IMP
Process View
lung development
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "lung development"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| FGFR2 | fibroblast growth factor receptor 2 | 0.998 | Mouse | |
| FGF1 | fibroblast growth factor 1 (acidic) | 0.978 | Human | |
| FHL2 | four and a half LIM domains 2 | 0.899 | ||
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.897 | ||
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.814 | Mouse | |
| NRP1 | neuropilin 1 | 0.606 | ||
| TBX5 | T-box 5 | 0.559 | Mouse | |
| SMAD2 | SMAD family member 2 | 0.517 | Mouse | |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.471 | Mouse Rat | |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.469 | Mouse | |
| SMAD3 | SMAD family member 3 | 0.467 | ||
| VEGFA | vascular endothelial growth factor A | 0.456 | Mouse Rat | |
| NKX2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.413 | Human | |
| ENG | endoglin | 0.326 | ||
| JAG1 | jagged 1 | 0.325 | ||
| FGFR1 | fibroblast growth factor receptor 1 | 0.315 | Mouse | |
| BMP2 | bone morphogenetic protein 2 | 0.289 | Human | |
| FGF10 | fibroblast growth factor 10 | 0.270 | ||
| GH1 | growth hormone 1 | 0.257 | Rat | |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.222 | Human | |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.204 | ||
| FLNA | filamin A, alpha | 0.187 | ||
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.154 | ||
| CSH1 | chorionic somatomammotropin hormone 1 (placental lactogen) | 0.150 | Rat | |
| NCOR2 | nuclear receptor corepressor 2 | 0.140 | Mouse | |
| NCOA6 | nuclear receptor coactivator 6 | 0.136 | ||
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.131 | ||
| DAB2 | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | 0.118 | ||
| CRK | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.108 | ||
| KAT2B | K(lysine) acetyltransferase 2B | 0.108 | ||
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.107 | ||
| ACVR1 | activin A receptor, type I | 0.104 | ||
| PAX8 | paired box 8 | 0.102 | ||
| GH2 | growth hormone 2 | 0.098 | Rat | |
| NLRC4 | NLR family, CARD domain containing 4 | 0.093 | ||
| GABPA | GA binding protein transcription factor, alpha subunit 60kDa | 0.092 | ||
| PKD2 | polycystic kidney disease 2 (autosomal dominant) | 0.087 | ||
| POLA2 | polymerase (DNA directed), alpha 2 (70kD subunit) | 0.082 | ||
| UTRN | utrophin | 0.082 | ||
| ARNT | aryl hydrocarbon receptor nuclear translocator | 0.081 | ||
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.080 | ||
| RPTOR | regulatory associated protein of MTOR, complex 1 | 0.078 | ||
| ATXN1 | ataxin 1 | 0.077 | Mouse | |
| U2AF1 | U2 small nuclear RNA auxiliary factor 1 | 0.075 | ||
| STK3 | serine/threonine kinase 3 | 0.075 | ||
| TTR | transthyretin | 0.073 | ||
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.071 | ||
| FN1 | fibronectin 1 | 0.069 | ||
| CYR61 | cysteine-rich, angiogenic inducer, 61 | 0.065 | ||
| JAG2 | jagged 2 | 0.065 | ||
| PSEN1 | presenilin 1 | 0.062 | ||
| FADS1 | fatty acid desaturase 1 | 0.061 | ||
| FGF8 | fibroblast growth factor 8 (androgen-induced) | 0.057 | ||
| FHL3 | four and a half LIM domains 3 | 0.054 | ||
| AR | androgen receptor | 0.051 | ||
| PDGFB | platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) | 0.050 | ||
| CSH2 | chorionic somatomammotropin hormone 2 | 0.049 | Rat | |
| ITGB4 | integrin, beta 4 | 0.048 | ||
| SIRT1 | sirtuin 1 | 0.048 | ||
| SHC2 | SHC (Src homology 2 domain containing) transforming protein 2 | 0.046 | ||
| FGF18 | fibroblast growth factor 18 | 0.044 | ||
| PDZD11 | PDZ domain containing 11 | 0.042 | ||
| NKX3-1 | NK3 homeobox 1 | 0.042 | ||
| CSHL1 | chorionic somatomammotropin hormone-like 1 | 0.041 | Rat | |
| MAML1 | mastermind-like 1 (Drosophila) | 0.040 | ||
| FLNB | filamin B, beta | 0.039 | ||
| EGLN1 | egl nine homolog 1 (C. elegans) | 0.039 | ||
| SPEN | spen homolog, transcriptional regulator (Drosophila) | 0.038 | ||
| FGF4 | fibroblast growth factor 4 | 0.037 | Human | |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.037 | Mouse | |
| FLT1 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 0.035 | ||
| ATXN1L | ataxin 1-like | 0.035 | ||
| SORBS3 | sorbin and SH3 domain containing 3 | 0.034 | ||
| COL2A1 | collagen, type II, alpha 1 | 0.034 | ||
| PUM1 | pumilio homolog 1 (Drosophila) | 0.034 | ||
| GATA4 | GATA binding protein 4 | 0.033 | Mouse | |
| BMP4 | bone morphogenetic protein 4 | 0.033 | ||
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.032 | ||
| SRSF6 | serine/arginine-rich splicing factor 6 | 0.032 | ||
| HSPG2 | heparan sulfate proteoglycan 2 | 0.031 | ||
| SRPK1 | SRSF protein kinase 1 | 0.031 | ||
| PXN | paxillin | 0.031 | ||
| TGFB3 | transforming growth factor, beta 3 | 0.031 | Mouse | |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.030 | ||
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.029 | ||
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.028 | ||
| GPSM2 | G-protein signaling modulator 2 | 0.028 | Mouse | |
| EHMT2 | euchromatic histone-lysine N-methyltransferase 2 | 0.028 | ||
| SKI | v-ski sarcoma viral oncogene homolog (avian) | 0.027 | ||
| EBP | emopamil binding protein (sterol isomerase) | 0.027 | ||
| PLCG1 | phospholipase C, gamma 1 | 0.027 | ||
| PGR | progesterone receptor | 0.026 | ||
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2 | 0.026 | ||
| CACYBP | calcyclin binding protein | 0.026 | ||
| WNT1 | wingless-type MMTV integration site family, member 1 | 0.026 | Human | |
| FSTL1 | follistatin-like 1 | 0.025 | ||
| KLF13 | Kruppel-like factor 13 | 0.025 | ||
| POU5F1 | POU class 5 homeobox 1 | 0.025 | ||
| ARL4D | ADP-ribosylation factor-like 4D | 0.025 | ||
| CREBBP | CREB binding protein | 0.025 | ||
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.025 | ||
| HNF4A | hepatocyte nuclear factor 4, alpha | 0.024 | ||
| GATAD2B | GATA zinc finger domain containing 2B | 0.024 | ||
| NCOA3 | nuclear receptor coactivator 3 | 0.023 | ||
| PRPF38A | PRP38 pre-mRNA processing factor 38 (yeast) domain containing A | 0.022 | ||
| KDR | kinase insert domain receptor (a type III receptor tyrosine kinase) | 0.022 | Mouse | |
| SP1 | Sp1 transcription factor | 0.022 | Mouse | |
| SFRP1 | secreted frizzled-related protein 1 | 0.022 | ||
| FOXF1 | forkhead box F1 | 0.021 | ||
| FGF7 | fibroblast growth factor 7 | 0.021 | ||
| NCOA1 | nuclear receptor coactivator 1 | 0.021 | ||
| SNW1 | SNW domain containing 1 | 0.021 | ||
| LUM | lumican | 0.020 | ||
| CCDC6 | coiled-coil domain containing 6 | 0.020 | ||
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.019 | ||
| TLN1 | talin 1 | 0.019 | ||
| FOXD3 | forkhead box D3 | 0.019 | ||
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.019 | ||
| BRD4 | bromodomain containing 4 | 0.019 | ||
| NRP2 | neuropilin 2 | 0.018 | ||
| RIC8A | resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) | 0.018 | ||
| PURA | purine-rich element binding protein A | 0.018 | ||
| FGF2 | fibroblast growth factor 2 (basic) | 0.018 | Human Mouse | |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.018 | ||
| NCOR1 | nuclear receptor corepressor 1 | 0.018 | ||
| BCAM | basal cell adhesion molecule (Lutheran blood group) | 0.018 | ||
| ZMYND11 | zinc finger, MYND-type containing 11 | 0.018 | ||
| PDGFC | platelet derived growth factor C | 0.018 | ||
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.018 | ||
| FOXF2 | forkhead box F2 | 0.017 | Human | |
| WNT3A | wingless-type MMTV integration site family, member 3A | 0.017 | ||
| PTPRC | protein tyrosine phosphatase, receptor type, C | 0.017 | ||
| LRP1 | low density lipoprotein receptor-related protein 1 | 0.017 | ||
| FCHO2 | FCH domain only 2 | 0.017 | ||
| FGF3 | fibroblast growth factor 3 | 0.017 | Human | |
| SALL2 | sal-like 2 (Drosophila) | 0.017 | ||
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | 0.017 | ||
| MAX | MYC associated factor X | 0.016 | ||
| SFTPC | surfactant protein C | 0.016 | ||
| FOXC2 | forkhead box C2 (MFH-1, mesenchyme forkhead 1) | 0.016 | ||
| TCF4 | transcription factor 4 | 0.016 | ||
| SDC2 | syndecan 2 | 0.016 | ||
| ERBB2IP | erbb2 interacting protein | 0.016 | ||
| MKL1 | megakaryoblastic leukemia (translocation) 1 | 0.016 | ||
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.016 | ||
| CTGF | connective tissue growth factor | 0.016 | Mouse Rat | |
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.015 | ||
| CDH5 | cadherin 5, type 2 (vascular endothelium) | 0.015 | ||
| IL6ST | interleukin 6 signal transducer (gp130, oncostatin M receptor) | 0.015 | ||
| FZD7 | frizzled homolog 7 (Drosophila) | 0.015 | ||
| SOX9 | SRY (sex determining region Y)-box 9 | 0.015 | Mouse | |
| SOX1 | SRY (sex determining region Y)-box 1 | 0.015 | ||
| TBX2 | T-box 2 | 0.015 | ||
| PLEC | plectin | 0.015 | ||
| FZD1 | frizzled homolog 1 (Drosophila) | 0.015 | Rat | |
| MYOD1 | myogenic differentiation 1 | 0.015 | ||
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | 0.015 | ||
| ONECUT1 | one cut homeobox 1 | 0.014 | ||
| MMP11 | matrix metallopeptidase 11 (stromelysin 3) | 0.014 | ||
| SMAD7 | SMAD family member 7 | 0.014 | ||
| TNFRSF1B | tumor necrosis factor receptor superfamily, member 1B | 0.014 | ||
| DLX4 | distal-less homeobox 4 | 0.014 | ||
| CLU | clusterin | 0.014 | ||
| IHH | Indian hedgehog | 0.014 | ||
| SMAD1 | SMAD family member 1 | 0.014 | ||
| TCF12 | transcription factor 12 | 0.013 | ||
| PFN1 | profilin 1 | 0.013 | ||
| EGFR | epidermal growth factor receptor | 0.013 | ||
| RECQL5 | RecQ protein-like 5 | 0.013 | ||
| GLI2 | GLI family zinc finger 2 | 0.013 | Mouse | |
| QARS | glutaminyl-tRNA synthetase | 0.013 | ||
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.013 | Mouse | |
| CDC25A | cell division cycle 25 homolog A (S. pombe) | 0.013 | ||
| NR5A1 | nuclear receptor subfamily 5, group A, member 1 | 0.013 | ||
| INPPL1 | inositol polyphosphate phosphatase-like 1 | 0.013 | ||
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.013 | ||
| SMAD6 | SMAD family member 6 | 0.013 | ||
| SP3 | Sp3 transcription factor | 0.012 | Mouse | |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.012 | Rat | |
| ZIC1 | Zic family member 1 (odd-paired homolog, Drosophila) | 0.012 | Human | |
| POU2F1 | POU class 2 homeobox 1 | 0.012 | ||
| MEF2C | myocyte enhancer factor 2C | 0.012 | ||
| VEZF1 | vascular endothelial zinc finger 1 | 0.012 | ||
| TGFB2 | transforming growth factor, beta 2 | 0.012 | ||
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.012 | ||
| PPARA | peroxisome proliferator-activated receptor alpha | 0.012 | ||
| FADS2 | fatty acid desaturase 2 | 0.012 | ||
| HOXD1 | homeobox D1 | 0.012 | ||
| ST8SIA2 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 | 0.012 | ||
| STC1 | stanniocalcin 1 | 0.012 | ||
| BMP7 | bone morphogenetic protein 7 | 0.012 | ||
| COL13A1 | collagen, type XIII, alpha 1 | 0.012 | ||
| CDC25B | cell division cycle 25 homolog B (S. pombe) | 0.012 | ||
| CSNK1E | casein kinase 1, epsilon | 0.012 | ||
| S100B | S100 calcium binding protein B | 0.012 | ||
| RSPO2 | R-spondin 2 homolog (Xenopus laevis) | 0.012 | Mouse | |
| ITGB5 | integrin, beta 5 | 0.012 | ||
| EGLN3 | egl nine homolog 3 (C. elegans) | 0.012 | ||
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.011 | Mouse | |
| TNK2 | tyrosine kinase, non-receptor, 2 | 0.011 | ||
| GRB7 | growth factor receptor-bound protein 7 | 0.011 | ||
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 0.011 | ||
| BMP1 | bone morphogenetic protein 1 | 0.011 | ||
| MEIS2 | Meis homeobox 2 | 0.011 | ||
| TNRC6A | trinucleotide repeat containing 6A | 0.011 | ||
| FYN | FYN oncogene related to SRC, FGR, YES | 0.011 | ||
| VHL | von Hippel-Lindau tumor suppressor | 0.011 | ||
| HOXB13 | homeobox B13 | 0.011 | ||
| TECPR1 | tectonin beta-propeller repeat containing 1 | 0.011 | ||
| THBS1 | thrombospondin 1 | 0.011 | ||
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.011 | ||
| WNT11 | wingless-type MMTV integration site family, member 11 | 0.011 | ||
| NFIA | nuclear factor I/A | 0.011 | ||
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.011 | ||
| FGFR3 | fibroblast growth factor receptor 3 | 0.011 | Mouse | |
| DMWD | dystrophia myotonica, WD repeat containing | 0.011 | ||
| SRF | serum response factor (c-fos serum response element-binding transcription factor) | 0.011 | Mouse | |
| CD151 | CD151 molecule (Raph blood group) | 0.011 | ||
| MED15 | mediator complex subunit 15 | 0.011 | ||
| TIA1 | TIA1 cytotoxic granule-associated RNA binding protein | 0.011 | ||
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.011 | Rat | |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | 0.011 | ||
| CACNA1G | calcium channel, voltage-dependent, T type, alpha 1G subunit | 0.011 | ||
| ESR1 | estrogen receptor 1 | 0.011 | ||
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | 0.010 | ||
| STK36 | serine/threonine kinase 36 | 0.010 | ||
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.010 | ||
| COL6A1 | collagen, type VI, alpha 1 | 0.010 | ||
| MAPK8 | mitogen-activated protein kinase 8 | 0.010 | ||
| SHB | Src homology 2 domain containing adaptor protein B | 0.010 | ||
| SLC9A3R2 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 | 0.010 | ||
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.010 | Mouse | |
| BIN1 | bridging integrator 1 | 0.010 | ||
| CYP26A1 | cytochrome P450, family 26, subfamily A, polypeptide 1 | 0.010 | ||
| FGF19 | fibroblast growth factor 19 | 0.010 | ||
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.010 | ||
| CCNL1 | cyclin L1 | 0.010 | ||
| ALX4 | ALX homeobox 4 | 0.010 | ||
| TCF3 | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) | 0.010 |