IMP: Integrative Multi-species Prediction

Homo sapiens

26 genes annotated in human

endocrine gland cancer

DOID:170

An organ system cancer located in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endocrine gland cancer"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "endocrine gland cancer" (in gray)

Name	Description	Probability	Func Analog Organism
BRCA2	breast cancer 2, early onset	0.948
SMAD4	SMAD family member 4	0.836
SORBS2	sorbin and SH3 domain containing 2	0.701
CTR9	Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.693
LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.655
FANCD2	Fanconi anemia, complementation group D2	0.632
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.550
SMAD2	SMAD family member 2	0.405	Human
NDUFS2	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	0.392
STRADA	STE20-related kinase adaptor alpha	0.355
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.328
TCF12	transcription factor 12	0.303
BRCA1	breast cancer 1, early onset	0.286
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.285
SKIL	SKI-like oncogene	0.253
PALB2	partner and localizer of BRCA2	0.243
BARD1	BRCA1 associated RING domain 1	0.229
BBS4	Bardet-Biedl syndrome 4	0.205
PAF1	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.197
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.152
SRI	sorcin	0.145
PLCG1	phospholipase C, gamma 1	0.134
WRN	Werner syndrome, RecQ helicase-like	0.110
RB1	retinoblastoma 1	0.106
AKAP10	A kinase (PRKA) anchor protein 10	0.101
USO1	USO1 vesicle docking protein homolog (yeast)	0.100
IMMT	inner membrane protein, mitochondrial	0.100
STRADB	STE20-related kinase adaptor beta	0.099
SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	0.097
ETFB	electron-transfer-flavoprotein, beta polypeptide	0.093
IGSF21	immunoglobin superfamily, member 21	0.089
NGF	nerve growth factor (beta polypeptide)	0.085
CCDC90B	coiled-coil domain containing 90B	0.083
KIAA0368	KIAA0368	0.082
ZMYND11	zinc finger, MYND-type containing 11	0.081
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.075
RAD52	RAD52 homolog (S. cerevisiae)	0.072
TRIM24	tripartite motif containing 24	0.069
NDUFV1	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	0.065
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.062
TCEA1	transcription elongation factor A (SII), 1	0.060
HIPK1	homeodomain interacting protein kinase 1	0.054
TRIM33	tripartite motif containing 33	0.050
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.049
ERBB2IP	erbb2 interacting protein	0.049
SMAD1	SMAD family member 1	0.047	Human
NELL2	NEL-like 2 (chicken)	0.047
SPRY4	sprouty homolog 4 (Drosophila)	0.046
BLM	Bloom syndrome, RecQ helicase-like	0.046
PDS5B	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.045
NDUFA2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa	0.044
BRAP	BRCA1 associated protein	0.040
TNIP2	TNFAIP3 interacting protein 2	0.040
TM9SF2	transmembrane 9 superfamily member 2	0.039
ZFYVE9	zinc finger, FYVE domain containing 9	0.038
SLK	STE20-like kinase	0.038
EEF1A1	eukaryotic translation elongation factor 1 alpha 1	0.037
TM9SF3	transmembrane 9 superfamily member 3	0.036
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.035
TGFBR1	transforming growth factor, beta receptor 1	0.034
USP9X	ubiquitin specific peptidase 9, X-linked	0.034
SOS1	son of sevenless homolog 1 (Drosophila)	0.034
PRDX5	peroxiredoxin 5	0.034
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.033
SYCP3	synaptonemal complex protein 3	0.032
AR	androgen receptor	0.032
HMOX2	heme oxygenase (decycling) 2	0.032
TP53	tumor protein p53	0.031
PDE4DIP	phosphodiesterase 4D interacting protein	0.030
PMVK	phosphomevalonate kinase	0.030
RALGDS	ral guanine nucleotide dissociation stimulator	0.029
ITSN1	intersectin 1 (SH3 domain protein)	0.029
TBCB	tubulin folding cofactor B	0.029
NDUFB5	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa	0.028
RASSF2	Ras association (RalGDS/AF-6) domain family member 2	0.028
ITFG1	integrin alpha FG-GAP repeat containing 1	0.027
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.027
PJA2	praja ring finger 2	0.027
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.027
CLTB	clathrin, light chain B	0.026
RANBP9	RAN binding protein 9	0.026
XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	0.025
DCP1A	DCP1 decapping enzyme homolog A (S. cerevisiae)	0.025
SHOC2	soc-2 suppressor of clear homolog (C. elegans)	0.025
UQCRFS1	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	0.025
SNAPIN	SNAP-associated protein	0.024
RSF1	remodeling and spacing factor 1	0.024
BRD7	bromodomain containing 7	0.024
C1orf9	chromosome 1 open reading frame 9	0.024
TTC8	tetratricopeptide repeat domain 8	0.024
SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.024
C19orf39	chromosome 19 open reading frame 39	0.023
PFDN1	prefoldin subunit 1	0.023
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.022
DPP8	dipeptidyl-peptidase 8	0.022
ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	0.022
FAM32A	family with sequence similarity 32, member A	0.022
CDK12	cyclin-dependent kinase 12	0.021
NDUFS6	NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)	0.021
PEBP1	phosphatidylethanolamine binding protein 1	0.021
SDF2	stromal cell-derived factor 2	0.021
ACAT1	acetyl-CoA acetyltransferase 1	0.021
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.021
CHIC2	cysteine-rich hydrophobic domain 2	0.021
STK4	serine/threonine kinase 4	0.021
PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)	0.020
GMFB	glia maturation factor, beta	0.020
GTF2E1	general transcription factor IIE, polypeptide 1, alpha 56kDa	0.020
BMI1	BMI1 polycomb ring finger oncogene	0.020
PRKAR2A	protein kinase, cAMP-dependent, regulatory, type II, alpha	0.020	Human
DCP1B	DCP1 decapping enzyme homolog B (S. cerevisiae)	0.020
FIS1	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)	0.020
UTP14C	UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)	0.020
UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	0.020
ADRB2	adrenergic, beta-2-, receptor, surface	0.019
SSX2IP	synovial sarcoma, X breakpoint 2 interacting protein	0.019
ZCCHC8	zinc finger, CCHC domain containing 8	0.019
INSR	insulin receptor	0.019
PAM	peptidylglycine alpha-amidating monooxygenase	0.019
LAMTOR2	late endosomal/lysosomal adaptor, MAPK and MTOR activator 2	0.019
PCDHA4	protocadherin alpha 4	0.019
HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	0.019
CCT2	chaperonin containing TCP1, subunit 2 (beta)	0.018
H2AFX	H2A histone family, member X	0.018
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.018
CENPB	centromere protein B, 80kDa	0.018
C20orf30	chromosome 20 open reading frame 30	0.018
PLEKHF2	pleckstrin homology domain containing, family F (with FYVE domain) member 2	0.018
COPS7A	COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)	0.018
ZNF292	zinc finger protein 292	0.018
ROMO1	reactive oxygen species modulator 1	0.018
MRPL54	mitochondrial ribosomal protein L54	0.018
C14orf119	chromosome 14 open reading frame 119	0.017
ACACA	acetyl-CoA carboxylase alpha	0.017
APC	adenomatous polyposis coli	0.017
CHD4	chromodomain helicase DNA binding protein 4	0.017
ZMYM2	zinc finger, MYM-type 2	0.017
CLSPN	claspin	0.017
ANAPC7	anaphase promoting complex subunit 7	0.017
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.017
NPTN	neuroplastin	0.017
CD2AP	CD2-associated protein	0.016
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.016
PRDX6	peroxiredoxin 6	0.016
RNF20	ring finger protein 20	0.016
ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	0.016
TRIP4	thyroid hormone receptor interactor 4	0.016
NCOR1	nuclear receptor corepressor 1	0.016
EZR	ezrin	0.016
NIPSNAP3A	nipsnap homolog 3A (C. elegans)	0.016
EDF1	endothelial differentiation-related factor 1	0.015
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.015
MARK4	MAP/microtubule affinity-regulating kinase 4	0.015
ADCY1	adenylate cyclase 1 (brain)	0.015
BAZ1A	bromodomain adjacent to zinc finger domain, 1A	0.015
C9orf46	chromosome 9 open reading frame 46	0.015
BAG1	BCL2-associated athanogene	0.015
SEPW1	selenoprotein W, 1	0.015
TSSC4	tumor suppressing subtransferable candidate 4	0.015
SEC31A	SEC31 homolog A (S. cerevisiae)	0.015
STX7	syntaxin 7	0.015
COPB1	coatomer protein complex, subunit beta 1	0.015
GATAD2B	GATA zinc finger domain containing 2B	0.015
GOLPH3	golgi phosphoprotein 3 (coat-protein)	0.015
POLR2L	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa	0.014
SPAG7	sperm associated antigen 7	0.014
EXOC8	exocyst complex component 8	0.014
MSH3	mutS homolog 3 (E. coli)	0.014
HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	0.014
BAX	BCL2-associated X protein	0.014
SYNJ1	synaptojanin 1	0.014
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.014
CDC16	cell division cycle 16 homolog (S. cerevisiae)	0.014
NRBF2	nuclear receptor binding factor 2	0.014
RNF2	ring finger protein 2	0.014
COX6B1	cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)	0.014
VPS25	vacuolar protein sorting 25 homolog (S. cerevisiae)	0.014
FAM118B	family with sequence similarity 118, member B	0.014
CEP192	centrosomal protein 192kDa	0.014
NDUFA3	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa	0.014
ZBED5	zinc finger, BED-type containing 5	0.014
RAB1A	RAB1A, member RAS oncogene family	0.014
SSBP2	single-stranded DNA binding protein 2	0.013
ACTR10	actin-related protein 10 homolog (S. cerevisiae)	0.013
CSE1L	CSE1 chromosome segregation 1-like (yeast)	0.013
HOXB7	homeobox B7	0.013
ZNF350	zinc finger protein 350	0.013
NLK	nemo-like kinase	0.013
RPS6KC1	ribosomal protein S6 kinase, 52kDa, polypeptide 1	0.013
TRAPPC8	trafficking protein particle complex 8	0.013
MRPL27	mitochondrial ribosomal protein L27	0.013
NDUFB9	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa	0.013
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.013
RRAS2	related RAS viral (r-ras) oncogene homolog 2	0.013	Human
ANAPC4	anaphase promoting complex subunit 4	0.013
ZC3H14	zinc finger CCCH-type containing 14	0.013
ZNF180	zinc finger protein 180	0.013
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.013
PEBP4	phosphatidylethanolamine-binding protein 4	0.013
C14orf129	chromosome 14 open reading frame 129	0.012
SNRK	SNF related kinase	0.012
HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	0.012
NNT	nicotinamide nucleotide transhydrogenase	0.012
SPRY2	sprouty homolog 2 (Drosophila)	0.012
TFPT	TCF3 (E2A) fusion partner (in childhood Leukemia)	0.012
HTT	huntingtin	0.012
SCAF8	SR-related CTD-associated factor 8	0.012
PDLIM3	PDZ and LIM domain 3	0.012
EPS8	epidermal growth factor receptor pathway substrate 8	0.012
TRMT12	tRNA methyltransferase 12 homolog (S. cerevisiae)	0.012
SH2B2	SH2B adaptor protein 2	0.012
EGLN1	egl nine homolog 1 (C. elegans)	0.012
PEX19	peroxisomal biogenesis factor 19	0.012
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.012
GFRA1	GDNF family receptor alpha 1	0.012
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.012
RAP2C	RAP2C, member of RAS oncogene family	0.012
DACH1	dachshund homolog 1 (Drosophila)	0.012
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.012
DOCK8	dedicator of cytokinesis 8	0.012
ILVBL	ilvB (bacterial acetolactate synthase)-like	0.012
TMCO1	transmembrane and coiled-coil domains 1	0.012
MGA	MAX gene associated	0.012
PHIP	pleckstrin homology domain interacting protein	0.012
ELK1	ELK1, member of ETS oncogene family	0.012
KCNE3	potassium voltage-gated channel, Isk-related family, member 3	0.012
CREBL2	cAMP responsive element binding protein-like 2	0.012
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.012
NOSIP	nitric oxide synthase interacting protein	0.012
C20orf43	chromosome 20 open reading frame 43	0.012
RFK	riboflavin kinase	0.012
VAMP7	vesicle-associated membrane protein 7	0.012
PET112L	PET112-like (yeast)	0.012
CAMSAP1	calmodulin regulated spectrin-associated protein 1	0.012
C19orf56	chromosome 19 open reading frame 56	0.011
COX6A1	cytochrome c oxidase subunit VIa polypeptide 1	0.011
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.011
AP2M1	adaptor-related protein complex 2, mu 1 subunit	0.011
SEC16A	SEC16 homolog A (S. cerevisiae)	0.011
CAB39	calcium binding protein 39	0.011
ZNHIT1	zinc finger, HIT-type containing 1	0.011
NDUFB2	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa	0.011
WASF1	WAS protein family, member 1	0.011
MAP2K2	mitogen-activated protein kinase kinase 2	0.011
RAP1A	RAP1A, member of RAS oncogene family	0.011
MRPL44	mitochondrial ribosomal protein L44	0.011
VPS4B	vacuolar protein sorting 4 homolog B (S. cerevisiae)	0.011
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.011
TAF1B	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	0.011
TCF4	transcription factor 4	0.011
SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	0.011
SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1	0.011
MTMR4	myotubularin related protein 4	0.011
TUBB2A	tubulin, beta 2A	0.011
WDR61	WD repeat domain 61	0.011
MBIP	MAP3K12 binding inhibitory protein 1	0.011
DHX33	DEAH (Asp-Glu-Ala-His) box polypeptide 33	0.011
TRAPPC2L	trafficking protein particle complex 2-like	0.011
PCTP	phosphatidylcholine transfer protein	0.011
CDC26	cell division cycle 26 homolog (S. cerevisiae)	0.011
SUPT4H1	suppressor of Ty 4 homolog 1 (S. cerevisiae)	0.011
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.011
NEDD8	neural precursor cell expressed, developmentally down-regulated 8	0.011
PRKAG1	protein kinase, AMP-activated, gamma 1 non-catalytic subunit	0.011
GTF2I	general transcription factor IIi	0.011
TXNRD1	thioredoxin reductase 1	0.011
HSBP1	heat shock factor binding protein 1	0.011
SEC22B	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)	0.011
PARG	poly (ADP-ribose) glycohydrolase	0.011
GFI1B	growth factor independent 1B transcription repressor	0.011
C21orf33	chromosome 21 open reading frame 33	0.011
CSNK1G2	casein kinase 1, gamma 2	0.010
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.010
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.010
SRP54	signal recognition particle 54kDa	0.010
KCTD9	potassium channel tetramerisation domain containing 9	0.010
CHGB	chromogranin B (secretogranin 1)	0.010
CEP72	centrosomal protein 72kDa	0.010
ORMDL3	ORM1-like 3 (S. cerevisiae)	0.010
UBL5	ubiquitin-like 5	0.010
RNF14	ring finger protein 14	0.010
TBC1D1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	0.010
NCOA4	nuclear receptor coactivator 4	0.010
FAM18B1	family with sequence similarity 18, member B1	0.010
CPOX	coproporphyrinogen oxidase	0.010
SLC30A1	solute carrier family 30 (zinc transporter), member 1	0.010
CHMP5	chromatin modifying protein 5	0.010
PTEN	phosphatase and tensin homolog	0.008
MINPP1	multiple inositol-polyphosphate phosphatase 1	0.007
KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.007
STK11	serine/threonine kinase 11	0.006
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.004
RET	ret proto-oncogene	0.004
GOLGA5	golgin A5	0.003
CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.003
SDHAF2	succinate dehydrogenase complex assembly factor 2	0.003
NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	0.002
SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	0.002
NDUFA13	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13	0.002
PCM1	pericentriolar material 1	0.002
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	0.001
SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa	0.001
PALLD	palladin, cytoskeletal associated protein	0.001
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	0.001