IMP: Integrative Multi-species Prediction

Homo sapiens

23 genes annotated in human

male gonad development

The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "male gonad development"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "male gonad development" (in gray)

Name	Description	Probability	Func Analog Organism
FGFR2	fibroblast growth factor receptor 2	0.981
FGFR1	fibroblast growth factor receptor 1	0.769
AKR1C2	aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)	0.760	Human
TAL1	T-cell acute lymphocytic leukemia 1	0.758
LAT	linker for activation of T cells	0.692
AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)	0.582	Human
FGF1	fibroblast growth factor 1 (acidic)	0.529	Human
MPDZ	multiple PDZ domain protein	0.421
PDX1	pancreatic and duodenal homeobox 1	0.363
NCOA3	nuclear receptor coactivator 3	0.357
TRIP6	thyroid hormone receptor interactor 6	0.353
ESR1	estrogen receptor 1	0.342	Mouse Rat
PAX3	paired box 3	0.326
AR	androgen receptor	0.306	Mouse
CDH5	cadherin 5, type 2 (vascular endothelium)	0.282
FGF10	fibroblast growth factor 10	0.274	Human
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.241
BCL2	B-cell CLL/lymphoma 2	0.237	Mouse
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.211
KCNE1	potassium voltage-gated channel, Isk-related family, member 1	0.210
CREBBP	CREB binding protein	0.200
ARID4A	AT rich interactive domain 4A (RBP1-like)	0.192	Mouse
EGR1	early growth response 1	0.176	Human
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.166
AKR1C3	aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)	0.164
ARID4B	AT rich interactive domain 4B (RBP1-like)	0.151	Mouse
EGR3	early growth response 3	0.145	Human
GATA4	GATA binding protein 4	0.141
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.133
NGF	nerve growth factor (beta polypeptide)	0.132
NCOA1	nuclear receptor coactivator 1	0.124
GFI1B	growth factor independent 1B transcription repressor	0.120
PLCG1	phospholipase C, gamma 1	0.118
POU5F1	POU class 5 homeobox 1	0.113
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.112
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.111	Human
FANCD2	Fanconi anemia, complementation group D2	0.110
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.107
BCL2L1	BCL2-like 1	0.106	Mouse
AP1M1	adaptor-related protein complex 1, mu 1 subunit	0.106
BAD	BCL2-associated agonist of cell death	0.104
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.101
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.096
BRCA1	breast cancer 1, early onset	0.094
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.091
SNAI1	snail homolog 1 (Drosophila)	0.090
RORA	RAR-related orphan receptor A	0.088
FZD1	frizzled homolog 1 (Drosophila)	0.085
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.082
RAD50	RAD50 homolog (S. cerevisiae)	0.082
PAX8	paired box 8	0.081
EGR2	early growth response 2	0.077	Human
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.077
HDAC1	histone deacetylase 1	0.072
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.072
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.063
FANCE	Fanconi anemia, complementation group E	0.061
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.060
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.060
MSH6	mutS homolog 6 (E. coli)	0.060
PGF	placental growth factor	0.059
WNT1	wingless-type MMTV integration site family, member 1	0.059	Human
TBX5	T-box 5	0.058
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.057
FANCB	Fanconi anemia, complementation group B	0.057
RET	ret proto-oncogene	0.057
FGF8	fibroblast growth factor 8 (androgen-induced)	0.054
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.053
SOX2	SRY (sex determining region Y)-box 2	0.053	Human
PROX1	prospero homeobox 1	0.051
RNR2	l-rRNA	0.051
HDAC2	histone deacetylase 2	0.051
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.050
NEUROD1	neurogenic differentiation 1	0.050
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.050
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.047
KITLG	KIT ligand	0.046
ZNF292	zinc finger protein 292	0.044
BAX	BCL2-associated X protein	0.044	Mouse
SH3BP4	SH3-domain binding protein 4	0.043
SF3A2	splicing factor 3a, subunit 2, 66kDa	0.042
FGF4	fibroblast growth factor 4	0.042	Human
FGF18	fibroblast growth factor 18	0.041
SMAD4	SMAD family member 4	0.041
SFRP5	secreted frizzled-related protein 5	0.041
DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.040
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.039
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.039
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.038
ACP5	acid phosphatase 5, tartrate resistant	0.038
MEOX2	mesenchyme homeobox 2	0.037
GDNF	glial cell derived neurotrophic factor	0.036	Rat
FGF7	fibroblast growth factor 7	0.036	Human
BCAR1	breast cancer anti-estrogen resistance 1	0.036
HNF4A	hepatocyte nuclear factor 4, alpha	0.036
CTNND1	catenin (cadherin-associated protein), delta 1	0.035
LBX1	ladybird homeobox 1	0.034
NRP1	neuropilin 1	0.034
SMAD1	SMAD family member 1	0.033
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.032
HBP1	HMG-box transcription factor 1	0.032
EGFR	epidermal growth factor receptor	0.032
FOXD3	forkhead box D3	0.031
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.031
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.031
COL2A1	collagen, type II, alpha 1	0.030
FANCC	Fanconi anemia, complementation group C	0.030
MGEA5	meningioma expressed antigen 5 (hyaluronidase)	0.028
CALCA	calcitonin-related polypeptide alpha	0.027
SF3B4	splicing factor 3b, subunit 4, 49kDa	0.027
HOXB5	homeobox B5	0.026
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.026
HOXA10	homeobox A10	0.026
CAT	catalase	0.026
TBX1	T-box 1	0.026
GATA5	GATA binding protein 5	0.026	Human
MYST2	MYST histone acetyltransferase 2	0.025
FOXC1	forkhead box C1	0.025
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.025
INHBB	inhibin, beta B	0.025	Human
PAX7	paired box 7	0.024
SFRP1	secreted frizzled-related protein 1	0.024	Mouse
RNF144B	ring finger protein 144B	0.024
FGF2	fibroblast growth factor 2 (basic)	0.023	Human
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.023
VEGFA	vascular endothelial growth factor A	0.023
CDX2	caudal type homeobox 2	0.023
GAB1	GRB2-associated binding protein 1	0.023
HOXB13	homeobox B13	0.023
EIF4G2	eukaryotic translation initiation factor 4 gamma, 2	0.022
TBX2	T-box 2	0.022
KDM5B	lysine (K)-specific demethylase 5B	0.022
DHH	desert hedgehog	0.022
FGF3	fibroblast growth factor 3	0.022	Human
INHA	inhibin, alpha	0.022	Rat
SMAD7	SMAD family member 7	0.022
HOXD1	homeobox D1	0.022
SMAD2	SMAD family member 2	0.022
PGR	progesterone receptor	0.021
GSK3B	glycogen synthase kinase 3 beta	0.021	Fly
FOXA2	forkhead box A2	0.021
AQP5	aquaporin 5	0.021
PAX2	paired box 2	0.021
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.021
POU3F2	POU class 3 homeobox 2	0.021
ESRRG	estrogen-related receptor gamma	0.021
PTPRB	protein tyrosine phosphatase, receptor type, B	0.020
TP53BP2	tumor protein p53 binding protein, 2	0.020
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.020
HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	0.020
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.020
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.020
CLASP2	cytoplasmic linker associated protein 2	0.019
HOXD12	homeobox D12	0.019	Fly
HMGA2	high mobility group AT-hook 2	0.019
LDLR	low density lipoprotein receptor	0.019
SIM2	single-minded homolog 2 (Drosophila)	0.019
BARX1	BARX homeobox 1	0.019
LRP6	low density lipoprotein receptor-related protein 6	0.018
CALCR	calcitonin receptor	0.018
WNT2	wingless-type MMTV integration site family member 2	0.018	Human
SIX6	SIX homeobox 6	0.018
HOXD13	homeobox D13	0.018
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.018
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.018
DMRT1	doublesex and mab-3 related transcription factor 1	0.018
RXRA	retinoid X receptor, alpha	0.018
BCL2L2	BCL2-like 2	0.018
OTP	orthopedia homeobox	0.018
RAD23B	RAD23 homolog B (S. cerevisiae)	0.017
BHLHE23	basic helix-loop-helix family, member e23	0.017
PDGFA	platelet-derived growth factor alpha polypeptide	0.017
MYOD1	myogenic differentiation 1	0.017
FOXA1	forkhead box A1	0.017
HOXD9	homeobox D9	0.017
SALL2	sal-like 2 (Drosophila)	0.017	Fly
HAND2	heart and neural crest derivatives expressed 2	0.017
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.017
MSH3	mutS homolog 3 (E. coli)	0.017
FOXF1	forkhead box F1	0.017
FST	follistatin	0.017
ATM	ataxia telangiectasia mutated	0.016
FRS2	fibroblast growth factor receptor substrate 2	0.016
HES2	hairy and enhancer of split 2 (Drosophila)	0.016
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.016
AMHR2	anti-Mullerian hormone receptor, type II	0.016
RANBP9	RAN binding protein 9	0.016
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.016	Human
TTR	transthyretin	0.015
BIK	BCL2-interacting killer (apoptosis-inducing)	0.015
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.015
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.015
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.015
NGFR	nerve growth factor receptor	0.015
SOX9	SRY (sex determining region Y)-box 9	0.015
SOX11	SRY (sex determining region Y)-box 11	0.015	Human
NKX2-1	NK2 homeobox 1	0.015	Mouse
ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.015
MED25	mediator complex subunit 25	0.015
PHF3	PHD finger protein 3	0.015
TIMP2	TIMP metallopeptidase inhibitor 2	0.015
FOXN4	forkhead box N4	0.015
CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.014
HMX1	H6 family homeobox 1	0.014
SOX1	SRY (sex determining region Y)-box 1	0.014	Human
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.014
IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	0.014
IGF1R	insulin-like growth factor 1 receptor	0.014
TLX2	T-cell leukemia homeobox 2	0.014
POU2F3	POU class 2 homeobox 3	0.014
SOS1	son of sevenless homolog 1 (Drosophila)	0.014
PTPN4	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	0.014
MED1	mediator complex subunit 1	0.014
SPDEF	SAM pointed domain containing ets transcription factor	0.014
FZD7	frizzled homolog 7 (Drosophila)	0.014
HIC1	hypermethylated in cancer 1	0.014
NEUROG3	neurogenin 3	0.014
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.014
MBNL2	muscleblind-like 2 (Drosophila)	0.014
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.014
FOXG1	forkhead box G1	0.014
MDC1	mediator of DNA-damage checkpoint 1	0.013
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.013	Mouse
ESR2	estrogen receptor 2 (ER beta)	0.013	Rat
RBM4	RNA binding motif protein 4	0.013
SPRY4	sprouty homolog 4 (Drosophila)	0.013
NPAS1	neuronal PAS domain protein 1	0.013
CTGF	connective tissue growth factor	0.013
IL11	interleukin 11	0.013
WNT3	wingless-type MMTV integration site family, member 3	0.013	Human
DUSP23	dual specificity phosphatase 23	0.013
POMC	proopiomelanocortin	0.013
INO80	INO80 homolog (S. cerevisiae)	0.012
PDE6D	phosphodiesterase 6D, cGMP-specific, rod, delta	0.012
LAMA5	laminin, alpha 5	0.012
PTGER3	prostaglandin E receptor 3 (subtype EP3)	0.012
FZD8	frizzled homolog 8 (Drosophila)	0.012
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.012
GAS1	growth arrest-specific 1	0.012
FANCF	Fanconi anemia, complementation group F	0.012
SMC1A	structural maintenance of chromosomes 1A	0.012
TBXA2R	thromboxane A2 receptor	0.012
POU4F3	POU class 4 homeobox 3	0.012
TXNDC5	thioredoxin domain containing 5 (endoplasmic reticulum)	0.012
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.012
SSBP1	single-stranded DNA binding protein 1	0.012
KCTD1	potassium channel tetramerisation domain containing 1	0.012
PSEN2	presenilin 2 (Alzheimer disease 4)	0.012
HMGA1	high mobility group AT-hook 1	0.012
ACAN	aggrecan	0.012
ALX3	ALX homeobox 3	0.012
BMP7	bone morphogenetic protein 7	0.012
WT1	Wilms tumor 1	0.011
NBN	nibrin	0.011
WNT10A	wingless-type MMTV integration site family, member 10A	0.011	Human
GOLGA2	golgin A2	0.011
SOX4	SRY (sex determining region Y)-box 4	0.011	Human
C1QL1	complement component 1, q subcomponent-like 1	0.011
IRX4	iroquois homeobox 4	0.011
HSPG2	heparan sulfate proteoglycan 2	0.011
SP1	Sp1 transcription factor	0.011
AMBRA1	autophagy/beclin-1 regulator 1	0.011
TG	thyroglobulin	0.011
SHH	sonic hedgehog	0.011
CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	0.011
DIO3	deiodinase, iodothyronine, type III	0.011
PBX1	pre-B-cell leukemia homeobox 1	0.011
DLX4	distal-less homeobox 4	0.011
LTK	leukocyte receptor tyrosine kinase	0.011
PDGFC	platelet derived growth factor C	0.011
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.011
APP	amyloid beta (A4) precursor protein	0.011
SLC18A3	solute carrier family 18 (vesicular acetylcholine), member 3	0.011
NPY2R	neuropeptide Y receptor Y2	0.011
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.011	Human Mouse
SIX3	SIX homeobox 3	0.011
KLHL24	kelch-like 24 (Drosophila)	0.011
NEUROG2	neurogenin 2	0.011
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.011
PKN2	protein kinase N2	0.011
GOLGA4	golgin A4	0.011
CTAG2	cancer/testis antigen 2	0.011
CFD	complement factor D (adipsin)	0.011
TLX1	T-cell leukemia homeobox 1	0.011
CCNG2	cyclin G2	0.011
RBBP8	retinoblastoma binding protein 8	0.011
COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	0.011
PDE10A	phosphodiesterase 10A	0.010
PSMD8	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8	0.010
USP42	ubiquitin specific peptidase 42	0.010
RUNX2	runt-related transcription factor 2	0.010
GOLGB1	golgin B1	0.010
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.010	Human
PYY	peptide YY	0.010
ELK1	ELK1, member of ETS oncogene family	0.010
GAL	galanin prepropeptide	0.010
PTHLH	parathyroid hormone-like hormone	0.010
CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	0.010	Rat
CAV1	caveolin 1, caveolae protein, 22kDa	0.010
ENTPD2	ectonucleoside triphosphate diphosphohydrolase 2	0.010
KIAA1370	KIAA1370	0.010
TACR1	tachykinin receptor 1	0.010
DHX40	DEAH (Asp-Glu-Ala-His) box polypeptide 40	0.010
SIX1	SIX homeobox 1	0.010
ACVR1B	activin A receptor, type IB	0.010