IMP: Integrative Multi-species Prediction

Homo sapiens

4 genes annotated in human

myeloid dendritic cell activation

The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "myeloid dendritic cell activation"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "myeloid dendritic cell activation" (in gray)

Name	Description	Probability	Func Analog Organism
TGFB1	transforming growth factor, beta 1	0.947	Mouse
NOTCH1	notch 1	0.768
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.683
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.515	Mouse
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.495
DAZAP2	DAZ associated protein 2	0.447
ENG	endoglin	0.358
TGFB3	transforming growth factor, beta 3	0.332
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.319
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.246
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.186
IRAK1	interleukin-1 receptor-associated kinase 1	0.174
TGFBR1	transforming growth factor, beta receptor 1	0.174
NLRC4	NLR family, CARD domain containing 4	0.170
FSTL1	follistatin-like 1	0.160
JAG1	jagged 1	0.157
NCSTN	nicastrin	0.146
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.129
BAG3	BCL2-associated athanogene 3	0.128
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.114
CD80	CD80 molecule	0.114
ATXN1L	ataxin 1-like	0.108
PEX14	peroxisomal biogenesis factor 14	0.103
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.093
MEFV	Mediterranean fever	0.092
MAML1	mastermind-like 1 (Drosophila)	0.077
BATF	basic leucine zipper transcription factor, ATF-like	0.071	Mouse
NRP1	neuropilin 1	0.071
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.059
APP	amyloid beta (A4) precursor protein	0.058
XIAP	X-linked inhibitor of apoptosis	0.055
PKP4	plakophilin 4	0.055
IRAK2	interleukin-1 receptor-associated kinase 2	0.049
BCL3	B-cell CLL/lymphoma 3	0.048
PELI3	pellino homolog 3 (Drosophila)	0.043
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.042
ATXN3	ataxin 3	0.042
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.041
TRAF3IP2	TRAF3 interacting protein 2	0.037
SQSTM1	sequestosome 1	0.037
PSEN2	presenilin 2 (Alzheimer disease 4)	0.037
NCOR2	nuclear receptor corepressor 2	0.036
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.034
CD40	CD40 molecule, TNF receptor superfamily member 5	0.032
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.032
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.032
AIM2	absent in melanoma 2	0.031
UBE2Z	ubiquitin-conjugating enzyme E2Z	0.029
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.029
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.029
NUMBL	numb homolog (Drosophila)-like	0.027
FLNB	filamin B, beta	0.027
PEX5	peroxisomal biogenesis factor 5	0.026
PSMD13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.026
TGFBR3	transforming growth factor, beta receptor III	0.025
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.024
IL21R	interleukin 21 receptor	0.023
IRF4	interferon regulatory factor 4	0.023	Mouse
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.023
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.022
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.022
CD33	CD33 molecule	0.022
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.022
TRAF3	TNF receptor-associated factor 3	0.021
TYMP	thymidine phosphorylase	0.021
BECN1	beclin 1, autophagy related	0.020
DPEP2	dipeptidase 2	0.020
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.019
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.019
PTAFR	platelet-activating factor receptor	0.019
CDK5RAP3	CDK5 regulatory subunit associated protein 3	0.018
GFI1	growth factor independent 1 transcription repressor	0.018
CD48	CD48 molecule	0.018
CIR1	corepressor interacting with RBPJ, 1	0.018
ZNF675	zinc finger protein 675	0.018
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.017
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.017
RUNX3	runt-related transcription factor 3	0.017
SIGLEC7	sialic acid binding Ig-like lectin 7	0.017
NCF2	neutrophil cytosolic factor 2	0.016
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.016
DLL1	delta-like 1 (Drosophila)	0.016
SESN2	sestrin 2	0.016
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.016
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.016
CD22	CD22 molecule	0.016
SIRPA	signal-regulatory protein alpha	0.016
JUNB	jun B proto-oncogene	0.016
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.016
APOBR	apolipoprotein B receptor	0.015
IL2RA	interleukin 2 receptor, alpha	0.015
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.015
THBS1	thrombospondin 1	0.015
IL10RA	interleukin 10 receptor, alpha	0.015
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.015
ZNF746	zinc finger protein 746	0.014
CCNL2	cyclin L2	0.014
EBI3	Epstein-Barr virus induced 3	0.014
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.014
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.014
ADAM8	ADAM metallopeptidase domain 8	0.014
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.014
IL4R	interleukin 4 receptor	0.014
KEAP1	kelch-like ECH-associated protein 1	0.014
DOK2	docking protein 2, 56kDa	0.014
NLRP3	NLR family, pyrin domain containing 3	0.013
SLAMF1	signaling lymphocytic activation molecule family member 1	0.013
LGALS9	lectin, galactoside-binding, soluble, 9	0.013
SLC15A3	solute carrier family 15, member 3	0.013
IRF8	interferon regulatory factor 8	0.013
NOTCH3	notch 3	0.013
IQGAP1	IQ motif containing GTPase activating protein 1	0.013
FHOD3	formin homology 2 domain containing 3	0.013
NOD2	nucleotide-binding oligomerization domain containing 2	0.013
HLA-DMB	major histocompatibility complex, class II, DM beta	0.013
ETV7	ets variant 7	0.012
SIGLEC10	sialic acid binding Ig-like lectin 10	0.012
ALOX5	arachidonate 5-lipoxygenase	0.012
TLR8	toll-like receptor 8	0.012
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.012
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.012
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.012
PLEK	pleckstrin	0.012
CD72	CD72 molecule	0.012
DDIT3	DNA-damage-inducible transcript 3	0.012
CYTH4	cytohesin 4	0.012
TACC1	transforming, acidic coiled-coil containing protein 1	0.012
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.012
CD28	CD28 molecule	0.012
NPIP	nuclear pore complex interacting protein	0.012
CCR7	chemokine (C-C motif) receptor 7	0.012
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.012
CD27	CD27 molecule	0.011
IFNG	interferon, gamma	0.011
CIITA	class II, major histocompatibility complex, transactivator	0.011
CD83	CD83 molecule	0.011
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.011
POU2F2	POU class 2 homeobox 2	0.011
ABHD16A	abhydrolase domain containing 16A	0.011
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.011
TREM1	triggering receptor expressed on myeloid cells 1	0.011
PECAM1	platelet/endothelial cell adhesion molecule	0.011
CTNNBL1	catenin, beta like 1	0.011
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.011
CTNND1	catenin (cadherin-associated protein), delta 1	0.011
CCL22	chemokine (C-C motif) ligand 22	0.011
ACP5	acid phosphatase 5, tartrate resistant	0.010
BAX	BCL2-associated X protein	0.010
CARD9	caspase recruitment domain family, member 9	0.010
HMHA1	histocompatibility (minor) HA-1	0.010
STXBP2	syntaxin binding protein 2	0.010
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.010
GABARAPL1	GABA(A) receptor-associated protein like 1	0.010
ZRANB1	zinc finger, RAN-binding domain containing 1	0.010
IKZF1	IKAROS family zinc finger 1 (Ikaros)	0.010
CD180	CD180 molecule	0.010
TRPV2	transient receptor potential cation channel, subfamily V, member 2	0.010
TICAM1	toll-like receptor adaptor molecule 1	0.010