IMP: Integrative Multi-species Prediction

Homo sapiens

4 genes annotated in human

endodermal cell fate specification

The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endodermal cell fate specification"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "endodermal cell fate specification" (in gray)

Name	Description	Probability	Func Analog Organism
SP1	Sp1 transcription factor	1.000
SMAD7	SMAD family member 7	0.999
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.999	Worm
BMP2	bone morphogenetic protein 2	0.999	Zebrafish
PAX3	paired box 3	0.998
POU3F2	POU class 3 homeobox 2	0.996	Human
FYN	FYN oncogene related to SRC, FGR, YES	0.994	Worm
BMPR1A	bone morphogenetic protein receptor, type IA	0.994	Fly
FOXD3	forkhead box D3	0.985
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.982	Worm
SMAD2	SMAD family member 2	0.972
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.972	Worm
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.971	Worm
SMAD4	SMAD family member 4	0.963
SOX10	SRY (sex determining region Y)-box 10	0.962	Human
SOX2	SRY (sex determining region Y)-box 2	0.924
SMAD1	SMAD family member 1	0.917	Fly
CSNK1E	casein kinase 1, epsilon	0.874
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.863
LCK	lymphocyte-specific protein tyrosine kinase	0.862	Worm
SMAD3	SMAD family member 3	0.846
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.811
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.764
BMP7	bone morphogenetic protein 7	0.753	Zebrafish
CTNNBIP1	catenin, beta interacting protein 1	0.740
JAG1	jagged 1	0.722
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.692
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.688
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.646
AXIN1	axin 1	0.602
NOG	noggin	0.586	Zebrafish
MAPK8	mitogen-activated protein kinase 8	0.583
SMAD5	SMAD family member 5	0.558	Fly
SYK	spleen tyrosine kinase	0.504
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.502
PLCG1	phospholipase C, gamma 1	0.496
RANBP2	RAN binding protein 2	0.492
FSTL1	follistatin-like 1	0.441
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.433
CTNND1	catenin (cadherin-associated protein), delta 1	0.409
GDF5	growth differentiation factor 5	0.407
SNIP1	Smad nuclear interacting protein 1	0.405
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.401
WT1	Wilms tumor 1	0.384
NOTCH3	notch 3	0.366
APC	adenomatous polyposis coli	0.366	Worm
LRP6	low density lipoprotein receptor-related protein 6	0.360
FGF1	fibroblast growth factor 1 (acidic)	0.359
SOX21	SRY (sex determining region Y)-box 21	0.336
MEOX2	mesenchyme homeobox 2	0.263
ZNF512B	zinc finger protein 512B	0.260
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.259
FGF2	fibroblast growth factor 2 (basic)	0.249
HCK	hemopoietic cell kinase	0.219
SOX11	SRY (sex determining region Y)-box 11	0.210	Human
FGFR2	fibroblast growth factor receptor 2	0.205
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.204
TRAF6	TNF receptor-associated factor 6	0.200
LRRK2	leucine-rich repeat kinase 2	0.179
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.176
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.175
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.167
SALL2	sal-like 2 (Drosophila)	0.158
CEP164	centrosomal protein 164kDa	0.153
MAML1	mastermind-like 1 (Drosophila)	0.152
NOVA2	neuro-oncological ventral antigen 2	0.151
BBS10	Bardet-Biedl syndrome 10	0.151
SMAD6	SMAD family member 6	0.149
HCFC1	host cell factor C1 (VP16-accessory protein)	0.146
ZFYVE9	zinc finger, FYVE domain containing 9	0.145
GAS7	growth arrest-specific 7	0.142
FOXG1	forkhead box G1	0.136
CLTC	clathrin, heavy chain (Hc)	0.136
SOX9	SRY (sex determining region Y)-box 9	0.131	Human
SPRR2A	small proline-rich protein 2A	0.128
NOSTRIN	nitric oxide synthase trafficker	0.125
DSP	desmoplakin	0.118
GTPBP5	GTP binding protein 5 (putative)	0.115
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.114
KLF5	Kruppel-like factor 5 (intestinal)	0.106
MDFI	MyoD family inhibitor	0.101
HNF1A	HNF1 homeobox A	0.100
CADM4	cell adhesion molecule 4	0.100
POU3F3	POU class 3 homeobox 3	0.098	Human
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.098
SMAD9	SMAD family member 9	0.097
FBXL15	F-box and leucine-rich repeat protein 15	0.096
OTP	orthopedia homeobox	0.095
FRS2	fibroblast growth factor receptor substrate 2	0.090
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	0.090
BMP4	bone morphogenetic protein 4	0.089	Zebrafish
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.087
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.086
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.084
KLHL12	kelch-like 12 (Drosophila)	0.083
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.082
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.082
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.081
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.081
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.079	Worm
DUSP5	dual specificity phosphatase 5	0.076
FYB	FYN binding protein	0.074
XIAP	X-linked inhibitor of apoptosis	0.074
MCC	mutated in colorectal cancers	0.072
CXXC5	CXXC finger protein 5	0.071
GSK3B	glycogen synthase kinase 3 beta	0.067
PAX6	paired box 6	0.067
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.065
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.064
FOXA2	forkhead box A2	0.064
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.063
ASCL1	achaete-scute complex homolog 1 (Drosophila)	0.062
TRAF4	TNF receptor-associated factor 4	0.062
MYOD1	myogenic differentiation 1	0.061
SOX5	SRY (sex determining region Y)-box 5	0.061
ZIC3	Zic family member 3 (odd-paired homolog, Drosophila)	0.061
SOX1	SRY (sex determining region Y)-box 1	0.060	Human
PDX1	pancreatic and duodenal homeobox 1	0.059
HIC1	hypermethylated in cancer 1	0.058
FOXO1	forkhead box O1	0.057
MSX1	msh homeobox 1	0.056
SIM2	single-minded homolog 2 (Drosophila)	0.056
MYST2	MYST histone acetyltransferase 2	0.056
BAHD1	bromo adjacent homology domain containing 1	0.055
FAM110C	family with sequence similarity 110, member C	0.054
RAC3	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	0.054
TGFB2	transforming growth factor, beta 2	0.053
ZNF746	zinc finger protein 746	0.052
SOX7	SRY (sex determining region Y)-box 7	0.051	Human
HTT	huntingtin	0.051
RNF11	ring finger protein 11	0.051
C2orf44	chromosome 2 open reading frame 44	0.051
PAX2	paired box 2	0.051
OLIG2	oligodendrocyte lineage transcription factor 2	0.050
U2AF2	U2 small nuclear RNA auxiliary factor 2	0.050
ATF7IP	activating transcription factor 7 interacting protein	0.050
INHBB	inhibin, beta B	0.050
TBX2	T-box 2	0.050
NLK	nemo-like kinase	0.049	Worm
FGFR3	fibroblast growth factor receptor 3	0.049
TAOK1	TAO kinase 1	0.049
DPPA2	developmental pluripotency associated 2	0.049
SALL3	sal-like 3 (Drosophila)	0.049
JAG2	jagged 2	0.048
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.047
PHACTR3	phosphatase and actin regulator 3	0.047
FZD10	frizzled homolog 10 (Drosophila)	0.047
HIPK2	homeodomain interacting protein kinase 2	0.047
BECN1	beclin 1, autophagy related	0.047
POU5F1	POU class 5 homeobox 1	0.047
PKP4	plakophilin 4	0.047
POU3F4	POU class 3 homeobox 4	0.045	Human
ZBTB8A	zinc finger and BTB domain containing 8A	0.045
SNX33	sorting nexin 33	0.045
SNX9	sorting nexin 9	0.045
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.044
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.044
NEUROG3	neurogenin 3	0.043
FOXO3	forkhead box O3	0.043
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.043
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.043
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.042
PTCH1	patched 1	0.041
AR	androgen receptor	0.041
ACAP3	ArfGAP with coiled-coil, ankyrin repeat and PH domains 3	0.041
NCOA2	nuclear receptor coactivator 2	0.040
HES1	hairy and enhancer of split 1, (Drosophila)	0.040
ZNF148	zinc finger protein 148	0.040
POU3F1	POU class 3 homeobox 1	0.039	Human
FAM110A	family with sequence similarity 110, member A	0.039
MKL2	MKL/myocardin-like 2	0.039
PDCD6IP	programmed cell death 6 interacting protein	0.039
HOXD9	homeobox D9	0.039
PITX1	paired-like homeodomain 1	0.039
NKX2-1	NK2 homeobox 1	0.039
SHANK2	SH3 and multiple ankyrin repeat domains 2	0.038
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.038
SIX2	SIX homeobox 2	0.038
KIFC2	kinesin family member C2	0.037
GATA5	GATA binding protein 5	0.037
FOXC1	forkhead box C1	0.037
SMO	smoothened homolog (Drosophila)	0.036
TBX1	T-box 1	0.036
DLL1	delta-like 1 (Drosophila)	0.036
DBN1	drebrin 1	0.036
HES2	hairy and enhancer of split 2 (Drosophila)	0.036
PAX7	paired box 7	0.036
MON1A	MON1 homolog A (yeast)	0.036
TTYH1	tweety homolog 1 (Drosophila)	0.036
SOX4	SRY (sex determining region Y)-box 4	0.035	Human
COL2A1	collagen, type II, alpha 1	0.035
TLX2	T-cell leukemia homeobox 2	0.035
GBX2	gastrulation brain homeobox 2	0.034
SALL1	sal-like 1 (Drosophila)	0.033
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.033
SFRP5	secreted frizzled-related protein 5	0.033
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.033
GLIS2	GLIS family zinc finger 2	0.033
UBASH3B	ubiquitin associated and SH3 domain containing B	0.032
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.032
POU4F1	POU class 4 homeobox 1	0.032	Human
PCDH17	protocadherin 17	0.032
NCK1	NCK adaptor protein 1	0.032
HOXD13	homeobox D13	0.032
HOXB7	homeobox B7	0.032
PROX1	prospero homeobox 1	0.032
GALR1	galanin receptor 1	0.032
BMPR1B	bone morphogenetic protein receptor, type IB	0.031	Fly
CD79A	CD79a molecule, immunoglobulin-associated alpha	0.031
ENC1	ectodermal-neural cortex 1 (with BTB-like domain)	0.031
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.031
SH3BP2	SH3-domain binding protein 2	0.031
ZMYND8	zinc finger, MYND-type containing 8	0.031
RNF19A	ring finger protein 19A	0.031
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.031
ACVR1	activin A receptor, type I	0.030
HOXB13	homeobox B13	0.030
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	0.030
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.030
SPRED1	sprouty-related, EVH1 domain containing 1	0.030
CSF1R	colony stimulating factor 1 receptor	0.030
DUSP4	dual specificity phosphatase 4	0.030	Zebrafish
IL11	interleukin 11	0.030
DCP1A	DCP1 decapping enzyme homolog A (S. cerevisiae)	0.030
GATA4	GATA binding protein 4	0.030
HOXD1	homeobox D1	0.030
NKD2	naked cuticle homolog 2 (Drosophila)	0.030
HOXD3	homeobox D3	0.029
FST	follistatin	0.029
TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)	0.029
NEUROD1	neurogenic differentiation 1	0.029
DSG2	desmoglein 2	0.029
FOXA1	forkhead box A1	0.029
EFNB2	ephrin-B2	0.029
DCX	doublecortin	0.029
PMEPA1	prostate transmembrane protein, androgen induced 1	0.029
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.029
ATN1	atrophin 1	0.029
TIFA	TRAF-interacting protein with forkhead-associated domain	0.028
SOX3	SRY (sex determining region Y)-box 3	0.028	Human
KIF5B	kinesin family member 5B	0.028
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.028
C17orf63	chromosome 17 open reading frame 63	0.028
EDN3	endothelin 3	0.027
GRIK3	glutamate receptor, ionotropic, kainate 3	0.027
PCBD1	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	0.027
ONECUT1	one cut homeobox 1	0.027
NKX2-2	NK2 homeobox 2	0.027
PRPF3	PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)	0.027
LHX1	LIM homeobox 1	0.027
SH3PXD2A	SH3 and PX domains 2A	0.027
TENC1	tensin like C1 domain containing phosphatase (tensin 2)	0.027
TM4SF1	transmembrane 4 L six family member 1	0.027
ITGB4	integrin, beta 4	0.027
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.027
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.027
FBLN1	fibulin 1	0.027
SIX3	SIX homeobox 3	0.027
F3	coagulation factor III (thromboplastin, tissue factor)	0.027
POU2F3	POU class 2 homeobox 3	0.026	Human
FKBP5	FK506 binding protein 5	0.026
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.026
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.026
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.026
SALL4	sal-like 4 (Drosophila)	0.026
TBX5	T-box 5	0.026
PITX2	paired-like homeodomain 2	0.026
DUSP9	dual specificity phosphatase 9	0.026
AMOTL2	angiomotin like 2	0.026
NPTX1	neuronal pentraxin I	0.025
EFNA2	ephrin-A2	0.025
DLX4	distal-less homeobox 4	0.025
TRPM1	transient receptor potential cation channel, subfamily M, member 1	0.025
DAAM1	dishevelled associated activator of morphogenesis 1	0.025
PIAS1	protein inhibitor of activated STAT, 1	0.025
HMGA2	high mobility group AT-hook 2	0.025
PSMF1	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)	0.025
PDCD6	programmed cell death 6	0.025
SCNN1G	sodium channel, nonvoltage-gated 1, gamma	0.025
ARHGAP12	Rho GTPase activating protein 12	0.025
PAX8	paired box 8	0.025
SOX15	SRY (sex determining region Y)-box 15	0.025	Human
GDF6	growth differentiation factor 6	0.025
TRPS1	trichorhinophalangeal syndrome I	0.025
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.025	Worm
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.025
COL9A2	collagen, type IX, alpha 2	0.024
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.024
HMX2	H6 family homeobox 2	0.024
FZD8	frizzled homolog 8 (Drosophila)	0.024
TP73	tumor protein p73	0.024
ELK1	ELK1, member of ETS oncogene family	0.024
SHH	sonic hedgehog	0.024
FAM19A5	family with sequence similarity 19 (chemokine (C-C motif)-like), member A5	0.024
EYA2	eyes absent homolog 2 (Drosophila)	0.024
ZBED5	zinc finger, BED-type containing 5	0.024
CDX2	caudal type homeobox 2	0.024
ETV5	ets variant 5	0.024
ATXN1	ataxin 1	0.024
CPSF7	cleavage and polyadenylation specific factor 7, 59kDa	0.024
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.024
DIDO1	death inducer-obliterator 1	0.023
ARHGEF19	Rho guanine nucleotide exchange factor (GEF) 19	0.023
EFNB3	ephrin-B3	0.023
SFRP1	secreted frizzled-related protein 1	0.023
XPC	xeroderma pigmentosum, complementation group C	0.023
FOXD1	forkhead box D1	0.023
HOXD12	homeobox D12	0.023
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.023
DACH1	dachshund homolog 1 (Drosophila)	0.023
TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	0.023
HES5	hairy and enhancer of split 5 (Drosophila)	0.023
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.023
URB1	URB1 ribosome biogenesis 1 homolog (S. cerevisiae)	0.023
CDH4	cadherin 4, type 1, R-cadherin (retinal)	0.023
ALX3	ALX homeobox 3	0.023
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.023
MNX1	motor neuron and pancreas homeobox 1	0.023
HMGA1	high mobility group AT-hook 1	0.023
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.023	Worm
CD22	CD22 molecule	0.023
HS3ST1	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	0.023
LPAR4	lysophosphatidic acid receptor 4	0.023
GRB7	growth factor receptor-bound protein 7	0.022
KAL1	Kallmann syndrome 1 sequence	0.022
HOXC8	homeobox C8	0.022
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.022
INSM1	insulinoma-associated 1	0.022
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.022
EFS	embryonal Fyn-associated substrate	0.022
RAX	retina and anterior neural fold homeobox	0.022
FOXL1	forkhead box L1	0.022
FZD7	frizzled homolog 7 (Drosophila)	0.022
CTNND2	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)	0.022
FGF8	fibroblast growth factor 8 (androgen-induced)	0.022
EYA1	eyes absent homolog 1 (Drosophila)	0.022
SOX8	SRY (sex determining region Y)-box 8	0.022	Human
TRIL	TLR4 interactor with leucine-rich repeats	0.022
DCP1B	DCP1 decapping enzyme homolog B (S. cerevisiae)	0.022
BCL10	B-cell CLL/lymphoma 10	0.022
EGR3	early growth response 3	0.022
PCDH10	protocadherin 10	0.022
NEBL	nebulette	0.022
CEP97	centrosomal protein 97kDa	0.021
ICK	intestinal cell (MAK-like) kinase	0.021
CLDN7	claudin 7	0.021
FOXF1	forkhead box F1	0.021
PRKG1	protein kinase, cGMP-dependent, type I	0.021
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.021
MPL	myeloproliferative leukemia virus oncogene	0.021
FNBP1L	formin binding protein 1-like	0.021
PLK2	polo-like kinase 2	0.021
MYO6	myosin VI	0.021
ARRDC3	arrestin domain containing 3	0.021
KHDRBS3	KH domain containing, RNA binding, signal transduction associated 3	0.021
C1QL1	complement component 1, q subcomponent-like 1	0.021
FUT9	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	0.021
MECOM	MDS1 and EVI1 complex locus	0.021
PNMT	phenylethanolamine N-methyltransferase	0.021
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.021
SHB	Src homology 2 domain containing adaptor protein B	0.021
CCNK	cyclin K	0.021
PTHLH	parathyroid hormone-like hormone	0.021
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	0.020
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.020
UTF1	undifferentiated embryonic cell transcription factor 1	0.020
ZIC2	Zic family member 2 (odd-paired homolog, Drosophila)	0.020
HOXA2	homeobox A2	0.020
TGIF2	TGFB-induced factor homeobox 2	0.020
EFNA1	ephrin-A1	0.020
FAM46B	family with sequence similarity 46, member B	0.020
BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)	0.020
KCNK12	potassium channel, subfamily K, member 12	0.020
CHD7	chromodomain helicase DNA binding protein 7	0.020
SH2B2	SH2B adaptor protein 2	0.020
CRABP1	cellular retinoic acid binding protein 1	0.020
GPR17	G protein-coupled receptor 17	0.020
VAX2	ventral anterior homeobox 2	0.020
ISL1	ISL LIM homeobox 1	0.020
TNS3	tensin 3	0.020
SP5	Sp5 transcription factor	0.020
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.020
WIF1	WNT inhibitory factor 1	0.020
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.020
EFNA3	ephrin-A3	0.020
MSX2	msh homeobox 2	0.020
OCLN	occludin	0.019
AHR	aryl hydrocarbon receptor	0.019
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.019
PITX3	paired-like homeodomain 3	0.019
KRT2	keratin 2	0.019
RGS14	regulator of G-protein signaling 14	0.019
NEUROG1	neurogenin 1	0.019
FAT1	FAT tumor suppressor homolog 1 (Drosophila)	0.019
GPR4	G protein-coupled receptor 4	0.019
SOX17	SRY (sex determining region Y)-box 17	0.019	Human Mouse
C8orf4	chromosome 8 open reading frame 4	0.019
PPP6C	protein phosphatase 6, catalytic subunit	0.019
SOSTDC1	sclerostin domain containing 1	0.019
CITED1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	0.019
CNKSR1	connector enhancer of kinase suppressor of Ras 1	0.019
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.019
GATA6	GATA binding protein 6	0.019
LHX5	LIM homeobox 5	0.019
TCF4	transcription factor 4	0.019
PTPRR	protein tyrosine phosphatase, receptor type, R	0.019
CIITA	class II, major histocompatibility complex, transactivator	0.019
GAD1	glutamate decarboxylase 1 (brain, 67kDa)	0.019
NKX2-8	NK2 homeobox 8	0.019
PTPRF	protein tyrosine phosphatase, receptor type, F	0.019
WIPF1	WAS/WASL interacting protein family, member 1	0.019
TNFAIP8L1	tumor necrosis factor, alpha-induced protein 8-like 1	0.019
EPHB3	EPH receptor B3	0.019
NELL1	NEL-like 1 (chicken)	0.019
VIL1	villin 1	0.019
KLHL35	kelch-like 35 (Drosophila)	0.019
GMEB1	glucocorticoid modulatory element binding protein 1	0.019
NCK2	NCK adaptor protein 2	0.019
CXCR5	chemokine (C-X-C motif) receptor 5	0.019
ONECUT2	one cut homeobox 2	0.019
DST	dystonin	0.019
MAPK3	mitogen-activated protein kinase 3	0.019
RBM11	RNA binding motif protein 11	0.019
APC2	adenomatosis polyposis coli 2	0.018
SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.018
JAM2	junctional adhesion molecule 2	0.018
GPRC5A	G protein-coupled receptor, family C, group 5, member A	0.018
TNIK	TRAF2 and NCK interacting kinase	0.018
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.018
NHLH2	nescient helix loop helix 2	0.018
HOXD11	homeobox D11	0.018
PROM1	prominin 1	0.018
FSCN2	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	0.018
ZRANB1	zinc finger, RAN-binding domain containing 1	0.018
L1TD1	LINE-1 type transposase domain containing 1	0.018
MYCL1	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)	0.018
FGD1	FYVE, RhoGEF and PH domain containing 1	0.018
MYEF2	myelin expression factor 2	0.018
NPAS3	neuronal PAS domain protein 3	0.018
ZMYND11	zinc finger, MYND-type containing 11	0.018
SHANK3	SH3 and multiple ankyrin repeat domains 3	0.018
FBN2	fibrillin 2	0.018
OTX2	orthodenticle homeobox 2	0.018
DDI1	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	0.018
ZNF281	zinc finger protein 281	0.018
CRX	cone-rod homeobox	0.018
FOXQ1	forkhead box Q1	0.018
MAP2K7	mitogen-activated protein kinase kinase 7	0.018
HOXB9	homeobox B9	0.018
ZNF251	zinc finger protein 251	0.018
IRX2	iroquois homeobox 2	0.018
SRRM3	serine/arginine repetitive matrix 3	0.018
CALCR	calcitonin receptor	0.018
USP13	ubiquitin specific peptidase 13 (isopeptidase T-3)	0.018
GPER	G protein-coupled estrogen receptor 1	0.018
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.018
TIGD5	tigger transposable element derived 5	0.018
EN1	engrailed homeobox 1	0.018
FOXD2	forkhead box D2	0.018
NKD1	naked cuticle homolog 1 (Drosophila)	0.018
NR2F2	nuclear receptor subfamily 2, group F, member 2	0.018
NOTCH2	notch 2	0.018
CTBP2	C-terminal binding protein 2	0.018
KLRG2	killer cell lectin-like receptor subfamily G, member 2	0.018
COL4A6	collagen, type IV, alpha 6	0.018
ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.018
IGFBP2	insulin-like growth factor binding protein 2, 36kDa	0.018
WNT6	wingless-type MMTV integration site family, member 6	0.018
NRTN	neurturin	0.018
CRLF1	cytokine receptor-like factor 1	0.018
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.018
IRX5	iroquois homeobox 5	0.018
VPS24	vacuolar protein sorting 24 homolog (S. cerevisiae)	0.017
WSCD1	WSC domain containing 1	0.017
TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	0.017
RET	ret proto-oncogene	0.017
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.017
LTK	leukocyte receptor tyrosine kinase	0.017
MDK	midkine (neurite growth-promoting factor 2)	0.017
IRX1	iroquois homeobox 1	0.017
EDN1	endothelin 1	0.017
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.017
BHLHE22	basic helix-loop-helix family, member e22	0.017
CUX1	cut-like homeobox 1	0.017
SOX18	SRY (sex determining region Y)-box 18	0.017	Human
PAX5	paired box 5	0.017
PKP2	plakophilin 2	0.017
SRCIN1	SRC kinase signaling inhibitor 1	0.017
BNC1	basonuclin 1	0.017
SHROOM2	shroom family member 2	0.017
MATK	megakaryocyte-associated tyrosine kinase	0.017
ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.017
NUMBL	numb homolog (Drosophila)-like	0.017
DLG5	discs, large homolog 5 (Drosophila)	0.017
FOXB1	forkhead box B1	0.017
PCGF3	polycomb group ring finger 3	0.017
C21orf7	chromosome 21 open reading frame 7	0.017
MTPN	myotrophin	0.017
SPRY4	sprouty homolog 4 (Drosophila)	0.017
TUBB2B	tubulin, beta 2B	0.017
GAS1	growth arrest-specific 1	0.017
FBXO30	F-box protein 30	0.017
PPIL4	peptidylprolyl isomerase (cyclophilin)-like 4	0.017
ZNF500	zinc finger protein 500	0.017
IRX4	iroquois homeobox 4	0.017
EPHA7	EPH receptor A7	0.017
TFCP2L1	transcription factor CP2-like 1	0.017
DSC2	desmocollin 2	0.017
ITGB8	integrin, beta 8	0.017
CRHR2	corticotropin releasing hormone receptor 2	0.017
TRAF2	TNF receptor-associated factor 2	0.017
DPYSL5	dihydropyrimidinase-like 5	0.017
PCDH8	protocadherin 8	0.017
WNT10A	wingless-type MMTV integration site family, member 10A	0.017
ASCL2	achaete-scute complex homolog 2 (Drosophila)	0.017
RADIL	Ras association and DIL domains	0.017
XPNPEP2	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	0.017
GJC2	gap junction protein, gamma 2, 47kDa	0.016
ZFHX4	zinc finger homeobox 4	0.016
RYR3	ryanodine receptor 3	0.016
CHAC1	ChaC, cation transport regulator homolog 1 (E. coli)	0.016
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.016
LRP4	low density lipoprotein receptor-related protein 4	0.016
ZNF165	zinc finger protein 165	0.016
FOXF2	forkhead box F2	0.016
MYH10	myosin, heavy chain 10, non-muscle	0.016
NKX3-2	NK3 homeobox 2	0.016
FGFR4	fibroblast growth factor receptor 4	0.016
FGF18	fibroblast growth factor 18	0.016
LEF1	lymphoid enhancer-binding factor 1	0.016
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.016
NCOA1	nuclear receptor coactivator 1	0.016
BRD3	bromodomain containing 3	0.016
SIM1	single-minded homolog 1 (Drosophila)	0.016
C1orf68	chromosome 1 open reading frame 68	0.016
EP300	E1A binding protein p300	0.016
D4S234E	DNA segment on chromosome 4 (unique) 234 expressed sequence	0.016
GAL	galanin prepropeptide	0.016
PPP1R13L	protein phosphatase 1, regulatory (inhibitor) subunit 13 like	0.016
MAP2K6	mitogen-activated protein kinase kinase 6	0.016
EFNB1	ephrin-B1	0.016
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.016
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.016
GATA3	GATA binding protein 3	0.016
DPPA4	developmental pluripotency associated 4	0.016
POLR3D	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	0.016
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.016
GGN	gametogenetin	0.016
WNT2	wingless-type MMTV integration site family member 2	0.016
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.016
PTF1A	pancreas specific transcription factor, 1a	0.016
KCNJ10	potassium inwardly-rectifying channel, subfamily J, member 10	0.016
PTPRK	protein tyrosine phosphatase, receptor type, K	0.016
FLNB	filamin B, beta	0.016
GPR26	G protein-coupled receptor 26	0.016
SIX6	SIX homeobox 6	0.016
MAP2K1	mitogen-activated protein kinase kinase 1	0.016
HOXC4	homeobox C4	0.016
WWTR1	WW domain containing transcription regulator 1	0.016
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.016
TGFB1	transforming growth factor, beta 1	0.016
EMX2	empty spiracles homeobox 2	0.016
CDR2L	cerebellar degeneration-related protein 2-like	0.016
BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	0.016
RYK	RYK receptor-like tyrosine kinase	0.016
GRAP	GRB2-related adaptor protein	0.016
CTGF	connective tissue growth factor	0.016
KRT14	keratin 14	0.016
CALCA	calcitonin-related polypeptide alpha	0.016
MED28	mediator complex subunit 28	0.016
BDNF	brain-derived neurotrophic factor	0.016
PNOC	prepronociceptin	0.016
DOK1	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	0.016
DLK1	delta-like 1 homolog (Drosophila)	0.016
SOCS1	suppressor of cytokine signaling 1	0.015
GATA2	GATA binding protein 2	0.015
CDH5	cadherin 5, type 2 (vascular endothelium)	0.015
KCNN3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	0.015
T	T, brachyury homolog (mouse)	0.015
CAPN6	calpain 6	0.015
LGR5	leucine-rich repeat containing G protein-coupled receptor 5	0.015
FBP1	fructose-1,6-bisphosphatase 1	0.015
RBMXL2	RNA binding motif protein, X-linked-like 2	0.015
TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	0.015
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.015
UTRN	utrophin	0.015
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.015
NR2F1	nuclear receptor subfamily 2, group F, member 1	0.015
MTMR10	myotubularin related protein 10	0.015
TRIB1	tribbles homolog 1 (Drosophila)	0.015
MYO10	myosin X	0.015
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.015
EN2	engrailed homeobox 2	0.015
SLC12A1	solute carrier family 12 (sodium/potassium/chloride transporters), member 1	0.015
LHX2	LIM homeobox 2	0.015
RAB11FIP3	RAB11 family interacting protein 3 (class II)	0.015
SH2D1A	SH2 domain containing 1A	0.015
HOXA3	homeobox A3	0.015
FOXJ1	forkhead box J1	0.015
TRAF5	TNF receptor-associated factor 5	0.015
COL9A3	collagen, type IX, alpha 3	0.015
ADARB1	adenosine deaminase, RNA-specific, B1	0.015
MEX3B	mex-3 homolog B (C. elegans)	0.015
PPP5C	protein phosphatase 5, catalytic subunit	0.015
ADRA2C	adrenergic, alpha-2C-, receptor	0.015
DIO3	deiodinase, iodothyronine, type III	0.015
IRX3	iroquois homeobox 3	0.015
TLL2	tolloid-like 2	0.015
NCOA6	nuclear receptor coactivator 6	0.015
HUNK	hormonally up-regulated Neu-associated kinase	0.015
MICAL1	microtubule associated monoxygenase, calponin and LIM domain containing 1	0.015
BMX	BMX non-receptor tyrosine kinase	0.015
SOX13	SRY (sex determining region Y)-box 13	0.015
NFIB	nuclear factor I/B	0.015
C1orf61	chromosome 1 open reading frame 61	0.015
AQP5	aquaporin 5	0.015
MTF1	metal-regulatory transcription factor 1	0.015
KIF3A	kinesin family member 3A	0.015
ANKRD13A	ankyrin repeat domain 13A	0.015
SSTR5	somatostatin receptor 5	0.015
FOXL2	forkhead box L2	0.015
ADD2	adducin 2 (beta)	0.015
EMX1	empty spiracles homeobox 1	0.015
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.015
MATN4	matrilin 4	0.015
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.015
NKX6-1	NK6 homeobox 1	0.015
TBX19	T-box 19	0.015
NPAS1	neuronal PAS domain protein 1	0.015
ATXN1L	ataxin 1-like	0.015
CHERP	calcium homeostasis endoplasmic reticulum protein	0.015
ELAVL3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.015
GJA4	gap junction protein, alpha 4, 37kDa	0.015
IGDCC4	immunoglobulin superfamily, DCC subclass, member 4	0.015
VGLL4	vestigial like 4 (Drosophila)	0.015
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.015
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.015
TRIM2	tripartite motif containing 2	0.015
GABRG3	gamma-aminobutyric acid (GABA) A receptor, gamma 3	0.015
CR1	complement component (3b/4b) receptor 1 (Knops blood group)	0.015
SIX1	SIX homeobox 1	0.015
TTC22	tetratricopeptide repeat domain 22	0.015
ZNF608	zinc finger protein 608	0.015
GPC4	glypican 4	0.014
HOXA13	homeobox A13	0.014
FGF9	fibroblast growth factor 9 (glia-activating factor)	0.014
SOCS7	suppressor of cytokine signaling 7	0.014
NR2E1	nuclear receptor subfamily 2, group E, member 1	0.014
PIAS2	protein inhibitor of activated STAT, 2	0.014
MYH3	myosin, heavy chain 3, skeletal muscle, embryonic	0.014
LYPD3	LY6/PLAUR domain containing 3	0.014
LFNG	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.014
TNFRSF21	tumor necrosis factor receptor superfamily, member 21	0.014
HOXB5	homeobox B5	0.014
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.014
ADCY8	adenylate cyclase 8 (brain)	0.014
NR5A2	nuclear receptor subfamily 5, group A, member 2	0.014
CA3	carbonic anhydrase III, muscle specific	0.014
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.014
HOXC5	homeobox C5	0.014
SBK1	SH3-binding domain kinase 1	0.014
DMRT1	doublesex and mab-3 related transcription factor 1	0.014
RRAS2	related RAS viral (r-ras) oncogene homolog 2	0.014
FRZB	frizzled-related protein	0.014
LBX1	ladybird homeobox 1	0.014
FZD2	frizzled homolog 2 (Drosophila)	0.014
RASIP1	Ras interacting protein 1	0.014
KRIT1	KRIT1, ankyrin repeat containing	0.014
FABP7	fatty acid binding protein 7, brain	0.014
BMP6	bone morphogenetic protein 6	0.014
SEMG2	semenogelin II	0.014
ROR1	receptor tyrosine kinase-like orphan receptor 1	0.014
C5orf55	chromosome 5 open reading frame 55	0.014
NEUROD2	neurogenic differentiation 2	0.014
MSTN	myostatin	0.014
HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	0.014
EPHA4	EPH receptor A4	0.014
SH3KBP1	SH3-domain kinase binding protein 1	0.014
KISS1R	KISS1 receptor	0.014
CDH6	cadherin 6, type 2, K-cadherin (fetal kidney)	0.014
HCN4	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	0.014
CKB	creatine kinase, brain	0.014
CD70	CD70 molecule	0.014
SRM	spermidine synthase	0.014
NET1	neuroepithelial cell transforming 1	0.014
HTR7	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)	0.014
TMSB15A	thymosin beta 15a	0.014
PEG10	paternally expressed 10	0.014
P2RX3	purinergic receptor P2X, ligand-gated ion channel, 3	0.014
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.014
TGFBR1	transforming growth factor, beta receptor 1	0.014
NPPB	natriuretic peptide B	0.014
GCM2	glial cells missing homolog 2 (Drosophila)	0.014
AJAP1	adherens junctions associated protein 1	0.014
RBP1	retinol binding protein 1, cellular	0.014
BHLHE23	basic helix-loop-helix family, member e23	0.014
HOXA5	homeobox A5	0.014
NANOG	Nanog homeobox	0.014
PPP2R3A	protein phosphatase 2, regulatory subunit B'', alpha	0.014
DMRT3	doublesex and mab-3 related transcription factor 3	0.014
OPRK1	opioid receptor, kappa 1	0.014
ARX	aristaless related homeobox	0.014
TBX3	T-box 3	0.014
STOX2	storkhead box 2	0.014
SLC46A2	solute carrier family 46, member 2	0.014
GLI3	GLI family zinc finger 3	0.014
STC1	stanniocalcin 1	0.014
ZNF707	zinc finger protein 707	0.014
SIX5	SIX homeobox 5	0.013
KCNQ1	potassium voltage-gated channel, KQT-like subfamily, member 1	0.013
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.013
MBP	myelin basic protein	0.013
RFX4	regulatory factor X, 4 (influences HLA class II expression)	0.013
NDRG1	N-myc downstream regulated 1	0.013
GFAP	glial fibrillary acidic protein	0.013
KCNS3	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	0.013
CLDN5	claudin 5	0.013
TCF15	transcription factor 15 (basic helix-loop-helix)	0.013
ARHGEF1	Rho guanine nucleotide exchange factor (GEF) 1	0.013
SHISA2	shisa homolog 2 (Xenopus laevis)	0.013
BMP5	bone morphogenetic protein 5	0.013
NRCAM	neuronal cell adhesion molecule	0.013
STK32B	serine/threonine kinase 32B	0.013
PEA15	phosphoprotein enriched in astrocytes 15	0.013
NRG2	neuregulin 2	0.013
CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.013
AUTS2	autism susceptibility candidate 2	0.013
GP5	glycoprotein V (platelet)	0.013
STMN3	stathmin-like 3	0.013
TWIST1	twist homolog 1 (Drosophila)	0.013
CXADR	coxsackie virus and adenovirus receptor	0.013
CHST3	carbohydrate (chondroitin 6) sulfotransferase 3	0.013
MYO1B	myosin IB	0.013
SCNN1A	sodium channel, nonvoltage-gated 1 alpha	0.013
ZNF74	zinc finger protein 74	0.013
LASS1	LAG1 homolog, ceramide synthase 1	0.013
HOXC6	homeobox C6	0.013
TIGD3	tigger transposable element derived 3	0.013
HOXD10	homeobox D10	0.013
HAS2	hyaluronan synthase 2	0.013
ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	0.013
ARHGAP5	Rho GTPase activating protein 5	0.013
FRAS1	Fraser syndrome 1	0.013
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.013
HOXB3	homeobox B3	0.013
TADA3	transcriptional adaptor 3	0.013
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.013
PDLIM7	PDZ and LIM domain 7 (enigma)	0.013
NRXN1	neurexin 1	0.013
GRB14	growth factor receptor-bound protein 14	0.013