IMP
Process View
metaphase anaphase transition of mitotic cell cycle
The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
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Click on a gene's description to view its network relationships with genes known to be involved in "metaphase anaphase transition of mitotic cell cycle"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| CDC20 | cell division cycle 20 homolog (S. cerevisiae) | 1.000 | Yeast Worm Fly | |
| CDC27 | cell division cycle 27 homolog (S. cerevisiae) | 1.000 | ||
| BUB1B | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 0.999 | Mouse Fly | |
| ANAPC4 | anaphase promoting complex subunit 4 | 0.994 | ||
| CDK2 | cyclin-dependent kinase 2 | 0.991 | ||
| CDC16 | cell division cycle 16 homolog (S. cerevisiae) | 0.984 | Fly | |
| ANAPC5 | anaphase promoting complex subunit 5 | 0.962 | ||
| CCNA2 | cyclin A2 | 0.937 | ||
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 0.931 | ||
| CCNB1 | cyclin B1 | 0.900 | ||
| POMP | proteasome maturation protein | 0.654 | ||
| ANAPC7 | anaphase promoting complex subunit 7 | 0.654 | ||
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | 0.634 | ||
| SMC6 | structural maintenance of chromosomes 6 | 0.570 | ||
| BUB1 | budding uninhibited by benzimidazoles 1 homolog (yeast) | 0.534 | Fly | |
| CDC26 | cell division cycle 26 homolog (S. cerevisiae) | 0.420 | ||
| CBX5 | chromobox homolog 5 | 0.420 | ||
| ANAPC11 | anaphase promoting complex subunit 11 | 0.401 | ||
| CDC23 | cell division cycle 23 homolog (S. cerevisiae) | 0.339 | ||
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.330 | ||
| NSMCE1 | non-SMC element 1 homolog (S. cerevisiae) | 0.317 | ||
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | 0.301 | ||
| RBL1 | retinoblastoma-like 1 (p107) | 0.284 | Human | |
| AURKB | aurora kinase B | 0.275 | ||
| SMC3 | structural maintenance of chromosomes 3 | 0.264 | ||
| CD44 | CD44 molecule (Indian blood group) | 0.261 | ||
| MAD2L2 | MAD2 mitotic arrest deficient-like 2 (yeast) | 0.217 | ||
| PSMD4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 0.216 | ||
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 0.204 | ||
| PPP1CA | protein phosphatase 1, catalytic subunit, alpha isozyme | 0.204 | ||
| CKS1B | CDC28 protein kinase regulatory subunit 1B | 0.177 | ||
| TFDP1 | transcription factor Dp-1 | 0.159 | ||
| PAG1 | phosphoprotein associated with glycosphingolipid microdomains 1 | 0.152 | ||
| RAD21 | RAD21 homolog (S. pombe) | 0.144 | ||
| CCNB2 | cyclin B2 | 0.139 | ||
| PTTG1 | pituitary tumor-transforming 1 | 0.136 | ||
| ANAPC1 | anaphase promoting complex subunit 1 | 0.133 | Worm | |
| RB1 | retinoblastoma 1 | 0.128 | ||
| STAG1 | stromal antigen 1 | 0.127 | ||
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.125 | ||
| CDKN3 | cyclin-dependent kinase inhibitor 3 | 0.122 | ||
| CDT1 | chromatin licensing and DNA replication factor 1 | 0.116 | ||
| SKP2 | S-phase kinase-associated protein 2 (p45) | 0.111 | ||
| PSMC3 | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | 0.104 | ||
| PSMC2 | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | 0.104 | ||
| E2F1 | E2F transcription factor 1 | 0.100 | ||
| CHAF1A | chromatin assembly factor 1, subunit A (p150) | 0.094 | ||
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | 0.081 | ||
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.080 | ||
| PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 0.078 | ||
| PSMD6 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 0.077 | ||
| SLC9A3R1 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | 0.077 | ||
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | 0.076 | ||
| NSMCE4A | non-SMC element 4 homolog A (S. cerevisiae) | 0.071 | ||
| RBBP8 | retinoblastoma binding protein 8 | 0.070 | ||
| FBXO5 | F-box protein 5 | 0.066 | ||
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.065 | ||
| SKA1 | spindle and kinetochore associated complex subunit 1 | 0.065 | ||
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.061 | ||
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 0.061 | ||
| DOT1L | DOT1-like, histone H3 methyltransferase (S. cerevisiae) | 0.059 | ||
| DSN1 | DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) | 0.058 | ||
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 0.057 | ||
| CHEK1 | CHK1 checkpoint homolog (S. pombe) | 0.057 | ||
| ZWINT | ZW10 interactor | 0.055 | ||
| PSMD13 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 | 0.053 | ||
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2 | 0.053 | ||
| NDC80 | NDC80 homolog, kinetochore complex component (S. cerevisiae) | 0.053 | ||
| SKA3 | spindle and kinetochore associated complex subunit 3 | 0.052 | ||
| TTK | TTK protein kinase | 0.049 | Yeast | |
| CASC5 | cancer susceptibility candidate 5 | 0.048 | ||
| MED1 | mediator complex subunit 1 | 0.045 | ||
| PSMC4 | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | 0.045 | ||
| PSMA6 | proteasome (prosome, macropain) subunit, alpha type, 6 | 0.044 | ||
| PRNP | prion protein | 0.044 | ||
| RBL2 | retinoblastoma-like 2 (p130) | 0.043 | Human | |
| BRCA1 | breast cancer 1, early onset | 0.043 | ||
| MYH9 | myosin, heavy chain 9, non-muscle | 0.042 | ||
| CCNE1 | cyclin E1 | 0.041 | Fly | |
| TP53BP1 | tumor protein p53 binding protein 1 | 0.041 | ||
| FEN1 | flap structure-specific endonuclease 1 | 0.040 | ||
| PXN | paxillin | 0.040 | ||
| SMAD2 | SMAD family member 2 | 0.040 | ||
| TBC1D10A | TBC1 domain family, member 10A | 0.039 | ||
| NEK9 | NIMA (never in mitosis gene a)- related kinase 9 | 0.039 | ||
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.039 | ||
| HERC2 | hect domain and RLD 2 | 0.038 | ||
| BUB3 | budding uninhibited by benzimidazoles 3 homolog (yeast) | 0.038 | Worm Fly | |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.036 | ||
| MKI67 | antigen identified by monoclonal antibody Ki-67 | 0.035 | ||
| UHRF1 | ubiquitin-like with PHD and ring finger domains 1 | 0.035 | ||
| SIRT2 | sirtuin 2 | 0.035 | ||
| ANKRD52 | ankyrin repeat domain 52 | 0.034 | ||
| SKA2 | spindle and kinetochore associated complex subunit 2 | 0.034 | ||
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | 0.033 | ||
| TPX2 | TPX2, microtubule-associated, homolog (Xenopus laevis) | 0.033 | ||
| NEK2 | NIMA (never in mitosis gene a)-related kinase 2 | 0.033 | ||
| PPP2R5A | protein phosphatase 2, regulatory subunit B', alpha | 0.033 | ||
| SPC24 | SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) | 0.032 | ||
| INCENP | inner centromere protein antigens 135/155kDa | 0.031 | ||
| KIF18A | kinesin family member 18A | 0.030 | ||
| GSK3B | glycogen synthase kinase 3 beta | 0.030 | Fly | |
| CDK1 | cyclin-dependent kinase 1 | 0.030 | ||
| SGOL1 | shugoshin-like 1 (S. pombe) | 0.030 | ||
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.030 | ||
| BRCA2 | breast cancer 2, early onset | 0.029 | ||
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.029 | ||
| SMC4 | structural maintenance of chromosomes 4 | 0.028 | ||
| PTEN | phosphatase and tensin homolog | 0.028 | ||
| PRC1 | protein regulator of cytokinesis 1 | 0.028 | ||
| FXR2 | fragile X mental retardation, autosomal homolog 2 | 0.027 | ||
| E2F4 | E2F transcription factor 4, p107/p130-binding | 0.027 | ||
| MYBL2 | v-myb myeloblastosis viral oncogene homolog (avian)-like 2 | 0.027 | ||
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.027 | ||
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.027 | ||
| CCND1 | cyclin D1 | 0.027 | ||
| MYST1 | MYST histone acetyltransferase 1 | 0.026 | ||
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | 0.026 | ||
| ATAD2 | ATPase family, AAA domain containing 2 | 0.025 | ||
| CENPE | centromere protein E, 312kDa | 0.025 | ||
| SGOL2 | shugoshin-like 2 (S. pombe) | 0.025 | ||
| CDC42 | cell division cycle 42 (GTP binding protein, 25kDa) | 0.025 | ||
| LIN54 | lin-54 homolog (C. elegans) | 0.025 | ||
| CDC5L | CDC5 cell division cycle 5-like (S. pombe) | 0.025 | ||
| MAK | male germ cell-associated kinase | 0.024 | ||
| DEAF1 | deformed epidermal autoregulatory factor 1 (Drosophila) | 0.024 | ||
| UBE2S | ubiquitin-conjugating enzyme E2S | 0.024 | ||
| CLSPN | claspin | 0.024 | ||
| CDCA8 | cell division cycle associated 8 | 0.024 | ||
| NASP | nuclear autoantigenic sperm protein (histone-binding) | 0.023 | ||
| SERTAD4 | SERTA domain containing 4 | 0.023 | ||
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.023 | ||
| PPME1 | protein phosphatase methylesterase 1 | 0.022 | ||
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.022 | ||
| PSMB7 | proteasome (prosome, macropain) subunit, beta type, 7 | 0.022 | ||
| FOXM1 | forkhead box M1 | 0.022 | ||
| PSMB2 | proteasome (prosome, macropain) subunit, beta type, 2 | 0.022 | ||
| WBP4 | WW domain binding protein 4 (formin binding protein 21) | 0.022 | ||
| CCND3 | cyclin D3 | 0.022 | ||
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.022 | ||
| HIST1H4A | histone cluster 1, H4a | 0.022 | ||
| ATMIN | ATM interactor | 0.021 | ||
| STAG2 | stromal antigen 2 | 0.021 | ||
| C13orf34 | chromosome 13 open reading frame 34 | 0.021 | ||
| SYVN1 | synovial apoptosis inhibitor 1, synoviolin | 0.021 | ||
| CDC25A | cell division cycle 25 homolog A (S. pombe) | 0.021 | ||
| USP49 | ubiquitin specific peptidase 49 | 0.021 | Human | |
| KIF11 | kinesin family member 11 | 0.021 | ||
| KPNA3 | karyopherin alpha 3 (importin alpha 4) | 0.020 | ||
| TOP3A | topoisomerase (DNA) III alpha | 0.020 | ||
| BIRC5 | baculoviral IAP repeat containing 5 | 0.020 | ||
| RIF1 | RAP1 interacting factor homolog (yeast) | 0.020 | ||
| TK1 | thymidine kinase 1, soluble | 0.020 | ||
| CHAF1B | chromatin assembly factor 1, subunit B (p60) | 0.020 | ||
| PARP3 | poly (ADP-ribose) polymerase family, member 3 | 0.020 | ||
| CREBBP | CREB binding protein | 0.020 | ||
| PTK2B | PTK2B protein tyrosine kinase 2 beta | 0.020 | ||
| TROAP | trophinin associated protein (tastin) | 0.020 | ||
| E2F5 | E2F transcription factor 5, p130-binding | 0.020 | ||
| HIST1H4F | histone cluster 1, H4f | 0.020 | ||
| ANAPC16 | anaphase promoting complex subunit 16 | 0.019 | ||
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.019 | ||
| DEPDC1 | DEP domain containing 1 | 0.019 | ||
| ZW10 | ZW10, kinetochore associated, homolog (Drosophila) | 0.019 | ||
| PLK1 | polo-like kinase 1 | 0.019 | ||
| C13orf27 | chromosome 13 open reading frame 27 | 0.018 | ||
| AXIN1 | axin 1 | 0.018 | ||
| USP44 | ubiquitin specific peptidase 44 | 0.018 | ||
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.018 | ||
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.018 | ||
| SMC1A | structural maintenance of chromosomes 1A | 0.018 | ||
| CCDC99 | coiled-coil domain containing 99 | 0.018 | ||
| LIN9 | lin-9 homolog (C. elegans) | 0.017 | ||
| PKMYT1 | protein kinase, membrane associated tyrosine/threonine 1 | 0.017 | ||
| WAPAL | wings apart-like homolog (Drosophila) | 0.017 | ||
| ANAPC10 | anaphase promoting complex subunit 10 | 0.017 | Yeast | |
| AXIN2 | axin 2 | 0.016 | ||
| CUL2 | cullin 2 | 0.016 | ||
| OTUB1 | OTU domain, ubiquitin aldehyde binding 1 | 0.016 | ||
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.016 | ||
| PSMD9 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 | 0.016 | ||
| VHL | von Hippel-Lindau tumor suppressor | 0.016 | ||
| EML2 | echinoderm microtubule associated protein like 2 | 0.016 | ||
| CDC7 | cell division cycle 7 homolog (S. cerevisiae) | 0.016 | ||
| RAC2 | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 0.016 | ||
| DCLRE1B | DNA cross-link repair 1B | 0.016 | ||
| HIST1H1E | histone cluster 1, H1e | 0.015 | ||
| TRIP13 | thyroid hormone receptor interactor 13 | 0.015 | ||
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | 0.015 | ||
| RFWD2 | ring finger and WD repeat domain 2 | 0.015 | ||
| DYNC1I2 | dynein, cytoplasmic 1, intermediate chain 2 | 0.015 | ||
| ARIH2 | ariadne homolog 2 (Drosophila) | 0.015 | ||
| HIST1H1B | histone cluster 1, H1b | 0.015 | ||
| PSMD8 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | 0.015 | ||
| PPP5C | protein phosphatase 5, catalytic subunit | 0.014 | ||
| SHCBP1 | SHC SH2-domain binding protein 1 | 0.014 | ||
| MAD2L1BP | MAD2L1 binding protein | 0.014 | ||
| ORC2 | origin recognition complex, subunit 2 | 0.014 | ||
| PSMA2 | proteasome (prosome, macropain) subunit, alpha type, 2 | 0.014 | ||
| EPM2A | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | 0.014 | ||
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.014 | ||
| CD97 | CD97 molecule | 0.014 | ||
| EML4 | echinoderm microtubule associated protein like 4 | 0.014 | ||
| LMNA | lamin A/C | 0.014 | ||
| LILRB1 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | 0.013 | ||
| CENPJ | centromere protein J | 0.013 | ||
| PTK2 | PTK2 protein tyrosine kinase 2 | 0.013 | ||
| PDS5B | PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) | 0.013 | ||
| NSL1 | NSL1, MIND kinetochore complex component, homolog (S. cerevisiae) | 0.013 | ||
| PSMB6 | proteasome (prosome, macropain) subunit, beta type, 6 | 0.013 | ||
| EHD1 | EH-domain containing 1 | 0.013 | ||
| ANAPC13 | anaphase promoting complex subunit 13 | 0.012 | ||
| NDNL2 | necdin-like 2 | 0.012 | ||
| CEP55 | centrosomal protein 55kDa | 0.012 | ||
| MASTL | microtubule associated serine/threonine kinase-like | 0.012 | ||
| EZR | ezrin | 0.012 | Fly | |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | 0.012 | ||
| SHFM1 | split hand/foot malformation (ectrodactyly) type 1 | 0.012 | ||
| HIST1H2BB | histone cluster 1, H2bb | 0.012 | ||
| RHOG | ras homolog gene family, member G (rho G) | 0.012 | ||
| TUBGCP3 | tubulin, gamma complex associated protein 3 | 0.012 | ||
| HIST1H3F | histone cluster 1, H3f | 0.011 | ||
| PPP4C | protein phosphatase 4, catalytic subunit | 0.011 | ||
| ASF1A | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) | 0.011 | ||
| UCHL5 | ubiquitin carboxyl-terminal hydrolase L5 | 0.011 | ||
| CCDC101 | coiled-coil domain containing 101 | 0.011 | ||
| CCNE2 | cyclin E2 | 0.011 | Fly | |
| MAPRE1 | microtubule-associated protein, RP/EB family, member 1 | 0.011 | ||
| CDC45 | cell division cycle 45 homolog (S. cerevisiae) | 0.011 | ||
| HIST1H3C | histone cluster 1, H3c | 0.011 | Yeast | |
| MYO1C | myosin IC | 0.011 | ||
| ADAM17 | ADAM metallopeptidase domain 17 | 0.011 | ||
| CDCA3 | cell division cycle associated 3 | 0.011 | ||
| CDC25C | cell division cycle 25 homolog C (S. pombe) | 0.011 | ||
| PPP6R2 | protein phosphatase 6, regulatory subunit 2 | 0.011 | ||
| PSMA5 | proteasome (prosome, macropain) subunit, alpha type, 5 | 0.011 | ||
| PSMB1 | proteasome (prosome, macropain) subunit, beta type, 1 | 0.011 | ||
| MIS18BP1 | MIS18 binding protein 1 | 0.011 | ||
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.011 | ||
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 0.011 | ||
| LIN52 | lin-52 homolog (C. elegans) | 0.011 | ||
| PSMB3 | proteasome (prosome, macropain) subunit, beta type, 3 | 0.011 | ||
| MAPRE3 | microtubule-associated protein, RP/EB family, member 3 | 0.011 | ||
| KDM5C | lysine (K)-specific demethylase 5C | 0.011 | ||
| HUWE1 | HECT, UBA and WWE domain containing 1 | 0.010 | ||
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.010 | ||
| BAG2 | BCL2-associated athanogene 2 | 0.010 | ||
| PAXIP1 | PAX interacting (with transcription-activation domain) protein 1 | 0.010 | ||
| HIST1H2AB | histone cluster 1, H2ab | 0.010 | ||
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.010 | ||
| FYN | FYN oncogene related to SRC, FGR, YES | 0.010 | ||
| KIF5B | kinesin family member 5B | 0.010 | ||
| SLC39A7 | solute carrier family 39 (zinc transporter), member 7 | 0.010 | ||
| DNMT3B | DNA (cytosine-5-)-methyltransferase 3 beta | 0.010 | ||
| KDM4A | lysine (K)-specific demethylase 4A | 0.010 |