IMP: Integrative Multi-species Prediction

Homo sapiens

31 genes annotated in human

cellular amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular amino acid catabolic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "cellular amino acid catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
GGT1	gamma-glutamyltransferase 1	0.940
HADH	hydroxyacyl-CoA dehydrogenase	0.908
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.903
NOSTRIN	nitric oxide synthase trafficker	0.903
TUBGCP4	tubulin, gamma complex associated protein 4	0.822
ALDOB	aldolase B, fructose-bisphosphate	0.622
XIAP	X-linked inhibitor of apoptosis	0.518
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.504
C21orf33	chromosome 21 open reading frame 33	0.499
YARS	tyrosyl-tRNA synthetase	0.394
GCDH	glutaryl-CoA dehydrogenase	0.381
AARS	alanyl-tRNA synthetase	0.326
GGTLC1	gamma-glutamyltransferase light chain 1	0.317	Human
VAC14	Vac14 homolog (S. cerevisiae)	0.303
BCKDHB	branched chain keto acid dehydrogenase E1, beta polypeptide	0.265
MARS	methionyl-tRNA synthetase	0.204
TOM1L1	target of myb1 (chicken)-like 1	0.196
MCCC1	methylcrotonoyl-CoA carboxylase 1 (alpha)	0.190
GARS	glycyl-tRNA synthetase	0.171
GOT1	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	0.153
PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	0.133
EIF4EBP1	eukaryotic translation initiation factor 4E binding protein 1	0.116
EPT1	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)	0.097
GLUD1	glutamate dehydrogenase 1	0.088
GGT2	gamma-glutamyltransferase 2	0.088	Human
ACADSB	acyl-CoA dehydrogenase, short/branched chain	0.083
GLUD2	glutamate dehydrogenase 2	0.075
HIBADH	3-hydroxyisobutyrate dehydrogenase	0.074
AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	0.073
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.072
PHGDH	phosphoglycerate dehydrogenase	0.067
MAP2K5	mitogen-activated protein kinase kinase 5	0.063
ASNS	asparagine synthetase (glutamine-hydrolyzing)	0.062
LONP1	lon peptidase 1, mitochondrial	0.061
ALDH6A1	aldehyde dehydrogenase 6 family, member A1	0.060
TMEM106B	transmembrane protein 106B	0.058
DNAJA3	DnaJ (Hsp40) homolog, subfamily A, member 3	0.054
DLG2	discs, large homolog 2 (Drosophila)	0.052
GART	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	0.052
ALDH4A1	aldehyde dehydrogenase 4 family, member A1	0.051	Yeast
BCKDHA	branched chain keto acid dehydrogenase E1, alpha polypeptide	0.048
GPI	glucose-6-phosphate isomerase	0.048
NNT	nicotinamide nucleotide transhydrogenase	0.047
SARS	seryl-tRNA synthetase	0.044
IARS	isoleucyl-tRNA synthetase	0.041
PSAT1	phosphoserine aminotransferase 1	0.039
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	0.031
SLC25A15	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	0.031
CARS	cysteinyl-tRNA synthetase	0.030
AHCY	adenosylhomocysteinase	0.030
ALDH3A2	aldehyde dehydrogenase 3 family, member A2	0.030
TMEM97	transmembrane protein 97	0.029
CPT2	carnitine palmitoyltransferase 2	0.029
ECI2	enoyl-CoA delta isomerase 2	0.028
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.028
DHTKD1	dehydrogenase E1 and transketolase domain containing 1	0.027
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.027
PHYH	phytanoyl-CoA 2-hydroxylase	0.026
COQ9	coenzyme Q9 homolog (S. cerevisiae)	0.026
ATP5B	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	0.025
SORD	sorbitol dehydrogenase	0.025
NOS1AP	nitric oxide synthase 1 (neuronal) adaptor protein	0.025
HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	0.025
ECH1	enoyl CoA hydratase 1, peroxisomal	0.025
SLC22A7	solute carrier family 22 (organic anion transporter), member 7	0.025
MASP2	mannan-binding lectin serine peptidase 2	0.024
NDUFS1	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	0.024
SUCLG2	succinate-CoA ligase, GDP-forming, beta subunit	0.024
HAX1	HCLS1 associated protein X-1	0.024
CAT	catalase	0.024
DCXR	dicarbonyl/L-xylulose reductase	0.023
PCCB	propionyl CoA carboxylase, beta polypeptide	0.023
PDHA1	pyruvate dehydrogenase (lipoamide) alpha 1	0.023
PCYOX1	prenylcysteine oxidase 1	0.022	Mouse
IVD	isovaleryl-CoA dehydrogenase	0.022	Rat
APOC2	apolipoprotein C-II	0.022
SLC37A4	solute carrier family 37 (glucose-6-phosphate transporter), member 4	0.022
CA5A	carbonic anhydrase VA, mitochondrial	0.020
SUOX	sulfite oxidase	0.020
ALDH1L1	aldehyde dehydrogenase 1 family, member L1	0.019
SLC28A1	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	0.019
PEBP1	phosphatidylethanolamine binding protein 1	0.019
SHMT1	serine hydroxymethyltransferase 1 (soluble)	0.018
PC	pyruvate carboxylase	0.018
AFG3L2	AFG3 ATPase family gene 3-like 2 (S. cerevisiae)	0.018
ACAD8	acyl-CoA dehydrogenase family, member 8	0.018
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.018
BDH1	3-hydroxybutyrate dehydrogenase, type 1	0.017
ACADS	acyl-CoA dehydrogenase, C-2 to C-3 short chain	0.017
PON1	paraoxonase 1	0.017
PNPO	pyridoxamine 5'-phosphate oxidase	0.017
BHMT	betaine--homocysteine S-methyltransferase	0.016
SUPV3L1	suppressor of var1, 3-like 1 (S. cerevisiae)	0.016
EPHX2	epoxide hydrolase 2, cytoplasmic	0.015
NAMPT	nicotinamide phosphoribosyltransferase	0.015
HAAO	3-hydroxyanthranilate 3,4-dioxygenase	0.015
ABCC6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	0.015
BRE	brain and reproductive organ-expressed (TNFRSF1A modulator)	0.015
MCCC2	methylcrotonoyl-CoA carboxylase 2 (beta)	0.015
TRAP1	TNF receptor-associated protein 1	0.015
MBNL1	muscleblind-like (Drosophila)	0.014
HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	0.014
CTH	cystathionase (cystathionine gamma-lyase)	0.014
GPD1L	glycerol-3-phosphate dehydrogenase 1-like	0.014
SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.014
BTD	biotinidase	0.014
ELAVL3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.014
IDH2	isocitrate dehydrogenase 2 (NADP+), mitochondrial	0.014
TIMM44	translocase of inner mitochondrial membrane 44 homolog (yeast)	0.014
MRPS2	mitochondrial ribosomal protein S2	0.014
AUH	AU RNA binding protein/enoyl-CoA hydratase	0.014
MBL2	mannose-binding lectin (protein C) 2, soluble	0.014
EPRS	glutamyl-prolyl-tRNA synthetase	0.014
GCAT	glycine C-acetyltransferase	0.013
APEH	N-acylaminoacyl-peptide hydrolase	0.013
ATP5SL	ATP5S-like	0.013
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.013
PLG	plasminogen	0.013
C9orf5	chromosome 9 open reading frame 5	0.013
NIPSNAP1	nipsnap homolog 1 (C. elegans)	0.013
SEPT11	septin 11	0.013
GPT2	glutamic pyruvate transaminase (alanine aminotransferase) 2	0.013
C10orf57	chromosome 10 open reading frame 57	0.013
ACO2	aconitase 2, mitochondrial	0.013
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.013
ATF2	activating transcription factor 2	0.013
SFXN2	sideroflexin 2	0.013
SLC16A1	solute carrier family 16, member 1 (monocarboxylic acid transporter 1)	0.013
PAH	phenylalanine hydroxylase	0.013	Fly
COX15	COX15 homolog, cytochrome c oxidase assembly protein (yeast)	0.013
ARG1	arginase, liver	0.013	Rat
HSD17B8	hydroxysteroid (17-beta) dehydrogenase 8	0.013
HGD	homogentisate 1,2-dioxygenase	0.013
MAT1A	methionine adenosyltransferase I, alpha	0.013
MECR	mitochondrial trans-2-enoyl-CoA reductase	0.012
AGXT	alanine-glyoxylate aminotransferase	0.012
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.012
TARS2	threonyl-tRNA synthetase 2, mitochondrial (putative)	0.012
C8B	complement component 8, beta polypeptide	0.012
METTL7A	methyltransferase like 7A	0.012
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.012
ALDH5A1	aldehyde dehydrogenase 5 family, member A1	0.012
ATRN	attractin	0.012
ORM1	orosomucoid 1	0.012
VDAC1	voltage-dependent anion channel 1	0.012
MDH2	malate dehydrogenase 2, NAD (mitochondrial)	0.012
C17orf28	chromosome 17 open reading frame 28	0.012
ALAD	aminolevulinate dehydratase	0.012
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.012
SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.011
OTC	ornithine carbamoyltransferase	0.011
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.011
TM7SF2	transmembrane 7 superfamily member 2	0.011
MTHFD1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.011
FOXRED1	FAD-dependent oxidoreductase domain containing 1	0.011
PIPOX	pipecolic acid oxidase	0.011
MLEC	malectin	0.011
MS4A2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.011
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.011
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.011
GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	0.011	Yeast
ALPI	alkaline phosphatase, intestinal	0.011
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.011
APOA5	apolipoprotein A-V	0.011
DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	0.011	Human
GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.011
G6PC	glucose-6-phosphatase, catalytic subunit	0.011
TRAPPC6A	trafficking protein particle complex 6A	0.011
AZGP1	alpha-2-glycoprotein 1, zinc-binding	0.011
HAL	histidine ammonia-lyase	0.011
MIPEP	mitochondrial intermediate peptidase	0.011
C9	complement component 9	0.011
SSTR2	somatostatin receptor 2	0.011
AK3	adenylate kinase 3	0.011
PEX7	peroxisomal biogenesis factor 7	0.010
FXN	frataxin	0.010
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.010
DPYS	dihydropyrimidinase	0.010
AKAP1	A kinase (PRKA) anchor protein 1	0.010
POP1	processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)	0.010
ASGR2	asialoglycoprotein receptor 2	0.010
HNF4A	hepatocyte nuclear factor 4, alpha	0.010
CBS	cystathionine-beta-synthase	0.010
RETSAT	retinol saturase (all-trans-retinol 13,14-reductase)	0.010
ACOX1	acyl-CoA oxidase 1, palmitoyl	0.010
IL17RC	interleukin 17 receptor C	0.010
DHODH	dihydroorotate dehydrogenase	0.010
ALDOA	aldolase A, fructose-bisphosphate	0.010
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.010
HSPA9	heat shock 70kDa protein 9 (mortalin)	0.010
TSFM	Ts translation elongation factor, mitochondrial	0.010
TAT	tyrosine aminotransferase	0.010
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.010