IMP: Integrative Multi-species Prediction

Homo sapiens

30 genes annotated in human

aplastic anemia

DOID:12449

An anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "aplastic anemia"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "aplastic anemia" (in gray)

Name	Description	Probability
FANCG	Fanconi anemia, complementation group G	1.000
FANCD2	Fanconi anemia, complementation group D2	1.000
FANCE	Fanconi anemia, complementation group E	1.000
FANCA	Fanconi anemia, complementation group A	1.000
BRCA2	breast cancer 2, early onset	1.000
FANCB	Fanconi anemia, complementation group B	0.994
BRCA1	breast cancer 1, early onset	0.992
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.985
FANCM	Fanconi anemia, complementation group M	0.979
FANCF	Fanconi anemia, complementation group F	0.949
FANCL	Fanconi anemia, complementation group L	0.924
MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	0.859
RPL27	ribosomal protein L27	0.825
RPS10	ribosomal protein S10	0.816
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.803
RPS29	ribosomal protein S29	0.737
RPS15A	ribosomal protein S15a	0.730
SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	0.667
SLX1B	SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)	0.662
RPS27	ribosomal protein S27	0.661
RPS23	ribosomal protein S23	0.655
RPL9	ribosomal protein L9	0.614
RPS7	ribosomal protein S7	0.611
RAD50	RAD50 homolog (S. cerevisiae)	0.564
RPL6	ribosomal protein L6	0.551
FANCC	Fanconi anemia, complementation group C	0.461
RPS28	ribosomal protein S28	0.449
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.426
RPS16	ribosomal protein S16	0.383
MUS81	MUS81 endonuclease homolog (S. cerevisiae)	0.382
BLM	Bloom syndrome, RecQ helicase-like	0.351
RPS13	ribosomal protein S13	0.340
ERCC4	excision repair cross-complementing rodent repair deficiency, complementation group 4	0.333
RAD18	RAD18 homolog (S. cerevisiae)	0.333
RPL11	ribosomal protein L11	0.295
C19orf39	chromosome 19 open reading frame 39	0.274
APITD1	apoptosis-inducing, TAF9-like domain 1	0.254
RPS19	ribosomal protein S19	0.252
EME1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.250
RPS21	ribosomal protein S21	0.209
RPS6	ribosomal protein S6	0.202
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.200
C20orf94	chromosome 20 open reading frame 94	0.191
RPS3	ribosomal protein S3	0.186
RPL39	ribosomal protein L39	0.178
TERF2	telomeric repeat binding factor 2	0.174
RPS15	ribosomal protein S15	0.158
RPS11	ribosomal protein S11	0.155
RPL31	ribosomal protein L31	0.154
RPS18	ribosomal protein S18	0.149
RPS20	ribosomal protein S20	0.148
RPL35	ribosomal protein L35	0.147
RAD51L1	RAD51-like 1 (S. cerevisiae)	0.142
RPLP2	ribosomal protein, large, P2	0.140
RPS14	ribosomal protein S14	0.135
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.130
MSH6	mutS homolog 6 (E. coli)	0.127
C17orf70	chromosome 17 open reading frame 70	0.122
RPS25	ribosomal protein S25	0.114
XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	0.105
RAD51L3	RAD51-like 3 (S. cerevisiae)	0.098
PALB2	partner and localizer of BRCA2	0.086
RPS4X	ribosomal protein S4, X-linked	0.085
XRCC2	X-ray repair complementing defective repair in Chinese hamster cells 2	0.083
RPL23	ribosomal protein L23	0.077
MDC1	mediator of DNA-damage checkpoint 1	0.076
ERCC1	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)	0.071
PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	0.065
RPL24	ribosomal protein L24	0.062
RPS27A	ribosomal protein S27a	0.060
RPS12	ribosomal protein S12	0.057
RPL38	ribosomal protein L38	0.054
RPS2	ribosomal protein S2	0.049
RAD51AP1	RAD51 associated protein 1	0.049
BARD1	BRCA1 associated RING domain 1	0.047
RPS5	ribosomal protein S5	0.045
RPL34	ribosomal protein L34	0.042
RPL30	ribosomal protein L30	0.040
RPL23A	ribosomal protein L23a	0.040
TOP3A	topoisomerase (DNA) III alpha	0.038
RPS17	ribosomal protein S17	0.037
RPL36A	ribosomal protein L36a	0.036
RPL21	ribosomal protein L21	0.034
RPS26	ribosomal protein S26	0.034
RPA1	replication protein A1, 70kDa	0.032
RPS24	ribosomal protein S24	0.030
RPL41	ribosomal protein L41	0.029
RPL12	ribosomal protein L12	0.028
RPS3A	ribosomal protein S3A	0.027
FAU	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed	0.027
POLH	polymerase (DNA directed), eta	0.025
H2AFX	H2A histone family, member X	0.024
RPL7A	ribosomal protein L7a	0.024
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	0.024
RPSA	ribosomal protein SA	0.021
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.021
WDHD1	WD repeat and HMG-box DNA binding protein 1	0.020
HINT1	histidine triad nucleotide binding protein 1	0.019
RPL14	ribosomal protein L14	0.018
SYCP3	synaptonemal complex protein 3	0.018
RAD52	RAD52 homolog (S. cerevisiae)	0.018
RNF8	ring finger protein 8	0.018
RPL19	ribosomal protein L19	0.018
ATM	ataxia telangiectasia mutated	0.017
RPL18	ribosomal protein L18	0.017
HELLS	helicase, lymphoid-specific	0.016
UBA52	ubiquitin A-52 residue ribosomal protein fusion product 1	0.016
RPS8	ribosomal protein S8	0.016
RPL28	ribosomal protein L28	0.016
RPL36AL	ribosomal protein L36a-like	0.016
ZSCAN16	zinc finger and SCAN domain containing 16	0.015
PABPC3	poly(A) binding protein, cytoplasmic 3	0.015
RPL10A	ribosomal protein L10a	0.014
RPL17	ribosomal protein L17	0.014
HIPK2	homeodomain interacting protein kinase 2	0.013
VRK2	vaccinia related kinase 2	0.012
RPL37A	ribosomal protein L37a	0.012
EXO1	exonuclease 1	0.012
HP	haptoglobin	0.012
RBL1	retinoblastoma-like 1 (p107)	0.012
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.012
RPL35A	ribosomal protein L35a	0.011
ARRB2	arrestin, beta 2	0.011
NEDD8	neural precursor cell expressed, developmentally down-regulated 8	0.011
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.011
SENP8	SUMO/sentrin specific peptidase family member 8	0.011
RPS27L	ribosomal protein S27-like	0.011
NME2	non-metastatic cells 2, protein (NM23B) expressed in	0.010
NBN	nibrin	0.003
FANCI	Fanconi anemia, complementation group I	0.003
SLC25A38	solute carrier family 25, member 38	0.003
IFNG	interferon, gamma	0.002
ALAS2	aminolevulinate, delta-, synthase 2	0.001
RAD51C	RAD51 homolog C (S. cerevisiae)	0.001
RPL5	ribosomal protein L5	0.000