IMP: Integrative Multi-species Prediction

Homo sapiens

3 genes annotated in human

central nervous system projection neuron axonogenesis

GO:0021952

Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "central nervous system projection neuron axonogenesis"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "central nervous system projection neuron axonogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
PELP1	proline, glutamate and leucine rich protein 1	0.734
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.626
UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	0.463
SUMO3	SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)	0.351	Fly
DUSP1	dual specificity phosphatase 1	0.222
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.197
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.178
SENP1	SUMO1/sentrin specific peptidase 1	0.155	Fly
USPL1	ubiquitin specific peptidase like 1	0.155
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.146
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.140
PTPRN	protein tyrosine phosphatase, receptor type, N	0.117
DISC1	disrupted in schizophrenia 1	0.099
CPE	carboxypeptidase E	0.095
RANGAP1	Ran GTPase activating protein 1	0.087
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.078
SAE1	SUMO1 activating enzyme subunit 1	0.077
GRB7	growth factor receptor-bound protein 7	0.070
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.069
MAPK14	mitogen-activated protein kinase 14	0.063
TCEAL5	transcription elongation factor A (SII)-like 5	0.058
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.057
PFDN1	prefoldin subunit 1	0.056
HDAC3	histone deacetylase 3	0.054
NTN1	netrin 1	0.052
WDR18	WD repeat domain 18	0.046
PKM2	pyruvate kinase, muscle	0.046
PBX1	pre-B-cell leukemia homeobox 1	0.037
CLIP1	CAP-GLY domain containing linker protein 1	0.037
MYO10	myosin X	0.035
ATN1	atrophin 1	0.034
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.033
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.032
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.032
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.031
NFIA	nuclear factor I/A	0.030
SCAND1	SCAN domain containing 1	0.030
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.029
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.028
ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa	0.028
TEX10	testis expressed 10	0.027
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.025
CXXC1	CXXC finger protein 1	0.025
RDH11	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	0.023
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.023
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.023
DUSP3	dual specificity phosphatase 3	0.022
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.021
PCDH17	protocadherin 17	0.021
UBE3A	ubiquitin protein ligase E3A	0.021
PIAS4	protein inhibitor of activated STAT, 4	0.021
PPP4R1	protein phosphatase 4, regulatory subunit 1	0.021
DEF6	differentially expressed in FDCP 6 homolog (mouse)	0.020
ZNF219	zinc finger protein 219	0.020
EGR3	early growth response 3	0.020
USP39	ubiquitin specific peptidase 39	0.020
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.020
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.020
LTBP2	latent transforming growth factor beta binding protein 2	0.019
SOX11	SRY (sex determining region Y)-box 11	0.019
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.019
MAP2K1	mitogen-activated protein kinase kinase 1	0.019
UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	0.019
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.019
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.019
DAPK1	death-associated protein kinase 1	0.018
USP21	ubiquitin specific peptidase 21	0.018
MAZ	MYC-associated zinc finger protein (purine-binding transcription factor)	0.018
SPARCL1	SPARC-like 1 (hevin)	0.018
EDNRA	endothelin receptor type A	0.018
LMO2	LIM domain only 2 (rhombotin-like 1)	0.018
RAB14	RAB14, member RAS oncogene family	0.018
MEIS2	Meis homeobox 2	0.018
GRB10	growth factor receptor-bound protein 10	0.017
COTL1	coactosin-like 1 (Dictyostelium)	0.017
LAS1L	LAS1-like (S. cerevisiae)	0.017
NR2F1	nuclear receptor subfamily 2, group F, member 1	0.017
FLRT2	fibronectin leucine rich transmembrane protein 2	0.017
GNB2	guanine nucleotide binding protein (G protein), beta polypeptide 2	0.017
SFRP1	secreted frizzled-related protein 1	0.017
COL3A1	collagen, type III, alpha 1	0.017
LPHN3	latrophilin 3	0.017
PHF17	PHD finger protein 17	0.017
SP100	SP100 nuclear antigen	0.016
SNRNP40	small nuclear ribonucleoprotein 40kDa (U5)	0.016
PRRX1	paired related homeobox 1	0.016
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.016
MFAP4	microfibrillar-associated protein 4	0.016
ELK1	ELK1, member of ETS oncogene family	0.016
ARRB2	arrestin, beta 2	0.016
FAM82A2	family with sequence similarity 82, member A2	0.016
WDR48	WD repeat domain 48	0.016
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.016
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.016
TNRC6B	trinucleotide repeat containing 6B	0.016
COL11A1	collagen, type XI, alpha 1	0.015
MEN1	multiple endocrine neoplasia I	0.015
FBLN1	fibulin 1	0.015
MAP2K2	mitogen-activated protein kinase kinase 2	0.015
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.015
RABGAP1	RAB GTPase activating protein 1	0.015
MAP1B	microtubule-associated protein 1B	0.015
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.015
SEMA5A	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.015
SLIT2	slit homolog 2 (Drosophila)	0.015
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.015
DRAP1	DR1-associated protein 1 (negative cofactor 2 alpha)	0.015
ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b	0.015
RGS4	regulator of G-protein signaling 4	0.015
RBBP5	retinoblastoma binding protein 5	0.015
PTN	pleiotrophin	0.015
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.014
RPS6KA4	ribosomal protein S6 kinase, 90kDa, polypeptide 4	0.014
PPP2R2D	protein phosphatase 2, regulatory subunit B, delta	0.014
SULF1	sulfatase 1	0.014
COL1A2	collagen, type I, alpha 2	0.014
FABP7	fatty acid binding protein 7, brain	0.014
NRXN1	neurexin 1	0.014
KCND2	potassium voltage-gated channel, Shal-related subfamily, member 2	0.014
CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.014
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.014
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.014
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.013
H2AFY	H2A histone family, member Y	0.013
PAX6	paired box 6	0.013
PTPRN2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.013
CHRDL1	chordin-like 1	0.013
PARVA	parvin, alpha	0.013
PCDH8	protocadherin 8	0.013
CELF2	CUGBP, Elav-like family member 2	0.013
KCNRG	potassium channel regulator	0.013
ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	0.013
CD2BP2	CD2 (cytoplasmic tail) binding protein 2	0.013
POSTN	periostin, osteoblast specific factor	0.013
EFNB3	ephrin-B3	0.013
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.013
EPHA7	EPH receptor A7	0.013
TMSB4X	thymosin beta 4, X-linked	0.013
RNF146	ring finger protein 146	0.013
COL5A2	collagen, type V, alpha 2	0.013
KCND3	potassium voltage-gated channel, Shal-related subfamily, member 3	0.013
COL14A1	collagen, type XIV, alpha 1	0.013
CHRD	chordin	0.013
GLI3	GLI family zinc finger 3	0.013
PPP1R1B	protein phosphatase 1, regulatory (inhibitor) subunit 1B	0.013
RARA	retinoic acid receptor, alpha	0.013
THY1	Thy-1 cell surface antigen	0.013
BTBD10	BTB (POZ) domain containing 10	0.012
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.012
LST1	leukocyte specific transcript 1	0.012
SFRP4	secreted frizzled-related protein 4	0.012
SIX3	SIX homeobox 3	0.012
PCDHB12	protocadherin beta 12	0.012
STMN2	stathmin-like 2	0.012
BNC2	basonuclin 2	0.012
RGS19	regulator of G-protein signaling 19	0.012
MAP2K4	mitogen-activated protein kinase kinase 4	0.012
POU3F2	POU class 3 homeobox 2	0.012
ATP6V0D1	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1	0.012
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	0.012
FGF3	fibroblast growth factor 3	0.012
FOXG1	forkhead box G1	0.012
MID1	midline 1 (Opitz/BBB syndrome)	0.012
CARHSP1	calcium regulated heat stable protein 1, 24kDa	0.012
FOXF2	forkhead box F2	0.012
PNKD	paroxysmal nonkinesigenic dyskinesia	0.012
MRAS	muscle RAS oncogene homolog	0.012
FAT4	FAT tumor suppressor homolog 4 (Drosophila)	0.012
EGR2	early growth response 2	0.012
PVRL3	poliovirus receptor-related 3	0.012
CHGA	chromogranin A (parathyroid secretory protein 1)	0.012
ARF5	ADP-ribosylation factor 5	0.012
GLT8D2	glycosyltransferase 8 domain containing 2	0.012
ANK2	ankyrin 2, neuronal	0.012
EPHA3	EPH receptor A3	0.012
TADA3	transcriptional adaptor 3	0.012
PAFAH1B2	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)	0.012
CDK5	cyclin-dependent kinase 5	0.012
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	0.012
MBD1	methyl-CpG binding domain protein 1	0.012
IGF1	insulin-like growth factor 1 (somatomedin C)	0.012
SLITRK3	SLIT and NTRK-like family, member 3	0.012
DCX	doublecortin	0.012	Mouse
SETX	senataxin	0.012
SORCS3	sortilin-related VPS10 domain containing receptor 3	0.012
RAB8A	RAB8A, member RAS oncogene family	0.012
TCF4	transcription factor 4	0.012
CCDC80	coiled-coil domain containing 80	0.012
ARPC1A	actin related protein 2/3 complex, subunit 1A, 41kDa	0.012
CLSTN2	calsyntenin 2	0.011
SOX1	SRY (sex determining region Y)-box 1	0.011
IGFBP5	insulin-like growth factor binding protein 5	0.011
PSMB10	proteasome (prosome, macropain) subunit, beta type, 10	0.011
FZD7	frizzled homolog 7 (Drosophila)	0.011
SHOX2	short stature homeobox 2	0.011
LDB2	LIM domain binding 2	0.011
MPRIP	myosin phosphatase Rho interacting protein	0.011
ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	0.011
NTM	neurotrimin	0.011
SLC17A6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	0.011
RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.011
DACT1	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)	0.011
SATB1	SATB homeobox 1	0.011
PEF1	penta-EF-hand domain containing 1	0.011
RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	0.011
ENAH	enabled homolog (Drosophila)	0.011
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.011
SLC9A6	solute carrier family 9 (sodium/hydrogen exchanger), member 6	0.011
TRIL	TLR4 interactor with leucine-rich repeats	0.011
DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	0.011
FBXL7	F-box and leucine-rich repeat protein 7	0.011
ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	0.011
NOVA1	neuro-oncological ventral antigen 1	0.011
TRIP6	thyroid hormone receptor interactor 6	0.011
TBC1D14	TBC1 domain family, member 14	0.011
TIPRL	TIP41, TOR signaling pathway regulator-like (S. cerevisiae)	0.011
NEUROD1	neurogenic differentiation 1	0.011
COL5A1	collagen, type V, alpha 1	0.011
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.011
EFNB2	ephrin-B2	0.011
POU3F1	POU class 3 homeobox 1	0.011
MPP1	membrane protein, palmitoylated 1, 55kDa	0.011
APPL2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	0.011
PCNX	pecanex homolog (Drosophila)	0.011
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.011
INA	internexin neuronal intermediate filament protein, alpha	0.011
PTPRD	protein tyrosine phosphatase, receptor type, D	0.011
L3MBTL2	l(3)mbt-like 2 (Drosophila)	0.011
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.011
FHOD3	formin homology 2 domain containing 3	0.011
NOV	nephroblastoma overexpressed gene	0.011
NOL9	nucleolar protein 9	0.011
FNBP1	formin binding protein 1	0.011
CDH6	cadherin 6, type 2, K-cadherin (fetal kidney)	0.011
TTYH3	tweety homolog 3 (Drosophila)	0.011
ZNF205	zinc finger protein 205	0.011
COL13A1	collagen, type XIII, alpha 1	0.011
COL6A1	collagen, type VI, alpha 1	0.011
PSENEN	presenilin enhancer 2 homolog (C. elegans)	0.011
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.011
GAS1	growth arrest-specific 1	0.011
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.011
BCKDK	branched chain ketoacid dehydrogenase kinase	0.010
MEF2A	myocyte enhancer factor 2A	0.010
HERC1	hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1	0.010
PTPRG	protein tyrosine phosphatase, receptor type, G	0.010
LPPR4	lipid phosphate phosphatase-related protein type 4	0.010
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.010
PTPRK	protein tyrosine phosphatase, receptor type, K	0.010
GPM6B	glycoprotein M6B	0.010
PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)	0.010
MICAL1	microtubule associated monoxygenase, calponin and LIM domain containing 1	0.010
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.010
C10orf116	chromosome 10 open reading frame 116	0.010
MGP	matrix Gla protein	0.010
TWIST1	twist homolog 1 (Drosophila)	0.010
TBX5	T-box 5	0.010
RGL1	ral guanine nucleotide dissociation stimulator-like 1	0.010
PENK	proenkephalin	0.010
BAIAP2	BAI1-associated protein 2	0.010
EFEMP1	EGF containing fibulin-like extracellular matrix protein 1	0.010
LHX2	LIM homeobox 2	0.010
EXOC3L1	exocyst complex component 3-like 1	0.010
ZBTB20	zinc finger and BTB domain containing 20	0.010
LENG8	leukocyte receptor cluster (LRC) member 8	0.010
DCLK1	doublecortin-like kinase 1	0.010	Mouse
ZFHX4	zinc finger homeobox 4	0.010
RBMS3	RNA binding motif, single stranded interacting protein 3	0.010
EFNA5	ephrin-A5	0.010
LIMCH1	LIM and calponin homology domains 1	0.010
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.010
NOVA2	neuro-oncological ventral antigen 2	0.010
KIAA1462	KIAA1462	0.010
MEGF11	multiple EGF-like-domains 11	0.010
SVEP1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	0.010
AEBP1	AE binding protein 1	0.010
SNCAIP	synuclein, alpha interacting protein	0.010
ODZ4	odz, odd Oz/ten-m homolog 4 (Drosophila)	0.010
LCP1	lymphocyte cytosolic protein 1 (L-plastin)	0.010