IMP: Integrative Multi-species Prediction

Homo sapiens

4 genes annotated in human

reciprocal dna recombination

A DNA recombination process that results in the equal exchange of genetic material between the recombining DNA molecules.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "reciprocal dna recombination"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "reciprocal dna recombination" (in gray)

Name	Description	Probability	Func Analog Organism
RPA1	replication protein A1, 70kDa	0.988	Yeast
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.835	Yeast
H2AFX	H2A histone family, member X	0.833
SMC1A	structural maintenance of chromosomes 1A	0.725
BRCA2	breast cancer 2, early onset	0.707
APITD1	apoptosis-inducing, TAF9-like domain 1	0.694
MSH5	mutS homolog 5 (E. coli)	0.618	Yeast Worm
BLM	Bloom syndrome, RecQ helicase-like	0.496	Worm Fly
BRCA1	breast cancer 1, early onset	0.398
MSH4	mutS homolog 4 (E. coli)	0.397	Yeast
WRN	Werner syndrome, RecQ helicase-like	0.377
RAD52	RAD52 homolog (S. cerevisiae)	0.344	Yeast
NBN	nibrin	0.279
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.227
FANCD2	Fanconi anemia, complementation group D2	0.216
MCMBP	minichromosome maintenance complex binding protein	0.211
RPA3	replication protein A3, 14kDa	0.199
MCM6	minichromosome maintenance complex component 6	0.180
RAD50	RAD50 homolog (S. cerevisiae)	0.148
FANCM	Fanconi anemia, complementation group M	0.140
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.140
MDC1	mediator of DNA-damage checkpoint 1	0.130
FANCG	Fanconi anemia, complementation group G	0.130
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.122
PALB2	partner and localizer of BRCA2	0.113
PARP1	poly (ADP-ribose) polymerase 1	0.105
XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	0.095
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.089
ORC3	origin recognition complex, subunit 3	0.081
RPA2	replication protein A2, 32kDa	0.076	Yeast
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.075
TOP3A	topoisomerase (DNA) III alpha	0.068
MCM2	minichromosome maintenance complex component 2	0.065
MCM3	minichromosome maintenance complex component 3	0.062
MSH6	mutS homolog 6 (E. coli)	0.061
ATM	ataxia telangiectasia mutated	0.059
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.056	Yeast
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.054
TERF2	telomeric repeat binding factor 2	0.053
FANCB	Fanconi anemia, complementation group B	0.051
ORC2	origin recognition complex, subunit 2	0.049
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.048
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.045
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.045
CENPM	centromere protein M	0.044
RFC1	replication factor C (activator 1) 1, 145kDa	0.043
PDS5B	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.040
DSCC1	defective in sister chromatid cohesion 1 homolog (S. cerevisiae)	0.040
MCM4	minichromosome maintenance complex component 4	0.039
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.035
TERF1	telomeric repeat binding factor (NIMA-interacting) 1	0.033
ORC1	origin recognition complex, subunit 1	0.033
PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	0.031
PRNP	prion protein	0.031
RAD9A	RAD9 homolog A (S. pombe)	0.030
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.028	Yeast
CLIP1	CAP-GLY domain containing linker protein 1	0.024
RAD1	RAD1 homolog (S. pombe)	0.023
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.023
DAXX	death-domain associated protein	0.023
TELO2	TEL2, telomere maintenance 2, homolog (S. cerevisiae)	0.023
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.023
ZNF337	zinc finger protein 337	0.022	Human
TTI1	Tel2 interacting protein 1 homolog (S. pombe)	0.021
MCM10	minichromosome maintenance complex component 10	0.021
RAD18	RAD18 homolog (S. cerevisiae)	0.021
FANCF	Fanconi anemia, complementation group F	0.021
ZNF133	zinc finger protein 133	0.020	Human
RAD51AP1	RAD51 associated protein 1	0.020
ORC5	origin recognition complex, subunit 5	0.020
SSRP1	structure specific recognition protein 1	0.020
STRA13	stimulated by retinoic acid 13 homolog (mouse)	0.019
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.019
SEPT7	septin 7	0.018
ORC6	origin recognition complex, subunit 6	0.018
SYCP3	synaptonemal complex protein 3	0.017
TOP1	topoisomerase (DNA) I	0.017
TDP1	tyrosyl-DNA phosphodiesterase 1	0.017
BCL2L1	BCL2-like 1	0.017
WASF1	WAS protein family, member 1	0.017
RMI1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)	0.016
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.016
C16orf75	chromosome 16 open reading frame 75	0.015
MUS81	MUS81 endonuclease homolog (S. cerevisiae)	0.015
PRIM1	primase, DNA, polypeptide 1 (49kDa)	0.015
FKBP5	FK506 binding protein 5	0.014
DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	0.014
TPR	translocated promoter region (to activated MET oncogene)	0.014
C19orf40	chromosome 19 open reading frame 40	0.014
RNF20	ring finger protein 20	0.014
RAD51L1	RAD51-like 1 (S. cerevisiae)	0.014
ERCC4	excision repair cross-complementing rodent repair deficiency, complementation group 4	0.014
PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	0.013
MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	0.013
ORC4	origin recognition complex, subunit 4	0.013
SPAG5	sperm associated antigen 5	0.013
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	0.013
APLF	aprataxin and PNKP like factor	0.012
TK1	thymidine kinase 1, soluble	0.012
XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	0.012
DZIP3	DAZ interacting protein 3, zinc finger	0.012
TP53BP1	tumor protein p53 binding protein 1	0.012
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.012
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.012
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.012
ZNF16	zinc finger protein 16	0.012
EXO1	exonuclease 1	0.012
ZNF187	zinc finger protein 187	0.012
NUBP2	nucleotide binding protein 2 (MinD homolog, E. coli)	0.011
RAD54B	RAD54 homolog B (S. cerevisiae)	0.011	Yeast
MSH3	mutS homolog 3 (E. coli)	0.011
PLK4	polo-like kinase 4	0.011
RECQL4	RecQ protein-like 4	0.011
DROSHA	drosha, ribonuclease type III	0.011
POLH	polymerase (DNA directed), eta	0.011
TCF19	transcription factor 19	0.011
PRPSAP2	phosphoribosyl pyrophosphate synthetase-associated protein 2	0.011
SCRIB	scribbled homolog (Drosophila)	0.011
POLG2	polymerase (DNA directed), gamma 2, accessory subunit	0.011
LOXL4	lysyl oxidase-like 4	0.011
TIMELESS	timeless homolog (Drosophila)	0.011
MLH3	mutL homolog 3 (E. coli)	0.011
CKAP5	cytoskeleton associated protein 5	0.011
TIAM2	T-cell lymphoma invasion and metastasis 2	0.011
DDX11	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	0.011
BICD2	bicaudal D homolog 2 (Drosophila)	0.011
CENPF	centromere protein F, 350/400kDa (mitosin)	0.011
APC	adenomatous polyposis coli	0.011
ACYP1	acylphosphatase 1, erythrocyte (common) type	0.010
ZNF862	zinc finger protein 862	0.010
GRB7	growth factor receptor-bound protein 7	0.010
FN3KRP	fructosamine 3 kinase related protein	0.010
TRIM37	tripartite motif containing 37	0.010
C20orf94	chromosome 20 open reading frame 94	0.010
ELF2	E74-like factor 2 (ets domain transcription factor)	0.010
FANCA	Fanconi anemia, complementation group A	0.010
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.010
RAD51L3	RAD51-like 3 (S. cerevisiae)	0.010
LOC81691	exonuclease NEF-sp	0.010