IMP: Integrative Multi-species Prediction

Homo sapiens

7 genes annotated in human

mitotic g2 dna damage checkpoint

A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "mitotic g2 dna damage checkpoint"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "mitotic g2 dna damage checkpoint" (in gray)

Name	Description	Probability	Func Analog Organism
BRCA1	breast cancer 1, early onset	0.924
PARP1	poly (ADP-ribose) polymerase 1	0.803
CDK2	cyclin-dependent kinase 2	0.788
RB1	retinoblastoma 1	0.776
TP53	tumor protein p53	0.666
PCNA	proliferating cell nuclear antigen	0.535
E2F1	E2F transcription factor 1	0.458
H2AFX	H2A histone family, member X	0.385
CDK8	cyclin-dependent kinase 8	0.286	Fly
NBN	nibrin	0.240
CUL1	cullin 1	0.207	Fly
EME1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.185
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.145	Mouse Fly
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.123
MSH6	mutS homolog 6 (E. coli)	0.090
RBL1	retinoblastoma-like 1 (p107)	0.089	Fly
SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	0.088
RAD50	RAD50 homolog (S. cerevisiae)	0.083
TOPBP1	topoisomerase (DNA) II binding protein 1	0.083	Fly
RBBP8	retinoblastoma binding protein 8	0.081
MCM2	minichromosome maintenance complex component 2	0.080
MED1	mediator complex subunit 1	0.080
CNOT6	CCR4-NOT transcription complex, subunit 6	0.066
COPS6	COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)	0.053	Fly
CCNA2	cyclin A2	0.048
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.047
MDC1	mediator of DNA-damage checkpoint 1	0.047
HDAC1	histone deacetylase 1	0.045
COPS8	COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)	0.044
CSNK2B	casein kinase 2, beta polypeptide	0.043
MED13	mediator complex subunit 13	0.042
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.042
FANCD2	Fanconi anemia, complementation group D2	0.042
MED10	mediator complex subunit 10	0.041
DDB1	damage-specific DNA binding protein 1, 127kDa	0.037
COPS5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.037	Fly
ORC2	origin recognition complex, subunit 2	0.036
RPA2	replication protein A2, 32kDa	0.035
CNOT1	CCR4-NOT transcription complex, subunit 1	0.034
PPP2R5B	protein phosphatase 2, regulatory subunit B', beta	0.032
TFDP1	transcription factor Dp-1	0.031
GPI	glucose-6-phosphate isomerase	0.031
MCM6	minichromosome maintenance complex component 6	0.030
FOXM1	forkhead box M1	0.029
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.029
ATM	ataxia telangiectasia mutated	0.028
CUL4A	cullin 4A	0.028
BTG1	B-cell translocation gene 1, anti-proliferative	0.028
MED28	mediator complex subunit 28	0.026
UBXN7	UBX domain protein 7	0.025
MED23	mediator complex subunit 23	0.025
MCM7	minichromosome maintenance complex component 7	0.024	Fly
UBA1	ubiquitin-like modifier activating enzyme 1	0.023
CNOT8	CCR4-NOT transcription complex, subunit 8	0.023	Fly
WRN	Werner syndrome, RecQ helicase-like	0.023
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.022
MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	0.022
MYBL2	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	0.021
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.021
RBL2	retinoblastoma-like 2 (p130)	0.020	Fly
RFWD2	ring finger and WD repeat domain 2	0.019
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.019
COPS4	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)	0.019	Fly
MED29	mediator complex subunit 29	0.019
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.018
CNOT3	CCR4-NOT transcription complex, subunit 3	0.018
MED26	mediator complex subunit 26	0.018
PRMT1	protein arginine methyltransferase 1	0.018
E2F4	E2F transcription factor 4, p107/p130-binding	0.018
MED4	mediator complex subunit 4	0.017
COPS7A	COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)	0.017	Fly
ATR	ataxia telangiectasia and Rad3 related	0.017	Fly
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.017
HDGF	hepatoma-derived growth factor	0.016
CCNC	cyclin C	0.016	Fly
UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	0.016
CCNE1	cyclin E1	0.015
BLM	Bloom syndrome, RecQ helicase-like	0.014
FBXO11	F-box protein 11	0.014
SIRT1	sirtuin 1	0.014
TPI1	triosephosphate isomerase 1	0.014
MCM5	minichromosome maintenance complex component 5	0.014
TP53BP1	tumor protein p53 binding protein 1	0.013
PGK1	phosphoglycerate kinase 1	0.013
GPS1	G protein pathway suppressor 1	0.012	Fly
CDT1	chromatin licensing and DNA replication factor 1	0.012
NEDD8	neural precursor cell expressed, developmentally down-regulated 8	0.012
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.012
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.012
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.011
CDK1	cyclin-dependent kinase 1	0.011	Mouse Fly
SKP2	S-phase kinase-associated protein 2 (p45)	0.011
RECQL	RecQ protein-like (DNA helicase Q1-like)	0.011
CNOT7	CCR4-NOT transcription complex, subunit 7	0.011	Fly
PKM2	pyruvate kinase, muscle	0.011
CNOT6L	CCR4-NOT transcription complex, subunit 6-like	0.011
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.010	Zebrafish
CUL3	cullin 3	0.010