IMP: Integrative Multi-species Prediction

Homo sapiens

2 genes annotated in human

citrate metabolic process

The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "citrate metabolic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "citrate metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
HDAC2	histone deacetylase 2	0.999
HDAC1	histone deacetylase 1	0.998
PDHA1	pyruvate dehydrogenase (lipoamide) alpha 1	0.823
IDH3A	isocitrate dehydrogenase 3 (NAD+) alpha	0.778
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.712
PRKAR2A	protein kinase, cAMP-dependent, regulatory, type II, alpha	0.494
NCAPG	non-SMC condensin I complex, subunit G	0.457
ACO2	aconitase 2, mitochondrial	0.414
GOT2	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	0.387
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.366
DLAT	dihydrolipoamide S-acetyltransferase	0.357
INSR	insulin receptor	0.312
PFDN1	prefoldin subunit 1	0.293
PDHX	pyruvate dehydrogenase complex, component X	0.275
ATP5B	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	0.275
IDH3G	isocitrate dehydrogenase 3 (NAD+) gamma	0.271
AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	0.266
USPL1	ubiquitin specific peptidase like 1	0.265
SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.252
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.244
NCAPD2	non-SMC condensin I complex, subunit D2	0.243
PDHB	pyruvate dehydrogenase (lipoamide) beta	0.236
FH	fumarate hydratase	0.213
C3orf15	chromosome 3 open reading frame 15	0.210
GOT1	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	0.210
MDH2	malate dehydrogenase 2, NAD (mitochondrial)	0.168
EGFR	epidermal growth factor receptor	0.160
NDUFS2	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	0.159
PTPRB	protein tyrosine phosphatase, receptor type, B	0.152
RBBP4	retinoblastoma binding protein 4	0.129
HDAC3	histone deacetylase 3	0.121
JAK2	Janus kinase 2	0.119
AFG3L2	AFG3 ATPase family gene 3-like 2 (S. cerevisiae)	0.106
HADH	hydroxyacyl-CoA dehydrogenase	0.106
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.094
BCAR1	breast cancer anti-estrogen resistance 1	0.091
SUCLG1	succinate-CoA ligase, alpha subunit	0.086
MTA3	metastasis associated 1 family, member 3	0.078
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.077
STAP2	signal transducing adaptor family member 2	0.069
IL2RB	interleukin 2 receptor, beta	0.068
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.060
OXA1L	oxidase (cytochrome c) assembly 1-like	0.060
TUBA1A	tubulin, alpha 1a	0.055
PTPN2	protein tyrosine phosphatase, non-receptor type 2	0.053
IDH3B	isocitrate dehydrogenase 3 (NAD+) beta	0.051
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.050
CUX1	cut-like homeobox 1	0.049
PTPN9	protein tyrosine phosphatase, non-receptor type 9	0.049
GPI	glucose-6-phosphate isomerase	0.048
C21orf33	chromosome 21 open reading frame 33	0.045
MTA2	metastasis associated 1 family, member 2	0.045
CHD4	chromodomain helicase DNA binding protein 4	0.044
PRKCA	protein kinase C, alpha	0.042
NFS1	NFS1 nitrogen fixation 1 homolog (S. cerevisiae)	0.037
JAK1	Janus kinase 1	0.036
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.036
COQ9	coenzyme Q9 homolog (S. cerevisiae)	0.033
HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	0.032
CTTN	cortactin	0.031
SOCS2	suppressor of cytokine signaling 2	0.031
IDH2	isocitrate dehydrogenase 2 (NADP+), mitochondrial	0.030
ATP5A1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	0.029
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.029
RBBP7	retinoblastoma binding protein 7	0.027
TXN2	thioredoxin 2	0.026
PRMT2	protein arginine methyltransferase 2	0.026
FAF1	Fas (TNFRSF6) associated factor 1	0.024
ADRBK1	adrenergic, beta, receptor kinase 1	0.024
MYCBP	c-myc binding protein	0.024
PURA	purine-rich element binding protein A	0.024
STARD7	StAR-related lipid transfer (START) domain containing 7	0.023
SAMM50	sorting and assembly machinery component 50 homolog (S. cerevisiae)	0.022
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.022
IRS1	insulin receptor substrate 1	0.021
SIRT2	sirtuin 2	0.021
MIPEP	mitochondrial intermediate peptidase	0.021
DUSP7	dual specificity phosphatase 7	0.021
ASNA1	arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)	0.021
MECR	mitochondrial trans-2-enoyl-CoA reductase	0.021
LRRC47	leucine rich repeat containing 47	0.021
EPOR	erythropoietin receptor	0.020
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.020
EXT2	exostosin 2	0.020
GATAD2A	GATA zinc finger domain containing 2A	0.019
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.019
E2F3	E2F transcription factor 3	0.019
GHR	growth hormone receptor	0.019	Mouse
E2F2	E2F transcription factor 2	0.018
MFN2	mitofusin 2	0.018
BRE	brain and reproductive organ-expressed (TNFRSF1A modulator)	0.018
GPD1L	glycerol-3-phosphate dehydrogenase 1-like	0.018
UQCRC1	ubiquinol-cytochrome c reductase core protein I	0.018
UQCRC2	ubiquinol-cytochrome c reductase core protein II	0.017
RCOR1	REST corepressor 1	0.017
KAT2B	K(lysine) acetyltransferase 2B	0.017
AHR	aryl hydrocarbon receptor	0.016
LAT	linker for activation of T cells	0.016
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.016
GATAD2B	GATA zinc finger domain containing 2B	0.016
ACAT1	acetyl-CoA acetyltransferase 1	0.016
COPS7A	COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)	0.016
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.015
PEBP1	phosphatidylethanolamine binding protein 1	0.015
CYCS	cytochrome c, somatic	0.015
MAPK14	mitogen-activated protein kinase 14	0.015
INCENP	inner centromere protein antigens 135/155kDa	0.015
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.015
DLST	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	0.015
ALAS1	aminolevulinate, delta-, synthase 1	0.014
PGR	progesterone receptor	0.014
DDB1	damage-specific DNA binding protein 1, 127kDa	0.014
OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	0.014
CDK2AP1	cyclin-dependent kinase 2 associated protein 1	0.014
NCOA6	nuclear receptor coactivator 6	0.014
C10orf46	chromosome 10 open reading frame 46	0.014
BCKDHA	branched chain keto acid dehydrogenase E1, alpha polypeptide	0.013
HIGD2A	HIG1 hypoxia inducible domain family, member 2A	0.013
DHRS11	dehydrogenase/reductase (SDR family) member 11	0.013
ZMYM3	zinc finger, MYM-type 3	0.013
H2AFY	H2A histone family, member Y	0.013
PARP1	poly (ADP-ribose) polymerase 1	0.013
MBD2	methyl-CpG binding domain protein 2	0.013
MTA1	metastasis associated 1	0.012
C20orf43	chromosome 20 open reading frame 43	0.012
SLC25A11	solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11	0.012
FRK	fyn-related kinase	0.012
ACAD8	acyl-CoA dehydrogenase family, member 8	0.012
CAV1	caveolin 1, caveolae protein, 22kDa	0.012
NCAPH2	non-SMC condensin II complex, subunit H2	0.012
NFYC	nuclear transcription factor Y, gamma	0.012
USP53	ubiquitin specific peptidase 53	0.012
NDUFV1	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	0.012
HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	0.012
TBC1D14	TBC1 domain family, member 14	0.011
RSAD1	radical S-adenosyl methionine domain containing 1	0.011
TSR2	TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)	0.011
PFKM	phosphofructokinase, muscle	0.011
ING2	inhibitor of growth family, member 2	0.011
MMS19	MMS19 nucleotide excision repair homolog (S. cerevisiae)	0.011
CBX5	chromobox homolog 5	0.011
WDR13	WD repeat domain 13	0.011
APOO	apolipoprotein O	0.011
ATP6V0D1	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1	0.011
ACADVL	acyl-CoA dehydrogenase, very long chain	0.011
TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	0.011
PSRC1	proline/serine-rich coiled-coil 1	0.011
C3orf10	chromosome 3 open reading frame 10	0.011
ALDH9A1	aldehyde dehydrogenase 9 family, member A1	0.011
DGAT1	diacylglycerol O-acyltransferase 1	0.011
FRZB	frizzled-related protein	0.010
ECHS1	enoyl CoA hydratase, short chain, 1, mitochondrial	0.010
AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.010
TH1L	TH1-like (Drosophila)	0.010
SAP30	Sin3A-associated protein, 30kDa	0.010
SLC35A4	solute carrier family 35, member A4	0.010
PARL	presenilin associated, rhomboid-like	0.010
UBTF	upstream binding transcription factor, RNA polymerase I	0.010