IMP: Integrative Multi-species Prediction

Homo sapiens

4 genes annotated in human

thyroid hormone metabolic process

The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "thyroid hormone metabolic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "thyroid hormone metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	1.000	Human
TAL1	T-cell acute lymphocytic leukemia 1	0.985
SULT1A2	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2	0.953	Human
SULT1A4	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4	0.918	Human
NKX2-1	NK2 homeobox 1	0.371
ALS2CR12	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12	0.295
MEOX1	mesenchyme homeobox 1	0.177
PML	promyelocytic leukemia	0.160
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.103
TGS1	trimethylguanosine synthase 1	0.084
SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	0.076	Human
ARHGAP22	Rho GTPase activating protein 22	0.075
MED10	mediator complex subunit 10	0.059
TBX5	T-box 5	0.055
TUBB2B	tubulin, beta 2B	0.052
SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1	0.050	Human
MED29	mediator complex subunit 29	0.045
MED6	mediator complex subunit 6	0.043
CGB5	chorionic gonadotropin, beta polypeptide 5	0.042
MED13	mediator complex subunit 13	0.039
KLF13	Kruppel-like factor 13	0.036
LPHN1	latrophilin 1	0.035
SDC2	syndecan 2	0.035
RYBP	RING1 and YY1 binding protein	0.033
TNPO1	transportin 1	0.032
RARA	retinoic acid receptor, alpha	0.029
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.028
CDK19	cyclin-dependent kinase 19	0.028
CDK8	cyclin-dependent kinase 8	0.027
THRA	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	0.026
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.025
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.024
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.024
ZFPM1	zinc finger protein, multitype 1	0.023
ENOX1	ecto-NOX disulfide-thiol exchanger 1	0.021
GATA4	GATA binding protein 4	0.021	Human
WT1	Wilms tumor 1	0.020
BZRAP1	benzodiazapine receptor (peripheral) associated protein 1	0.020
IGSF21	immunoglobin superfamily, member 21	0.019
TBX1	T-box 1	0.019
PCDHA4	protocadherin alpha 4	0.018
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.018
BBS1	Bardet-Biedl syndrome 1	0.018
KNG1	kininogen 1	0.018
DNAJB5	DnaJ (Hsp40) homolog, subfamily B, member 5	0.018
DHH	desert hedgehog	0.018
LMO2	LIM domain only 2 (rhombotin-like 1)	0.018
SRRM4	serine/arginine repetitive matrix 4	0.018
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.017
MED4	mediator complex subunit 4	0.017
USP2	ubiquitin specific peptidase 2	0.017
HSPB1	heat shock 27kDa protein 1	0.017
MEGF8	multiple EGF-like-domains 8	0.016
LTBP4	latent transforming growth factor beta binding protein 4	0.016
MED14	mediator complex subunit 14	0.016
THRAP3	thyroid hormone receptor associated protein 3	0.015
PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)	0.015
DAXX	death-domain associated protein	0.015
HAND2	heart and neural crest derivatives expressed 2	0.015
TADA2A	transcriptional adaptor 2A	0.015
LHX1	LIM homeobox 1	0.015
MEGF6	multiple EGF-like-domains 6	0.015
ESR2	estrogen receptor 2 (ER beta)	0.015
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.015
S100A2	S100 calcium binding protein A2	0.015
RXRA	retinoid X receptor, alpha	0.014
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.014
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.014
C1QTNF1	C1q and tumor necrosis factor related protein 1	0.014
RBBP5	retinoblastoma binding protein 5	0.014
S100A4	S100 calcium binding protein A4	0.014
ALDOB	aldolase B, fructose-bisphosphate	0.014
ACADVL	acyl-CoA dehydrogenase, very long chain	0.014
FSHB	follicle stimulating hormone, beta polypeptide	0.014
COL2A1	collagen, type II, alpha 1	0.013
G6PC	glucose-6-phosphatase, catalytic subunit	0.013
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.013
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.013
HNF1B	HNF1 homeobox B	0.013
SIM2	single-minded homolog 2 (Drosophila)	0.013
MATN2	matrilin 2	0.013
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.013
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.013
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	0.013
PAX7	paired box 7	0.013
SLC6A13	solute carrier family 6 (neurotransmitter transporter, GABA), member 13	0.013
BHLHE23	basic helix-loop-helix family, member e23	0.013
HMX1	H6 family homeobox 1	0.013
GSTM4	glutathione S-transferase mu 4	0.012
WBP1	WW domain binding protein 1	0.012
HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	0.012
PKLR	pyruvate kinase, liver and RBC	0.012
MEOX2	mesenchyme homeobox 2	0.012
AMIGO2	adhesion molecule with Ig-like domain 2	0.012
TTPA	tocopherol (alpha) transfer protein	0.012
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.012
YLPM1	YLP motif containing 1	0.012
PAX2	paired box 2	0.012	Human
INA	internexin neuronal intermediate filament protein, alpha	0.011
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.011
MED18	mediator complex subunit 18	0.011
GATA5	GATA binding protein 5	0.011	Human
CLCNKB	chloride channel Kb	0.011
HIPK2	homeodomain interacting protein kinase 2	0.011
POU4F1	POU class 4 homeobox 1	0.011
NEUROD2	neurogenic differentiation 2	0.011
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.011
OVOL1	ovo-like 1(Drosophila)	0.011
BHMT	betaine--homocysteine S-methyltransferase	0.011
CYBRD1	cytochrome b reductase 1	0.011
MED19	mediator complex subunit 19	0.011
HOXD9	homeobox D9	0.011
TM4SF5	transmembrane 4 L six family member 5	0.011
HOXA11	homeobox A11	0.011
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.011
HOXC5	homeobox C5	0.011
GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	0.011
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.011
MED25	mediator complex subunit 25	0.011
SFRP5	secreted frizzled-related protein 5	0.010
CCDC106	coiled-coil domain containing 106	0.010
STX5	syntaxin 5	0.010
SLURP1	secreted LY6/PLAUR domain containing 1	0.010
CABP1	calcium binding protein 1	0.010
TOP1	topoisomerase (DNA) I	0.010
ADH6	alcohol dehydrogenase 6 (class V)	0.010
EMX1	empty spiracles homeobox 1	0.010
ARC	activity-regulated cytoskeleton-associated protein	0.010
CRTAP	cartilage associated protein	0.010
WWOX	WW domain containing oxidoreductase	0.010