IMP: Integrative Multi-species Prediction

Homo sapiens

29 genes annotated in human

cognitive disorder

DOID:1561

A disease of mental health that affects cognitive functions including memory processing, perception and problem solving.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cognitive disorder"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "cognitive disorder" (in gray)

Name	Description	Probability	Func Analog Organism
PSEN1	presenilin 1	1.000
APP	amyloid beta (A4) precursor protein	0.831
PSEN2	presenilin 2 (Alzheimer disease 4)	0.751
LAMP1	lysosomal-associated membrane protein 1	0.685
APOE	apolipoprotein E	0.615
NCSTN	nicastrin	0.565
PKP4	plakophilin 4	0.562
NOSTRIN	nitric oxide synthase trafficker	0.520
A2M	alpha-2-macroglobulin	0.474
GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	0.434
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.404
FLNB	filamin B, beta	0.313
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.219	Human
APOC1	apolipoprotein C-I	0.217
ECSIT	ECSIT homolog (Drosophila)	0.175
CIB1	calcium and integrin binding 1 (calmyrin)	0.150
IGF2R	insulin-like growth factor 2 receptor	0.149
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.148
HP	haptoglobin	0.146
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.130
DOCK7	dedicator of cytokinesis 7	0.128
BACE1	beta-site APP-cleaving enzyme 1	0.118
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.115
MAP1A	microtubule-associated protein 1A	0.109
PLAUR	plasminogen activator, urokinase receptor	0.106
PLTP	phospholipid transfer protein	0.098
SORT1	sortilin 1	0.094	Human
MCMBP	minichromosome maintenance complex binding protein	0.092
TP53BP1	tumor protein p53 binding protein 1	0.078
SMC1A	structural maintenance of chromosomes 1A	0.067
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.065
APLP2	amyloid beta (A4) precursor-like protein 2	0.061	Human
SYN1	synapsin I	0.059	Human
PDIA3	protein disulfide isomerase family A, member 3	0.056
ACTN2	actinin, alpha 2	0.053
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.052
APLP1	amyloid beta (A4) precursor-like protein 1	0.050
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.047
SYNRG	synergin, gamma	0.045
SNCAIP	synuclein, alpha interacting protein	0.044
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.044
ZFYVE1	zinc finger, FYVE domain containing 1	0.043
GAA	glucosidase, alpha; acid	0.043
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.042
MDC1	mediator of DNA-damage checkpoint 1	0.041	Human
SRI	sorcin	0.038
BCL2L1	BCL2-like 1	0.035
GGA1	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	0.034
CTSA	cathepsin A	0.032
ATP6AP1	ATPase, H+ transporting, lysosomal accessory protein 1	0.030
MAPT	microtubule-associated protein tau	0.030
CTSD	cathepsin D	0.029
DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.029
TNFRSF21	tumor necrosis factor receptor superfamily, member 21	0.028
GCDH	glutaryl-CoA dehydrogenase	0.027
PPP5C	protein phosphatase 5, catalytic subunit	0.025
IQGAP1	IQ motif containing GTPase activating protein 1	0.025
SYNE1	spectrin repeat containing, nuclear envelope 1	0.025
NUMB	numb homolog (Drosophila)	0.025
ADAM9	ADAM metallopeptidase domain 9	0.024
SNAP23	synaptosomal-associated protein, 23kDa	0.023
SEPT8	septin 8	0.023
ATXN3	ataxin 3	0.023
TRAF3IP1	TNF receptor-associated factor 3 interacting protein 1	0.023
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.023
WDR5	WD repeat domain 5	0.023
PLAT	plasminogen activator, tissue	0.022	Human
SPG21	spastic paraplegia 21 (autosomal recessive, Mast syndrome)	0.021
LCAT	lecithin-cholesterol acyltransferase	0.021
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.021
UBQLN1	ubiquilin 1	0.021
PRAM1	PML-RARA regulated adaptor molecule 1	0.020
CALR	calreticulin	0.020
C16orf53	chromosome 16 open reading frame 53	0.020
MAST1	microtubule associated serine/threonine kinase 1	0.020
ELAVL3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.020
CPD	carboxypeptidase D	0.019
CCDC141	coiled-coil domain containing 141	0.018
PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)	0.018
NCAPD3	non-SMC condensin II complex, subunit D3	0.017
RBBP5	retinoblastoma binding protein 5	0.017
CTCF	CCCTC-binding factor (zinc finger protein)	0.017
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.017
FKBP8	FK506 binding protein 8, 38kDa	0.017
RNF32	ring finger protein 32	0.016
MEMO1	mediator of cell motility 1	0.016
LOXL4	lysyl oxidase-like 4	0.016
KALRN	kalirin, RhoGEF kinase	0.016
SPTBN4	spectrin, beta, non-erythrocytic 4	0.016
NOS3	nitric oxide synthase 3 (endothelial cell)	0.016
EPS15	epidermal growth factor receptor pathway substrate 15	0.016
TTR	transthyretin	0.016
SNRNP40	small nuclear ribonucleoprotein 40kDa (U5)	0.016
IL13RA1	interleukin 13 receptor, alpha 1	0.015
ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	0.015
HK2	hexokinase 2	0.014
CLU	clusterin	0.014
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.014
CDK9	cyclin-dependent kinase 9	0.014
TRIM32	tripartite motif containing 32	0.014
RABAC1	Rab acceptor 1 (prenylated)	0.013
TPPP	tubulin polymerization promoting protein	0.013
APOA1	apolipoprotein A-I	0.013	Human
SEL1L	sel-1 suppressor of lin-12-like (C. elegans)	0.013
CD46	CD46 molecule, complement regulatory protein	0.013
RABEP1	rabaptin, RAB GTPase binding effector protein 1	0.013
LRP1	low density lipoprotein receptor-related protein 1	0.013
PSAP	prosaposin	0.013
PRNP	prion protein	0.013
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.013
APOC2	apolipoprotein C-II	0.013
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.013
MYT1L	myelin transcription factor 1-like	0.012
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.012
BIK	BCL2-interacting killer (apoptosis-inducing)	0.012
TGFBR1	transforming growth factor, beta receptor 1	0.012
GNS	glucosamine (N-acetyl)-6-sulfatase	0.012
TIAM2	T-cell lymphoma invasion and metastasis 2	0.012
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.012
NUCB1	nucleobindin 1	0.012
FAM63B	family with sequence similarity 63, member B	0.012
B2M	beta-2-microglobulin	0.012
SCARB2	scavenger receptor class B, member 2	0.012
TERF2	telomeric repeat binding factor 2	0.011
ALB	albumin	0.011
TREM2	triggering receptor expressed on myeloid cells 2	0.011
NLRP2	NLR family, pyrin domain containing 2	0.011
ARFIP1	ADP-ribosylation factor interacting protein 1	0.011
CSTF2T	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant	0.011
GRN	granulin	0.011
SRSF4	serine/arginine-rich splicing factor 4	0.011
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.010
TMCC2	transmembrane and coiled-coil domain family 2	0.010
DNASE2	deoxyribonuclease II, lysosomal	0.010
TRAM1	translocation associated membrane protein 1	0.010
TGFB2	transforming growth factor, beta 2	0.010
BLMH	bleomycin hydrolase	0.006
CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	0.005
SNCB	synuclein, beta	0.005
MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	0.004
RTN4R	reticulon 4 receptor	0.004
SYN2	synapsin II	0.004
MPO	myeloperoxidase	0.004
TPH2	tryptophan hydroxylase 2	0.004
SORL1	sortilin-related receptor, L(DLR class) A repeats containing	0.003
FKBP5	FK506 binding protein 5	0.003
GBA	glucosidase, beta, acid	0.003
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A	0.003
DRD3	dopamine receptor D3	0.002
HFE	hemochromatosis	0.002
ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.002
PLD3	phospholipase D family, member 3	0.002
COMT	catechol-O-methyltransferase	0.002
DISC1	disrupted in schizophrenia 1	0.002
PLAU	plasminogen activator, urokinase	0.001
PAXIP1	PAX interacting (with transcription-activation domain) protein 1	0.000
ADAM10	ADAM metallopeptidase domain 10	0.000