IMP: Integrative Multi-species Prediction

Homo sapiens

29 genes annotated in human

mitochondrial metabolism disease

DOID:700

An inherited metabolic disorder that involves mitochondrial metabolism dysfunction.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in humanInclude functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "mitochondrial metabolism disease"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "mitochondrial metabolism disease" (in gray)

Name	Description	Probability
NDUFS3	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)	0.993
NDUFS2	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	0.989
NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	0.984
NDUFS8	NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)	0.974
NDUFV1	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	0.969
NDUFB9	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa	0.969
NDUFS7	NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)	0.967
NDUFA2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa	0.936
NDUFB8	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa	0.931
SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	0.905
NDUFA9	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa	0.850
CYC1	cytochrome c-1	0.740
NDUFB10	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa	0.442
SAMM50	sorting and assembly machinery component 50 homolog (S. cerevisiae)	0.374
NDUFB7	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa	0.349
ATP5B	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	0.278
NDUFA8	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa	0.244
NDUFA12	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12	0.230
NDUFS6	NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)	0.220
NDUFA7	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa	0.193
SFXN4	sideroflexin 4	0.164
SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.151
METTL17	methyltransferase like 17	0.149
EIF2B3	eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa	0.129
AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	0.123
NDUFS1	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	0.103
ICT1	immature colon carcinoma transcript 1	0.089
COQ3	coenzyme Q3 homolog, methyltransferase (S. cerevisiae)	0.079
EXOSC10	exosome component 10	0.056
SUCLG1	succinate-CoA ligase, alpha subunit	0.055
UQCRFS1	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	0.049
UQCRB	ubiquinol-cytochrome c reductase binding protein	0.049
NDUFA10	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa	0.048
IVD	isovaleryl-CoA dehydrogenase	0.048
PET112L	PET112-like (yeast)	0.046
GOT1	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	0.045
SLC25A3	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	0.036
OXA1L	oxidase (cytochrome c) assembly 1-like	0.035
NFS1	NFS1 nitrogen fixation 1 homolog (S. cerevisiae)	0.035
COQ5	coenzyme Q5 homolog, methyltransferase (S. cerevisiae)	0.033
NDUFS4	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)	0.033
TIMM13	translocase of inner mitochondrial membrane 13 homolog (yeast)	0.032
NDUFB5	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa	0.031
COX16	COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)	0.029
MCCC1	methylcrotonoyl-CoA carboxylase 1 (alpha)	0.028
MRPL46	mitochondrial ribosomal protein L46	0.027
CBR4	carbonyl reductase 4	0.026
NDUFAF1	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1	0.024
ACAD9	acyl-CoA dehydrogenase family, member 9	0.024
PCCB	propionyl CoA carboxylase, beta polypeptide	0.023
ATP5O	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	0.022
NDUFB6	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa	0.022
SURF1	surfeit 1	0.022
ACO2	aconitase 2, mitochondrial	0.022
HDHD2	haloacid dehalogenase-like hydrolase domain containing 2	0.022
ATP5H	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d	0.022
MRPL35	mitochondrial ribosomal protein L35	0.021
CBARA1	calcium binding atopy-related autoantigen 1	0.020
C20orf7	chromosome 20 open reading frame 7	0.020
TYMP	thymidine phosphorylase	0.020
MRPS21	mitochondrial ribosomal protein S21	0.019
MGST3	microsomal glutathione S-transferase 3	0.019
MRPS22	mitochondrial ribosomal protein S22	0.018
MRPS36	mitochondrial ribosomal protein S36	0.018
SDR39U1	short chain dehydrogenase/reductase family 39U, member 1	0.018
ATP5C1	ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1	0.018
C1orf31	chromosome 1 open reading frame 31	0.017
COX15	COX15 homolog, cytochrome c oxidase assembly protein (yeast)	0.017
NDUFA6	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa	0.017
MRPL45	mitochondrial ribosomal protein L45	0.017
USP30	ubiquitin specific peptidase 30	0.017
NPRL2	nitrogen permease regulator-like 2 (S. cerevisiae)	0.016
ATP5G1	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)	0.016
MRPS11	mitochondrial ribosomal protein S11	0.016
PIN4	protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)	0.016
NDUFA1	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa	0.015
MRPL16	mitochondrial ribosomal protein L16	0.015
PTCD2	pentatricopeptide repeat domain 2	0.015
OXSM	3-oxoacyl-ACP synthase, mitochondrial	0.015
TIMM9	translocase of inner mitochondrial membrane 9 homolog (yeast)	0.015
MRPL15	mitochondrial ribosomal protein L15	0.015
TMEM126A	transmembrane protein 126A	0.014
CCDC56	coiled-coil domain containing 56	0.014
PDHA1	pyruvate dehydrogenase (lipoamide) alpha 1	0.014
DPH5	DPH5 homolog (S. cerevisiae)	0.014
DHODH	dihydroorotate dehydrogenase	0.014
UQCRC1	ubiquinol-cytochrome c reductase core protein I	0.014
C8orf59	chromosome 8 open reading frame 59	0.014
MRPS14	mitochondrial ribosomal protein S14	0.013
COQ9	coenzyme Q9 homolog (S. cerevisiae)	0.013
GNPAT	glyceronephosphate O-acyltransferase	0.013
SLC5A6	solute carrier family 5 (sodium-dependent vitamin transporter), member 6	0.013
ISG15	ISG15 ubiquitin-like modifier	0.013
TACO1	translational activator of mitochondrially encoded cytochrome c oxidase I	0.013
TSFM	Ts translation elongation factor, mitochondrial	0.013
HIF1AN	hypoxia inducible factor 1, alpha subunit inhibitor	0.012
DERA	deoxyribose-phosphate aldolase (putative)	0.012
RABEPK	Rab9 effector protein with kelch motifs	0.012
IDH3B	isocitrate dehydrogenase 3 (NAD+) beta	0.012
AFG3L2	AFG3 ATPase family gene 3-like 2 (S. cerevisiae)	0.012
NDUFV3	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa	0.012
FOXRED1	FAD-dependent oxidoreductase domain containing 1	0.012
COQ6	coenzyme Q6 homolog, monooxygenase (S. cerevisiae)	0.012
IFT46	intraflagellar transport 46 homolog (Chlamydomonas)	0.012
CCDC51	coiled-coil domain containing 51	0.011
KLHDC2	kelch domain containing 2	0.011
ECI1	enoyl-CoA delta isomerase 1	0.011
C12orf45	chromosome 12 open reading frame 45	0.011
MRPL52	mitochondrial ribosomal protein L52	0.011
LARS2	leucyl-tRNA synthetase 2, mitochondrial	0.011
TMEM186	transmembrane protein 186	0.011
MRRF	mitochondrial ribosome recycling factor	0.011
NDUFS5	NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)	0.011
PFKM	phosphofructokinase, muscle	0.011
SLC25A38	solute carrier family 25, member 38	0.010
FARS2	phenylalanyl-tRNA synthetase 2, mitochondrial	0.010
OXNAD1	oxidoreductase NAD-binding domain containing 1	0.010
UQCC	ubiquinol-cytochrome c reductase complex chaperone	0.010
POLR3B	polymerase (RNA) III (DNA directed) polypeptide B	0.010
C3orf1	chromosome 3 open reading frame 1	0.010
C3orf75	chromosome 3 open reading frame 75	0.010
ZCRB1	zinc finger CCHC-type and RNA binding motif 1	0.010
FAM192A	family with sequence similarity 192, member A	0.010
KIF20B	kinesin family member 20B	0.010
COQ2	coenzyme Q2 homolog, prenyltransferase (yeast)	0.009
COX10	COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)	0.007
BCS1L	BCS1-like (S. cerevisiae)	0.006
ATPAF2	ATP synthase mitochondrial F1 complex assembly factor 2	0.006
FAM36A	family with sequence similarity 36, member A	0.005
TIMM8A	translocase of inner mitochondrial membrane 8 homolog A (yeast)	0.005
ADCK3	aarF domain containing kinase 3	0.004
C14orf153	chromosome 14 open reading frame 153	0.004
PDSS2	prenyl (decaprenyl) diphosphate synthase, subunit 2	0.003
C8orf38	chromosome 8 open reading frame 38	0.003
PDSS1	prenyl (decaprenyl) diphosphate synthase, subunit 1	0.002
C2orf64	chromosome 2 open reading frame 64	0.002
SCO2	SCO cytochrome oxidase deficient homolog 2 (yeast)	0.002
LOC100131801	hypothetical protein LOC100131801	0.001
NDUFAF2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2	0.001