IMP
Process View
development of primary male sexual characteristics
The process whose specific outcome is the progression of the primary male sexual characteristics over time, from their formation to the mature structures. The primary male sexual characteristics are the testes, and they develop in response to sex hormone secretion.
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Click on a gene's description to view its network relationships with genes known to be involved in "development of primary male sexual characteristics"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| FGFR2 | fibroblast growth factor receptor 2 | 0.986 | ||
| ESR1 | estrogen receptor 1 | 0.979 | Mouse Rat | |
| TAL1 | T-cell acute lymphocytic leukemia 1 | 0.908 | ||
| PLCG1 | phospholipase C, gamma 1 | 0.679 | ||
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.539 | Human Mouse | |
| AR | androgen receptor | 0.403 | Mouse | |
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.377 | ||
| BCL2 | B-cell CLL/lymphoma 2 | 0.348 | Mouse | |
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.343 | ||
| FANCD2 | Fanconi anemia, complementation group D2 | 0.325 | ||
| PDX1 | pancreatic and duodenal homeobox 1 | 0.276 | ||
| BCL2L1 | BCL2-like 1 | 0.270 | Mouse | |
| HNF4A | hepatocyte nuclear factor 4, alpha | 0.237 | ||
| KDR | kinase insert domain receptor (a type III receptor tyrosine kinase) | 0.222 | Human | |
| TRIP6 | thyroid hormone receptor interactor 6 | 0.206 | ||
| CREBBP | CREB binding protein | 0.206 | ||
| CDKN2A | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 0.185 | ||
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.184 | ||
| EGR1 | early growth response 1 | 0.167 | Human | |
| NGF | nerve growth factor (beta polypeptide) | 0.165 | ||
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.159 | ||
| AKR1C2 | aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) | 0.155 | Human | |
| AKR1C3 | aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) | 0.154 | ||
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.151 | ||
| VEGFA | vascular endothelial growth factor A | 0.148 | ||
| MSH6 | mutS homolog 6 (E. coli) | 0.134 | ||
| EGR3 | early growth response 3 | 0.128 | Human | |
| NR5A1 | nuclear receptor subfamily 5, group A, member 1 | 0.114 | ||
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.105 | Mouse | |
| CDH5 | cadherin 5, type 2 (vascular endothelium) | 0.102 | ||
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 0.101 | ||
| NCOA3 | nuclear receptor coactivator 3 | 0.101 | ||
| EGR2 | early growth response 2 | 0.099 | Human | |
| FOXD3 | forkhead box D3 | 0.097 | ||
| MCL1 | myeloid cell leukemia sequence 1 (BCL2-related) | 0.096 | ||
| AKR1C1 | aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) | 0.094 | Human | |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.093 | Mouse | |
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2 | 0.092 | ||
| FGFR1 | fibroblast growth factor receptor 1 | 0.089 | ||
| POU5F1 | POU class 5 homeobox 1 | 0.089 | ||
| RORA | RAR-related orphan receptor A | 0.085 | ||
| PAX8 | paired box 8 | 0.084 | ||
| NRP1 | neuropilin 1 | 0.082 | ||
| NKX2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.079 | ||
| HDAC2 | histone deacetylase 2 | 0.078 | ||
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.077 | ||
| AP1M1 | adaptor-related protein complex 1, mu 1 subunit | 0.074 | ||
| FZD1 | frizzled homolog 1 (Drosophila) | 0.073 | ||
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.071 | ||
| SMAD7 | SMAD family member 7 | 0.069 | ||
| PCNA | proliferating cell nuclear antigen | 0.068 | ||
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.067 | ||
| PDGFB | platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) | 0.065 | ||
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.063 | ||
| KITLG | KIT ligand | 0.062 | ||
| BAK1 | BCL2-antagonist/killer 1 | 0.060 | ||
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.058 | Human | |
| SH3BP4 | SH3-domain binding protein 4 | 0.056 | ||
| GSK3B | glycogen synthase kinase 3 beta | 0.055 | Fly | |
| MPDZ | multiple PDZ domain protein | 0.055 | ||
| BRCA1 | breast cancer 1, early onset | 0.054 | ||
| PROX1 | prospero homeobox 1 | 0.051 | ||
| SOX2 | SRY (sex determining region Y)-box 2 | 0.048 | Human | |
| FGF18 | fibroblast growth factor 18 | 0.047 | ||
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.047 | ||
| BAX | BCL2-associated X protein | 0.047 | Mouse | |
| RAD50 | RAD50 homolog (S. cerevisiae) | 0.046 | ||
| HDAC1 | histone deacetylase 1 | 0.046 | ||
| PGF | placental growth factor | 0.045 | ||
| RBPMS | RNA binding protein with multiple splicing | 0.044 | ||
| GHR | growth hormone receptor | 0.043 | ||
| NEUROD1 | neurogenic differentiation 1 | 0.042 | ||
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.039 | ||
| NR0B1 | nuclear receptor subfamily 0, group B, member 1 | 0.039 | ||
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.038 | ||
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.036 | ||
| HTR2C | 5-hydroxytryptamine (serotonin) receptor 2C | 0.035 | ||
| FGF8 | fibroblast growth factor 8 (androgen-induced) | 0.035 | ||
| GATA4 | GATA binding protein 4 | 0.034 | ||
| MLH1 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | 0.034 | ||
| WNT1 | wingless-type MMTV integration site family, member 1 | 0.034 | Human | |
| SMAD4 | SMAD family member 4 | 0.032 | ||
| SF3B4 | splicing factor 3b, subunit 4, 49kDa | 0.032 | ||
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.032 | ||
| GDNF | glial cell derived neurotrophic factor | 0.032 | Rat | |
| FOXC2 | forkhead box C2 (MFH-1, mesenchyme forkhead 1) | 0.031 | ||
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.031 | ||
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.030 | Mouse | |
| GFI1B | growth factor independent 1B transcription repressor | 0.030 | ||
| BID | BH3 interacting domain death agonist | 0.029 | ||
| RNR2 | l-rRNA | 0.029 | ||
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.029 | ||
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.028 | ||
| TTR | transthyretin | 0.028 | ||
| NCOA1 | nuclear receptor coactivator 1 | 0.027 | ||
| SPDEF | SAM pointed domain containing ets transcription factor | 0.027 | ||
| POU3F2 | POU class 3 homeobox 2 | 0.027 | ||
| GATA5 | GATA binding protein 5 | 0.027 | Human | |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.027 | ||
| FLT1 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 0.027 | Human | |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.026 | ||
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.026 | ||
| CRK | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.026 | ||
| LAT | linker for activation of T cells | 0.026 | ||
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.026 | ||
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.025 | ||
| KCTD1 | potassium channel tetramerisation domain containing 1 | 0.025 | ||
| PGR | progesterone receptor | 0.024 | ||
| SFRP5 | secreted frizzled-related protein 5 | 0.024 | ||
| RET | ret proto-oncogene | 0.024 | ||
| PSEN1 | presenilin 1 | 0.024 | ||
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.023 | ||
| SNAI1 | snail homolog 1 (Drosophila) | 0.021 | ||
| SNRPC | small nuclear ribonucleoprotein polypeptide C | 0.021 | ||
| FGF3 | fibroblast growth factor 3 | 0.021 | Human | |
| ERG | v-ets erythroblastosis virus E26 oncogene homolog (avian) | 0.021 | ||
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 | 0.020 | ||
| CAT | catalase | 0.020 | ||
| LDLR | low density lipoprotein receptor | 0.020 | ||
| DHH | desert hedgehog | 0.020 | ||
| LBX1 | ladybird homeobox 1 | 0.020 | ||
| MSH3 | mutS homolog 3 (E. coli) | 0.019 | ||
| FYN | FYN oncogene related to SRC, FGR, YES | 0.019 | ||
| TBX2 | T-box 2 | 0.019 | ||
| SOX9 | SRY (sex determining region Y)-box 9 | 0.019 | ||
| ESR2 | estrogen receptor 2 (ER beta) | 0.019 | Rat | |
| ESRRG | estrogen-related receptor gamma | 0.019 | ||
| CDX2 | caudal type homeobox 2 | 0.018 | ||
| PTPN4 | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) | 0.018 | ||
| LYAR | Ly1 antibody reactive homolog (mouse) | 0.018 | ||
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.018 | ||
| HGF | hepatocyte growth factor (hepapoietin A; scatter factor) | 0.018 | ||
| WT1 | Wilms tumor 1 | 0.018 | ||
| FST | follistatin | 0.018 | ||
| FOXO1 | forkhead box O1 | 0.018 | ||
| BHLHE23 | basic helix-loop-helix family, member e23 | 0.018 | ||
| MEIS1 | Meis homeobox 1 | 0.018 | ||
| SHC2 | SHC (Src homology 2 domain containing) transforming protein 2 | 0.018 | ||
| TLX2 | T-cell leukemia homeobox 2 | 0.018 | ||
| HOXA10 | homeobox A10 | 0.018 | ||
| SFRP1 | secreted frizzled-related protein 1 | 0.018 | Mouse | |
| ZNF292 | zinc finger protein 292 | 0.018 | ||
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.018 | ||
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.017 | ||
| GAB1 | GRB2-associated binding protein 1 | 0.017 | ||
| SALL2 | sal-like 2 (Drosophila) | 0.017 | Fly | |
| VEGFC | vascular endothelial growth factor C | 0.017 | ||
| BCL2L2 | BCL2-like 2 | 0.017 | ||
| PAX7 | paired box 7 | 0.016 | ||
| SP1 | Sp1 transcription factor | 0.016 | ||
| HAND2 | heart and neural crest derivatives expressed 2 | 0.016 | ||
| FANCM | Fanconi anemia, complementation group M | 0.016 | ||
| MYLK2 | myosin light chain kinase 2 | 0.016 | ||
| PPP1R14A | protein phosphatase 1, regulatory (inhibitor) subunit 14A | 0.016 | ||
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.016 | ||
| UTF1 | undifferentiated embryonic cell transcription factor 1 | 0.016 | ||
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.016 | ||
| ELK1 | ELK1, member of ETS oncogene family | 0.016 | ||
| DVL3 | dishevelled, dsh homolog 3 (Drosophila) | 0.016 | ||
| ACP5 | acid phosphatase 5, tartrate resistant | 0.015 | ||
| STAT5A | signal transducer and activator of transcription 5A | 0.015 | ||
| INHA | inhibin, alpha | 0.015 | Rat | |
| WNT10A | wingless-type MMTV integration site family, member 10A | 0.015 | Human | |
| RNF144B | ring finger protein 144B | 0.015 | ||
| EGFR | epidermal growth factor receptor | 0.015 | ||
| FOXA1 | forkhead box A1 | 0.015 | ||
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.015 | ||
| HNRNPUL1 | heterogeneous nuclear ribonucleoprotein U-like 1 | 0.014 | ||
| MMP11 | matrix metallopeptidase 11 (stromelysin 3) | 0.014 | ||
| FOXN4 | forkhead box N4 | 0.014 | ||
| FHL2 | four and a half LIM domains 2 | 0.014 | ||
| ACACA | acetyl-CoA carboxylase alpha | 0.014 | ||
| TGFB1 | transforming growth factor, beta 1 | 0.014 | ||
| NGFR | nerve growth factor receptor | 0.014 | ||
| WNT4 | wingless-type MMTV integration site family, member 4 | 0.014 | ||
| HOXB13 | homeobox B13 | 0.014 | ||
| HMGA2 | high mobility group AT-hook 2 | 0.014 | ||
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.014 | ||
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.014 | ||
| MDM4 | Mdm4 p53 binding protein homolog (mouse) | 0.014 | ||
| MPL | myeloproliferative leukemia virus oncogene | 0.014 | ||
| DUSP23 | dual specificity phosphatase 23 | 0.013 | ||
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.013 | ||
| MYST2 | MYST histone acetyltransferase 2 | 0.013 | ||
| WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | 0.013 | ||
| OTP | orthopedia homeobox | 0.013 | ||
| FOXC1 | forkhead box C1 | 0.013 | ||
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | 0.013 | ||
| PTHLH | parathyroid hormone-like hormone | 0.013 | ||
| AMHR2 | anti-Mullerian hormone receptor, type II | 0.013 | ||
| HOXD1 | homeobox D1 | 0.013 | ||
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.013 | ||
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 0.013 | Mouse | |
| SLC6A2 | solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 | 0.013 | ||
| HSPG2 | heparan sulfate proteoglycan 2 | 0.013 | ||
| BBC3 | BCL2 binding component 3 | 0.013 | ||
| CYP26A1 | cytochrome P450, family 26, subfamily A, polypeptide 1 | 0.013 | ||
| MBNL2 | muscleblind-like 2 (Drosophila) | 0.013 | ||
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.013 | ||
| RBBP8 | retinoblastoma binding protein 8 | 0.013 | ||
| LAMA5 | laminin, alpha 5 | 0.013 | ||
| EPOR | erythropoietin receptor | 0.013 | ||
| TBX1 | T-box 1 | 0.013 | ||
| FANCE | Fanconi anemia, complementation group E | 0.013 | ||
| MGEA5 | meningioma expressed antigen 5 (hyaluronidase) | 0.013 | ||
| SMAD1 | SMAD family member 1 | 0.013 | ||
| FZD7 | frizzled homolog 7 (Drosophila) | 0.012 | ||
| FGF4 | fibroblast growth factor 4 | 0.012 | Human | |
| NAB2 | NGFI-A binding protein 2 (EGR1 binding protein 2) | 0.012 | ||
| MED1 | mediator complex subunit 1 | 0.012 | ||
| DMRT1 | doublesex and mab-3 related transcription factor 1 | 0.012 | ||
| CALCA | calcitonin-related polypeptide alpha | 0.012 | ||
| MARCKSL1 | MARCKS-like 1 | 0.012 | ||
| HES2 | hairy and enhancer of split 2 (Drosophila) | 0.012 | ||
| CALCR | calcitonin receptor | 0.012 | ||
| HMX1 | H6 family homeobox 1 | 0.012 | ||
| BARX1 | BARX homeobox 1 | 0.012 | ||
| HOXD13 | homeobox D13 | 0.012 | ||
| DAB2 | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | 0.012 | ||
| SFRP4 | secreted frizzled-related protein 4 | 0.012 | ||
| THBS1 | thrombospondin 1 | 0.012 | ||
| POLD3 | polymerase (DNA-directed), delta 3, accessory subunit | 0.012 | ||
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.012 | ||
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.012 | ||
| CCND3 | cyclin D3 | 0.012 | ||
| FGF2 | fibroblast growth factor 2 (basic) | 0.012 | Human | |
| PPP5C | protein phosphatase 5, catalytic subunit | 0.011 | ||
| SIX1 | SIX homeobox 1 | 0.011 | ||
| CLASP2 | cytoplasmic linker associated protein 2 | 0.011 | ||
| GPN1 | GPN-loop GTPase 1 | 0.011 | ||
| CDK6 | cyclin-dependent kinase 6 | 0.011 | ||
| AQP5 | aquaporin 5 | 0.011 | ||
| EP300 | E1A binding protein p300 | 0.011 | ||
| CUL4B | cullin 4B | 0.011 | ||
| COL2A1 | collagen, type II, alpha 1 | 0.011 | ||
| NR0B2 | nuclear receptor subfamily 0, group B, member 2 | 0.011 | Human | |
| WNT3 | wingless-type MMTV integration site family, member 3 | 0.011 | Human | |
| FOXA2 | forkhead box A2 | 0.011 | ||
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 0.011 | ||
| BECN1 | beclin 1, autophagy related | 0.011 | ||
| FANCC | Fanconi anemia, complementation group C | 0.011 | ||
| KDM5B | lysine (K)-specific demethylase 5B | 0.011 | ||
| GOLGB1 | golgin B1 | 0.011 | ||
| TAOK1 | TAO kinase 1 | 0.011 | ||
| POU2F3 | POU class 2 homeobox 3 | 0.011 | ||
| IRX4 | iroquois homeobox 4 | 0.011 | ||
| SLC9A3R2 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 | 0.011 | ||
| GAS1 | growth arrest-specific 1 | 0.011 | ||
| HRK | harakiri, BCL2 interacting protein (contains only BH3 domain) | 0.011 | ||
| PTEN | phosphatase and tensin homolog | 0.011 | ||
| POMC | proopiomelanocortin | 0.011 | ||
| MRE11A | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | 0.010 | ||
| HOXB5 | homeobox B5 | 0.010 | ||
| GOLGA2 | golgin A2 | 0.010 | ||
| ALX3 | ALX homeobox 3 | 0.010 | ||
| SIM2 | single-minded homolog 2 (Drosophila) | 0.010 | ||
| INHBB | inhibin, beta B | 0.010 | Human | |
| CLU | clusterin | 0.010 | ||
| MMP2 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 0.010 | ||
| ENG | endoglin | 0.010 | ||
| BAD | BCL2-associated agonist of cell death | 0.010 | ||
| SMAD2 | SMAD family member 2 | 0.010 | ||
| FAS | Fas (TNF receptor superfamily, member 6) | 0.010 | ||
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.010 | ||
| RXRA | retinoid X receptor, alpha | 0.010 | ||
| COL13A1 | collagen, type XIII, alpha 1 | 0.010 | ||
| CHRD | chordin | 0.010 | ||
| KCNJ5 | potassium inwardly-rectifying channel, subfamily J, member 5 | 0.010 | ||
| WIF1 | WNT inhibitory factor 1 | 0.010 | ||
| FOXG1 | forkhead box G1 | 0.010 | ||
| TLX1 | T-cell leukemia homeobox 1 | 0.010 |