IMP
Process View
negative regulation of proteasomal ubiquitin dependent protein catabolic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of proteasomal ubiquitin dependent protein catabolic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| BUB1B | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 0.111 | Fly | |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | 0.105 | ||
| CDC27 | cell division cycle 27 homolog (S. cerevisiae) | 0.059 | ||
| BUB3 | budding uninhibited by benzimidazoles 3 homolog (yeast) | 0.050 | Worm Fly | |
| BUB1 | budding uninhibited by benzimidazoles 1 homolog (yeast) | 0.049 | Fly | |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 0.036 | ||
| DOT1L | DOT1-like, histone H3 methyltransferase (S. cerevisiae) | 0.033 | ||
| GFI1B | growth factor independent 1B transcription repressor | 0.032 | ||
| BRCA2 | breast cancer 2, early onset | 0.030 | ||
| CDC20 | cell division cycle 20 homolog (S. cerevisiae) | 0.028 | Yeast | |
| TPBG | trophoblast glycoprotein | 0.026 | ||
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.025 | ||
| CDK2 | cyclin-dependent kinase 2 | 0.024 | ||
| CASC5 | cancer susceptibility candidate 5 | 0.023 | ||
| SMC3 | structural maintenance of chromosomes 3 | 0.021 | ||
| COPS8 | COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) | 0.020 | ||
| SKA1 | spindle and kinetochore associated complex subunit 1 | 0.020 | ||
| SKA3 | spindle and kinetochore associated complex subunit 3 | 0.018 | ||
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.018 | ||
| SYVN1 | synovial apoptosis inhibitor 1, synoviolin | 0.018 | ||
| ASF1A | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) | 0.018 | ||
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 0.018 | ||
| VCP | valosin containing protein | 0.018 | ||
| MRE11A | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | 0.017 | ||
| USPL1 | ubiquitin specific peptidase like 1 | 0.017 | ||
| SKA2 | spindle and kinetochore associated complex subunit 2 | 0.017 | ||
| CCNB1 | cyclin B1 | 0.017 | ||
| TINF2 | TERF1 (TRF1)-interacting nuclear factor 2 | 0.017 | ||
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.016 | ||
| NUF2 | NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) | 0.016 | ||
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.016 | ||
| CBX5 | chromobox homolog 5 | 0.015 | ||
| CCNA2 | cyclin A2 | 0.015 | ||
| ANAPC11 | anaphase promoting complex subunit 11 | 0.015 | ||
| BAG2 | BCL2-associated athanogene 2 | 0.015 | ||
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.014 | Human | |
| H2AFX | H2A histone family, member X | 0.014 | ||
| ADAM17 | ADAM metallopeptidase domain 17 | 0.014 | ||
| FXR2 | fragile X mental retardation, autosomal homolog 2 | 0.014 | ||
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.013 | ||
| HUWE1 | HECT, UBA and WWE domain containing 1 | 0.013 | ||
| FANCD2 | Fanconi anemia, complementation group D2 | 0.013 | ||
| SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | 0.013 | ||
| HNRNPUL1 | heterogeneous nuclear ribonucleoprotein U-like 1 | 0.013 | ||
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.013 | ||
| TP53BP1 | tumor protein p53 binding protein 1 | 0.013 | ||
| DLG1 | discs, large homolog 1 (Drosophila) | 0.012 | ||
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | 0.012 | ||
| DDB1 | damage-specific DNA binding protein 1, 127kDa | 0.012 | ||
| MDC1 | mediator of DNA-damage checkpoint 1 | 0.012 | ||
| EIF3D | eukaryotic translation initiation factor 3, subunit D | 0.012 | ||
| RFWD2 | ring finger and WD repeat domain 2 | 0.012 | ||
| HERC2 | hect domain and RLD 2 | 0.012 | ||
| MAD2L1BP | MAD2L1 binding protein | 0.012 | ||
| PRNP | prion protein | 0.012 | ||
| VCPIP1 | valosin containing protein (p97)/p47 complex interacting protein 1 | 0.012 | ||
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | 0.012 | ||
| MYST1 | MYST histone acetyltransferase 1 | 0.012 | ||
| CREBBP | CREB binding protein | 0.012 | ||
| RANBP9 | RAN binding protein 9 | 0.012 | ||
| CEP55 | centrosomal protein 55kDa | 0.012 | ||
| ATMIN | ATM interactor | 0.011 | ||
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | 0.011 | ||
| NSMCE1 | non-SMC element 1 homolog (S. cerevisiae) | 0.011 | ||
| LRR1 | leucine rich repeat protein 1 | 0.011 | ||
| NDC80 | NDC80 homolog, kinetochore complex component (S. cerevisiae) | 0.011 | ||
| C19orf39 | chromosome 19 open reading frame 39 | 0.011 | ||
| CHAF1B | chromatin assembly factor 1, subunit B (p60) | 0.011 | ||
| PLK4 | polo-like kinase 4 | 0.011 | ||
| CKS1B | CDC28 protein kinase regulatory subunit 1B | 0.011 | ||
| PPP2R1A | protein phosphatase 2, regulatory subunit A, alpha | 0.011 | Yeast | |
| TP53 | tumor protein p53 | 0.011 | ||
| TYRP1 | tyrosinase-related protein 1 | 0.011 | ||
| ZFR | zinc finger RNA binding protein | 0.011 | ||
| LMNA | lamin A/C | 0.011 | ||
| KPNA3 | karyopherin alpha 3 (importin alpha 4) | 0.011 | ||
| CENPJ | centromere protein J | 0.011 | ||
| COPS2 | COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) | 0.011 | ||
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.010 | ||
| POMP | proteasome maturation protein | 0.010 | ||
| ZNF207 | zinc finger protein 207 | 0.010 | ||
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.010 | ||
| AURKB | aurora kinase B | 0.010 | ||
| CENPE | centromere protein E, 312kDa | 0.010 | Mouse | |
| UBXN7 | UBX domain protein 7 | 0.010 | ||
| SOD1 | superoxide dismutase 1, soluble | 0.010 | ||
| BTBD2 | BTB (POZ) domain containing 2 | 0.010 | ||
| MASTL | microtubule associated serine/threonine kinase-like | 0.010 | ||
| HIST1H4A | histone cluster 1, H4a | 0.010 | ||
| PRC1 | protein regulator of cytokinesis 1 | 0.010 | ||
| PARP3 | poly (ADP-ribose) polymerase family, member 3 | 0.010 |