IMP
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Homo sapiens
16 genes annotated in human
tauopathy
DOID:680
A neurodegenerative disease that has material basis in the pathological aggregation of tau protein in so-called neurofibrillary tangles (NFT) in the human brain.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "tauopathy"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| PSEN1 | presenilin 1 | 1.000 | ||
| APOE | apolipoprotein E | 0.826 | ||
| PSEN2 | presenilin 2 (Alzheimer disease 4) | 0.750 | ||
| APP | amyloid beta (A4) precursor protein | 0.635 | ||
| NOSTRIN | nitric oxide synthase trafficker | 0.520 | ||
| PKP4 | plakophilin 4 | 0.519 | ||
| A2M | alpha-2-macroglobulin | 0.474 | ||
| GGA2 | golgi-associated, gamma adaptin ear containing, ARF binding protein 2 | 0.434 | ||
| APBA1 | amyloid beta (A4) precursor protein-binding, family A, member 1 | 0.423 | ||
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.404 | ||
| FLNB | filamin B, beta | 0.313 | ||
| SORT1 | sortilin 1 | 0.270 | Human | |
| APBB1 | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | 0.219 | Human | |
| APOC1 | apolipoprotein C-I | 0.217 | ||
| ECSIT | ECSIT homolog (Drosophila) | 0.175 | ||
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.150 | ||
| NCSTN | nicastrin | 0.136 | ||
| LRP1 | low density lipoprotein receptor-related protein 1 | 0.127 | ||
| HP | haptoglobin | 0.123 | ||
| PLAUR | plasminogen activator, urokinase receptor | 0.106 | ||
| PLTP | phospholipid transfer protein | 0.090 | ||
| MAPK8IP1 | mitogen-activated protein kinase 8 interacting protein 1 | 0.079 | ||
| TP53BP1 | tumor protein p53 binding protein 1 | 0.065 | ||
| APH1A | anterior pharynx defective 1 homolog A (C. elegans) | 0.048 | ||
| BACE1 | beta-site APP-cleaving enzyme 1 | 0.048 | ||
| PLAT | plasminogen activator, tissue | 0.045 | Human | |
| GAA | glucosidase, alpha; acid | 0.043 | ||
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.039 | ||
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.029 | ||
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.029 | ||
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.027 | ||
| SRI | sorcin | 0.026 | ||
| CDC37 | cell division cycle 37 homolog (S. cerevisiae) | 0.023 | ||
| SEPT8 | septin 8 | 0.023 | ||
| SYNRG | synergin, gamma | 0.023 | ||
| NUMB | numb homolog (Drosophila) | 0.023 | ||
| DLG4 | discs, large homolog 4 (Drosophila) | 0.022 | ||
| LCAT | lecithin-cholesterol acyltransferase | 0.021 | ||
| MDC1 | mediator of DNA-damage checkpoint 1 | 0.021 | Human | |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.021 | ||
| UBQLN1 | ubiquilin 1 | 0.021 | ||
| C16orf53 | chromosome 16 open reading frame 53 | 0.020 | ||
| SCARB2 | scavenger receptor class B, member 2 | 0.019 | ||
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.017 | ||
| FAM63B | family with sequence similarity 63, member B | 0.017 | ||
| CPD | carboxypeptidase D | 0.017 | ||
| EPS15 | epidermal growth factor receptor pathway substrate 15 | 0.015 | ||
| CLU | clusterin | 0.015 | ||
| TSC22D1 | TSC22 domain family, member 1 | 0.015 | ||
| ZFYVE1 | zinc finger, FYVE domain containing 1 | 0.015 | ||
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.014 | ||
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.014 | Human | |
| PRAM1 | PML-RARA regulated adaptor molecule 1 | 0.014 | ||
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.014 | ||
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 0.014 | ||
| MAST1 | microtubule associated serine/threonine kinase 1 | 0.013 | ||
| GGA1 | golgi-associated, gamma adaptin ear containing, ARF binding protein 1 | 0.013 | ||
| TGM2 | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 0.013 | ||
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.013 | ||
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.012 | ||
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.012 | ||
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.012 | ||
| RNF32 | ring finger protein 32 | 0.012 | ||
| MMP2 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 0.012 | ||
| CALR | calreticulin | 0.011 | ||
| CD46 | CD46 molecule, complement regulatory protein | 0.011 | ||
| IGF2R | insulin-like growth factor 2 receptor | 0.011 | ||
| ADAM9 | ADAM metallopeptidase domain 9 | 0.011 | ||
| LDLR | low density lipoprotein receptor | 0.011 | ||
| ELAVL3 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) | 0.011 | ||
| GCDH | glutaryl-CoA dehydrogenase | 0.011 | ||
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.010 | ||
| TMCC2 | transmembrane and coiled-coil domain family 2 | 0.010 | ||
| NOS3 | nitric oxide synthase 3 (endothelial cell) | 0.010 | ||
| HOMER3 | homer homolog 3 (Drosophila) | 0.010 | ||
| TRIM32 | tripartite motif containing 32 | 0.010 | ||
| BLMH | bleomycin hydrolase | 0.004 | ||
| ACE | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 0.002 | ||
| PLD3 | phospholipase D family, member 3 | 0.002 | ||
| HFE | hemochromatosis | 0.002 | ||
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.002 | ||
| MPO | myeloperoxidase | 0.002 | ||
| PAXIP1 | PAX interacting (with transcription-activation domain) protein 1 | 0.000 | ||
| PLAU | plasminogen activator, urokinase | 0.000 | ||
| ADAM10 | ADAM metallopeptidase domain 10 | 0.000 |