IMP: Integrative Multi-species Prediction

Homo sapiens

1 genes annotated in human

lung epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "lung epithelial cell differentiation"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "lung epithelial cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
PPARA	peroxisome proliferator-activated receptor alpha	0.934
NOTCH1	notch 1	0.438
NCOR2	nuclear receptor corepressor 2	0.420	Mouse
CCNE1	cyclin E1	0.420
ATXN1L	ataxin 1-like	0.379
STK3	serine/threonine kinase 3	0.339
AP2A1	adaptor-related protein complex 2, alpha 1 subunit	0.288
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.287
NCOA2	nuclear receptor coactivator 2	0.264
PGR	progesterone receptor	0.199
NCOR1	nuclear receptor corepressor 1	0.198
RXRA	retinoid X receptor, alpha	0.194
EP300	E1A binding protein p300	0.148
BCL6	B-cell CLL/lymphoma 6	0.148
NUMA1	nuclear mitotic apparatus protein 1	0.129	Mouse
DARS	aspartyl-tRNA synthetase	0.118
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.115
QARS	glutaminyl-tRNA synthetase	0.108
GPSM2	G-protein signaling modulator 2	0.105	Mouse
MAML1	mastermind-like 1 (Drosophila)	0.098
CDK2	cyclin-dependent kinase 2	0.091
TCF4	transcription factor 4	0.069
FBXW7	F-box and WD repeat domain containing 7	0.068
PRKCZ	protein kinase C, zeta	0.068
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.067
JAG1	jagged 1	0.066
EPRS	glutamyl-prolyl-tRNA synthetase	0.059
NCOA6	nuclear receptor coactivator 6	0.059
RARA	retinoic acid receptor, alpha	0.058
AR	androgen receptor	0.056
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.055
FOXO1	forkhead box O1	0.052
RASSF3	Ras association (RalGDS/AF-6) domain family member 3	0.052
PAX8	paired box 8	0.050
HDAC5	histone deacetylase 5	0.050
PICALM	phosphatidylinositol binding clathrin assembly protein	0.048
NCOA3	nuclear receptor coactivator 3	0.047
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.047
HDAC3	histone deacetylase 3	0.040
CNO	cappuccino homolog (mouse)	0.039
CREBBP	CREB binding protein	0.037
PBX1	pre-B-cell leukemia homeobox 1	0.037
NCOA1	nuclear receptor coactivator 1	0.036
MED1	mediator complex subunit 1	0.036
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.035
KARS	lysyl-tRNA synthetase	0.035
NFIA	nuclear factor I/A	0.035
LNX1	ligand of numb-protein X 1	0.035
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.033	Mouse
SAP30	Sin3A-associated protein, 30kDa	0.033
GSK3B	glycogen synthase kinase 3 beta	0.030
KAT2B	K(lysine) acetyltransferase 2B	0.030
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.029
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.029
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.029
MEIS2	Meis homeobox 2	0.028
HOXA10	homeobox A10	0.027
IARS	isoleucyl-tRNA synthetase	0.027
MEIS1	Meis homeobox 1	0.026
HDAC10	histone deacetylase 10	0.026
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.025
ATXN1	ataxin 1	0.025
HOXA7	homeobox A7	0.024
SP1	Sp1 transcription factor	0.023
STK4	serine/threonine kinase 4	0.022
THRA	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	0.022	Mouse
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.022
ONECUT1	one cut homeobox 1	0.022
NOTCH2	notch 2	0.021
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.021
KIAA2026	KIAA2026	0.020
FNDC3A	fibronectin type III domain containing 3A	0.020
HOXB5	homeobox B5	0.019
SEC16A	SEC16 homolog A (S. cerevisiae)	0.019
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.019
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.019
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.019
CCDC6	coiled-coil domain containing 6	0.018
NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive	0.018
TOX4	TOX high mobility group box family member 4	0.018
RUNX1	runt-related transcription factor 1	0.018
HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	0.017
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.017
GATAD2B	GATA zinc finger domain containing 2B	0.017
AGFG1	ArfGAP with FG repeats 1	0.017
HDAC7	histone deacetylase 7	0.017
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.017
IGBP1	immunoglobulin (CD79A) binding protein 1	0.017
RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	0.016
KLF13	Kruppel-like factor 13	0.016
PSRC1	proline/serine-rich coiled-coil 1	0.016
HIPK3	homeodomain interacting protein kinase 3	0.016
POU2F1	POU class 2 homeobox 1	0.016
SMAD1	SMAD family member 1	0.016
FOXJ1	forkhead box J1	0.016
RXRB	retinoid X receptor, beta	0.016
ESR1	estrogen receptor 1	0.016
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.016
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.015
PIAS1	protein inhibitor of activated STAT, 1	0.015
MED25	mediator complex subunit 25	0.015
MPDZ	multiple PDZ domain protein	0.015
JDP2	Jun dimerization protein 2	0.015
CNOT4	CCR4-NOT transcription complex, subunit 4	0.015
SGK1	serum/glucocorticoid regulated kinase 1	0.015
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.015
CCNB2	cyclin B2	0.015
ACVR1	activin A receptor, type I	0.014
SCNN1A	sodium channel, nonvoltage-gated 1 alpha	0.014
ING2	inhibitor of growth family, member 2	0.014
CHD3	chromodomain helicase DNA binding protein 3	0.014
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.014
QKI	quaking homolog, KH domain RNA binding (mouse)	0.014
FERMT2	fermitin family member 2	0.014
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.014
MAGEB18	melanoma antigen family B, 18	0.014
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.014
OXA1L	oxidase (cytochrome c) assembly 1-like	0.014
MEF2A	myocyte enhancer factor 2A	0.014
GLIS2	GLIS family zinc finger 2	0.014
CCDC115	coiled-coil domain containing 115	0.013
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.013
SIAH1	seven in absentia homolog 1 (Drosophila)	0.013
HOXA4	homeobox A4	0.013
TBL1X	transducin (beta)-like 1X-linked	0.013
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.013
E2F1	E2F transcription factor 1	0.013
RBMS1	RNA binding motif, single stranded interacting protein 1	0.013
HDAC1	histone deacetylase 1	0.013
MYST2	MYST histone acetyltransferase 2	0.013
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.013
BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	0.013
GNAI1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	0.013
HIPK2	homeodomain interacting protein kinase 2	0.013
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.013
SOX2	SRY (sex determining region Y)-box 2	0.013
ATF6	activating transcription factor 6	0.013
HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	0.012
CTDSP2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	0.012
TFF1	trefoil factor 1	0.012
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.012
USP22	ubiquitin specific peptidase 22	0.012
HOXA2	homeobox A2	0.012
RHOB	ras homolog gene family, member B	0.012
MLPH	melanophilin	0.012
CPD	carboxypeptidase D	0.012
PROX1	prospero homeobox 1	0.012
CAPN9	calpain 9	0.011
KHDRBS3	KH domain containing, RNA binding, signal transduction associated 3	0.011
PRR15L	proline rich 15-like	0.011
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.011
RARS	arginyl-tRNA synthetase	0.011
DENND5A	DENN/MADD domain containing 5A	0.011
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.011
LIMCH1	LIM and calponin homology domains 1	0.011
EIF4B	eukaryotic translation initiation factor 4B	0.011
HOXA1	homeobox A1	0.011
MEF2C	myocyte enhancer factor 2C	0.011
ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	0.011
GDI2	GDP dissociation inhibitor 2	0.011
FBP1	fructose-1,6-bisphosphatase 1	0.011
MED12	mediator complex subunit 12	0.011
PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	0.011
C9orf7	chromosome 9 open reading frame 7	0.011
GARS	glycyl-tRNA synthetase	0.011
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.011
CCND1	cyclin D1	0.011
C12orf52	chromosome 12 open reading frame 52	0.011
TSC22D2	TSC22 domain family, member 2	0.011
EIF2C3	eukaryotic translation initiation factor 2C, 3	0.011
EMG1	EMG1 nucleolar protein homolog (S. cerevisiae)	0.011
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.011
EXT1	exostosin 1	0.011
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.011
PABPC4	poly(A) binding protein, cytoplasmic 4 (inducible form)	0.010
SOX4	SRY (sex determining region Y)-box 4	0.010
FZD7	frizzled homolog 7 (Drosophila)	0.010
SCGB2A1	secretoglobin, family 2A, member 1	0.010
EPB41L1	erythrocyte membrane protein band 4.1-like 1	0.010
HOXA11	homeobox A11	0.010
TFF3	trefoil factor 3 (intestinal)	0.010
GRB10	growth factor receptor-bound protein 10	0.010
ENAH	enabled homolog (Drosophila)	0.010
HCFC1	host cell factor C1 (VP16-accessory protein)	0.010
SPDEF	SAM pointed domain containing ets transcription factor	0.010	Mouse
EIF2C4	eukaryotic translation initiation factor 2C, 4	0.010
KLF6	Kruppel-like factor 6	0.010