161	0.074
VSX1	visual system homeobox 1	0.074
FZD8	frizzled homolog 8 (Drosophila)	0.073
OTOP3	otopetrin 3	0.073
VAX2	ventral anterior homeobox 2	0.072	Zebrafish
FAM123A	family with sequence similarity 123A	0.071
CRMP1	collapsin response mediator protein 1	0.071
MCC	mutated in colorectal cancers	0.071
GLI3	GLI family zinc finger 3	0.071	Mouse
NCK2	NCK adaptor protein 2	0.071
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.069
TCF4	transcription factor 4	0.069
STC1	stanniocalcin 1	0.069
PITX3	paired-like homeodomain 3	0.069
EMX1	empty spiracles homeobox 1	0.069
WNT3A	wingless-type MMTV integration site family, member 3A	0.068
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.068
ADARB2	adenosine deaminase, RNA-specific, B2	0.068
TCF15	transcription factor 15 (basic helix-loop-helix)	0.068	Human
ZNF263	zinc finger protein 263	0.067
KCNC2	potassium voltage-gated channel, Shaw-related subfamily, member 2	0.067
BMP7	bone morphogenetic protein 7	0.066
NOSTRIN	nitric oxide synthase trafficker	0.066
GLI2	GLI family zinc finger 2	0.066	Zebrafish
MID1IP1	MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))	0.065
PPP5C	protein phosphatase 5, catalytic subunit	0.065
GTF3C1	general transcription factor IIIC, polypeptide 1, alpha 220kDa	0.065
APP	amyloid beta (A4) precursor protein	0.064
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.064
HIC1	hypermethylated in cancer 1	0.063
HOXC6	homeobox C6	0.063
ISL1	ISL LIM homeobox 1	0.063	Mouse
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.063
DCC	deleted in colorectal carcinoma	0.063
AGAP1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	0.062
NKX2-8	NK2 homeobox 8	0.061
DDR1	discoidin domain receptor tyrosine kinase 1	0.061
HOXB7	homeobox B7	0.061
HOXA7	homeobox A7	0.061
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.060
SIM1	single-minded homolog 1 (Drosophila)	0.060
CABLES2	Cdk5 and Abl enzyme substrate 2	0.060
WNT11	wingless-type MMTV integration site family, member 11	0.060
PCDHA2	protocadherin alpha 2	0.059
EPHB3	EPH receptor B3	0.059
ONECUT2	one cut homeobox 2	0.059
PTF1A	pancreas specific transcription factor, 1a	0.059	Human
WT1	Wilms tumor 1	0.059
BARHL2	BarH-like homeobox 2	0.059
RAX	retina and anterior neural fold homeobox	0.059
PTS	6-pyruvoyltetrahydropterin synthase	0.058
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	0.058
RIN1	Ras and Rab interactor 1	0.058
EN2	engrailed homeobox 2	0.058
USP50	ubiquitin specific peptidase 50	0.057
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.057
PRRX1	paired related homeobox 1	0.057
PRNP	prion protein	0.057
IRX5	iroquois homeobox 5	0.057
PHOX2B	paired-like homeobox 2b	0.057	Mouse
TBX2	T-box 2	0.057
TBR1	T-box, brain, 1	0.056
EFNB1	ephrin-B1	0.056
PAX3	paired box 3	0.056
HOXC9	homeobox C9	0.055
MECOM	MDS1 and EVI1 complex locus	0.055
PBRM1	polybromo 1	0.055
PROX1	prospero homeobox 1	0.055
ALX1	ALX homeobox 1	0.055
SPTBN4	spectrin, beta, non-erythrocytic 4	0.055
LTK	leukocyte receptor tyrosine kinase	0.055
IGSF3	immunoglobulin superfamily, member 3	0.054
HOXC4	homeobox C4	0.054
CPNE6	copine VI (neuronal)	0.054
DLX5	distal-less homeobox 5	0.054	Zebrafish
FOXC1	forkhead box C1	0.054
NELL1	NEL-like 1 (chicken)	0.054
RECK	reversion-inducing-cysteine-rich protein with kazal motifs	0.054
ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.054
GRIK3	glutamate receptor, ionotropic, kainate 3	0.054
COL4A6	collagen, type IV, alpha 6	0.053
OLIG2	oligodendrocyte lineage transcription factor 2	0.053
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.053
PRDM8	PR domain containing 8	0.053
DCX	doublecortin	0.053
GFRA3	GDNF family receptor alpha 3	0.053
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.053
EPHB4	EPH receptor B4	0.053
NDUFA12	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12	0.052
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.052
SLC18A3	solute carrier family 18 (vesicular acetylcholine), member 3	0.052
TLL2	tolloid-like 2	0.052
CADM4	cell adhesion molecule 4	0.051
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.051
SLITRK3	SLIT and NTRK-like family, member 3	0.051
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.051
DLGAP2	discs, large (Drosophila) homolog-associated protein 2	0.051
FZD10	frizzled homolog 10 (Drosophila)	0.051
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.051
SPRR2A	small proline-rich protein 2A	0.050
FOXN1	forkhead box N1	0.050
KCNJ16	potassium inwardly-rectifying channel, subfamily J, member 16	0.050
GATA3	GATA binding protein 3	0.050
JAG1	jagged 1	0.050
AMELX	amelogenin, X-linked	0.050
NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.050
DLX1	distal-less homeobox 1	0.050	Fly
PAX1	paired box 1	0.050
DYNC1I1	dynein, cytoplasmic 1, intermediate chain 1	0.049
GJA3	gap junction protein, alpha 3, 46kDa	0.049
NKX2-4	NK2 homeobox 4	0.049
GRM8	glutamate receptor, metabotropic 8	0.049
SOX1	SRY (sex determining region Y)-box 1	0.049
HIPK2	homeodomain interacting protein kinase 2	0.049
SCARF2	scavenger receptor class F, member 2	0.049
MAST2	microtubule associated serine/threonine kinase 2	0.049
ADAM12	ADAM metallopeptidase domain 12	0.049
FOXF1	forkhead box F1	0.049
NEK1	NIMA (never in mitosis gene a)-related kinase 1	0.048
SLC6A5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.048
INSM1	insulinoma-associated 1	0.048
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.048
UNC5B	unc-5 homolog B (C. elegans)	0.048
PKNOX2	PBX/knotted 1 homeobox 2	0.048
SHANK2	SH3 and multiple ankyrin repeat domains 2	0.048
HAND1	heart and neural crest derivatives expressed 1	0.048	Human
HMX3	H6 family homeobox 3	0.048
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.048
POU3F3	POU class 3 homeobox 3	0.048
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.047
CRIP2	cysteine-rich protein 2	0.047
OAF	OAF homolog (Drosophila)	0.047
ZNF536	zinc finger protein 536	0.047
DOK1	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	0.047
HOXC10	homeobox C10	0.047
MAB21L1	mab-21-like 1 (C. elegans)	0.047
LHX4	LIM homeobox 4	0.047
PLXNB1	plexin B1	0.047
HEMGN	hemogen	0.047
RBMXL2	RNA binding motif protein, X-linked-like 2	0.047
EMP1	epithelial membrane protein 1	0.047
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.046
IRX4	iroquois homeobox 4	0.046
NEUROG2	neurogenin 2	0.046	Human
ST18	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	0.046
FGF20	fibroblast growth factor 20	0.046
PAX4	paired box 4	0.046
ARF5	ADP-ribosylation factor 5	0.045
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.045
EFNA5	ephrin-A5	0.045
SFRP1	secreted frizzled-related protein 1	0.045
EVX1	even-skipped homeobox 1	0.045
HAP1	huntingtin-associated protein 1	0.044
COL13A1	collagen, type XIII, alpha 1	0.044
DIO3	deiodinase, iodothyronine, type III	0.044
MSX2	msh homeobox 2	0.044
PCDHB11	protocadherin beta 11	0.044
HOXC12	homeobox C12	0.043
BMP8B	bone morphogenetic protein 8b	0.043
POU3F4	POU class 3 homeobox 4	0.043
KCNQ2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.043
NRG2	neuregulin 2	0.043
COL4A5	collagen, type IV, alpha 5	0.043
COMMD8	COMM domain containing 8	0.043
RBBP5	retinoblastoma binding protein 5	0.043
MLL2	myeloid/lymphoid or mixed-lineage leukemia 2	0.043
LYPD1	LY6/PLAUR domain containing 1	0.043
GATA6	GATA binding protein 6	0.043
SOS2	son of sevenless homolog 2 (Drosophila)	0.042
TENC1	tensin like C1 domain containing phosphatase (tensin 2)	0.042
EFS	embryonal Fyn-associated substrate	0.042
SOX9	SRY (sex determining region Y)-box 9	0.042
CHN2	chimerin (chimaerin) 2	0.042
EGR1	early growth response 1	0.042
SUPT6H	suppressor of Ty 6 homolog (S. cerevisiae)	0.042
CSPG5	chondroitin sulfate proteoglycan 5 (neuroglycan C)	0.042
EPHB2	EPH receptor B2	0.042	Mouse
TUBB6	tubulin, beta 6	0.042
INA	internexin neuronal intermediate filament protein, alpha	0.042
SKOR1	SKI family transcriptional corepressor 1	0.042
DMRT3	doublesex and mab-3 related transcription factor 3	0.042
VCL	vinculin	0.041
GAD1	glutamate decarboxylase 1 (brain, 67kDa)	0.041
LRRFIP1	leucine rich repeat (in FLII) interacting protein 1	0.041
AJAP1	adherens junctions associated protein 1	0.041
POU3F1	POU class 3 homeobox 1	0.041
RYR3	ryanodine receptor 3	0.041
RORB	RAR-related orphan receptor B	0.041
GRM7	glutamate receptor, metabotropic 7	0.040
TLX3	T-cell leukemia homeobox 3	0.040
BRD2	bromodomain containing 2	0.040
BHLHE40	basic helix-loop-helix family, member e40	0.040
PAX9	paired box 9	0.040
TGFB2	transforming growth factor, beta 2	0.040
PRPH	peripherin	0.040
MAB21L2	mab-21-like 2 (C. elegans)	0.040
CYR61	cysteine-rich, angiogenic inducer, 61	0.040
CMIP	c-Maf-inducing protein	0.040
ARID3C	AT rich interactive domain 3C (BRIGHT-like)	0.040
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.040
DLX3	distal-less homeobox 3	0.040	Zebrafish
CCDC85B	coiled-coil domain containing 85B	0.040
HCN4	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	0.040
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.040
LHX3	LIM homeobox 3	0.040
INSRR	insulin receptor-related receptor	0.040
PRDM12	PR domain containing 12	0.039
NKX1-2	NK1 homeobox 2	0.039
PCDH8	protocadherin 8	0.039
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.039
PVRL3	poliovirus receptor-related 3	0.039
MATN4	matrilin 4	0.039
EBF3	early B-cell factor 3	0.039
RPF1	ribosome production factor 1 homolog (S. cerevisiae)	0.039
CCDC48	coiled-coil domain containing 48	0.039
DNAH2	dynein, axonemal, heavy chain 2	0.039
WNT10B	wingless-type MMTV integration site family, member 10B	0.039
MLNR	motilin receptor	0.039
CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.039
ACTN1	actinin, alpha 1	0.039
CDH4	cadherin 4, type 1, R-cadherin (retinal)	0.039	Zebrafish
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.038
MRPS22	mitochondrial ribosomal protein S22	0.038
GABRG3	gamma-aminobutyric acid (GABA) A receptor, gamma 3	0.038
UNCX	UNC homeobox	0.038
ENTPD2	ectonucleoside triphosphate diphosphohydrolase 2	0.038
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.038
VAV2	vav 2 guanine nucleotide exchange factor	0.038
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.038
GABRB1	gamma-aminobutyric acid (GABA) A receptor, beta 1	0.038
GTF2H3	general transcription factor IIH, polypeptide 3, 34kDa	0.038
NCCRP1	non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)	0.037
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.037
GPC5	glypican 5	0.037
GBX2	gastrulation brain homeobox 2	0.037
WNT10A	wingless-type MMTV integration site family, member 10A	0.037
LPPR1	lipid phosphate phosphatase-related protein type 1	0.037
FER	fer (fps/fes related) tyrosine kinase	0.037
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.037
NGB	neuroglobin	0.037
GDF6	growth differentiation factor 6	0.037
RIPPLY2	ripply2 homolog (zebrafish)	0.037
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.037
SCRT2	scratch homolog 2, zinc finger protein (Drosophila)	0.037
CCNO	cyclin O	0.037
IER3	immediate early response 3	0.037
SLC8A2	solute carrier family 8 (sodium/calcium exchanger), member 2	0.037
TRAPPC6A	trafficking protein particle complex 6A	0.037
TTPA	tocopherol (alpha) transfer protein	0.037
MRFAP1	Morf4 family associated protein 1	0.037
HMX2	H6 family homeobox 2	0.037
SIX4	SIX homeobox 4	0.037	Mouse
SALL3	sal-like 3 (Drosophila)	0.037
ECHDC1	enoyl CoA hydratase domain containing 1	0.037
CRABP2	cellular retinoic acid binding protein 2	0.037
GATA5	GATA binding protein 5	0.037
RARG	retinoic acid receptor, gamma	0.037
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	0.036
DUSP6	dual specificity phosphatase 6	0.036
COL27A1	collagen, type XXVII, alpha 1	0.036
ATOH1	atonal homolog 1 (Drosophila)	0.036	Human
OCLN	occludin	0.036
PRR11	proline rich 11	0.036
WSCD1	WSC domain containing 1	0.036
SALL4	sal-like 4 (Drosophila)	0.036
TJP1	tight junction protein 1 (zona occludens 1)	0.035
PTHLH	parathyroid hormone-like hormone	0.035
SSTR5	somatostatin receptor 5	0.035
DAPP1	dual adaptor of phosphotyrosine and 3-phosphoinositides	0.035
OTX1	orthodenticle homeobox 1	0.035
EPHA5	EPH receptor A5	0.035
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.035
SCUBE3	signal peptide, CUB domain, EGF-like 3	0.035
TRPV4	transient receptor potential cation channel, subfamily V, member 4	0.035
CACNA1B	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.035
KCNS1	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1	0.035
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.034
FDX1	ferredoxin 1	0.034
DSCR6	Down syndrome critical region gene 6	0.034
NR2F1	nuclear receptor subfamily 2, group F, member 1	0.034
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.034
T	T, brachyury homolog (mouse)	0.034
LHX1	LIM homeobox 1	0.034
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.034
FOXD1	forkhead box D1	0.034
NKX2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.034
DRD4	dopamine receptor D4	0.034
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.034
MAPK4	mitogen-activated protein kinase 4	0.034
NOVA2	neuro-oncological ventral antigen 2	0.034
GTPBP8	GTP-binding protein 8 (putative)	0.034
LRDD	leucine-rich repeats and death domain containing	0.033
DOCK1	dedicator of cytokinesis 1	0.033
NKX2-2	NK2 homeobox 2	0.033	Rat
CDK6	cyclin-dependent kinase 6	0.033
SCGN	secretagogin, EF-hand calcium binding protein	0.033
TWIST2	twist homolog 2 (Drosophila)	0.033
RAI1	retinoic acid induced 1	0.033
LAMA5	laminin, alpha 5	0.033
HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	0.033
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.033
GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3	0.033
MESP1	mesoderm posterior 1 homolog (mouse)	0.033
TEAD2	TEA domain family member 2	0.033
HOXB2	homeobox B2	0.033	Human Mouse
NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)	0.033
SST	somatostatin	0.033
GHR	growth hormone receptor	0.033
LY6G6F	lymphocyte antigen 6 complex, locus G6F	0.033
PRRX2	paired related homeobox 2	0.033
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.033
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.032
SLC2A14	solute carrier family 2 (facilitated glucose transporter), member 14	0.032
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.032
LSM11	LSM11, U7 small nuclear RNA associated	0.032
ALOX12B	arachidonate 12-lipoxygenase, 12R type	0.032
MEOX2	mesenchyme homeobox 2	0.032
SEMA6D	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.032
NPR3	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	0.032
RND1	Rho family GTPase 1	0.032
GRM3	glutamate receptor, metabotropic 3	0.032
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.032
CDK5R2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.032
SALL2	sal-like 2 (Drosophila)	0.032
ALK	anaplastic lymphoma receptor tyrosine kinase	0.032
BARHL1	BarH-like homeobox 1	0.032
CCNH	cyclin H	0.032
HES3	hairy and enhancer of split 3 (Drosophila)	0.032	Mouse
SLC17A6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	0.032
DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.032
FRYL	FRY-like	0.032
CAPNS1	calpain, small subunit 1	0.032
ICAM4	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	0.032
CRYBA2	crystallin, beta A2	0.031
ONECUT1	one cut homeobox 1	0.031
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.031
EFNB3	ephrin-B3	0.031
TIGD3	tigger transposable element derived 3	0.031
VSTM2A	V-set and transmembrane domain containing 2A	0.031
MRPS33	mitochondrial ribosomal protein S33	0.031
CCDC140	coiled-coil domain containing 140	0.031
OTOP1	otopetrin 1	0.031
PGF	placental growth factor	0.031
ZNF503	zinc finger protein 503	0.031
OPRK1	opioid receptor, kappa 1	0.031
ICAM5	intercellular adhesion molecule 5, telencephalin	0.031
DBX1	developing brain homeobox 1	0.031
MMD2	monocyte to macrophage differentiation-associated 2	0.031
BHLHE22	basic helix-loop-helix family, member e22	0.031
TUBA1C	tubulin, alpha 1c	0.031
SALL1	sal-like 1 (Drosophila)	0.031	Mouse
SMO	smoothened homolog (Drosophila)	0.031	Rat
GNG4	guanine nucleotide binding protein (G protein), gamma 4	0.031
PRDM6	PR domain containing 6	0.031
DCLK2	doublecortin-like kinase 2	0.031
ZNF679	zinc finger protein 679	0.031
MYO10	myosin X	0.031
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.031
CA10	carbonic anhydrase X	0.031
AQPEP	laeverin	0.031
ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)	0.030
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.030
AP2M1	adaptor-related protein complex 2, mu 1 subunit	0.030
KCTD15	potassium channel tetramerisation domain containing 15	0.030
XRCC2	X-ray repair complementing defective repair in Chinese hamster cells 2	0.030
ADCY8	adenylate cyclase 8 (brain)	0.030
BAI2	brain-specific angiogenesis inhibitor 2	0.030
ASCL2	achaete-scute complex homolog 2 (Drosophila)	0.030
SGTB	small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta	0.030
EVX2	even-skipped homeobox 2	0.030
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.030
GPR88	G protein-coupled receptor 88	0.030
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.030
SSTR2	somatostatin receptor 2	0.030
FBN2	fibrillin 2	0.030
EPHA7	EPH receptor A7	0.030
RIMS4	regulating synaptic membrane exocytosis 4	0.030
GPR1	G protein-coupled receptor 1	0.030
LAMA1	laminin, alpha 1	0.030
GRM6	glutamate receptor, metabotropic 6	0.030
LBX2	ladybird homeobox 2	0.029
DLGAP4	discs, large (Drosophila) homolog-associated protein 4	0.029
LRRC26	leucine rich repeat containing 26	0.029
HIST1H4L	histone cluster 1, H4l	0.029
RBMS1	RNA binding motif, single stranded interacting protein 1	0.029
LINGO1	leucine rich repeat and Ig domain containing 1	0.029
NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	0.029
GABRA4	gamma-aminobutyric acid (GABA) A receptor, alpha 4	0.029
DPYSL2	dihydropyrimidinase-like 2	0.029
RAB33A	RAB33A, member RAS oncogene family	0.029
WIZ	widely interspaced zinc finger motifs	0.029
KRT37	keratin 37	0.029
TRIP6	thyroid hormone receptor interactor 6	0.029
NOS1	nitric oxide synthase 1 (neuronal)	0.029
PAX8	paired box 8	0.029
OLIG3	oligodendrocyte transcription factor 3	0.029
ETNK2	ethanolamine kinase 2	0.029
PRDM16	PR domain containing 16	0.029
FAM110C	family with sequence similarity 110, member C	0.029
NEUROD2	neurogenic differentiation 2	0.029	Human
MPP1	membrane protein, palmitoylated 1, 55kDa	0.029
DUSP10	dual specificity phosphatase 10	0.029
ASCL1	achaete-scute complex homolog 1 (Drosophila)	0.029
DMBX1	diencephalon/mesencephalon homeobox 1	0.029
PIK3CD	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.029
PXDN	peroxidasin homolog (Drosophila)	0.029
SOX12	SRY (sex determining region Y)-box 12	0.029
AFF2	AF4/FMR2 family, member 2	0.028
KCNA4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.028
TRPA1	transient receptor potential cation channel, subfamily A, member 1	0.028
DPYSL5	dihydropyrimidinase-like 5	0.028
ACPP	acid phosphatase, prostate	0.028
CRLF1	cytokine receptor-like factor 1	0.028
SLITRK5	SLIT and NTRK-like family, member 5	0.028
ACAN	aggrecan	0.028
GDNF	glial cell derived neurotrophic factor	0.028
LRPAP1	low density lipoprotein receptor-related protein associated protein 1	0.028
NEURL	neuralized homolog (Drosophila)	0.028
CHD5	chromodomain helicase DNA binding protein 5	0.028
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.028
PCDH7	protocadherin 7	0.028
UNC5C	unc-5 homolog C (C. elegans)	0.028
LHX8	LIM homeobox 8	0.028
CSMD1	CUB and Sushi multiple domains 1	0.028
PTPN21	protein tyrosine phosphatase, non-receptor type 21	0.028
GEMIN7	gem (nuclear organelle) associated protein 7	0.028
SEC16A	SEC16 homolog A (S. cerevisiae)	0.028
SNTB2	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	0.028
ANKRD43	ankyrin repeat domain 43	0.028
DLK1	delta-like 1 homolog (Drosophila)	0.028
HTR1E	5-hydroxytryptamine (serotonin) receptor 1E	0.028
SEMA3F	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.028	Mouse
DIRAS2	DIRAS family, GTP-binding RAS-like 2	0.027
SOX14	SRY (sex determining region Y)-box 14	0.027
EXOC7	exocyst complex component 7	0.027
C17orf102	chromosome 17 open reading frame 102	0.027
WNT16	wingless-type MMTV integration site family, member 16	0.027
TGFB3	transforming growth factor, beta 3	0.027
NTNG1	netrin G1	0.027
MADCAM1	mucosal vascular addressin cell adhesion molecule 1	0.027
LHFPL3	lipoma HMGIC fusion partner-like 3	0.027
RSPO1	R-spondin homolog (Xenopus laevis)	0.027
CYP11B2	cytochrome P450, family 11, subfamily B, polypeptide 2	0.027
ISL2	ISL LIM homeobox 2	0.027
MATK	megakaryocyte-associated tyrosine kinase	0.027
WNT5A	wingless-type MMTV integration site family, member 5A	0.027
FOXB2	forkhead box B2	0.027
VWC2	von Willebrand factor C domain containing 2	0.027
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.027	Rat
GRIN2D	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	0.027
IL11	interleukin 11	0.027
CARHSP1	calcium regulated heat stable protein 1, 24kDa	0.027
IRF6	interferon regulatory factor 6	0.027
SLC1A6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	0.027
POMC	proopiomelanocortin	0.027
NDP	Norrie disease (pseudoglioma)	0.027
FZD1	frizzled homolog 1 (Drosophila)	0.027
LGR5	leucine-rich repeat containing G protein-coupled receptor 5	0.027
PRSS12	protease, serine, 12 (neurotrypsin, motopsin)	0.027
FIBP	fibroblast growth factor (acidic) intracellular binding protein	0.027
INHBB	inhibin, beta B	0.027
BICD1	bicaudal D homolog 1 (Drosophila)	0.027
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.027
KCNA5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.027
GSC	goosecoid homeobox	0.027
SPRY4	sprouty homolog 4 (Drosophila)	0.027
PCDH9	protocadherin 9	0.027
SLC34A1	solute carrier family 34 (sodium phosphate), member 1	0.027
BCAR3	breast cancer anti-estrogen resistance 3	0.027
GHSR	growth hormone secretagogue receptor	0.027
KAL1	Kallmann syndrome 1 sequence	0.027
KAZALD1	Kazal-type serine peptidase inhibitor domain 1	0.027
EYA4	eyes absent homolog 4 (Drosophila)	0.027
GSX2	GS homeobox 2	0.027
GCG	glucagon	0.027
LEF1	lymphoid enhancer-binding factor 1	0.027
KIAA1217	KIAA1217	0.027
PLLP	plasmolipin	0.027
FGF5	fibroblast growth factor 5	0.027
ETV1	ets variant 1	0.027
ULBP1	UL16 binding protein 1	0.027
DOCK7	dedicator of cytokinesis 7	0.027
CBLN1	cerebellin 1 precursor	0.027
LMX1A	LIM homeobox transcription factor 1, alpha	0.026
ZFHX4	zinc finger homeobox 4	0.026
LOX	lysyl oxidase	0.026
KCTD8	potassium channel tetramerisation domain containing 8	0.026
APLP1	amyloid beta (A4) precursor-like protein 1	0.026
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.026