IMP
Process View
double strand break repair via nonhomologous end joining
The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "double strand break repair via nonhomologous end joining"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| BRCA1 | breast cancer 1, early onset | 0.967 | ||
| H2AFX | H2A histone family, member X | 0.948 | ||
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.945 | ||
| PARP1 | poly (ADP-ribose) polymerase 1 | 0.941 | ||
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.929 | ||
| XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4 | 0.831 | ||
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.810 | ||
| RPA1 | replication protein A1, 70kDa | 0.767 | ||
| MDC1 | mediator of DNA-damage checkpoint 1 | 0.721 | ||
| MSH6 | mutS homolog 6 (E. coli) | 0.640 | ||
| BLM | Bloom syndrome, RecQ helicase-like | 0.492 | Fly | |
| NBN | nibrin | 0.410 | ||
| APLF | aprataxin and PNKP like factor | 0.367 | ||
| PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 0.310 | ||
| FANCD2 | Fanconi anemia, complementation group D2 | 0.296 | ||
| WRN | Werner syndrome, RecQ helicase-like | 0.266 | ||
| PCNA | proliferating cell nuclear antigen | 0.235 | ||
| PSMB4 | proteasome (prosome, macropain) subunit, beta type, 4 | 0.208 | ||
| CDK2 | cyclin-dependent kinase 2 | 0.192 | Yeast | |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.131 | ||
| RAD51 | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | 0.117 | ||
| BRCA2 | breast cancer 2, early onset | 0.112 | ||
| CHEK1 | CHK1 checkpoint homolog (S. pombe) | 0.110 | ||
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.108 | ||
| SMC1A | structural maintenance of chromosomes 1A | 0.094 | ||
| CHAF1A | chromatin assembly factor 1, subunit A (p150) | 0.087 | ||
| RAD50 | RAD50 homolog (S. cerevisiae) | 0.078 | ||
| XRCC1 | X-ray repair complementing defective repair in Chinese hamster cells 1 | 0.077 | ||
| MRE11A | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | 0.068 | Yeast | |
| MSH2 | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | 0.053 | ||
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | 0.050 | ||
| TP53 | tumor protein p53 | 0.044 | ||
| PSMD4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 0.043 | ||
| APTX | aprataxin | 0.038 | ||
| PNKP | polynucleotide kinase 3'-phosphatase | 0.038 | ||
| CSNK2A1 | casein kinase 2, alpha 1 polypeptide | 0.035 | ||
| PSMB7 | proteasome (prosome, macropain) subunit, beta type, 7 | 0.030 | ||
| PSMA6 | proteasome (prosome, macropain) subunit, alpha type, 6 | 0.026 | ||
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.026 | ||
| POLD3 | polymerase (DNA-directed), delta 3, accessory subunit | 0.026 | ||
| ATM | ataxia telangiectasia mutated | 0.025 | ||
| RBBP8 | retinoblastoma binding protein 8 | 0.025 | ||
| PSMA3 | proteasome (prosome, macropain) subunit, alpha type, 3 | 0.025 | ||
| RBM10 | RNA binding motif protein 10 | 0.025 | ||
| MCM3 | minichromosome maintenance complex component 3 | 0.025 | ||
| PSMD6 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 0.024 | ||
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.024 | ||
| ATR | ataxia telangiectasia and Rad3 related | 0.023 | ||
| LIG4 | ligase IV, DNA, ATP-dependent | 0.022 | ||
| PSMD13 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 | 0.021 | ||
| POMP | proteasome maturation protein | 0.021 | ||
| MLH1 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | 0.019 | Mouse | |
| ORC1 | origin recognition complex, subunit 1 | 0.019 | ||
| PSMA1 | proteasome (prosome, macropain) subunit, alpha type, 1 | 0.017 | ||
| RPA2 | replication protein A2, 32kDa | 0.017 | ||
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | 0.016 | ||
| PSMB2 | proteasome (prosome, macropain) subunit, beta type, 2 | 0.016 | ||
| PSMA2 | proteasome (prosome, macropain) subunit, alpha type, 2 | 0.016 | ||
| FANCA | Fanconi anemia, complementation group A | 0.015 | ||
| CHEK2 | CHK2 checkpoint homolog (S. pombe) | 0.015 | ||
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.015 | ||
| DHX30 | DEAH (Asp-Glu-Ala-His) box polypeptide 30 | 0.014 | ||
| PSMC5 | proteasome (prosome, macropain) 26S subunit, ATPase, 5 | 0.014 | ||
| TIMELESS | timeless homolog (Drosophila) | 0.014 | ||
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | 0.014 | ||
| RB1 | retinoblastoma 1 | 0.014 | ||
| RAD21 | RAD21 homolog (S. pombe) | 0.014 | ||
| PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | 0.013 | ||
| SSRP1 | structure specific recognition protein 1 | 0.012 | ||
| POLA2 | polymerase (DNA directed), alpha 2 (70kD subunit) | 0.012 | ||
| PSMA4 | proteasome (prosome, macropain) subunit, alpha type, 4 | 0.012 | ||
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | 0.012 | ||
| E2F1 | E2F transcription factor 1 | 0.011 | ||
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.011 | ||
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | 0.011 | ||
| FANCG | Fanconi anemia, complementation group G | 0.011 | ||
| PSMC2 | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | 0.011 | ||
| HMGA1 | high mobility group AT-hook 1 | 0.010 | Human |