IMP: Integrative Multi-species Prediction

Homo sapiens

32 genes annotated in human

Multi-species View

negative regulation of i kappab kinase nf kappab signaling

GO:0043124

Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of i kappab kinase nf kappab signaling"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of i kappab kinase nf kappab signaling" (in gray)

Name	Description	Probability	Func Analog Organism
RIPK2	receptor-interacting serine-threonine kinase 2	0.867	Human
BIRC3	baculoviral IAP repeat containing 3	0.722
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.628	Human
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.628
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.613
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.607
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.589
BIRC2	baculoviral IAP repeat containing 2	0.556
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.545
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.489
C1QA	complement component 1, q subcomponent, A chain	0.449	Human
XIAP	X-linked inhibitor of apoptosis	0.446
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.440
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.394
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.242	Human
CFLAR	CASP8 and FADD-like apoptosis regulator	0.239
TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	0.213
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.195	Human
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.178	Human
TNIP2	TNFAIP3 interacting protein 2	0.160
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.156
NLRC4	NLR family, CARD domain containing 4	0.154
TRAF1	TNF receptor-associated factor 1	0.149
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.141	Human Rat
IL4R	interleukin 4 receptor	0.127
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.114
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.114
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.103
HIPK3	homeodomain interacting protein kinase 3	0.102
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.096
FAS	Fas (TNF receptor superfamily, member 6)	0.090
IFNAR1	interferon (alpha, beta and omega) receptor 1	0.089
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.079	Human
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.079
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.064
GFM1	G elongation factor, mitochondrial 1	0.058
C1QC	complement component 1, q subcomponent, C chain	0.055	Human
CUL1	cullin 1	0.050
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.050
TNIP1	TNFAIP3 interacting protein 1	0.049
APAF1	apoptotic peptidase activating factor 1	0.047
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.047	Human
TRAF6	TNF receptor-associated factor 6	0.046
EP300	E1A binding protein p300	0.044
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.044
TRAF3	TNF receptor-associated factor 3	0.042
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.041	Human
BBS10	Bardet-Biedl syndrome 10	0.041
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.039
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.036
IRF1	interferon regulatory factor 1	0.034
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.034
JAK1	Janus kinase 1	0.034
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.034
IRF9	interferon regulatory factor 9	0.029
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.029
IL2RB	interleukin 2 receptor, beta	0.028
MYH9	myosin, heavy chain 9, non-muscle	0.027
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.027
ZNF84	zinc finger protein 84	0.024
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.023
RANBP3	RAN binding protein 3	0.023
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.023
C1QB	complement component 1, q subcomponent, B chain	0.023	Human
BCAR1	breast cancer anti-estrogen resistance 1	0.023
ZNF260	zinc finger protein 260	0.022
OPTN	optineurin	0.022
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.022
TRAF5	TNF receptor-associated factor 5	0.021
CSNK1E	casein kinase 1, epsilon	0.021
IL12RB2	interleukin 12 receptor, beta 2	0.020
ZNF585A	zinc finger protein 585A	0.020
NMI	N-myc (and STAT) interactor	0.020
SNAI1	snail homolog 1 (Drosophila)	0.019
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.019
ZNF432	zinc finger protein 432	0.018
DIABLO	diablo, IAP-binding mitochondrial protein	0.018
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.018
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.017
ACTN1	actinin, alpha 1	0.017
KAT2B	K(lysine) acetyltransferase 2B	0.017
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.017
TRIM63	tripartite motif containing 63	0.017	Human
FLNA	filamin A, alpha	0.016
CCDC90B	coiled-coil domain containing 90B	0.016
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.016
PFN1	profilin 1	0.016
HOXA9	homeobox A9	0.016
PYDC2	pyrin domain containing 2	0.016
USP15	ubiquitin specific peptidase 15	0.016
FLNB	filamin B, beta	0.015
RIPK3	receptor-interacting serine-threonine kinase 3	0.015	Human
STAT5A	signal transducer and activator of transcription 5A	0.015	Human
MEFV	Mediterranean fever	0.015
PXN	paxillin	0.014
RIPK4	receptor-interacting serine-threonine kinase 4	0.014	Human
ZNF189	zinc finger protein 189	0.014
ZNF180	zinc finger protein 180	0.014
ARL4D	ADP-ribosylation factor-like 4D	0.013
ZNF569	zinc finger protein 569	0.013
ITK	IL2-inducible T-cell kinase	0.013
ZNF623	zinc finger protein 623	0.013
LEF1	lymphoid enhancer-binding factor 1	0.013
STAP2	signal transducing adaptor family member 2	0.013
CREBBP	CREB binding protein	0.013
LASP1	LIM and SH3 protein 1	0.013
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.013
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.013
PPP5C	protein phosphatase 5, catalytic subunit	0.013
NOD1	nucleotide-binding oligomerization domain containing 1	0.012
NOTCH1	notch 1	0.012
MTA2	metastasis associated 1 family, member 2	0.012
FBXW11	F-box and WD repeat domain containing 11	0.012	Mouse Fly
MYL12A	myosin, light chain 12A, regulatory, non-sarcomeric	0.012
ELF4	E74-like factor 4 (ets domain transcription factor)	0.012
NCF1	neutrophil cytosolic factor 1	0.012
JAK2	Janus kinase 2	0.012
ACTN4	actinin, alpha 4	0.012
ZNF571	zinc finger protein 571	0.012
MTA3	metastasis associated 1 family, member 3	0.012
ZNF567	zinc finger protein 567	0.012
ZNF559	zinc finger protein 559	0.012
PPARG	peroxisome proliferator-activated receptor gamma	0.012
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.012
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.012
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.011
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.011	Human
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.011
RXRA	retinoid X receptor, alpha	0.011
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.011
CLPX	ClpX caseinolytic peptidase X homolog (E. coli)	0.011
ZNF304	zinc finger protein 304	0.011
C5orf41	chromosome 5 open reading frame 41	0.010
NOG	noggin	0.010
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.010
SPRR2A	small proline-rich protein 2A	0.010
ZNF529	zinc finger protein 529	0.010
TRAF2	TNF receptor-associated factor 2	0.010
TBK1	TANK-binding kinase 1	0.010
TUBA1A	tubulin, alpha 1a	0.010
VCL	vinculin	0.010
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.010
CD40	CD40 molecule, TNF receptor superfamily member 5	0.010