IMP: Integrative Multi-species Prediction

Homo sapiens

12 genes annotated in human

postreplication repair

The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "postreplication repair"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "postreplication repair" (in gray)

Name	Description	Probability	Func Analog Organism
HIST1H2BD	histone cluster 1, H2bd	1.000	Yeast
HIST1H2BF	histone cluster 1, H2bf	1.000	Yeast
HIST1H2BE	histone cluster 1, H2be	1.000	Yeast
RAD18	RAD18 homolog (S. cerevisiae)	0.998
HIST1H1C	histone cluster 1, H1c	0.998
PCNA	proliferating cell nuclear antigen	0.997
HIST1H2BH	histone cluster 1, H2bh	0.997	Yeast
HIST1H2AC	histone cluster 1, H2ac	0.997
HIST1H2BG	histone cluster 1, H2bg	0.996	Yeast
HIST1H2BI	histone cluster 1, H2bi	0.994	Yeast
HIST1H3D	histone cluster 1, H3d	0.989
HIST1H2BK	histone cluster 1, H2bk	0.987	Yeast
HIST1H2BC	histone cluster 1, H2bc	0.979	Yeast
HIST2H2AA4	histone cluster 2, H2aa4	0.969
POLE3	polymerase (DNA directed), epsilon 3 (p17 subunit)	0.959	Yeast
POLH	polymerase (DNA directed), eta	0.951	Fly
HIST1H2AE	histone cluster 1, H2ae	0.880
HIST2H2BE	histone cluster 2, H2be	0.795	Yeast
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.739
HIST1H2AJ	histone cluster 1, H2aj	0.674
MSH6	mutS homolog 6 (E. coli)	0.527
FANCD2	Fanconi anemia, complementation group D2	0.411
REV1	REV1 homolog (S. cerevisiae)	0.306	Yeast Mouse
HIST1H2AI	histone cluster 1, H2ai	0.305
HIST1H3H	histone cluster 1, H3h	0.287
POLI	polymerase (DNA directed) iota	0.215	Fly
HIST1H4H	histone cluster 1, H4h	0.156
PABPC1	poly(A) binding protein, cytoplasmic 1	0.156
DZIP3	DAZ interacting protein 3, zinc finger	0.154
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.150
PAN3	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	0.129	Yeast
RPA3	replication protein A3, 14kDa	0.127
WRN	Werner syndrome, RecQ helicase-like	0.122
HIST1H2AG	histone cluster 1, H2ag	0.120
POLD1	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	0.112
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.111
POLE2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.089	Yeast
ING2	inhibitor of growth family, member 2	0.086
HIST1H2AM	histone cluster 1, H2am	0.079
H2AFX	H2A histone family, member X	0.076
RBBP8	retinoblastoma binding protein 8	0.073
ERCC6	excision repair cross-complementing rodent repair deficiency, complementation group 6	0.063
PAN2	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	0.061	Yeast
REV3L	REV3-like, catalytic subunit of DNA polymerase zeta (yeast)	0.059
POLD3	polymerase (DNA-directed), delta 3, accessory subunit	0.059
RNF11	ring finger protein 11	0.051
POLK	polymerase (DNA directed) kappa	0.049
CTDP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	0.048
HIST1H3G	histone cluster 1, H3g	0.047
GINS2	GINS complex subunit 2 (Psf2 homolog)	0.044
HIST1H2BJ	histone cluster 1, H2bj	0.044	Yeast
HIST1H2BB	histone cluster 1, H2bb	0.042	Yeast
CHRAC1	chromatin accessibility complex 1	0.041
RAD51AP1	RAD51 associated protein 1	0.037
MSH3	mutS homolog 3 (E. coli)	0.036
ATXN3	ataxin 3	0.032
HIST1H2BM	histone cluster 1, H2bm	0.032	Yeast
TNRC6B	trinucleotide repeat containing 6B	0.031
TNRC6A	trinucleotide repeat containing 6A	0.031
HIST1H2BO	histone cluster 1, H2bo	0.029	Yeast
HIST1H2AB	histone cluster 1, H2ab	0.029
SUPT5H	suppressor of Ty 5 homolog (S. cerevisiae)	0.029
EXO1	exonuclease 1	0.028
GINS1	GINS complex subunit 1 (Psf1 homolog)	0.028
DR1	down-regulator of transcription 1, TBP-binding (negative cofactor 2)	0.027
MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	0.026
UBE2N	ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)	0.026
CDK5RAP3	CDK5 regulatory subunit associated protein 3	0.026
SHPRH	SNF2 histone linker PHD RING helicase	0.021
PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	0.021
HIST1H4D	histone cluster 1, H4d	0.021
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.020
ZNRF1	zinc and ring finger 1	0.019
ANKRD32	ankyrin repeat domain 32	0.019
CLSPN	claspin	0.019
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.018
HIST1H2AL	histone cluster 1, H2al	0.018
HIST1H4E	histone cluster 1, H4e	0.017
RAD50	RAD50 homolog (S. cerevisiae)	0.016
MARCH5	membrane-associated ring finger (C3HC4) 5	0.015
HIST2H2AA3	histone cluster 2, H2aa3	0.015
HIST1H1E	histone cluster 1, H1e	0.015
CALCOCO2	calcium binding and coiled-coil domain 2	0.015
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.015
RNF168	ring finger protein 168	0.014
PAF1	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.014
PAIP2	poly(A) binding protein interacting protein 2	0.014
TIMELESS	timeless homolog (Drosophila)	0.014
WWOX	WW domain containing oxidoreductase	0.013
POLE4	polymerase (DNA-directed), epsilon 4 (p12 subunit)	0.012	Yeast
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.012
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.012
CBWD2	COBW domain containing 2	0.012
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.012
HIST2H4B	histone cluster 2, H4b	0.012
XAB2	XPA binding protein 2	0.012
HIST1H3A	histone cluster 1, H3a	0.011
HIST1H1D	histone cluster 1, H1d	0.011
PFN1	profilin 1	0.011
PCGF6	polycomb group ring finger 6	0.011
TCEA1	transcription elongation factor A (SII), 1	0.010
NBN	nibrin	0.010
RAD23B	RAD23 homolog B (S. cerevisiae)	0.010