IMP: Integrative Multi-species Prediction

Homo sapiens

16 genes annotated in human

leigh disease

DOID:3652

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "leigh disease"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "leigh disease" (in gray)

Name	Description	Probability
NDUFS3	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)	0.993
NDUFS2	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	0.989
NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	0.984
NDUFS8	NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)	0.974
NDUFV1	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	0.969
NDUFB9	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa	0.969
NDUFS7	NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)	0.967
NDUFB8	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa	0.931
NDUFA2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa	0.914
SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	0.905
NDUFA9	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa	0.850
CYC1	cytochrome c-1	0.740
NDUFB10	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa	0.442
SAMM50	sorting and assembly machinery component 50 homolog (S. cerevisiae)	0.374
NDUFB7	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa	0.349
ATP5B	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	0.278
NDUFA8	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa	0.233
NDUFA12	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12	0.230
NDUFS6	NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)	0.220
NDUFA7	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa	0.193
SFXN4	sideroflexin 4	0.164
EIF2B3	eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa	0.129
NDUFS1	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	0.103
ICT1	immature colon carcinoma transcript 1	0.089
COQ3	coenzyme Q3 homolog, methyltransferase (S. cerevisiae)	0.079
EXOSC10	exosome component 10	0.056
SUCLG1	succinate-CoA ligase, alpha subunit	0.055
UQCRFS1	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	0.049
GOT1	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	0.045
METTL17	methyltransferase like 17	0.038
SLC25A3	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	0.036
PET112L	PET112-like (yeast)	0.035
NDUFB5	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa	0.031
NDUFAF1	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1	0.024
NDUFA10	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa	0.023
ATP5O	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	0.022
ATP5H	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d	0.022
SURF1	surfeit 1	0.021
SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.021
NDUFS4	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)	0.021
MRPS22	mitochondrial ribosomal protein S22	0.018
C20orf7	chromosome 20 open reading frame 7	0.018
ATP5C1	ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1	0.018
NDUFA6	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa	0.017
ATP5G1	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)	0.016
AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	0.015
MRPL15	mitochondrial ribosomal protein L15	0.015
OXA1L	oxidase (cytochrome c) assembly 1-like	0.015
PDHA1	pyruvate dehydrogenase (lipoamide) alpha 1	0.014
UQCRC1	ubiquinol-cytochrome c reductase core protein I	0.014
PCCB	propionyl CoA carboxylase, beta polypeptide	0.013
COQ9	coenzyme Q9 homolog (S. cerevisiae)	0.013
NDUFB6	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa	0.013
IDH3B	isocitrate dehydrogenase 3 (NAD+) beta	0.012
NDUFV3	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa	0.012
DHODH	dihydroorotate dehydrogenase	0.010
FOXRED1	FAD-dependent oxidoreductase domain containing 1	0.006
COX10	COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)	0.003
BCS1L	BCS1-like (S. cerevisiae)	0.003
COX15	COX15 homolog, cytochrome c oxidase assembly protein (yeast)	0.002
C8orf38	chromosome 8 open reading frame 38	0.001
NDUFAF2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2	0.000