IMP: Integrative Multi-species Prediction

Homo sapiens

28 genes annotated in human

centrosome duplication

The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "centrosome duplication"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "centrosome duplication" (in gray)

Name	Description	Probability	Func Analog Organism
NEURL4	neuralized homolog 4 (Drosophila)	0.752
RPL18	ribosomal protein L18	0.671
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.600
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.599
RPL17	ribosomal protein L17	0.594	Fly
STIL	SCL/TAL1 interrupting locus	0.589
CENPJ	centromere protein J	0.558
CUL1	cullin 1	0.437
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.365
RPL32	ribosomal protein L32	0.342
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.334	Fly
FBXW11	F-box and WD repeat domain containing 11	0.297	Fly
RPL8	ribosomal protein L8	0.290
RPS18	ribosomal protein S18	0.282
RPL31	ribosomal protein L31	0.280
SASS6	spindle assembly 6 homolog (C. elegans)	0.276
RPL23	ribosomal protein L23	0.270
RPL19	ribosomal protein L19	0.257	Fly
RPLP0	ribosomal protein, large, P0	0.252
RPL21	ribosomal protein L21	0.243	Fly
CEP135	centrosomal protein 135kDa	0.223
RPL6	ribosomal protein L6	0.223
CDK1	cyclin-dependent kinase 1	0.222
RPL7A	ribosomal protein L7a	0.211	Fly
RPL27A	ribosomal protein L27a	0.207
RPL29	ribosomal protein L29	0.206
EEF1A1	eukaryotic translation elongation factor 1 alpha 1	0.201
BIRC5	baculoviral IAP repeat containing 5	0.191
RPL22	ribosomal protein L22	0.185
RPL24	ribosomal protein L24	0.165	Fly
RPS17	ribosomal protein S17	0.164
RPS6	ribosomal protein S6	0.153
AURKB	aurora kinase B	0.148	Fly
RPL41	ribosomal protein L41	0.142
CCNB1	cyclin B1	0.141
AURKA	aurora kinase A	0.140
RPS20	ribosomal protein S20	0.134
PRC1	protein regulator of cytokinesis 1	0.128	Fly
RPL9	ribosomal protein L9	0.122	Fly
BTRC	beta-transducin repeat containing	0.120	Fly
KIF23	kinesin family member 23	0.120	Fly
RPS16	ribosomal protein S16	0.118
RPL10	ribosomal protein L10	0.116
LIN9	lin-9 homolog (C. elegans)	0.115
RPL3	ribosomal protein L3	0.112	Fly
WEE1	WEE1 homolog (S. pombe)	0.108
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.108	Fly
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.106
RPL12	ribosomal protein L12	0.104
RAN	RAN, member RAS oncogene family	0.100
EEF1G	eukaryotic translation elongation factor 1 gamma	0.099
RPS21	ribosomal protein S21	0.097
RPL7	ribosomal protein L7	0.097	Fly
CCNA2	cyclin A2	0.093
RPL5	ribosomal protein L5	0.092
CCNF	cyclin F	0.088
NCL	nucleolin	0.086
TCP1	t-complex 1	0.086
RPL14	ribosomal protein L14	0.084	Fly
RPS10	ribosomal protein S10	0.075
RPS19	ribosomal protein S19	0.075
RPL10A	ribosomal protein L10a	0.074	Fly
RPS3	ribosomal protein S3	0.071
CKAP5	cytoskeleton associated protein 5	0.067
FOXM1	forkhead box M1	0.066
RPL30	ribosomal protein L30	0.065	Fly
C19orf39	chromosome 19 open reading frame 39	0.060
RPL27	ribosomal protein L27	0.058	Fly
CCNB2	cyclin B2	0.057
NLK	nemo-like kinase	0.057
RPS28	ribosomal protein S28	0.057
TACC3	transforming, acidic coiled-coil containing protein 3	0.057
RPS27A	ribosomal protein S27a	0.056
RPS4X	ribosomal protein S4, X-linked	0.056	Fly
RPL13	ribosomal protein L13	0.056	Fly
GTSE1	G-2 and S-phase expressed 1	0.056
XPO1	exportin 1 (CRM1 homolog, yeast)	0.054	Mouse Fly
CCNE1	cyclin E1	0.053
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.053
TJP1	tight junction protein 1 (zona occludens 1)	0.052
UBA52	ubiquitin A-52 residue ribosomal protein fusion product 1	0.052
PBK	PDZ binding kinase	0.050
RAD51AP1	RAD51 associated protein 1	0.049
RPS3A	ribosomal protein S3A	0.047
KIF4A	kinesin family member 4A	0.045
RPS13	ribosomal protein S13	0.044
CENPF	centromere protein F, 350/400kDa (mitosin)	0.044
RPL13A	ribosomal protein L13a	0.043	Fly
INCENP	inner centromere protein antigens 135/155kDa	0.042
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.041
PLK1	polo-like kinase 1	0.041	Human
SKP2	S-phase kinase-associated protein 2 (p45)	0.040
RPL15	ribosomal protein L15	0.040
RPLP1	ribosomal protein, large, P1	0.039
SMC6	structural maintenance of chromosomes 6	0.039
RPL4	ribosomal protein L4	0.039	Fly
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.038
RPS11	ribosomal protein S11	0.036
SMC4	structural maintenance of chromosomes 4	0.036
STARD9	StAR-related lipid transfer (START) domain containing 9	0.035
CDCA8	cell division cycle associated 8	0.035
CENPE	centromere protein E, 312kDa	0.035
BID	BH3 interacting domain death agonist	0.033
RPL36A	ribosomal protein L36a	0.033
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.032	Fly
RB1	retinoblastoma 1	0.032
RPS12	ribosomal protein S12	0.032
LIN54	lin-54 homolog (C. elegans)	0.032
CEP97	centrosomal protein 97kDa	0.031
DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.031
FBF1	Fas (TNFRSF6) binding factor 1	0.029
TBK1	TANK-binding kinase 1	0.029
TTK	TTK protein kinase	0.029
SDSL	serine dehydratase-like	0.028
SKA3	spindle and kinetochore associated complex subunit 3	0.028
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.028
TUBB3	tubulin, beta 3	0.028
CP110	CP110 protein	0.028
RPS24	ribosomal protein S24	0.027
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.027
SKP1	S-phase kinase-associated protein 1	0.027	Fly
CDC34	cell division cycle 34 homolog (S. cerevisiae)	0.027
CEP192	centrosomal protein 192kDa	0.026
RPLP2	ribosomal protein, large, P2	0.026
FBXW2	F-box and WD repeat domain containing 2	0.025
RPS7	ribosomal protein S7	0.024
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.023
BRCA1	breast cancer 1, early onset	0.023
RPL34	ribosomal protein L34	0.023
EEF1D	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	0.023
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.023
KIF20A	kinesin family member 20A	0.023
SPC24	SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.022
CAND1	cullin-associated and neddylation-dissociated 1	0.022
RACGAP1	Rac GTPase activating protein 1	0.022	Fly
RPS15A	ribosomal protein S15a	0.022
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.021
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.021
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.021
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.020
MASTL	microtubule associated serine/threonine kinase-like	0.020
RPS9	ribosomal protein S9	0.020
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.019
PLK4	polo-like kinase 4	0.019
KPNB1	karyopherin (importin) beta 1	0.018
ORC1	origin recognition complex, subunit 1	0.018
TRIM37	tripartite motif containing 37	0.018
CDK2	cyclin-dependent kinase 2	0.018
RPS25	ribosomal protein S25	0.018
RPL37A	ribosomal protein L37a	0.018
PRNP	prion protein	0.017
PPP2R5E	protein phosphatase 2, regulatory subunit B', epsilon isoform	0.017
TMEM194A	transmembrane protein 194A	0.017
SKA1	spindle and kinetochore associated complex subunit 1	0.017
KIF11	kinesin family member 11	0.017	Fly
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.017
RPS14	ribosomal protein S14	0.017
RPS8	ribosomal protein S8	0.016
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.016
GPSM2	G-protein signaling modulator 2	0.016
FBXW7	F-box and WD repeat domain containing 7	0.016
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.016
TUBGCP3	tubulin, gamma complex associated protein 3	0.016
ZFR	zinc finger RNA binding protein	0.016
NUF2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.016
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.016
KIAA1279	KIAA1279	0.016
EEF1B2	eukaryotic translation elongation factor 1 beta 2	0.016
SRP14	signal recognition particle 14kDa (homologous Alu RNA binding protein)	0.016
RPL37	ribosomal protein L37	0.015
KRR1	KRR1, small subunit (SSU) processome component, homolog (yeast)	0.015
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.015
PPP5C	protein phosphatase 5, catalytic subunit	0.015
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.015
NUP50	nucleoporin 50kDa	0.015
CCDC99	coiled-coil domain containing 99	0.015
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.015
MPHOSPH9	M-phase phosphoprotein 9	0.015
FBXO33	F-box protein 33	0.015
EEF2K	eukaryotic elongation factor-2 kinase	0.014
HJURP	Holliday junction recognition protein	0.014
TSG101	tumor susceptibility gene 101	0.014
CDCA4	cell division cycle associated 4	0.014
ARHGAP11A	Rho GTPase activating protein 11A	0.014
USP24	ubiquitin specific peptidase 24	0.014
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	0.013	Fly
SERTAD4	SERTA domain containing 4	0.013
SLMAP	sarcolemma associated protein	0.013
RPS29	ribosomal protein S29	0.013
CKS2	CDC28 protein kinase regulatory subunit 2	0.013
USPL1	ubiquitin specific peptidase like 1	0.013
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.013
SPAG5	sperm associated antigen 5	0.013
E2F3	E2F transcription factor 3	0.013
SELENBP1	selenium binding protein 1	0.013
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.013
TUBA1B	tubulin, alpha 1b	0.013
ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	0.013
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.013
PRPF38B	PRP38 pre-mRNA processing factor 38 (yeast) domain containing B	0.012
UQCRB	ubiquinol-cytochrome c reductase binding protein	0.012
RAD51C	RAD51 homolog C (S. cerevisiae)	0.012
RAD51L1	RAD51-like 1 (S. cerevisiae)	0.012
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.012
NCAPG	non-SMC condensin I complex, subunit G	0.012
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.012	Fly
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.012	Fly
G2E3	G2/M-phase specific E3 ubiquitin protein ligase	0.012
YEATS4	YEATS domain containing 4	0.012
MYO10	myosin X	0.012
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.012
CEP55	centrosomal protein 55kDa	0.012
PSRC1	proline/serine-rich coiled-coil 1	0.012
FANCL	Fanconi anemia, complementation group L	0.012
YAP1	Yes-associated protein 1	0.012
MDM1	Mdm1 nuclear protein homolog (mouse)	0.012
SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.012
RPS26	ribosomal protein S26	0.012
TUBB	tubulin, beta	0.011
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.011
GLTSCR2	glioma tumor suppressor candidate region gene 2	0.011
CCT6A	chaperonin containing TCP1, subunit 6A (zeta 1)	0.011
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.011
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.011
GNB2L1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	0.011
KIF18A	kinesin family member 18A	0.011
EIF3L	eukaryotic translation initiation factor 3, subunit L	0.011
HMMR	hyaluronan-mediated motility receptor (RHAMM)	0.011
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.010
SENP2	SUMO1/sentrin/SMT3 specific peptidase 2	0.010
HEMGN	hemogen	0.010
RPL38	ribosomal protein L38	0.010
ZSWIM7	zinc finger, SWIM-type containing 7	0.010
FRYL	FRY-like	0.010
TTF2	transcription termination factor, RNA polymerase II	0.010