IMP: Integrative Multi-species Prediction

Homo sapiens

21 genes annotated in human

breast cancer

DOID:1612

A thoracic cancer that originates in the mammary gland.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "breast cancer"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "breast cancer" (in gray)

Name	Description	Probability	Func Analog Organism
BRCA1	breast cancer 1, early onset	0.999
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.995
BRCA2	breast cancer 2, early onset	0.920
BLM	Bloom syndrome, RecQ helicase-like	0.621
H2AFX	H2A histone family, member X	0.430
C19orf39	chromosome 19 open reading frame 39	0.359
FANCD2	Fanconi anemia, complementation group D2	0.357
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.289
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.230
FANCA	Fanconi anemia, complementation group A	0.183
RB1	retinoblastoma 1	0.173
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.151	Human
TP53BP1	tumor protein p53 binding protein 1	0.144
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.143
MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	0.132
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.113
RAD51C	RAD51 homolog C (S. cerevisiae)	0.091
BARD1	BRCA1 associated RING domain 1	0.080
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.079
PALB2	partner and localizer of BRCA2	0.078
CDK2	cyclin-dependent kinase 2	0.069
EXO1	exonuclease 1	0.062
FADD	Fas (TNFRSF6)-associated via death domain	0.060
MDC1	mediator of DNA-damage checkpoint 1	0.056
BRAP	BRCA1 associated protein	0.048
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.047
IRS1	insulin receptor substrate 1	0.046
WRN	Werner syndrome, RecQ helicase-like	0.044
RPA1	replication protein A1, 70kDa	0.043
RAD18	RAD18 homolog (S. cerevisiae)	0.043
MORC3	MORC family CW-type zinc finger 3	0.039
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.031
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.031
ATG16L1	ATG16 autophagy related 16-like 1 (S. cerevisiae)	0.029
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.029
PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	0.029
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.029
CSTF2	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa	0.027
PLK1	polo-like kinase 1	0.026
POLQ	polymerase (DNA directed), theta	0.025
GINS2	GINS complex subunit 2 (Psf2 homolog)	0.025
ACACA	acetyl-CoA carboxylase alpha	0.025
NEIL3	nei endonuclease VIII-like 3 (E. coli)	0.024
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.024
RAD52	RAD52 homolog (S. cerevisiae)	0.023
XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	0.022
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.022
TDP1	tyrosyl-DNA phosphodiesterase 1	0.022
HBP1	HMG-box transcription factor 1	0.021
FBXO5	F-box protein 5	0.021
RICTOR	RPTOR independent companion of MTOR, complex 2	0.020
RAD51AP1	RAD51 associated protein 1	0.019
NR1D2	nuclear receptor subfamily 1, group D, member 2	0.019
ULK2	unc-51-like kinase 2 (C. elegans)	0.019
ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	0.019
ERBB2IP	erbb2 interacting protein	0.019
RAD54B	RAD54 homolog B (S. cerevisiae)	0.018
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.018
SLC38A2	solute carrier family 38, member 2	0.017
RRP9	ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)	0.017
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.017
RRM2B	ribonucleotide reductase M2 B (TP53 inducible)	0.017
SIRT1	sirtuin 1	0.016
ATG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.016
KLHL24	kelch-like 24 (Drosophila)	0.016
FHL2	four and a half LIM domains 2	0.016
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.016
PDS5B	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.015
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.015
PARN	poly(A)-specific ribonuclease (deadenylation nuclease)	0.015
MYST1	MYST histone acetyltransferase 1	0.014
IGSF21	immunoglobin superfamily, member 21	0.014
TBC1D15	TBC1 domain family, member 15	0.014
E2F1	E2F transcription factor 1	0.014
FAM175A	family with sequence similarity 175, member A	0.014
PTK2	PTK2 protein tyrosine kinase 2	0.014
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.014
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.014
SYCP3	synaptonemal complex protein 3	0.013
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.013
PSEN1	presenilin 1	0.013
ZNF350	zinc finger protein 350	0.013
OXR1	oxidation resistance 1	0.013
LRIF1	ligand dependent nuclear receptor interacting factor 1	0.013
SGOL1	shugoshin-like 1 (S. pombe)	0.013
RYBP	RING1 and YY1 binding protein	0.013
GINS4	GINS complex subunit 4 (Sld5 homolog)	0.013
GINS3	GINS complex subunit 3 (Psf3 homolog)	0.013
XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	0.012
GTF2I	general transcription factor IIi	0.012
BCL2	B-cell CLL/lymphoma 2	0.012
ZRANB1	zinc finger, RAN-binding domain containing 1	0.012
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.012
MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3	0.012
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.012
LRSAM1	leucine rich repeat and sterile alpha motif containing 1	0.012
TOPORS	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	0.012
AR	androgen receptor	0.012
C15orf42	chromosome 15 open reading frame 42	0.012
NLRP2	NLR family, pyrin domain containing 2	0.011
ATM	ataxia telangiectasia mutated	0.011
CEP55	centrosomal protein 55kDa	0.011
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.011
PTEN	phosphatase and tensin homolog	0.011
PPM1A	protein phosphatase, Mg2+/Mn2+ dependent, 1A	0.011
UIMC1	ubiquitin interaction motif containing 1	0.011
RECQL4	RecQ protein-like 4	0.011
WDR26	WD repeat domain 26	0.011
SPAG9	sperm associated antigen 9	0.010
JUP	junction plakoglobin	0.010
OBFC2B	oligonucleotide/oligosaccharide-binding fold containing 2B	0.010
BRD7	bromodomain containing 7	0.010
ARID4A	AT rich interactive domain 4A (RBP1-like)	0.010
C5orf41	chromosome 5 open reading frame 41	0.010
TBK1	TANK-binding kinase 1	0.010
AURKA	aurora kinase A	0.010
CARD11	caspase recruitment domain family, member 11	0.010
TRIM23	tripartite motif containing 23	0.010
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	0.006
RAD54L	RAD54-like (S. cerevisiae)	0.003
SLC22A18	solute carrier family 22, member 18	0.003
KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.003
HMMR	hyaluronan-mediated motility receptor (RHAMM)	0.003
RB1CC1	RB1-inducible coiled-coil 1	0.002
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.001
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.001
TSG101	tumor susceptibility gene 101	0.001
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.000
TP53	tumor protein p53	0.000
PHB	prohibitin	0.000