IMP: Integrative Multi-species Prediction

Homo sapiens

22 genes annotated in human

response to temperature stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in humanInclude functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to temperature stimulus"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "response to temperature stimulus" (in gray)

Name	Description	Probability	Func Analog Organism
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.990	Yeast Fly
HSPB8	heat shock 22kDa protein 8	0.959	Fly
CRYAB	crystallin, alpha B	0.943	Fly
HSPA8	heat shock 70kDa protein 8	0.911	Human Yeast Worm
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.902	Fly
BAG3	BCL2-associated athanogene 3	0.847
MAPK8	mitogen-activated protein kinase 8	0.777	Yeast Rat Worm Fly
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.708
JUN	jun proto-oncogene	0.696
FGFR2	fibroblast growth factor receptor 2	0.605
RB1	retinoblastoma 1	0.567
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.559
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.491	Yeast Fly
HSPA1B	heat shock 70kDa protein 1B	0.403
HSPH1	heat shock 105kDa/110kDa protein 1	0.402
HSPB1	heat shock 27kDa protein 1	0.380	Zebrafish Fly
TP53	tumor protein p53	0.356	Rat
FKBP4	FK506 binding protein 4, 59kDa	0.316
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.313
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.308
DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.305
FGFR1	fibroblast growth factor receptor 1	0.301
AHSA1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	0.294	Yeast
IL1B	interleukin 1, beta	0.284	Human Rat
ATF2	activating transcription factor 2	0.269
MAP2K4	mitogen-activated protein kinase kinase 4	0.228	Human
HSPA1A	heat shock 70kDa protein 1A	0.225
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.206
MAPK1	mitogen-activated protein kinase 1	0.203
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.189	Mouse
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.186
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.181	Fly
APP	amyloid beta (A4) precursor protein	0.176
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.159	Fly
MAPK14	mitogen-activated protein kinase 14	0.150	Yeast Fly
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.135
RPLP1	ribosomal protein, large, P1	0.132
CXCL3	chemokine (C-X-C motif) ligand 3	0.127	Rat
PPID	peptidylprolyl isomerase D	0.118	Yeast
CDK9	cyclin-dependent kinase 9	0.116	Fly
EEF1A1	eukaryotic translation elongation factor 1 alpha 1	0.115
UBC	ubiquitin C	0.113
ATF3	activating transcription factor 3	0.113
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.111
RBBP4	retinoblastoma binding protein 4	0.110	Human
DUSP1	dual specificity phosphatase 1	0.110
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.107
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.106
IL8	interleukin 8	0.100
RPS3A	ribosomal protein S3A	0.100
C2orf65	chromosome 2 open reading frame 65	0.099
RPS24	ribosomal protein S24	0.092
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.092	Rat
ARRB1	arrestin, beta 1	0.090
FGF10	fibroblast growth factor 10	0.087	Human
BAG2	BCL2-associated athanogene 2	0.086
STIP1	stress-induced-phosphoprotein 1	0.081
LRRK2	leucine-rich repeat kinase 2	0.079
HSPD1	heat shock 60kDa protein 1 (chaperonin)	0.078	Rat Fly
NOSTRIN	nitric oxide synthase trafficker	0.077
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.077
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.077
CRYGC	crystallin, gamma C	0.066
IGF1R	insulin-like growth factor 1 receptor	0.066	Worm
HNRNPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	0.066
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.064	Fly
ARRB2	arrestin, beta 2	0.063	Rat
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	0.063	Fly
EGFR	epidermal growth factor receptor	0.062
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.062
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.062	Yeast
PRKAR2A	protein kinase, cAMP-dependent, regulatory, type II, alpha	0.060
CXCL2	chemokine (C-X-C motif) ligand 2	0.060	Rat
PDIA6	protein disulfide isomerase family A, member 6	0.060
THOC5	THO complex 5	0.058
CALB1	calbindin 1, 28kDa	0.058
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	0.057	Fly
ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	0.057
HSPB2	heat shock 27kDa protein 2	0.055	Rat Fly
GCLM	glutamate-cysteine ligase, modifier subunit	0.054
CRYBB2	crystallin, beta B2	0.054
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.054	Fly
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.052
PTGES3	prostaglandin E synthase 3 (cytosolic)	0.052
HDAC1	histone deacetylase 1	0.052
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.052
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.050
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.047
ARNTL	aryl hydrocarbon receptor nuclear translocator-like	0.047
RPS23	ribosomal protein S23	0.045
PPP5C	protein phosphatase 5, catalytic subunit	0.044
BAG1	BCL2-associated athanogene	0.042
SIRT1	sirtuin 1	0.042
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.042	Rat
PARP1	poly (ADP-ribose) polymerase 1	0.041
THOC1	THO complex 1	0.040
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.040	Fly
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.040
HNRPDL	heterogeneous nuclear ribonucleoprotein D-like	0.039
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.038
NGF	nerve growth factor (beta polypeptide)	0.037
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.036
RBBP7	retinoblastoma binding protein 7	0.036
IL1R1	interleukin 1 receptor, type I	0.036	Rat
BAD	BCL2-associated agonist of cell death	0.035
PPARG	peroxisome proliferator-activated receptor gamma	0.035	Rat
MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	0.034
RPS4X	ribosomal protein S4, X-linked	0.034
NUP98	nucleoporin 98kDa	0.034
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.033
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.033
HDAC2	histone deacetylase 2	0.033
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.033
IL1RN	interleukin 1 receptor antagonist	0.032
PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.031
RPN2	ribophorin II	0.030
PDIA3	protein disulfide isomerase family A, member 3	0.030
COASY	CoA synthase	0.030
RPL18A	ribosomal protein L18a	0.030
FGF1	fibroblast growth factor 1 (acidic)	0.030
NXF1	nuclear RNA export factor 1	0.029
VAC14	Vac14 homolog (S. cerevisiae)	0.029
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.029
RPS2	ribosomal protein S2	0.028
RBMX	RNA binding motif protein, X-linked	0.028
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.028
PDCD6IP	programmed cell death 6 interacting protein	0.028
IL6	interleukin 6 (interferon, beta 2)	0.028
DNM1	dynamin 1	0.027	Fly
NRP1	neuropilin 1	0.027
MYD88	myeloid differentiation primary response gene (88)	0.026
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.026	Yeast
SOD1	superoxide dismutase 1, soluble	0.026
MATR3	matrin 3	0.026
DDIT3	DNA-damage-inducible transcript 3	0.026
MCM7	minichromosome maintenance complex component 7	0.026
IL1RAP	interleukin 1 receptor accessory protein	0.025
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.025	Fly
INSR	insulin receptor	0.025	Worm
TXN	thioredoxin	0.025
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.025
TCP1	t-complex 1	0.024
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.024
EEF1G	eukaryotic translation elongation factor 1 gamma	0.024
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.024
HSPE1	heat shock 10kDa protein 1 (chaperonin 10)	0.024
HIPK2	homeodomain interacting protein kinase 2	0.023
MAPK9	mitogen-activated protein kinase 9	0.023	Yeast Worm Fly
MAPK10	mitogen-activated protein kinase 10	0.023	Yeast Worm Fly
IRAK2	interleukin-1 receptor-associated kinase 2	0.023
CCL20	chemokine (C-C motif) ligand 20	0.023
RPL32	ribosomal protein L32	0.022
TOP1	topoisomerase (DNA) I	0.022
IRF2	interferon regulatory factor 2	0.021
MYCBP	c-myc binding protein	0.020
THOC4	THO complex 4	0.020
BCR	breakpoint cluster region	0.020
DUSP7	dual specificity phosphatase 7	0.019
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.019
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	0.019
EP300	E1A binding protein p300	0.019
SYNCRIP	synaptotagmin binding, cytoplasmic RNA interacting protein	0.019
GRB7	growth factor receptor-bound protein 7	0.019
ESRRG	estrogen-related receptor gamma	0.018
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.018
EPOR	erythropoietin receptor	0.018
PELI3	pellino homolog 3 (Drosophila)	0.018
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.018
NCOR1	nuclear receptor corepressor 1	0.018
DAPK1	death-associated protein kinase 1	0.018
GRB10	growth factor receptor-bound protein 10	0.018
ARRDC3	arrestin domain containing 3	0.017
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.017
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.017
RPL5	ribosomal protein L5	0.017
BBS10	Bardet-Biedl syndrome 10	0.017
LGALS3	lectin, galactoside-binding, soluble, 3	0.017
MYST2	MYST histone acetyltransferase 2	0.017
MAPK3	mitogen-activated protein kinase 3	0.017
ESR1	estrogen receptor 1	0.017
SAP30	Sin3A-associated protein, 30kDa	0.017
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.017
C3orf15	chromosome 3 open reading frame 15	0.017
NONO	non-POU domain containing, octamer-binding	0.016
BRD4	bromodomain containing 4	0.016
AR	androgen receptor	0.016
AKAP11	A kinase (PRKA) anchor protein 11	0.016
CACYBP	calcyclin binding protein	0.016
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	0.016
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.016
SQSTM1	sequestosome 1	0.016
RPS14	ribosomal protein S14	0.015
USPL1	ubiquitin specific peptidase like 1	0.015
DNM2	dynamin 2	0.015	Fly
RPL41	ribosomal protein L41	0.015
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.015
WASL	Wiskott-Aldrich syndrome-like	0.015
CAV1	caveolin 1, caveolae protein, 22kDa	0.015
MAPT	microtubule-associated protein tau	0.015
PGF	placental growth factor	0.015
CRYBA1	crystallin, beta A1	0.015
HNF4A	hepatocyte nuclear factor 4, alpha	0.015
CPNE6	copine VI (neuronal)	0.015
CLEC4G	C-type lectin domain family 4, member G	0.014
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.014
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.014	Worm
SOCS3	suppressor of cytokine signaling 3	0.014	Rat
UBE2W	ubiquitin-conjugating enzyme E2W (putative)	0.014
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.014
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.014
EEF2	eukaryotic translation elongation factor 2	0.014
ECSIT	ECSIT homolog (Drosophila)	0.014
SMAD3	SMAD family member 3	0.014
RPL3	ribosomal protein L3	0.014
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.014
DDX24	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	0.014
PTBP1	polypyrimidine tract binding protein 1	0.014
HDAC3	histone deacetylase 3	0.014
MAP1S	microtubule-associated protein 1S	0.014
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.014
RPSA	ribosomal protein SA	0.014
TBL3	transducin (beta)-like 3	0.013
NQO1	NAD(P)H dehydrogenase, quinone 1	0.013
CHORDC1	cysteine and histidine-rich domain (CHORD) containing 1	0.013	Mouse
C16orf70	chromosome 16 open reading frame 70	0.013
RPL17	ribosomal protein L17	0.013
RPL23	ribosomal protein L23	0.013
PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	0.013
EIF2B4	eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa	0.013
P4HB	prolyl 4-hydroxylase, beta polypeptide	0.013
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.013	Fly
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.013
BCL2L1	BCL2-like 1	0.013
TARDBP	TAR DNA binding protein	0.013
PTEN	phosphatase and tensin homolog	0.013	Worm
MAPK6	mitogen-activated protein kinase 6	0.012
IQCB1	IQ motif containing B1	0.012
MEF2A	myocyte enhancer factor 2A	0.012
EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	0.012
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.012
PCMT1	protein-L-isoaspartate (D-aspartate) O-methyltransferase	0.012
BCL2	B-cell CLL/lymphoma 2	0.012	Rat
FKBP5	FK506 binding protein 5	0.012
DUSP23	dual specificity phosphatase 23	0.012
CEP250	centrosomal protein 250kDa	0.012
MBD3	methyl-CpG binding domain protein 3	0.012
IRS1	insulin receptor substrate 1	0.012
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.012
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.012
SH3KBP1	SH3-domain kinase binding protein 1	0.012
RIPK3	receptor-interacting serine-threonine kinase 3	0.012
NCF2	neutrophil cytosolic factor 2	0.012
PRDX3	peroxiredoxin 3	0.012
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.012
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.012
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.012
PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta	0.012
FASN	fatty acid synthase	0.011
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.011
TRIB3	tribbles homolog 3 (Drosophila)	0.011
AMPH	amphiphysin	0.011
SRSF1	serine/arginine-rich splicing factor 1	0.011
CDCP1	CUB domain containing protein 1	0.011
EGR1	early growth response 1	0.011
ADRM1	adhesion regulating molecule 1	0.011
POLR2E	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa	0.011
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.011
IER3	immediate early response 3	0.011
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.011
PKN1	protein kinase N1	0.011
ITSN1	intersectin 1 (SH3 domain protein)	0.011
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.011	Fly
SH3GL1	SH3-domain GRB2-like 1	0.011
PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3	0.011
IL1R2	interleukin 1 receptor, type II	0.011
HSPA9	heat shock 70kDa protein 9 (mortalin)	0.011
XPO1	exportin 1 (CRM1 homolog, yeast)	0.011
MAP4K2	mitogen-activated protein kinase kinase kinase kinase 2	0.011
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.011
SOD2	superoxide dismutase 2, mitochondrial	0.011
CREBZF	CREB/ATF bZIP transcription factor	0.011
ADAM15	ADAM metallopeptidase domain 15	0.011
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.011
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.011	Fly
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.011
RPLP0	ribosomal protein, large, P0	0.011
TRIM28	tripartite motif containing 28	0.011
EPN1	epsin 1	0.010
ZCCHC10	zinc finger, CCHC domain containing 10	0.010
ADAM17	ADAM metallopeptidase domain 17	0.010
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.010
FGF7	fibroblast growth factor 7	0.010	Human
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.010	Yeast
EED	embryonic ectoderm development	0.010
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.010
STAT5A	signal transducer and activator of transcription 5A	0.010
MEF2C	myocyte enhancer factor 2C	0.010
RPL10	ribosomal protein L10	0.010
RNF126	ring finger protein 126	0.010
PARK7	Parkinson disease (autosomal recessive, early onset) 7	0.010
JUND	jun D proto-oncogene	0.010
RUNX1	runt-related transcription factor 1	0.010
RPL39	ribosomal protein L39	0.010