IMP: Integrative Multi-species Prediction

Homo sapiens

47 genes annotated in human

lysosomal storage disease

DOID:3211

An inherited metabolic disorder that involve an abnormal accumulation of substances inside the lysosome resulting from defects in lysosomal function.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "lysosomal storage disease"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "lysosomal storage disease" (in gray)

Name	Description	Probability	Func Analog Organism
CTSA	cathepsin A	1.000
LAMP1	lysosomal-associated membrane protein 1	1.000	Human
GRN	granulin	1.000
PSAP	prosaposin	1.000
TPP1	tripeptidyl peptidase I	1.000
HEXB	hexosaminidase B (beta polypeptide)	0.997
NEU1	sialidase 1 (lysosomal sialidase)	0.997
ASAH1	N-acylsphingosine amidohydrolase (acid ceramidase) 1	0.996
CTSB	cathepsin B	0.994
NPC2	Niemann-Pick disease, type C2	0.979
GM2A	GM2 ganglioside activator	0.971
GNS	glucosamine (N-acetyl)-6-sulfatase	0.966
LAMP2	lysosomal-associated membrane protein 2	0.964
CTSD	cathepsin D	0.961
GLB1	galactosidase, beta 1	0.902
GAA	glucosidase, alpha; acid	0.892
A2M	alpha-2-macroglobulin	0.789
C1orf85	chromosome 1 open reading frame 85	0.629
PLD3	phospholipase D family, member 3	0.575
ATP6AP1	ATPase, H+ transporting, lysosomal accessory protein 1	0.575
ITM2B	integral membrane protein 2B	0.524
ATP6AP2	ATPase, H+ transporting, lysosomal accessory protein 2	0.506
FUCA1	fucosidase, alpha-L- 1, tissue	0.493
CD63	CD63 molecule	0.470
HEXA	hexosaminidase A (alpha polypeptide)	0.436
CTSL1	cathepsin L1	0.398
MAN2B1	mannosidase, alpha, class 2B, member 1	0.376
MANBA	mannosidase, beta A, lysosomal	0.369
USP22	ubiquitin specific peptidase 22	0.351
TIMP2	TIMP metallopeptidase inhibitor 2	0.349
SLC38A7	solute carrier family 38, member 7	0.332
OS9	osteosarcoma amplified 9, endoplasmic reticulum lectin	0.318
MFSD1	major facilitator superfamily domain containing 1	0.292
SCPEP1	serine carboxypeptidase 1	0.278
FTL	ferritin, light polypeptide	0.275
HP	haptoglobin	0.255
CPD	carboxypeptidase D	0.236
CTSH	cathepsin H	0.224
TMEM127	transmembrane protein 127	0.219
CCPG1	cell cycle progression 1	0.212
APLP2	amyloid beta (A4) precursor-like protein 2	0.211
PEPD	peptidase D	0.201
APOC1	apolipoprotein C-I	0.196
NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	0.191
IGF2R	insulin-like growth factor 2 receptor	0.191
SLC35E1	solute carrier family 35, member E1	0.191
DUSP23	dual specificity phosphatase 23	0.190
CREG1	cellular repressor of E1A-stimulated genes 1	0.175
NCSTN	nicastrin	0.175
CTBS	chitobiase, di-N-acetyl-	0.174
CST3	cystatin C	0.164
PRCP	prolylcarboxypeptidase (angiotensinase C)	0.158
DNASE2	deoxyribonuclease II, lysosomal	0.138
GPNMB	glycoprotein (transmembrane) nmb	0.127
ANXA4	annexin A4	0.127
GABARAP	GABA(A) receptor-associated protein	0.126
IFI30	interferon, gamma-inducible protein 30	0.119
GBA	glucosidase, beta, acid	0.112
ATP6V1B2	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	0.110
ATP6V0E1	ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1	0.109
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.108
NAGA	N-acetylgalactosaminidase, alpha-	0.105
MR1	major histocompatibility complex, class I-related	0.103
HLA-C	major histocompatibility complex, class I, C	0.100
P2RX4	purinergic receptor P2X, ligand-gated ion channel, 4	0.099
TGOLN2	trans-golgi network protein 2	0.099
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.098
FCGRT	Fc fragment of IgG, receptor, transporter, alpha	0.096
ARL6IP5	ADP-ribosylation-like factor 6 interacting protein 5	0.095
GNPTG	N-acetylglucosamine-1-phosphate transferase, gamma subunit	0.093
HLA-G	major histocompatibility complex, class I, G	0.093
LEPROT	leptin receptor overlapping transcript	0.091
TOM1	target of myb1 (chicken)	0.090
SCARB2	scavenger receptor class B, member 2	0.085
FBXO6	F-box protein 6	0.076
EDEM2	ER degradation enhancer, mannosidase alpha-like 2	0.074
PGCP	plasma glutamate carboxypeptidase	0.071
FTH1	ferritin, heavy polypeptide 1	0.069
GPR137B	G protein-coupled receptor 137B	0.065
AGA	aspartylglucosaminidase	0.064
WIPI1	WD repeat domain, phosphoinositide interacting 1	0.063
NUCB1	nucleobindin 1	0.062
BRI3	brain protein I3	0.061
ATP6V0D1	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1	0.060
LGMN	legumain	0.059
LRP10	low density lipoprotein receptor-related protein 10	0.059
CSTB	cystatin B (stefin B)	0.054
TRIM27	tripartite motif containing 27	0.053
CAPG	capping protein (actin filament), gelsolin-like	0.052
PBXIP1	pre-B-cell leukemia homeobox interacting protein 1	0.050
RNF13	ring finger protein 13	0.050
HMOX1	heme oxygenase (decycling) 1	0.049
MAN2B2	mannosidase, alpha, class 2B, member 2	0.049
GUSB	glucuronidase, beta	0.049
GNPDA1	glucosamine-6-phosphate deaminase 1	0.046
LRP1	low density lipoprotein receptor-related protein 1	0.044
CLN3	ceroid-lipofuscinosis, neuronal 3	0.043
MVP	major vault protein	0.042
SH3BGRL	SH3 domain binding glutamic acid-rich protein like	0.041
PTTG1IP	pituitary tumor-transforming 1 interacting protein	0.041
C1GALT1C1	C1GALT1-specific chaperone 1	0.040
ACP2	acid phosphatase 2, lysosomal	0.040
IL10RB	interleukin 10 receptor, beta	0.040
PLA2G15	phospholipase A2, group XV	0.039
CLCN7	chloride channel 7	0.037
ACP5	acid phosphatase 5, tartrate resistant	0.037
NAGK	N-acetylglucosamine kinase	0.037
ATG7	ATG7 autophagy related 7 homolog (S. cerevisiae)	0.036
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	0.035
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.035
LMBRD1	LMBR1 domain containing 1	0.035
PLTP	phospholipid transfer protein	0.034
IL17RA	interleukin 17 receptor A	0.034
UNC45A	unc-45 homolog A (C. elegans)	0.034
TSC22D1	TSC22 domain family, member 1	0.034
ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	0.033
HSPG2	heparan sulfate proteoglycan 2	0.033
SUMF1	sulfatase modifying factor 1	0.033
RNPEP	arginyl aminopeptidase (aminopeptidase B)	0.032
TMEM179B	transmembrane protein 179B	0.032
SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	0.031
SIDT2	SID1 transmembrane family, member 2	0.031
SGSH	N-sulfoglucosamine sulfohydrolase	0.031
DRAM2	DNA-damage regulated autophagy modulator 2	0.029
LIPA	lipase A, lysosomal acid, cholesterol esterase	0.029
TMBIM4	transmembrane BAX inhibitor motif containing 4	0.029
RNF170	ring finger protein 170	0.028
GALC	galactosylceramidase	0.028
ZDHHC7	zinc finger, DHHC-type containing 7	0.026
NHLRC3	NHL repeat containing 3	0.026
TCN2	transcobalamin II	0.026
RNASET2	ribonuclease T2	0.025
EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	0.025
PPT1	palmitoyl-protein thioesterase 1	0.025
ZBED1	zinc finger, BED-type containing 1	0.025
LTA4H	leukotriene A4 hydrolase	0.023
VAT1	vesicle amine transport protein 1 homolog (T. californica)	0.023
CREBL2	cAMP responsive element binding protein-like 2	0.023
CRTAP	cartilage associated protein	0.022
CTSZ	cathepsin Z	0.022
TCIRG1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	0.022
TMBIM1	transmembrane BAX inhibitor motif containing 1	0.022
G6PD	glucose-6-phosphate dehydrogenase	0.021
JOSD1	Josephin domain containing 1	0.021
CD68	CD68 molecule	0.021
CTNS	cystinosis, nephropathic	0.021
NINJ1	ninjurin 1	0.021
NPL	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)	0.021
SLC38A6	solute carrier family 38, member 6	0.021
AMDHD2	amidohydrolase domain containing 2	0.021
C10orf26	chromosome 10 open reading frame 26	0.020
RETSAT	retinol saturase (all-trans-retinol 13,14-reductase)	0.020
SLC26A11	solute carrier family 26, member 11	0.020
RHOQ	ras homolog gene family, member Q	0.020
SLC31A2	solute carrier family 31 (copper transporters), member 2	0.020
LRPAP1	low density lipoprotein receptor-related protein associated protein 1	0.020
C6orf72	chromosome 6 open reading frame 72	0.020
TMEM59	transmembrane protein 59	0.020
YPEL5	yippee-like 5 (Drosophila)	0.019
ASB13	ankyrin repeat and SOCS box containing 13	0.019
SLC22A18	solute carrier family 22, member 18	0.019
MCOLN1	mucolipin 1	0.018
PLEKHB2	pleckstrin homology domain containing, family B (evectins) member 2	0.018
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.018
RNFT1	ring finger protein, transmembrane 1	0.018
FAM114A1	family with sequence similarity 114, member A1	0.018
LOXL4	lysyl oxidase-like 4	0.018
XIAP	X-linked inhibitor of apoptosis	0.017
MARCH2	membrane-associated ring finger (C3HC4) 2	0.017
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.017
RRAGC	Ras-related GTP binding C	0.017
ACSL1	acyl-CoA synthetase long-chain family member 1	0.017
HPS1	Hermansky-Pudlak syndrome 1	0.017
TSPAN31	tetraspanin 31	0.017
C18orf8	chromosome 18 open reading frame 8	0.017
HEBP1	heme binding protein 1	0.017
CTSO	cathepsin O	0.016
SLC24A6	solute carrier family 24 (sodium/potassium/calcium exchanger), member 6	0.016
FUCA2	fucosidase, alpha-L- 2, plasma	0.016
APP	amyloid beta (A4) precursor protein	0.016
WDR81	WD repeat domain 81	0.016
PIGT	phosphatidylinositol glycan anchor biosynthesis, class T	0.016
YIPF1	Yip1 domain family, member 1	0.016
UAP1L1	UDP-N-acteylglucosamine pyrophosphorylase 1-like 1	0.016
RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	0.016
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.016
DUSP3	dual specificity phosphatase 3	0.015
SLC25A11	solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11	0.015
ANKRA2	ankyrin repeat, family A (RFXANK-like), 2	0.015
C4orf29	chromosome 4 open reading frame 29	0.015
PCYOX1	prenylcysteine oxidase 1	0.015
GALNS	galactosamine (N-acetyl)-6-sulfate sulfatase	0.015
SEL1L	sel-1 suppressor of lin-12-like (C. elegans)	0.015
ATG2A	ATG2 autophagy related 2 homolog A (S. cerevisiae)	0.015
GANAB	glucosidase, alpha; neutral AB	0.015
PLD1	phospholipase D1, phosphatidylcholine-specific	0.015
SFXN3	sideroflexin 3	0.015
CPVL	carboxypeptidase, vitellogenic-like	0.015
MPPE1	metallophosphoesterase 1	0.015
C17orf62	chromosome 17 open reading frame 62	0.015
TMEM184C	transmembrane protein 184C	0.014
FAM21A	family with sequence similarity 21, member A	0.014
CSTA	cystatin A (stefin A)	0.014
TMEM104	transmembrane protein 104	0.014
LAPTM4A	lysosomal protein transmembrane 4 alpha	0.014
SPATA20	spermatogenesis associated 20	0.014
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.014
TAX1BP3	Tax1 (human T-cell leukemia virus type I) binding protein 3	0.014
ATRN	attractin	0.014
HEATR5A	HEAT repeat containing 5A	0.014
LGALS3BP	lectin, galactoside-binding, soluble, 3 binding protein	0.014
NAAA	N-acylethanolamine acid amidase	0.014
ERLIN2	ER lipid raft associated 2	0.014
C10orf57	chromosome 10 open reading frame 57	0.014
NFE2L1	nuclear factor (erythroid-derived 2)-like 1	0.013
MGAT1	mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	0.013
ACSF2	acyl-CoA synthetase family member 2	0.013
PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)	0.013
ANO10	anoctamin 10	0.013
ATP6V0A1	ATPase, H+ transporting, lysosomal V0 subunit a1	0.013
LGALS3	lectin, galactoside-binding, soluble, 3	0.013
ARSA	arylsulfatase A	0.013
RNF135	ring finger protein 135	0.013
SEPSECS	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	0.013
STX3	syntaxin 3	0.013
PI4K2A	phosphatidylinositol 4-kinase type 2 alpha	0.013
MAN2C1	mannosidase, alpha, class 2C, member 1	0.013
SLC12A9	solute carrier family 12 (potassium/chloride transporters), member 9	0.013
AUP1	ancient ubiquitous protein 1	0.013
FRAT1	frequently rearranged in advanced T-cell lymphomas	0.013
SIGMAR1	sigma non-opioid intracellular receptor 1	0.013
RWDD2A	RWD domain containing 2A	0.013
ACADVL	acyl-CoA dehydrogenase, very long chain	0.013
LITAF	lipopolysaccharide-induced TNF factor	0.013
IL13RA1	interleukin 13 receptor, alpha 1	0.013
NOS3	nitric oxide synthase 3 (endothelial cell)	0.013
BTD	biotinidase	0.013
DNASE1L1	deoxyribonuclease I-like 1	0.013
YIPF6	Yip1 domain family, member 6	0.013
RPN2	ribophorin II	0.013
ORAI3	ORAI calcium release-activated calcium modulator 3	0.013
APOC2	apolipoprotein C-II	0.012
PLXDC2	plexin domain containing 2	0.012
KIAA0930	KIAA0930	0.012
SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	0.012
CHPF2	chondroitin polymerizing factor 2	0.012
MRPL20	mitochondrial ribosomal protein L20	0.012
CYP27A1	cytochrome P450, family 27, subfamily A, polypeptide 1	0.012
MFSD5	major facilitator superfamily domain containing 5	0.012
CRYL1	crystallin, lambda 1	0.012
SLC29A3	solute carrier family 29 (nucleoside transporters), member 3	0.012
EXT2	exostosin 2	0.012
SLC35E3	solute carrier family 35, member E3	0.012
NAGLU	N-acetylglucosaminidase, alpha	0.012
MOSPD2	motile sperm domain containing 2	0.012
ZFYVE26	zinc finger, FYVE domain containing 26	0.012
IFNAR1	interferon (alpha, beta and omega) receptor 1	0.012
HSD17B14	hydroxysteroid (17-beta) dehydrogenase 14	0.012
PITPNA	phosphatidylinositol transfer protein, alpha	0.012
TK2	thymidine kinase 2, mitochondrial	0.012
KIF13B	kinesin family member 13B	0.012
C20orf3	chromosome 20 open reading frame 3	0.012
TMEM128	transmembrane protein 128	0.012
TBC1D22A	TBC1 domain family, member 22A	0.012
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.011
ZNF185	zinc finger protein 185 (LIM domain)	0.011
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.011
THBS3	thrombospondin 3	0.011
TXNDC12	thioredoxin domain containing 12 (endoplasmic reticulum)	0.011
FKBP15	FK506 binding protein 15, 133kDa	0.011
CTSK	cathepsin K	0.011
KRCC1	lysine-rich coiled-coil 1	0.011
C22orf25	chromosome 22 open reading frame 25	0.011
ARSD	arylsulfatase D	0.011	Human
ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	0.011
LMBRD2	LMBR1 domain containing 2	0.011
TMEM50B	transmembrane protein 50B	0.011
NR1H3	nuclear receptor subfamily 1, group H, member 3	0.011
SUSD1	sushi domain containing 1	0.011
TMEM164	transmembrane protein 164	0.011
DHRS7	dehydrogenase/reductase (SDR family) member 7	0.011
SEC22A	SEC22 vesicle trafficking protein homolog A (S. cerevisiae)	0.011
MARCH9	membrane-associated ring finger (C3HC4) 9	0.011
ABCG1	ATP-binding cassette, sub-family G (WHITE), member 1	0.011
CPEB4	cytoplasmic polyadenylation element binding protein 4	0.011
CDS2	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2	0.011
GALT	galactose-1-phosphate uridylyltransferase	0.011
NDST2	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	0.011
SNX19	sorting nexin 19	0.011
RAB7L1	RAB7, member RAS oncogene family-like 1	0.011
SLC9A8	solute carrier family 9 (sodium/hydrogen exchanger), member 8	0.011
SLC35D2	solute carrier family 35, member D2	0.011
GSTT1	glutathione S-transferase theta 1	0.011
C12orf26	chromosome 12 open reading frame 26	0.011
CPPED1	calcineurin-like phosphoesterase domain containing 1	0.011
C6orf89	chromosome 6 open reading frame 89	0.011
CAT	catalase	0.011
VWA5A	von Willebrand factor A domain containing 5A	0.011
FAM73A	family with sequence similarity 73, member A	0.011
GLT8D1	glycosyltransferase 8 domain containing 1	0.011
MSR1	macrophage scavenger receptor 1	0.011
C11orf54	chromosome 11 open reading frame 54	0.011
RAB9A	RAB9A, member RAS oncogene family	0.011
PIGG	phosphatidylinositol glycan anchor biosynthesis, class G	0.011
KIAA1598	KIAA1598	0.011
TP53I3	tumor protein p53 inducible protein 3	0.011
DIRC2	disrupted in renal carcinoma 2	0.011
ACO1	aconitase 1, soluble	0.011
PCTP	phosphatidylcholine transfer protein	0.011
WDR45	WD repeat domain 45	0.011
SLC46A3	solute carrier family 46, member 3	0.011
LRP5L	low density lipoprotein receptor-related protein 5-like	0.011
TMEM110	transmembrane protein 110	0.010
C5orf15	chromosome 5 open reading frame 15	0.010
TMEM9B	TMEM9 domain family, member B	0.010
RUFY1	RUN and FYVE domain containing 1	0.010
C18orf32	chromosome 18 open reading frame 32	0.010
WDR91	WD repeat domain 91	0.010
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.010
HSD17B11	hydroxysteroid (17-beta) dehydrogenase 11	0.010
CNDP2	CNDP dipeptidase 2 (metallopeptidase M20 family)	0.010
SLC16A6	solute carrier family 16, member 6 (monocarboxylic acid transporter 7)	0.010
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.010
QSOX1	quiescin Q6 sulfhydryl oxidase 1	0.010
SEPP1	selenoprotein P, plasma, 1	0.010
RASSF4	Ras association (RalGDS/AF-6) domain family member 4	0.010
VPS11	vacuolar protein sorting 11 homolog (S. cerevisiae)	0.010
FAM198B	family with sequence similarity 198, member B	0.010
PYCARD	PYD and CARD domain containing	0.010
TMEM176B	transmembrane protein 176B	0.010
MST1	macrophage stimulating 1 (hepatocyte growth factor-like)	0.010
GSTK1	glutathione S-transferase kappa 1	0.010
CXCL16	chemokine (C-X-C motif) ligand 16	0.010
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.010
DHRS1	dehydrogenase/reductase (SDR family) member 1	0.010
TPK1	thiamin pyrophosphokinase 1	0.010
GRAMD4	GRAM domain containing 4	0.010
SLC38A10	solute carrier family 38, member 10	0.010
PPARG	peroxisome proliferator-activated receptor gamma	0.010
PIGK	phosphatidylinositol glycan anchor biosynthesis, class K	0.010
SGPL1	sphingosine-1-phosphate lyase 1	0.010
RRAGD	Ras-related GTP binding D	0.010
USP27X	ubiquitin specific peptidase 27, X-linked	0.010
C4B	complement component 4B (Chido blood group)	0.010
TBC1D20	TBC1 domain family, member 20	0.010
SLC31A1	solute carrier family 31 (copper transporters), member 1	0.010
CTC1	CTS telomere maintenance complex component 1	0.010
LDLRAP1	low density lipoprotein receptor adaptor protein 1	0.010
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.010
HGSNAT	heparan-alpha-glucosaminide N-acetyltransferase	0.010
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.008
CLN8	ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)	0.008
CLN5	ceroid-lipofuscinosis, neuronal 5	0.007
ARSB	arylsulfatase B	0.007
GNE	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	0.007
IDUA	iduronidase, alpha-L-	0.007
ABHD5	abhydrolase domain containing 5	0.007
GLA	galactosidase, alpha	0.007
NPC1	Niemann-Pick disease, type C1	0.006
CLN6	ceroid-lipofuscinosis, neuronal 6, late infantile, variant	0.005
IDS	iduronate 2-sulfatase	0.004
CTSF	cathepsin F	0.004
MFSD8	major facilitator superfamily domain containing 8	0.003
DNAJC5	DnaJ (Hsp40) homolog, subfamily C, member 5	0.003
APOE	apolipoprotein E	0.003
HYAL1	hyaluronoglucosaminidase 1	0.002