IMP: Integrative Multi-species Prediction

Homo sapiens

33 genes annotated in human

charcot marie tooth disease

DOID:10595

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

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Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "charcot marie tooth disease" (in gray)

Name	Description	Probability	Func Analog Organism
BAG3	BCL2-associated athanogene 3	0.914
HSPB8	heat shock 22kDa protein 8	0.815
HSPB1	heat shock 27kDa protein 1	0.806
MARS	methionyl-tRNA synthetase	0.776
IARS	isoleucyl-tRNA synthetase	0.770
CRYAB	crystallin, alpha B	0.663	Human
DNM1	dynamin 1	0.465	Human
HSPB2	heat shock 27kDa protein 2	0.441	Human
SARS	seryl-tRNA synthetase	0.266
ASNS	asparagine synthetase (glutamine-hydrolyzing)	0.262
HSF1	heat shock transcription factor 1	0.262
EGR3	early growth response 3	0.228	Human
CARS	cysteinyl-tRNA synthetase	0.199
HSPB7	heat shock 27kDa protein family, member 7 (cardiovascular)	0.180
CLASP1	cytoplasmic linker associated protein 1	0.177
NCOA1	nuclear receptor coactivator 1	0.161
MARCH5	membrane-associated ring finger (C3HC4) 5	0.159
HSPA1B	heat shock 70kDa protein 1B	0.126
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.105
EGR1	early growth response 1	0.097	Human
RARA	retinoic acid receptor, alpha	0.094
RXRA	retinoid X receptor, alpha	0.090
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.080
KLC1	kinesin light chain 1	0.074
TSG101	tumor susceptibility gene 101	0.055
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.051
CTTN	cortactin	0.051
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.048
AARS	alanyl-tRNA synthetase	0.048
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.034
DNM2	dynamin 2	0.033
LDHA	lactate dehydrogenase A	0.030
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.029
BHLHE40	basic helix-loop-helix family, member e40	0.029
PRPF8	PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)	0.028
SQSTM1	sequestosome 1	0.028
YARS	tyrosyl-tRNA synthetase	0.026
SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)	0.025
EFTUD2	elongation factor Tu GTP binding domain containing 2	0.025
S100A10	S100 calcium binding protein A10	0.024
SF3B3	splicing factor 3b, subunit 3, 130kDa	0.023
ACP5	acid phosphatase 5, tartrate resistant	0.023
MGAT4B	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B	0.022
PLEC	plectin	0.021
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.021
FLNB	filamin B, beta	0.021
SREBF1	sterol regulatory element binding transcription factor 1	0.021
NINL	ninein-like	0.020
TARS	threonyl-tRNA synthetase	0.019
EIF1B	eukaryotic translation initiation factor 1B	0.019
SH3BP4	SH3-domain binding protein 4	0.018
FAM46A	family with sequence similarity 46, member A	0.018
SH3GL1	SH3-domain GRB2-like 1	0.018
FLNA	filamin A, alpha	0.018
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.017
IK	IK cytokine, down-regulator of HLA II	0.017
CD151	CD151 molecule (Raph blood group)	0.017
WASL	Wiskott-Aldrich syndrome-like	0.017
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.016
GARS	glycyl-tRNA synthetase	0.016
PSEN2	presenilin 2 (Alzheimer disease 4)	0.016
G6PD	glucose-6-phosphate dehydrogenase	0.015
TLE3	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)	0.015
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.014
SH3BP2	SH3-domain binding protein 2	0.014
RAB5A	RAB5A, member RAS oncogene family	0.014
VAC14	Vac14 homolog (S. cerevisiae)	0.014
TRIB3	tribbles homolog 3 (Drosophila)	0.014
SH3KBP1	SH3-domain kinase binding protein 1	0.014
FASN	fatty acid synthase	0.014
NONO	non-POU domain containing, octamer-binding	0.014
HSPB6	heat shock protein, alpha-crystallin-related, B6	0.013	Human
ITGB4	integrin, beta 4	0.013
PDCD6IP	programmed cell death 6 interacting protein	0.013
MAP4	microtubule-associated protein 4	0.013
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.013
PSAT1	phosphoserine aminotransferase 1	0.013
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.013
TYK2	tyrosine kinase 2	0.013
PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	0.013
PIAS4	protein inhibitor of activated STAT, 4	0.012
ALOX12	arachidonate 12-lipoxygenase	0.012
TARS2	threonyl-tRNA synthetase 2, mitochondrial (putative)	0.012
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.012
MED16	mediator complex subunit 16	0.011
RASAL2	RAS protein activator like 2	0.011
HIST2H3C	histone cluster 2, H3c	0.011
C16orf80	chromosome 16 open reading frame 80	0.011
CYB5B	cytochrome b5 type B (outer mitochondrial membrane)	0.011
MTHFD2	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	0.011
RNF115	ring finger protein 115	0.011
TRIM74	tripartite motif containing 74	0.011
KIF1C	kinesin family member 1C	0.011	Human
TUBB6	tubulin, beta 6	0.011
BLMH	bleomycin hydrolase	0.011
WARS	tryptophanyl-tRNA synthetase	0.011
SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.011
HUWE1	HECT, UBA and WWE domain containing 1	0.011
AHNAK	AHNAK nucleoprotein	0.011	Human
RAB7A	RAB7A, member RAS oncogene family	0.011
PHGDH	phosphoglycerate dehydrogenase	0.011
MAP3K4	mitogen-activated protein kinase kinase kinase 4	0.011
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.011
UBA1	ubiquitin-like modifier activating enzyme 1	0.010
MYO1E	myosin IE	0.010
EPRS	glutamyl-prolyl-tRNA synthetase	0.010
PPFIBP2	PTPRF interacting protein, binding protein 2 (liprin beta 2)	0.010
CRYAA	crystallin, alpha A	0.010	Human
ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.010
MED26	mediator complex subunit 26	0.010
TMBIM1	transmembrane BAX inhibitor motif containing 1	0.010
FGD4	FYVE, RhoGEF and PH domain containing 4	0.006
FIG4	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	0.005
GDAP1	ganglioside-induced differentiation-associated protein 1	0.005
KIF1B	kinesin family member 1B	0.005
TRPV4	transient receptor potential cation channel, subfamily V, member 4	0.005
MFN2	mitofusin 2	0.005
MPZ	myelin protein zero	0.004
DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	0.004
PMP22	peripheral myelin protein 22	0.004
GJB1	gap junction protein, beta 1, 32kDa	0.004
GNB4	guanine nucleotide binding protein (G protein), beta polypeptide 4	0.004
LITAF	lipopolysaccharide-induced TNF factor	0.004
PRX	periaxin	0.004
NEFL	neurofilament, light polypeptide	0.004
PLEKHG5	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	0.004
NDRG1	N-myc downstream regulated 1	0.004
LRSAM1	leucine rich repeat and sterile alpha motif containing 1	0.004
SBF2	SET binding factor 2	0.004
INF2	inverted formin, FH2 and WH2 domain containing	0.004
MED25	mediator complex subunit 25	0.004
EGR2	early growth response 2	0.003
SH3TC2	SH3 domain and tetratricopeptide repeats 2	0.003
AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	0.002
LMNA	lamin A/C	0.002
MTMR2	myotubularin related protein 2	0.002
PRPS1	phosphoribosyl pyrophosphate synthetase 1	0.002