IMP: Integrative Multi-species Prediction

Homo sapiens

65 genes annotated in human

Multi-species View

positive regulation of epithelial cell proliferation

GO:0050679

Any process that activates or increases the rate or extent of epithelial cell proliferation.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in humanInclude functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of epithelial cell proliferation"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of epithelial cell proliferation" (in gray)

Name	Description	Probability	Func Analog Organism
EGFR	epidermal growth factor receptor	1.000
FGFR2	fibroblast growth factor receptor 2	0.999	Mouse
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.999	Human
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.997	Human
FGF1	fibroblast growth factor 1 (acidic)	0.996	Human
NME2	non-metastatic cells 2, protein (NM23B) expressed in	0.989
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.972	Human
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.967
BMP2	bone morphogenetic protein 2	0.961
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.949
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.929
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.912
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.911	Human
TGFB1	transforming growth factor, beta 1	0.894	Rat
PAX3	paired box 3	0.876
CAV1	caveolin 1, caveolae protein, 22kDa	0.871
CCR5	chemokine (C-C motif) receptor 5	0.823
FGFR1	fibroblast growth factor receptor 1	0.817
CCL4	chemokine (C-C motif) ligand 4	0.811	Human
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.794
SMAD7	SMAD family member 7	0.763
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.755
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.730	Human
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.726
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.709	Human
RB1	retinoblastoma 1	0.700
CCL2	chemokine (C-C motif) ligand 2	0.698	Human
EGR3	early growth response 3	0.687
BMPR1A	bone morphogenetic protein receptor, type IA	0.669	Human Mouse
IL8	interleukin 8	0.635
CXCL2	chemokine (C-X-C motif) ligand 2	0.634
NRP1	neuropilin 1	0.625
IL6	interleukin 6 (interferon, beta 2)	0.619	Mouse
WNT2	wingless-type MMTV integration site family member 2	0.609	Human Rat
TNF	tumor necrosis factor	0.606
EGR1	early growth response 1	0.605	Human
JAG1	jagged 1	0.602
FKBP1A	FK506 binding protein 1A, 12kDa	0.594
BMP7	bone morphogenetic protein 7	0.562	Human
DSG2	desmoglein 2	0.561
CXCL9	chemokine (C-X-C motif) ligand 9	0.552
NME1	non-metastatic cells 1, protein (NM23A) expressed in	0.545
EGR2	early growth response 2	0.541	Human
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.511
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.502
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.497
BMP4	bone morphogenetic protein 4	0.492
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.468
IL1B	interleukin 1, beta	0.457
PSEN1	presenilin 1	0.457
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.445	Mouse
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.434
VEGFA	vascular endothelial growth factor A	0.432
PLCG1	phospholipase C, gamma 1	0.428
GDF5	growth differentiation factor 5	0.422	Human
POU3F2	POU class 3 homeobox 2	0.422
MPDZ	multiple PDZ domain protein	0.411
CXCL3	chemokine (C-X-C motif) ligand 3	0.404
PRKCA	protein kinase C, alpha	0.400
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.398	Human
FGF8	fibroblast growth factor 8 (androgen-induced)	0.398
ENG	endoglin	0.388
PDGFC	platelet derived growth factor C	0.379
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.368
BMPR1B	bone morphogenetic protein receptor, type IB	0.358	Human
CDK6	cyclin-dependent kinase 6	0.349
COL2A1	collagen, type II, alpha 1	0.330
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.328
CCL8	chemokine (C-C motif) ligand 8	0.327	Human
RND1	Rho family GTPase 1	0.307
NKX2-1	NK2 homeobox 1	0.290
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.274
FGF7	fibroblast growth factor 7	0.267
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.258	Human
SNTG2	syntrophin, gamma 2	0.258
MEOX2	mesenchyme homeobox 2	0.257
CXCL10	chemokine (C-X-C motif) ligand 10	0.255
NME4	non-metastatic cells 4, protein expressed in	0.254
POU5F1	POU class 5 homeobox 1	0.254
WNT1	wingless-type MMTV integration site family, member 1	0.248	Human
FOXD3	forkhead box D3	0.246
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.245	Human
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.243
JUP	junction plakoglobin	0.240
INHBA	inhibin, beta A	0.238
CCL13	chemokine (C-C motif) ligand 13	0.235	Human
NOTCH3	notch 3	0.232
ANG	angiogenin, ribonuclease, RNase A family, 5	0.228
FGF2	fibroblast growth factor 2 (basic)	0.223
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.220
PRKCD	protein kinase C, delta	0.219	Human
GSK3B	glycogen synthase kinase 3 beta	0.216
CYR61	cysteine-rich, angiogenic inducer, 61	0.209
HMGB1	high mobility group box 1	0.208	Human
FGF4	fibroblast growth factor 4	0.206	Human
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.205
SFRP1	secreted frizzled-related protein 1	0.205
SETD8	SET domain containing (lysine methyltransferase) 8	0.203
HIC1	hypermethylated in cancer 1	0.200
RGS1	regulator of G-protein signaling 1	0.200
PGF	placental growth factor	0.199	Human Rat
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.197
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.196
ARHGEF11	Rho guanine nucleotide exchange factor (GEF) 11	0.194
RALBP1	ralA binding protein 1	0.188
RNASE4	ribonuclease, RNase A family, 4	0.186	Human
DPP4	dipeptidyl-peptidase 4	0.185
PLDN	pallidin homolog (mouse)	0.184
HSPG2	heparan sulfate proteoglycan 2	0.182
MEOX1	mesenchyme homeobox 1	0.181
WNT5A	wingless-type MMTV integration site family, member 5A	0.176
APP	amyloid beta (A4) precursor protein	0.175
FSTL1	follistatin-like 1	0.174
CCL5	chemokine (C-C motif) ligand 5	0.173	Human Mouse
SEMA4A	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	0.172
CCL20	chemokine (C-C motif) ligand 20	0.172	Human
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.171
CSNK1A1	casein kinase 1, alpha 1	0.171
RARA	retinoic acid receptor, alpha	0.169
SRSF4	serine/arginine-rich splicing factor 4	0.169	Human
CH25H	cholesterol 25-hydroxylase	0.168
CTNND1	catenin (cadherin-associated protein), delta 1	0.167
RXRA	retinoid X receptor, alpha	0.164
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.163
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.158
NOXA1	NADPH oxidase activator 1	0.157
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.155
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.154
SNAI1	snail homolog 1 (Drosophila)	0.151
ITGB1BP3	integrin beta 1 binding protein 3	0.151
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.150
FZD1	frizzled homolog 1 (Drosophila)	0.147	Human
PTHLH	parathyroid hormone-like hormone	0.144
PLD3	phospholipase D family, member 3	0.139
PAX8	paired box 8	0.136	Human
CSF1	colony stimulating factor 1 (macrophage)	0.135
FGF10	fibroblast growth factor 10	0.135
KRT5	keratin 5	0.134
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.132
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.131
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.131
FGF3	fibroblast growth factor 3	0.129	Human
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.128
SRSF6	serine/arginine-rich splicing factor 6	0.125
PDGFA	platelet-derived growth factor alpha polypeptide	0.125	Human
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.124
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.124
CDH5	cadherin 5, type 2 (vascular endothelium)	0.123
TGFB3	transforming growth factor, beta 3	0.122
WDYHV1	WDYHV motif containing 1	0.121
COL5A1	collagen, type V, alpha 1	0.119
MMP19	matrix metallopeptidase 19	0.117
TG	thyroglobulin	0.117
TCF4	transcription factor 4	0.114
CXCL5	chemokine (C-X-C motif) ligand 5	0.112
NOG	noggin	0.112	Mouse
ARRDC3	arrestin domain containing 3	0.111
IRS1	insulin receptor substrate 1	0.110
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.110
ACVR1	activin A receptor, type I	0.109	Human
FGF18	fibroblast growth factor 18	0.108
PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	0.107
PTMA	prothymosin, alpha	0.106
FZD8	frizzled homolog 8 (Drosophila)	0.105	Human
MAPK7	mitogen-activated protein kinase 7	0.103
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.103
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.102
APC	adenomatous polyposis coli	0.101
CD83	CD83 molecule	0.097
INHBB	inhibin, beta B	0.097
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.096
GFPT2	glutamine-fructose-6-phosphate transaminase 2	0.094
SELE	selectin E	0.094
TGFB2	transforming growth factor, beta 2	0.093
SH3RF1	SH3 domain containing ring finger 1	0.092
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.092
PTEN	phosphatase and tensin homolog	0.092
GDNF	glial cell derived neurotrophic factor	0.092
VEGFC	vascular endothelial growth factor C	0.091	Human Rat
CXCL12	chemokine (C-X-C motif) ligand 12	0.089
CCL7	chemokine (C-C motif) ligand 7	0.088	Human
NOV	nephroblastoma overexpressed gene	0.088
PRKG1	protein kinase, cGMP-dependent, type I	0.087
FOXF2	forkhead box F2	0.087
CXCL13	chemokine (C-X-C motif) ligand 13	0.086
FKBP8	FK506 binding protein 8, 38kDa	0.085
TCEAL5	transcription elongation factor A (SII)-like 5	0.085
NGFR	nerve growth factor receptor	0.085
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.085
JAG2	jagged 2	0.085
WNT3A	wingless-type MMTV integration site family, member 3A	0.084	Human
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.084
WNT7A	wingless-type MMTV integration site family, member 7A	0.083
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.083
BCL2	B-cell CLL/lymphoma 2	0.083
LOXL2	lysyl oxidase-like 2	0.080
CCR1	chemokine (C-C motif) receptor 1	0.080
FOXF1	forkhead box F1	0.078
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.078
IL10	interleukin 10	0.076
SOX2	SRY (sex determining region Y)-box 2	0.076	Human
FGFR3	fibroblast growth factor receptor 3	0.076	Mouse
GAA	glucosidase, alpha; acid	0.076
TSC22D4	TSC22 domain family, member 4	0.075
NME3	non-metastatic cells 3, protein expressed in	0.074	Human
CCL11	chemokine (C-C motif) ligand 11	0.074
SOCS3	suppressor of cytokine signaling 3	0.073
CXCL11	chemokine (C-X-C motif) ligand 11	0.073
SRRM2	serine/arginine repetitive matrix 2	0.073
MAPK8	mitogen-activated protein kinase 8	0.073
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.073
PTGER3	prostaglandin E receptor 3 (subtype EP3)	0.072
CCNE1	cyclin E1	0.071
IFNG	interferon, gamma	0.071
SPRED1	sprouty-related, EVH1 domain containing 1	0.071
CCL3	chemokine (C-C motif) ligand 3	0.070	Human
PDX1	pancreatic and duodenal homeobox 1	0.070
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.070
PCGF2	polycomb group ring finger 2	0.070
NCOA1	nuclear receptor coactivator 1	0.069
NCF1	neutrophil cytosolic factor 1	0.069
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.069
RUNX1	runt-related transcription factor 1	0.069
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.068
KITLG	KIT ligand	0.068
CCL14	chemokine (C-C motif) ligand 14	0.068	Human
DSP	desmoplakin	0.067
OLIG2	oligodendrocyte lineage transcription factor 2	0.066
MYOD1	myogenic differentiation 1	0.066
HMGA2	high mobility group AT-hook 2	0.066
DDR2	discoidin domain receptor tyrosine kinase 2	0.066
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.065
MST1R	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	0.064
INSR	insulin receptor	0.064
PAX7	paired box 7	0.063
CYBA	cytochrome b-245, alpha polypeptide	0.063
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	0.062
USP46	ubiquitin specific peptidase 46	0.062
ELF5	E74-like factor 5 (ets domain transcription factor)	0.062
EFNB3	ephrin-B3	0.062
SOS1	son of sevenless homolog 1 (Drosophila)	0.062
PAWR	PRKC, apoptosis, WT1, regulator	0.062
ACAN	aggrecan	0.062
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.062
C2	complement component 2	0.061
IL7R	interleukin 7 receptor	0.061
RAX	retina and anterior neural fold homeobox	0.061
ICAM1	intercellular adhesion molecule 1	0.061
CCL19	chemokine (C-C motif) ligand 19	0.061	Human
PTPRB	protein tyrosine phosphatase, receptor type, B	0.060
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.060
SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)	0.060
WISP1	WNT1 inducible signaling pathway protein 1	0.059
FST	follistatin	0.059
LZTS2	leucine zipper, putative tumor suppressor 2	0.059
TIMP3	TIMP metallopeptidase inhibitor 3	0.059
MAPT	microtubule-associated protein tau	0.059
GLP1R	glucagon-like peptide 1 receptor	0.058
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.058
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.058
CCR4	chemokine (C-C motif) receptor 4	0.058
CCL22	chemokine (C-C motif) ligand 22	0.057	Human
TWIST1	twist homolog 1 (Drosophila)	0.057	Rat
COL14A1	collagen, type XIV, alpha 1	0.057
SFRP4	secreted frizzled-related protein 4	0.057	Human
NRP2	neuropilin 2	0.057
IL11	interleukin 11	0.057
CCR7	chemokine (C-C motif) receptor 7	0.057
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.056
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.056
HMGB2	high mobility group box 2	0.056
HTR4	5-hydroxytryptamine (serotonin) receptor 4	0.055	Human
CALCA	calcitonin-related polypeptide alpha	0.055
ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B	0.055
PLXDC1	plexin domain containing 1	0.055
NDP	Norrie disease (pseudoglioma)	0.055
CXCL14	chemokine (C-X-C motif) ligand 14	0.055
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.055
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.055
RASGRF1	Ras protein-specific guanine nucleotide-releasing factor 1	0.055
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.054
DAPK1	death-associated protein kinase 1	0.054
RET	ret proto-oncogene	0.054
DDX42	DEAD (Asp-Glu-Ala-Asp) box polypeptide 42	0.054
CD1B	CD1b molecule	0.054
CD151	CD151 molecule (Raph blood group)	0.053
GFAP	glial fibrillary acidic protein	0.053
HNF4A	hepatocyte nuclear factor 4, alpha	0.053
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	0.053
STK4	serine/threonine kinase 4	0.052
PRKCZ	protein kinase C, zeta	0.052	Human
STC1	stanniocalcin 1	0.052
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.051
SIM2	single-minded homolog 2 (Drosophila)	0.051
THBS1	thrombospondin 1	0.051	Human
WIF1	WNT inhibitory factor 1	0.051
DLL1	delta-like 1 (Drosophila)	0.051
CTSB	cathepsin B	0.050
RGS16	regulator of G-protein signaling 16	0.050
NUCB1	nucleobindin 1	0.050
SOX1	SRY (sex determining region Y)-box 1	0.050	Human
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.050	Human
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.049
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.049
WT1	Wilms tumor 1	0.049	Human
OGT	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	0.049
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.049
TLN1	talin 1	0.048
IRX4	iroquois homeobox 4	0.048
SATB2	SATB homeobox 2	0.048
BBS10	Bardet-Biedl syndrome 10	0.048
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.048
TLX1	T-cell leukemia homeobox 1	0.048
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.048
LRP6	low density lipoprotein receptor-related protein 6	0.048
PENK	proenkephalin	0.047
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.047
OSMR	oncostatin M receptor	0.047
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.047
CALCR	calcitonin receptor	0.047
KRT6C	keratin 6C	0.047
GLIS2	GLIS family zinc finger 2	0.047
GEM	GTP binding protein overexpressed in skeletal muscle	0.047
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.047
MAN2B1	mannosidase, alpha, class 2B, member 1	0.046
BCL2L1	BCL2-like 1	0.046
HAS2	hyaluronan synthase 2	0.046	Rat
MPEG1	macrophage expressed 1	0.046
SLAMF8	SLAM family member 8	0.046
PDCD6IP	programmed cell death 6 interacting protein	0.046
ADAMDEC1	ADAM-like, decysin 1	0.045
IL6R	interleukin 6 receptor	0.045
KRT34	keratin 34	0.045
F7	coagulation factor VII (serum prothrombin conversion accelerator)	0.044
PRRX1	paired related homeobox 1	0.044
TGFBR1	transforming growth factor, beta receptor 1	0.044	Human
PNN	pinin, desmosome associated protein	0.044
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.044
IGFBP5	insulin-like growth factor binding protein 5	0.044
SCRT1	scratch homolog 1, zinc finger protein (Drosophila)	0.044
STAT5A	signal transducer and activator of transcription 5A	0.044
BTG2	BTG family, member 2	0.044
TBX2	T-box 2	0.044
UBQLN4	ubiquilin 4	0.043
CCL1	chemokine (C-C motif) ligand 1	0.043	Human
F2R	coagulation factor II (thrombin) receptor	0.043
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.043
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.042
SF3B1	splicing factor 3b, subunit 1, 155kDa	0.042
GAS1	growth arrest-specific 1	0.042	Mouse
FZD7	frizzled homolog 7 (Drosophila)	0.042
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.042
NOTCH4	notch 4	0.042
CD86	CD86 molecule	0.042
SPIN1	spindlin 1	0.042
SMAD5	SMAD family member 5	0.042
FBLN1	fibulin 1	0.041
CD34	CD34 molecule	0.041
SSTR3	somatostatin receptor 3	0.041
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.041
RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2	0.041
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.041
FOXC1	forkhead box C1	0.041
CUL7	cullin 7	0.041
CDH6	cadherin 6, type 2, K-cadherin (fetal kidney)	0.041
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.040
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.040
KRT18	keratin 18	0.040
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.040
FEV	FEV (ETS oncogene family)	0.040
FPR3	formyl peptide receptor 3	0.040	Human
TAL1	T-cell acute lymphocytic leukemia 1	0.040
DARC	Duffy blood group, chemokine receptor	0.039
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.039
SOX11	SRY (sex determining region Y)-box 11	0.039	Human Mouse
MARCKSL1	MARCKS-like 1	0.039
AHR	aryl hydrocarbon receptor	0.039
DUSP2	dual specificity phosphatase 2	0.039
SOX21	SRY (sex determining region Y)-box 21	0.039
RARB	retinoic acid receptor, beta	0.038
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A	0.038	Human
KRT14	keratin 14	0.038
SFN	stratifin	0.038
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.038
GHRHR	growth hormone releasing hormone receptor	0.038
GDF6	growth differentiation factor 6	0.038	Human
HOXB1	homeobox B1	0.038
MSX1	msh homeobox 1	0.038
ASRGL1	asparaginase like 1	0.038
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.038
GAB2	GRB2-associated binding protein 2	0.037
AXL	AXL receptor tyrosine kinase	0.037
PYY	peptide YY	0.037
DIO3	deiodinase, iodothyronine, type III	0.037
HMX1	H6 family homeobox 1	0.037
TSPAN4	tetraspanin 4	0.037
NCAM1	neural cell adhesion molecule 1	0.037
POU4F2	POU class 4 homeobox 2	0.037
HBEGF	heparin-binding EGF-like growth factor	0.036
C1QL1	complement component 1, q subcomponent-like 1	0.036
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.036
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.036
CDX2	caudal type homeobox 2	0.036
CCR3	chemokine (C-C motif) receptor 3	0.036	Mouse
XIAP	X-linked inhibitor of apoptosis	0.036
FGFR4	fibroblast growth factor receptor 4	0.036
SOCS1	suppressor of cytokine signaling 1	0.036
CCND1	cyclin D1	0.036	Mouse
FIBCD1	fibrinogen C domain containing 1	0.036
NPAS1	neuronal PAS domain protein 1	0.036
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.035
ENTPD2	ectonucleoside triphosphate diphosphohydrolase 2	0.035
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.035
GATA4	GATA binding protein 4	0.035
EDN1	endothelin 1	0.035
RHEB	Ras homolog enriched in brain	0.035
IGFBP3	insulin-like growth factor binding protein 3	0.035
CABLES1	Cdk5 and Abl enzyme substrate 1	0.035
HDAC7	histone deacetylase 7	0.035
HCFC1R1	host cell factor C1 regulator 1 (XPO1 dependent)	0.035
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.034
MYH9	myosin, heavy chain 9, non-muscle	0.034
PSIP1	PC4 and SFRS1 interacting protein 1	0.034
CILP	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	0.034
CRYAB	crystallin, alpha B	0.034
CRHR1	corticotropin releasing hormone receptor 1	0.034
MAP2	microtubule-associated protein 2	0.034
COL13A1	collagen, type XIII, alpha 1	0.034
TRIM9	tripartite motif containing 9	0.034
MED25	mediator complex subunit 25	0.034
HS3ST2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	0.034
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.034	Mouse
RGS2	regulator of G-protein signaling 2, 24kDa	0.033
MUC1	mucin 1, cell surface associated	0.033
SFRP2	secreted frizzled-related protein 2	0.033	Human
COL6A1	collagen, type VI, alpha 1	0.033
HOXD1	homeobox D1	0.033
NTSR2	neurotensin receptor 2	0.033
SLC9A3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.033
FBLN2	fibulin 2	0.033
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.033
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.033
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.033
MAPK1IP1L	mitogen-activated protein kinase 1 interacting protein 1-like	0.033
PRPH	peripherin	0.033
FEZF2	FEZ family zinc finger 2	0.032
WNT11	wingless-type MMTV integration site family, member 11	0.032	Human
TREM2	triggering receptor expressed on myeloid cells 2	0.032
IDO1	indoleamine 2,3-dioxygenase 1	0.032
FZD10	frizzled homolog 10 (Drosophila)	0.032	Human
MMP25	matrix metallopeptidase 25	0.032
IDE	insulin-degrading enzyme	0.032
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.032
MSX2	msh homeobox 2	0.032
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.032
PTPRF	protein tyrosine phosphatase, receptor type, F	0.032
THRA	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	0.032
TLX3	T-cell leukemia homeobox 3	0.032
PDE10A	phosphodiesterase 10A	0.032
NEK1	NIMA (never in mitosis gene a)-related kinase 1	0.032
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.032
COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	0.031
PRKCB	protein kinase C, beta	0.031	Human
ACP5	acid phosphatase 5, tartrate resistant	0.031
BCL10	B-cell CLL/lymphoma 10	0.031
HIPK2	homeodomain interacting protein kinase 2	0.031
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.031
NGF	nerve growth factor (beta polypeptide)	0.031
NXF1	nuclear RNA export factor 1	0.031
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	0.031	Human
TOE1	target of EGR1, member 1 (nuclear)	0.031
SIX6	SIX homeobox 6	0.031
TGFA	transforming growth factor, alpha	0.031
FGF6	fibroblast growth factor 6	0.031	Human
ROR2	receptor tyrosine kinase-like orphan receptor 2	0.031
FGF19	fibroblast growth factor 19	0.031
CLDN4	claudin 4	0.031
S1PR5	sphingosine-1-phosphate receptor 5	0.031
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.031
PEBP4	phosphatidylethanolamine-binding protein 4	0.031
HAND1	heart and neural crest derivatives expressed 1	0.031
CDH4	cadherin 4, type 1, R-cadherin (retinal)	0.031	Human
ZIC3	Zic family member 3 (odd-paired homolog, Drosophila)	0.031
SOX17	SRY (sex determining region Y)-box 17	0.031	Human
SPP1	secreted phosphoprotein 1	0.031
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.030
PRDM8	PR domain containing 8	0.030
LBX1	ladybird homeobox 1	0.030
CCND3	cyclin D3	0.030
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.030	Human
BCAM	basal cell adhesion molecule (Lutheran blood group)	0.030
AQP9	aquaporin 9	0.030
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	0.030
WNT6	wingless-type MMTV integration site family, member 6	0.030	Human
TREM1	triggering receptor expressed on myeloid cells 1	0.030
PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	0.030
CDX1	caudal type homeobox 1	0.030
PCDH17	protocadherin 17	0.030
NUCKS1	nuclear casein kinase and cyclin-dependent kinase substrate 1	0.030
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.030
HRH3	histamine receptor H3	0.030	Rat
SIX3	SIX homeobox 3	0.030
RELN	reelin	0.029
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.029
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.029
GPR6	G protein-coupled receptor 6	0.029
TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)	0.029
CCKBR	cholecystokinin B receptor	0.029
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.029
SALL2	sal-like 2 (Drosophila)	0.029
MMP13	matrix metallopeptidase 13 (collagenase 3)	0.029
EN1	engrailed homeobox 1	0.029
RRBP1	ribosome binding protein 1 homolog 180kDa (dog)	0.029
IGF2R	insulin-like growth factor 2 receptor	0.029
ACVRL1	activin A receptor type II-like 1	0.029	Human Mouse
TF	transferrin	0.029
NFIB	nuclear factor I/B	0.029
HOXD9	homeobox D9	0.029
BARX2	BARX homeobox 2	0.029
CCND2	cyclin D2	0.029	Rat
ELF3	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	0.029
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.028
T	T, brachyury homolog (mouse)	0.028
ACVR1B	activin A receptor, type IB	0.028	Human
ADORA3	adenosine A3 receptor	0.028
GPC3	glypican 3	0.028
TH	tyrosine hydroxylase	0.028
COL10A1	collagen, type X, alpha 1	0.028
C5AR1	complement component 5a receptor 1	0.028
ECEL1	endothelin converting enzyme-like 1	0.028
GATA5	GATA binding protein 5	0.028
IL1A	interleukin 1, alpha	0.028
SFRP5	secreted frizzled-related protein 5	0.028	Human
PRKCE	protein kinase C, epsilon	0.028	Human
SOD3	superoxide dismutase 3, extracellular	0.028
UBD	ubiquitin D	0.028
OCA2	oculocutaneous albinism II	0.028
NKX6-1	NK6 homeobox 1	0.028
C3	complement component 3	0.028
FOXG1	forkhead box G1	0.028
PLAT	plasminogen activator, tissue	0.027
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.027
IHH	Indian hedgehog	0.027	Rat
HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	0.027
CHERP	calcium homeostasis endoplasmic reticulum protein	0.027
IRF4	interferon regulatory factor 4	0.027
CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	0.027
FLT4	fms-related tyrosine kinase 4	0.027
CDK2	cyclin-dependent kinase 2	0.027
ATP10A	ATPase, class V, type 10A	0.027
HOXD10	homeobox D10	0.027
CD163	CD163 molecule	0.027
ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	0.027
GJD2	gap junction protein, delta 2, 36kDa	0.027
COL4A6	collagen, type IV, alpha 6	0.027
UTF1	undifferentiated embryonic cell transcription factor 1	0.027
EFNB2	ephrin-B2	0.027
LRRC32	leucine rich repeat containing 32	0.027
NOS1	nitric oxide synthase 1 (neuronal)	0.027
SLIT2	slit homolog 2 (Drosophila)	0.027
EGFL6	EGF-like-domain, multiple 6	0.027
LHX1	LIM homeobox 1	0.027
NKD2	naked cuticle homolog 2 (Drosophila)	0.026
SIK1	salt-inducible kinase 1	0.026
GRIK3	glutamate receptor, ionotropic, kainate 3	0.026
SLA	Src-like-adaptor	0.026
CAPN6	calpain 6	0.026
GRP	gastrin-releasing peptide	0.026
KCNMA1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.026
RICTOR	RPTOR independent companion of MTOR, complex 2	0.026
IGF1R	insulin-like growth factor 1 receptor	0.026
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.026
MSC	musculin	0.026
EREG	epiregulin	0.026
VSX1	visual system homeobox 1	0.026
THBD	thrombomodulin	0.026
TEK	TEK tyrosine kinase, endothelial	0.026
FRZB	frizzled-related protein	0.026	Human
WNT9B	wingless-type MMTV integration site family, member 9B	0.026	Human
RGS4	regulator of G-protein signaling 4	0.026
SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	0.026
SOX9	SRY (sex determining region Y)-box 9	0.026
GAS6	growth arrest-specific 6	0.026
PECAM1	platelet/endothelial cell adhesion molecule	0.026
NELL1	NEL-like 1 (chicken)	0.025
ANKRD1	ankyrin repeat domain 1 (cardiac muscle)	0.025
RUNX3	runt-related transcription factor 3	0.025
HTR6	5-hydroxytryptamine (serotonin) receptor 6	0.025
FYB	FYN binding protein	0.025
BDNF	brain-derived neurotrophic factor	0.025
EPHB2	EPH receptor B2	0.025
FYN	FYN oncogene related to SRC, FGR, YES	0.025
IRS4	insulin receptor substrate 4	0.025
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.025
CCL23	chemokine (C-C motif) ligand 23	0.025	Human
RPL38	ribosomal protein L38	0.025
SHOX2	short stature homeobox 2	0.025
DHH	desert hedgehog	0.025
CNTN2	contactin 2 (axonal)	0.025
KRT8	keratin 8	0.025
TTYH1	tweety homolog 1 (Drosophila)	0.025
KIAA1199	KIAA1199	0.025
CHRND	cholinergic receptor, nicotinic, delta	0.025
SUGP1	SURP and G patch domain containing 1	0.025
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.025
FOXB1	forkhead box B1	0.025
SF3A2	splicing factor 3a, subunit 2, 66kDa	0.025
CCNB2	cyclin B2	0.024
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.024
SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.024
TNIK	TRAF2 and NCK interacting kinase	0.024
FOXE3	forkhead box E3	0.024	Mouse Rat
E2F3	E2F transcription factor 3	0.024
ADAMTS7	ADAM metallopeptidase with thrombospondin type 1 motif, 7	0.024
MSR1	macrophage scavenger receptor 1	0.024
TAC1	tachykinin, precursor 1	0.024
SLC18A3	solute carrier family 18 (vesicular acetylcholine), member 3	0.024
CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.024
LPAR1	lysophosphatidic acid receptor 1	0.024
EMP1	epithelial membrane protein 1	0.024
PITX3	paired-like homeodomain 3	0.024
BAX	BCL2-associated X protein	0.024
PLEK	pleckstrin	0.024
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.024
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.024
PEF1	penta-EF-hand domain containing 1	0.024
RIN1	Ras and Rab interactor 1	0.024
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.024	Human
CD69	CD69 molecule	0.024
KRT1	keratin 1	0.024
GHSR	growth hormone secretagogue receptor	0.024
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.024
GHR	growth hormone receptor	0.024
GJB3	gap junction protein, beta 3, 31kDa	0.024
WNT4	wingless-type MMTV integration site family, member 4	0.024	Human
DRD1	dopamine receptor D1	0.024	Human
ADRA2B	adrenergic, alpha-2B-, receptor	0.024
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.024
AR	androgen receptor	0.024
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.024	Rat
MAML1	mastermind-like 1 (Drosophila)	0.024
FOXL2	forkhead box L2	0.024
ATF3	activating transcription factor 3	0.023
CDCP1	CUB domain containing protein 1	0.023
DPT	dermatopontin	0.023
GDF10	growth differentiation factor 10	0.023	Human
APLNR	apelin receptor	0.023
SIX2	SIX homeobox 2	0.023
LHX2	LIM homeobox 2	0.023
EPPK1	epiplakin 1	0.023
ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	0.023
PDPK1	3-phosphoinositide dependent protein kinase-1	0.023
NEUROG2	neurogenin 2	0.023
FGFBP1	fibroblast growth factor binding protein 1	0.023
OPRD1	opioid receptor, delta 1	0.023
PTH2	parathyroid hormone 2	0.023
CTNNBIP1	catenin, beta interacting protein 1	0.023
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.023
GRB7	growth factor receptor-bound protein 7	0.023
MARK2	MAP/microtubule affinity-regulating kinase 2	0.023
GPR3	G protein-coupled receptor 3	0.023
DSG1	desmoglein 1	0.023
ITGB4	integrin, beta 4	0.023
HAP1	huntingtin-associated protein 1	0.023
TP73	tumor protein p73	0.023
OS9	osteosarcoma amplified 9, endoplasmic reticulum lectin	0.023
PLA2G2D	phospholipase A2, group IID	0.023
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.023
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.023
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.023
GBX2	gastrulation brain homeobox 2	0.023
A4GALT	alpha 1,4-galactosyltransferase	0.023
HSPB1	heat shock 27kDa protein 1	0.023
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.023
TP53BP2	tumor protein p53 binding protein, 2	0.023
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.023	Human
CHRNA4	cholinergic receptor, nicotinic, alpha 4	0.023
F2RL3	coagulation factor II (thrombin) receptor-like 3	0.023
HES2	hairy and enhancer of split 2 (Drosophila)	0.022
PML	promyelocytic leukemia	0.022
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.022
DIO2	deiodinase, iodothyronine, type II	0.022
STAT4	signal transducer and activator of transcription 4	0.022
NKX3-2	NK3 homeobox 2	0.022
BHLHE40	basic helix-loop-helix family, member e40	0.022
PITX2	paired-like homeodomain 2	0.022
HS3ST6	heparan sulfate (glucosamine) 3-O-sulfotransferase 6	0.022
VAT1	vesicle amine transport protein 1 homolog (T. californica)	0.022
CTGF	connective tissue growth factor	0.022
DBN1	drebrin 1	0.022
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.022
BMP6	bone morphogenetic protein 6	0.022
GREM1	gremlin 1	0.022
POU4F1	POU class 4 homeobox 1	0.022
GJA1	gap junction protein, alpha 1, 43kDa	0.022
HTR7	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)	0.022
NRG1	neuregulin 1	0.022
PAX2	paired box 2	0.022
PAX6	paired box 6	0.022
LYPD3	LY6/PLAUR domain containing 3	0.022
PTF1A	pancreas specific transcription factor, 1a	0.022
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.022
COL11A1	collagen, type XI, alpha 1	0.022
EMX2	empty spiracles homeobox 2	0.022
NTF3	neurotrophin 3	0.022
HRH1	histamine receptor H1	0.022
CCL17	chemokine (C-C motif) ligand 17	0.022	Human
AQP5	aquaporin 5	0.022
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.022
VIPR2	vasoactive intestinal peptide receptor 2	0.022
POU3F1	POU class 3 homeobox 1	0.022
NOTCH1	notch 1	0.021	Mouse
LAMP3	lysosomal-associated membrane protein 3	0.021
OR2AG1	olfactory receptor, family 2, subfamily AG, member 1	0.021
EPHA3	EPH receptor A3	0.021
CTSD	cathepsin D	0.021
TEF	thyrotrophic embryonic factor	0.021
CSF3	colony stimulating factor 3 (granulocyte)	0.021
EDNRB	endothelin receptor type B	0.021
TRIM29	tripartite motif containing 29	0.021
LHX5	LIM homeobox 5	0.021
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.021
F3	coagulation factor III (thromboplastin, tissue factor)	0.021
TNC	tenascin C	0.021
NR5A2	nuclear receptor subfamily 5, group A, member 2	0.021
RYK	RYK receptor-like tyrosine kinase	0.021
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	0.021
LTK	leukocyte receptor tyrosine kinase	0.021
ITGB8	integrin, beta 8	0.021
BNC1	basonuclin 1	0.021	Mouse
FCGRT	Fc fragment of IgG, receptor, transporter, alpha	0.021
HPSE2	heparanase 2	0.021
IL9	interleukin 9	0.021
BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	0.021
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.021
HTR1E	5-hydroxytryptamine (serotonin) receptor 1E	0.021	Human
EDIL3	EGF-like repeats and discoidin I-like domains 3	0.021
KCNE4	potassium voltage-gated channel, Isk-related family, member 4	0.021
ZNF331	zinc finger protein 331	0.021
NPM3	nucleophosmin/nucleoplasmin 3	0.021
SLIT3	slit homolog 3 (Drosophila)	0.021
ADRB3	adrenergic, beta-3-, receptor	0.021	Human
ATP4B	ATPase, H+/K+ exchanging, beta polypeptide	0.021
CSF1R	colony stimulating factor 1 receptor	0.021	Human
FZD2	frizzled homolog 2 (Drosophila)	0.021	Human
SGK1	serum/glucocorticoid regulated kinase 1	0.021
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.021
FMOD	fibromodulin	0.021
USP12	ubiquitin specific peptidase 12	0.021
RNH1	ribonuclease/angiogenin inhibitor 1	0.021