IMP: Integrative Multi-species Prediction

Homo sapiens

32 genes annotated in human

centrosome cycle

The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "centrosome cycle"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "centrosome cycle" (in gray)

Name	Description	Probability	Func Analog Organism
CENPJ	centromere protein J	0.826
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.795	Fly
RPL17	ribosomal protein L17	0.721	Fly
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.582
RPL21	ribosomal protein L21	0.582	Fly
RPL5	ribosomal protein L5	0.554
RPS10	ribosomal protein S10	0.550
RPL12	ribosomal protein L12	0.549
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.535
BRCA1	breast cancer 1, early onset	0.522	Mouse
RPL19	ribosomal protein L19	0.521	Fly
TOPBP1	topoisomerase (DNA) II binding protein 1	0.490
FBXW11	F-box and WD repeat domain containing 11	0.477	Fly
RPLP0	ribosomal protein, large, P0	0.450
RAN	RAN, member RAS oncogene family	0.432
CP110	CP110 protein	0.415
CUL1	cullin 1	0.407
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.404
SKA1	spindle and kinetochore associated complex subunit 1	0.375
APC	adenomatous polyposis coli	0.357
STIL	SCL/TAL1 interrupting locus	0.354
E2F1	E2F transcription factor 1	0.328
RPL27A	ribosomal protein L27a	0.324
SASS6	spindle assembly 6 homolog (C. elegans)	0.322
RPS3	ribosomal protein S3	0.284
PLK1	polo-like kinase 1	0.276	Human Worm
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.269	Fly
RPL6	ribosomal protein L6	0.265
BTRC	beta-transducin repeat containing	0.256	Fly
RB1	retinoblastoma 1	0.239
LIN9	lin-9 homolog (C. elegans)	0.233
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.232	Worm Fly
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.225	Fly
RPS3A	ribosomal protein S3A	0.225
RPL32	ribosomal protein L32	0.215
NEURL4	neuralized homolog 4 (Drosophila)	0.211
RPL7	ribosomal protein L7	0.192	Fly
CCNA2	cyclin A2	0.184
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.182
RPL8	ribosomal protein L8	0.174
WEE1	WEE1 homolog (S. pombe)	0.173	Fly
KIF23	kinesin family member 23	0.171	Fly
EEF1B2	eukaryotic translation elongation factor 1 beta 2	0.163
CCNB1	cyclin B1	0.158
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.146
RPL30	ribosomal protein L30	0.138	Fly
SKP1	S-phase kinase-associated protein 1	0.135	Fly
RPL10	ribosomal protein L10	0.135
CEP135	centrosomal protein 135kDa	0.128
RPL24	ribosomal protein L24	0.125	Fly
NCL	nucleolin	0.120
RPL15	ribosomal protein L15	0.118
DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.116
RPL7A	ribosomal protein L7a	0.115	Fly
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.115
AURKA	aurora kinase A	0.105	Mouse
EEF1G	eukaryotic translation elongation factor 1 gamma	0.103
CENPF	centromere protein F, 350/400kDa (mitosin)	0.103
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.102	Fly
AURKB	aurora kinase B	0.100	Fly
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.098
RANBP2	RAN binding protein 2	0.095
NLK	nemo-like kinase	0.094
RPLP1	ribosomal protein, large, P1	0.094
TCP1	t-complex 1	0.094
RPS17	ribosomal protein S17	0.093
RPL4	ribosomal protein L4	0.092	Fly
RPS6	ribosomal protein S6	0.092
GTSE1	G-2 and S-phase expressed 1	0.091
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.089
TUBGCP3	tubulin, gamma complex associated protein 3	0.085
RPL34	ribosomal protein L34	0.083
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.080
FOXM1	forkhead box M1	0.076
SKP2	S-phase kinase-associated protein 2 (p45)	0.074
CKAP5	cytoskeleton associated protein 5	0.074
RPL22	ribosomal protein L22	0.071
RPL23	ribosomal protein L23	0.071
PLK4	polo-like kinase 4	0.069
RPL29	ribosomal protein L29	0.067
RPL31	ribosomal protein L31	0.064
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.063
RPL10A	ribosomal protein L10a	0.062	Fly
RPL35	ribosomal protein L35	0.061	Fly
ATAD2	ATPase family, AAA domain containing 2	0.059
FBXO5	F-box protein 5	0.057
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.057
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.054
RPS21	ribosomal protein S21	0.053
EEF2	eukaryotic translation elongation factor 2	0.052
RPL18	ribosomal protein L18	0.051
TSG101	tumor susceptibility gene 101	0.049
RPL23A	ribosomal protein L23a	0.049	Fly
TACC3	transforming, acidic coiled-coil containing protein 3	0.049
KIF1B	kinesin family member 1B	0.049
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.048
RPS20	ribosomal protein S20	0.048
XPO1	exportin 1 (CRM1 homolog, yeast)	0.048	Mouse Fly
TOP1	topoisomerase (DNA) I	0.047
CLIP1	CAP-GLY domain containing linker protein 1	0.047
CENPE	centromere protein E, 312kDa	0.047
SMC4	structural maintenance of chromosomes 4	0.042
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.042	Worm Fly
KIAA1279	KIAA1279	0.042
APTX	aprataxin	0.042
RPL41	ribosomal protein L41	0.041
KPNB1	karyopherin (importin) beta 1	0.040
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.040
STARD9	StAR-related lipid transfer (START) domain containing 9	0.040
RAD51AP1	RAD51 associated protein 1	0.040
NUP153	nucleoporin 153kDa	0.039	Fly
TTK	TTK protein kinase	0.038
WDYHV1	WDYHV motif containing 1	0.037
ECT2	epithelial cell transforming sequence 2 oncogene	0.036
CDK1	cyclin-dependent kinase 1	0.036
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.036
CEP97	centrosomal protein 97kDa	0.035
YBX1	Y box binding protein 1	0.035
KIF2C	kinesin family member 2C	0.035	Fly
RAD21	RAD21 homolog (S. pombe)	0.035
NCAPG	non-SMC condensin I complex, subunit G	0.035
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.035
SMC3	structural maintenance of chromosomes 3	0.034
SIK2	salt-inducible kinase 2	0.034
UBE2A	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	0.034	Fly
CTNNBIP1	catenin, beta interacting protein 1	0.033
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.033	Mouse
TJP1	tight junction protein 1 (zona occludens 1)	0.033
RPL14	ribosomal protein L14	0.033	Fly
HDAC2	histone deacetylase 2	0.032
CCNF	cyclin F	0.032
YAP1	Yes-associated protein 1	0.032
HSPH1	heat shock 105kDa/110kDa protein 1	0.031
C13orf34	chromosome 13 open reading frame 34	0.031
NUP50	nucleoporin 50kDa	0.031
HAUS6	HAUS augmin-like complex, subunit 6	0.030
FRYL	FRY-like	0.030
USP24	ubiquitin specific peptidase 24	0.030
NEDD1	neural precursor cell expressed, developmentally down-regulated 1	0.030	Fly
CENPA	centromere protein A	0.030
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.029
ZFR	zinc finger RNA binding protein	0.029
RECQL4	RecQ protein-like 4	0.029
CDK2	cyclin-dependent kinase 2	0.029
GSK3B	glycogen synthase kinase 3 beta	0.029
CDCA4	cell division cycle associated 4	0.029
FBF1	Fas (TNFRSF6) binding factor 1	0.029
SDSL	serine dehydratase-like	0.029
LIN54	lin-54 homolog (C. elegans)	0.029
BID	BH3 interacting domain death agonist	0.028
AHSA1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	0.028
TROAP	trophinin associated protein (tastin)	0.028
TP53	tumor protein p53	0.028
TRIM37	tripartite motif containing 37	0.027
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.027
MASTL	microtubule associated serine/threonine kinase-like	0.027
DNAJB11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.026
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.026
BIRC5	baculoviral IAP repeat containing 5	0.026
RPL3	ribosomal protein L3	0.026	Fly
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.026
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.024
SPAG5	sperm associated antigen 5	0.024
TBK1	TANK-binding kinase 1	0.024
ZFYVE9	zinc finger, FYVE domain containing 9	0.024
TPR	translocated promoter region (to activated MET oncogene)	0.024
RPS19	ribosomal protein S19	0.024
MPHOSPH9	M-phase phosphoprotein 9	0.023
RAD51C	RAD51 homolog C (S. cerevisiae)	0.023
KIF4A	kinesin family member 4A	0.023
E2F3	E2F transcription factor 3	0.023
SGOL2	shugoshin-like 2 (S. pombe)	0.023
PSRC1	proline/serine-rich coiled-coil 1	0.023
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.023	Fly
KIF18A	kinesin family member 18A	0.023	Fly
NACA	nascent polypeptide-associated complex alpha subunit	0.023
TRAIP	TRAF interacting protein	0.022
SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.022
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.022
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.021
ESPL1	extra spindle pole bodies homolog 1 (S. cerevisiae)	0.021
TSC2	tuberous sclerosis 2	0.021
DSP	desmoplakin	0.021
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.020
RPS9	ribosomal protein S9	0.020
XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	0.020
DCK	deoxycytidine kinase	0.020
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.020
CENPQ	centromere protein Q	0.020
PPP5C	protein phosphatase 5, catalytic subunit	0.019
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.019
HSPA8	heat shock 70kDa protein 8	0.019
RPS4X	ribosomal protein S4, X-linked	0.019	Fly
RPL36A	ribosomal protein L36a	0.019
MIS18BP1	MIS18 binding protein 1	0.019
KIF20A	kinesin family member 20A	0.019
HDAC1	histone deacetylase 1	0.019
RPL9	ribosomal protein L9	0.018	Fly
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.018
KCNE3	potassium voltage-gated channel, Isk-related family, member 3	0.018
C19orf39	chromosome 19 open reading frame 39	0.018
BAZ1A	bromodomain adjacent to zinc finger domain, 1A	0.018
BAD	BCL2-associated agonist of cell death	0.018
CASP8AP2	caspase 8 associated protein 2	0.018
PRC1	protein regulator of cytokinesis 1	0.018	Fly
MKI67	antigen identified by monoclonal antibody Ki-67	0.018
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.018
STRN3	striatin, calmodulin binding protein 3	0.018
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.018
PRNP	prion protein	0.017
FANCL	Fanconi anemia, complementation group L	0.017
PBK	PDZ binding kinase	0.017
PDE6D	phosphodiesterase 6D, cGMP-specific, rod, delta	0.017
RHOA	ras homolog gene family, member A	0.017
RPS16	ribosomal protein S16	0.017
INCENP	inner centromere protein antigens 135/155kDa	0.017
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.017
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.017
HJURP	Holliday junction recognition protein	0.017
HSPA1B	heat shock 70kDa protein 1B	0.016
CDT1	chromatin licensing and DNA replication factor 1	0.016	Fly
CCT6A	chaperonin containing TCP1, subunit 6A (zeta 1)	0.016
RPL37	ribosomal protein L37	0.016
TUBB3	tubulin, beta 3	0.016
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.016
WHSC1	Wolf-Hirschhorn syndrome candidate 1	0.016
ORC1	origin recognition complex, subunit 1	0.016
TFDP1	transcription factor Dp-1	0.016
CRY1	cryptochrome 1 (photolyase-like)	0.016
KIF11	kinesin family member 11	0.016	Mouse Fly
GPSM2	G-protein signaling modulator 2	0.016
NUP54	nucleoporin 54kDa	0.016
RAD54L	RAD54-like (S. cerevisiae)	0.016
KNTC1	kinetochore associated 1	0.016
HEMGN	hemogen	0.016
ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	0.016
RPS18	ribosomal protein S18	0.016
CEP76	centrosomal protein 76kDa	0.016
TMEM194A	transmembrane protein 194A	0.015
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.015
MDM1	Mdm1 nuclear protein homolog (mouse)	0.015
RPS2	ribosomal protein S2	0.015
KIF15	kinesin family member 15	0.015
MPRIP	myosin phosphatase Rho interacting protein	0.015
CKS2	CDC28 protein kinase regulatory subunit 2	0.015
ARL3	ADP-ribosylation factor-like 3	0.015
GAPVD1	GTPase activating protein and VPS9 domains 1	0.015
ARIH1	ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)	0.015
WDHD1	WD repeat and HMG-box DNA binding protein 1	0.014
KIF2A	kinesin heavy chain member 2A	0.014	Fly
EEF1A1	eukaryotic translation elongation factor 1 alpha 1	0.014
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.014
CDC34	cell division cycle 34 homolog (S. cerevisiae)	0.014
EIF3G	eukaryotic translation initiation factor 3, subunit G	0.014
EIF3D	eukaryotic translation initiation factor 3, subunit D	0.014
SRP14	signal recognition particle 14kDa (homologous Alu RNA binding protein)	0.014
USP37	ubiquitin specific peptidase 37	0.014
SERTAD4	SERTA domain containing 4	0.014
FMR1	fragile X mental retardation 1	0.014
G3BP2	GTPase activating protein (SH3 domain) binding protein 2	0.014
STAU1	staufen, RNA binding protein, homolog 1 (Drosophila)	0.014
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.014
C5orf34	chromosome 5 open reading frame 34	0.014
CRELD2	cysteine-rich with EGF-like domains 2	0.014
CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.014
LIG1	ligase I, DNA, ATP-dependent	0.014
METTL4	methyltransferase like 4	0.014
ARL15	ADP-ribosylation factor-like 15	0.013
C10orf137	chromosome 10 open reading frame 137	0.013
SMC6	structural maintenance of chromosomes 6	0.013
CEP55	centrosomal protein 55kDa	0.013
CNOT6	CCR4-NOT transcription complex, subunit 6	0.013
KIF22	kinesin family member 22	0.013
UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	0.013	Fly
SIAH1	seven in absentia homolog 1 (Drosophila)	0.013
RPS28	ribosomal protein S28	0.013
TRIM39	tripartite motif containing 39	0.013
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.013
TAF1A	TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa	0.013
RNF126	ring finger protein 126	0.013
PELP1	proline, glutamate and leucine rich protein 1	0.013
MARK3	MAP/microtubule affinity-regulating kinase 3	0.013
EEF2K	eukaryotic elongation factor-2 kinase	0.013
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.013
CDKN3	cyclin-dependent kinase inhibitor 3	0.013
MED21	mediator complex subunit 21	0.012
RPS7	ribosomal protein S7	0.012
TP53BP2	tumor protein p53 binding protein, 2	0.012
KIAA0930	KIAA0930	0.012
DNA2	DNA replication helicase 2 homolog (yeast)	0.012
FBXW2	F-box and WD repeat domain containing 2	0.012
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.012
UBE2S	ubiquitin-conjugating enzyme E2S	0.012
CCDC99	coiled-coil domain containing 99	0.012
ZMYND11	zinc finger, MYND-type containing 11	0.012
RPL36	ribosomal protein L36	0.012
CDCA8	cell division cycle associated 8	0.012
ESR2	estrogen receptor 2 (ER beta)	0.012
MFAP1	microfibrillar-associated protein 1	0.012
DEK	DEK oncogene	0.012
RPL13	ribosomal protein L13	0.012	Fly
KLC1	kinesin light chain 1	0.012
CLSPN	claspin	0.012
FBXO33	F-box protein 33	0.012
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	0.012
C16orf59	chromosome 16 open reading frame 59	0.012
E2F2	E2F transcription factor 2	0.012
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.012	Worm Fly
GADD45GIP1	growth arrest and DNA-damage-inducible, gamma interacting protein 1	0.012
GEN1	Gen homolog 1, endonuclease (Drosophila)	0.012
SNW1	SNW domain containing 1	0.011
MIB1	mindbomb homolog 1 (Drosophila)	0.011
SELENBP1	selenium binding protein 1	0.011
G2E3	G2/M-phase specific E3 ubiquitin protein ligase	0.011
MTUS2	microtubule associated tumor suppressor candidate 2	0.011
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.011
KIF14	kinesin family member 14	0.011
WDR67	WD repeat domain 67	0.011
PPP1R2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.011
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.011
KIAA1731	KIAA1731	0.011
PUM1	pumilio homolog 1 (Drosophila)	0.011
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.011
BAG2	BCL2-associated athanogene 2	0.011
GABPB1	GA binding protein transcription factor, beta subunit 1	0.011
AZIN1	antizyme inhibitor 1	0.011
C18orf54	chromosome 18 open reading frame 54	0.011
RNF11	ring finger protein 11	0.011
CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.011
UBE2C	ubiquitin-conjugating enzyme E2C	0.011
ANKRD28	ankyrin repeat domain 28	0.011
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.011
IGF1R	insulin-like growth factor 1 receptor	0.011
ACYP1	acylphosphatase 1, erythrocyte (common) type	0.010
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.010
DEPDC1	DEP domain containing 1	0.010
CHIC2	cysteine-rich hydrophobic domain 2	0.010
ZMYM4	zinc finger, MYM-type 4	0.010
SMCHD1	structural maintenance of chromosomes flexible hinge domain containing 1	0.010
POLQ	polymerase (DNA directed), theta	0.010
TADA2A	transcriptional adaptor 2A	0.010
HMGB2	high mobility group box 2	0.010
RPS27A	ribosomal protein S27a	0.010
CCDC77	coiled-coil domain containing 77	0.010
MYO10	myosin X	0.010
SENP2	SUMO1/sentrin/SMT3 specific peptidase 2	0.010
HDAC7	histone deacetylase 7	0.010
ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	0.010
RAB21	RAB21, member RAS oncogene family	0.010
RNF38	ring finger protein 38	0.010
SRSF10	serine/arginine-rich splicing factor 10	0.010