IMP: Integrative Multi-species Prediction

Homo sapiens

5 genes annotated in human

synaptic vesicle transport

The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "synaptic vesicle transport"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "synaptic vesicle transport" (in gray)

Name	Description	Probability	Func Analog Organism
ITSN1	intersectin 1 (SH3 domain protein)	1.000	Fly
SNAP25	synaptosomal-associated protein, 25kDa	1.000	Fly
DNM2	dynamin 2	1.000	Fly
DNM1	dynamin 1	0.996	Fly
NUMB	numb homolog (Drosophila)	0.987
SH3GL3	SH3-domain GRB2-like 3	0.984	Fly
EPS15	epidermal growth factor receptor pathway substrate 15	0.981	Worm Fly
DLG4	discs, large homolog 4 (Drosophila)	0.970	Mouse
SH3GL2	SH3-domain GRB2-like 2	0.961	Mouse Fly
NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	0.958	Mouse
APP	amyloid beta (A4) precursor protein	0.956
AP2B1	adaptor-related protein complex 2, beta 1 subunit	0.933	Rat
SNX9	sorting nexin 9	0.888
VAMP3	vesicle-associated membrane protein 3 (cellubrevin)	0.771
APC	adenomatous polyposis coli	0.701
AP2M1	adaptor-related protein complex 2, mu 1 subunit	0.691
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.593
AMPH	amphiphysin	0.575	Mouse
DTNBP1	dystrobrevin binding protein 1	0.483
AGFG1	ArfGAP with FG repeats 1	0.453
CLASP1	cytoplasmic linker associated protein 1	0.407
NSF	N-ethylmaleimide-sensitive factor	0.397	Fly
STX4	syntaxin 4	0.382	Rat
GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	0.378
HTT	huntingtin	0.318
VIM	vimentin	0.313
SOS1	son of sevenless homolog 1 (Drosophila)	0.280
MAPT	microtubule-associated protein tau	0.251
SYNJ1	synaptojanin 1	0.238	Mouse Fly
MAP2K7	mitogen-activated protein kinase kinase 7	0.233
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.196
RAB1A	RAB1A, member RAS oncogene family	0.196
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	0.191	Fly
MEA1	male-enhanced antigen 1	0.182
KIF5B	kinesin family member 5B	0.177	Worm
MED31	mediator complex subunit 31	0.176
ARRB2	arrestin, beta 2	0.165
PACSIN1	protein kinase C and casein kinase substrate in neurons 1	0.146	Mouse
MAST1	microtubule associated serine/threonine kinase 1	0.145
RBM8A	RNA binding motif protein 8A	0.144
GSK3B	glycogen synthase kinase 3 beta	0.136
FGF10	fibroblast growth factor 10	0.134
SNAP23	synaptosomal-associated protein, 23kDa	0.129	Fly
STX1A	syntaxin 1A (brain)	0.127	Mouse Rat Fly
TOR1A	torsin family 1, member A (torsin A)	0.122
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.107	Fly
BLOC1S2	biogenesis of lysosomal organelles complex-1, subunit 2	0.104
PICALM	phosphatidylinositol binding clathrin assembly protein	0.103	Mouse Worm Fly
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.103
SH3KBP1	SH3-domain kinase binding protein 1	0.088
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.083
DPYSL4	dihydropyrimidinase-like 4	0.078
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.076
OCRL	oculocerebrorenal syndrome of Lowe	0.069
PRKCA	protein kinase C, alpha	0.064
RAB5A	RAB5A, member RAS oncogene family	0.063
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.057
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.057
RAB6A	RAB6A, member RAS oncogene family	0.056
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.045
PSEN1	presenilin 1	0.044	Mouse
HIP1	huntingtin interacting protein 1	0.042
ARF6	ADP-ribosylation factor 6	0.042
LRRK2	leucine-rich repeat kinase 2	0.042
ATP5A1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	0.041
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.039
STX5	syntaxin 5	0.038
GRB2	growth factor receptor-bound protein 2	0.037
LRSAM1	leucine rich repeat and sterile alpha motif containing 1	0.037
STON2	stonin 2	0.035
SH3GL1	SH3-domain GRB2-like 1	0.034	Fly
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.034
MUTED	muted homolog (mouse)	0.031
GDI1	GDP dissociation inhibitor 1	0.031
PLDN	pallidin homolog (mouse)	0.030	Mouse
FCHO2	FCH domain only 2	0.029
BLOC1S3	biogenesis of lysosomal organelles complex-1, subunit 3	0.029
RNF11	ring finger protein 11	0.028
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.028
SLC25A3	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	0.027
FNBP1	formin binding protein 1	0.027
TJP2	tight junction protein 2 (zona occludens 2)	0.027
LIN7A	lin-7 homolog A (C. elegans)	0.027	Mouse
EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	0.027
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.026
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.026
PRRC2C	proline-rich coiled-coil 2C	0.026
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.025
BSN	bassoon (presynaptic cytomatrix protein)	0.024
RAB7A	RAB7A, member RAS oncogene family	0.024
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.024
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.024
MTF1	metal-regulatory transcription factor 1	0.023
TNPO1	transportin 1	0.023
CLIP1	CAP-GLY domain containing linker protein 1	0.023
CRMP1	collapsin response mediator protein 1	0.023
TOR1AIP2	torsin A interacting protein 2	0.023
PSEN2	presenilin 2 (Alzheimer disease 4)	0.022
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.022
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.021
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.021	Mouse
STX12	syntaxin 12	0.020
COPS4	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)	0.020
PRKCE	protein kinase C, epsilon	0.020	Worm
RAB14	RAB14, member RAS oncogene family	0.019
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.019
UPF3A	UPF3 regulator of nonsense transcripts homolog A (yeast)	0.018
LDOC1	leucine zipper, down-regulated in cancer 1	0.018
SYT1	synaptotagmin I	0.018	Mouse Fly
FASLG	Fas ligand (TNF superfamily, member 6)	0.018
SDC2	syndecan 2	0.017
MYST2	MYST histone acetyltransferase 2	0.016
SNCAIP	synuclein, alpha interacting protein	0.016
ERC2	ELKS/RAB6-interacting/CAST family member 2	0.016
AGTPBP1	ATP/GTP binding protein 1	0.016
CPEB4	cytoplasmic polyadenylation element binding protein 4	0.015
SNX33	sorting nexin 33	0.015
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.015
KIFC2	kinesin family member C2	0.015
WASL	Wiskott-Aldrich syndrome-like	0.015
GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.015
SCYL2	SCY1-like 2 (S. cerevisiae)	0.014
BLOC1S1	biogenesis of lysosomal organelles complex-1, subunit 1	0.014
RUNDC3A	RUN domain containing 3A	0.014
PKP4	plakophilin 4	0.014
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.014
MAP2K1	mitogen-activated protein kinase kinase 1	0.013
DPPA4	developmental pluripotency associated 4	0.013
EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	0.013
ARL8B	ADP-ribosylation factor-like 8B	0.013
UPF1	UPF1 regulator of nonsense transcripts homolog (yeast)	0.013
SPAG9	sperm associated antigen 9	0.012	Worm
CD46	CD46 molecule, complement regulatory protein	0.012
MAPK8	mitogen-activated protein kinase 8	0.012
PRKCZ	protein kinase C, zeta	0.011
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.011
TAF4	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	0.011
RPH3A	rabphilin 3A homolog (mouse)	0.011
PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	0.011
UPF2	UPF2 regulator of nonsense transcripts homolog (yeast)	0.011
EPN1	epsin 1	0.010
GRIA2	glutamate receptor, ionotropic, AMPA 2	0.010
VAMP2	vesicle-associated membrane protein 2 (synaptobrevin 2)	0.010
MAP2K4	mitogen-activated protein kinase kinase 4	0.010