IMP: Integrative Multi-species Prediction

Homo sapiens

4 genes annotated in human

rna polymerase ii transcriptional preinitiation complex assembly

The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "rna polymerase ii transcriptional preinitiation complex assembly"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "rna polymerase ii transcriptional preinitiation complex assembly" (in gray)

Name	Description	Probability	Func Analog Organism
TBP	TATA box binding protein	1.000	Yeast Fly
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	1.000
TAF4	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	1.000
PSMD13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	1.000
PSMD10	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	1.000
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.999
PSMC2	proteasome (prosome, macropain) 26S subunit, ATPase, 2	0.999	Yeast
PSMC1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.999
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.999
PSMC6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	0.998	Yeast
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.997
GTF2B	general transcription factor IIB	0.992	Yeast
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.991
PSMC5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.982	Yeast
TAF5	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa	0.962
SP1	Sp1 transcription factor	0.941
TAF10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa	0.938	Yeast
PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.933
TAF11	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa	0.794	Fly
CREBBP	CREB binding protein	0.683
NCOA6	nuclear receptor coactivator 6	0.680
TAF1C	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa	0.668
PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3	0.626	Yeast
KAT2B	K(lysine) acetyltransferase 2B	0.621
CSNK1A1	casein kinase 1, alpha 1	0.605
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.596
HMGA1	high mobility group AT-hook 1	0.509
PSMC4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.509	Yeast
TAF6L	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	0.492
SETD7	SET domain containing (lysine methyltransferase) 7	0.449
TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	0.444	Fly
HMGB2	high mobility group box 2	0.443	Human
TAF9	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa	0.425	Yeast Fly
FAM190B	family with sequence similarity 190, member B	0.400
NCOA1	nuclear receptor coactivator 1	0.355
ARNT	aryl hydrocarbon receptor nuclear translocator	0.346
MED21	mediator complex subunit 21	0.344
GTF2A1	general transcription factor IIA, 1, 19/37kDa	0.331	Yeast
TAF13	TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa	0.324	Yeast
POLR2A	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	0.312
SSRP1	structure specific recognition protein 1	0.270	Yeast
TAF6	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	0.267	Yeast Fly
NCOR1	nuclear receptor corepressor 1	0.267
SMAD4	SMAD family member 4	0.264
PSMD9	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	0.260
PSMD14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.259
TAF12	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa	0.254	Yeast
NCOA7	nuclear receptor coactivator 7	0.248
TAF2	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa	0.234	Fly
MARK3	MAP/microtubule affinity-regulating kinase 3	0.231
EP300	E1A binding protein p300	0.225
GTF2E1	general transcription factor IIE, polypeptide 1, alpha 56kDa	0.219
HTT	huntingtin	0.207
MED26	mediator complex subunit 26	0.203
LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.197
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.189
TRRAP	transformation/transcription domain-associated protein	0.184
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.183
DR1	down-regulator of transcription 1, TBP-binding (negative cofactor 2)	0.175	Fly
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.174
PAF1	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.167
NUCKS1	nuclear casein kinase and cyclin-dependent kinase substrate 1	0.154
PAAF1	proteasomal ATPase-associated factor 1	0.154
MED25	mediator complex subunit 25	0.147
TAF3	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	0.140
AR	androgen receptor	0.139
HDGF	hepatoma-derived growth factor	0.136
PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	0.135
NCOA3	nuclear receptor coactivator 3	0.122
TRIM33	tripartite motif containing 33	0.121
PSMD8	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8	0.120
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.119
NCOA2	nuclear receptor coactivator 2	0.114
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.108
CDK7	cyclin-dependent kinase 7	0.099
RAD21	RAD21 homolog (S. pombe)	0.097
HMGB1	high mobility group box 1	0.096
PPARA	peroxisome proliferator-activated receptor alpha	0.096
BRF1	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)	0.093
PSMD3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	0.089
UCHL5	ubiquitin carboxyl-terminal hydrolase L5	0.086
RPS14	ribosomal protein S14	0.086
ZNF518A	zinc finger protein 518A	0.083
DRAP1	DR1-associated protein 1 (negative cofactor 2 alpha)	0.079	Fly
PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3	0.078
MAPK14	mitogen-activated protein kinase 14	0.078
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.077
TBPL1	TBP-like 1	0.076	Yeast
MED1	mediator complex subunit 1	0.075
RXRB	retinoid X receptor, beta	0.074
NFYC	nuclear transcription factor Y, gamma	0.073
ERCC3	excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)	0.071
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.071
PURA	purine-rich element binding protein A	0.071
KAT2A	K(lysine) acetyltransferase 2A	0.070
CUX1	cut-like homeobox 1	0.068
POU2F1	POU class 2 homeobox 1	0.068
E2F3	E2F transcription factor 3	0.067
MAGED2	melanoma antigen family D, 2	0.064
PRMT6	protein arginine methyltransferase 6	0.061
RPA1	replication protein A1, 70kDa	0.061
LSM1	LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.058
NFYB	nuclear transcription factor Y, beta	0.057
NCOR2	nuclear receptor corepressor 2	0.056
RAD23A	RAD23 homolog A (S. cerevisiae)	0.055
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.054
MTF2	metal response element binding transcription factor 2	0.053
ESR1	estrogen receptor 1	0.053
UBE2S	ubiquitin-conjugating enzyme E2S	0.052
TAF8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa	0.052
RB1	retinoblastoma 1	0.051
HMGN1	high mobility group nucleosome binding domain 1	0.049
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.048
MMADHC	methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria	0.046
RNF138	ring finger protein 138	0.042
PSMD5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 5	0.042
ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	0.041
ARNTL	aryl hydrocarbon receptor nuclear translocator-like	0.041
PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	0.041
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.040
GTF2F1	general transcription factor IIF, polypeptide 1, 74kDa	0.040
MAGEA11	melanoma antigen family A, 11	0.039
GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa	0.038
SORBS3	sorbin and SH3 domain containing 3	0.038
SUPT16H	suppressor of Ty 16 homolog (S. cerevisiae)	0.038	Yeast
EPG5	ectopic P-granules autophagy protein 5 homolog (C. elegans)	0.037
TAF1B	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	0.037
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.037
POLE3	polymerase (DNA directed), epsilon 3 (p17 subunit)	0.036
TFDP1	transcription factor Dp-1	0.034
ANP32E	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	0.033
SKIL	SKI-like oncogene	0.032
DMTF1	cyclin D binding myb-like transcription factor 1	0.032
ZNF410	zinc finger protein 410	0.032
DEK	DEK oncogene	0.031
BANF1	barrier to autointegration factor 1	0.030
NFYA	nuclear transcription factor Y, alpha	0.030
ZNF350	zinc finger protein 350	0.030
PPP2R4	protein phosphatase 2A activator, regulatory subunit 4	0.030
HDAC2	histone deacetylase 2	0.029
EXOSC10	exosome component 10	0.029
MACF1	microtubule-actin crosslinking factor 1	0.029
DUSP11	dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)	0.029
POLR1A	polymerase (RNA) I polypeptide A, 194kDa	0.028
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.026
RXRG	retinoid X receptor, gamma	0.026
LBR	lamin B receptor	0.026
KANK2	KN motif and ankyrin repeat domains 2	0.026
ATXN7	ataxin 7	0.026
SRSF11	serine/arginine-rich splicing factor 11	0.025
PGR	progesterone receptor	0.025
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.025
AP2M1	adaptor-related protein complex 2, mu 1 subunit	0.024
CD3EAP	CD3e molecule, epsilon associated protein	0.024
NEK9	NIMA (never in mitosis gene a)- related kinase 9	0.024
TADA3	transcriptional adaptor 3	0.024
CADM1	cell adhesion molecule 1	0.023
TXNL1	thioredoxin-like 1	0.023
RORA	RAR-related orphan receptor A	0.023
TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	0.023
ZNF830	zinc finger protein 830	0.022
KATNA1	katanin p60 (ATPase containing) subunit A 1	0.022
SHFM1	split hand/foot malformation (ectrodactyly) type 1	0.022
E2F2	E2F transcription factor 2	0.022
FRK	fyn-related kinase	0.021
TAF7	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa	0.021	Yeast
KIF13A	kinesin family member 13A	0.021
SLU7	SLU7 splicing factor homolog (S. cerevisiae)	0.021
CCDC6	coiled-coil domain containing 6	0.020
ANKRD12	ankyrin repeat domain 12	0.020
ZMYM2	zinc finger, MYM-type 2	0.020
AATF	apoptosis antagonizing transcription factor	0.020
SMAD1	SMAD family member 1	0.020
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.020
KLHL24	kelch-like 24 (Drosophila)	0.020
TAX1BP3	Tax1 (human T-cell leukemia virus type I) binding protein 3	0.020
SPIN1	spindlin 1	0.019
IK	IK cytokine, down-regulator of HLA II	0.019
ELF1	E74-like factor 1 (ets domain transcription factor)	0.019
SMAD9	SMAD family member 9	0.018
FOXO3	forkhead box O3	0.018
MBD1	methyl-CpG binding domain protein 1	0.018
CTDP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	0.018
GTF2E2	general transcription factor IIE, polypeptide 2, beta 34kDa	0.018
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.017
UBE2V2	ubiquitin-conjugating enzyme E2 variant 2	0.017
HDAC3	histone deacetylase 3	0.017
RPH3AL	rabphilin 3A-like (without C2 domains)	0.017
ZNF358	zinc finger protein 358	0.017
KPNA6	karyopherin alpha 6 (importin alpha 7)	0.017
ZBED5	zinc finger, BED-type containing 5	0.016
TRIP11	thyroid hormone receptor interactor 11	0.016
JMY	junction mediating and regulatory protein, p53 cofactor	0.016
CRLF3	cytokine receptor-like factor 3	0.016
GPSM2	G-protein signaling modulator 2	0.016
CCNB2	cyclin B2	0.016
NR2F6	nuclear receptor subfamily 2, group F, member 6	0.016
ZBTB38	zinc finger and BTB domain containing 38	0.016
PPARG	peroxisome proliferator-activated receptor gamma	0.016
POLR1E	polymerase (RNA) I polypeptide E, 53kDa	0.016
RNF40	ring finger protein 40	0.016
RBM25	RNA binding motif protein 25	0.016
PAIP2	poly(A) binding protein interacting protein 2	0.015
DCP1B	DCP1 decapping enzyme homolog B (S. cerevisiae)	0.015
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.015
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.015
THRB	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	0.015	Human
KPNA1	karyopherin alpha 1 (importin alpha 5)	0.015
SPAG9	sperm associated antigen 9	0.015
MEIS1	Meis homeobox 1	0.015
ARHGAP19	Rho GTPase activating protein 19	0.015
AAAS	achalasia, adrenocortical insufficiency, alacrimia	0.015
RBM15	RNA binding motif protein 15	0.015
E2F1	E2F transcription factor 1	0.015
VEGFB	vascular endothelial growth factor B	0.015
KIAA2026	KIAA2026	0.014
SNRPB2	small nuclear ribonucleoprotein polypeptide B	0.014
ZNF24	zinc finger protein 24	0.014
LMNB1	lamin B1	0.014
MORF4L2	mortality factor 4 like 2	0.014
ACY3	aspartoacylase (aminocyclase) 3	0.014
SRP54	signal recognition particle 54kDa	0.014
HIPK3	homeodomain interacting protein kinase 3	0.014
ATF6	activating transcription factor 6	0.014
MLF2	myeloid leukemia factor 2	0.014
KRT10	keratin 10	0.014
CGRRF1	cell growth regulator with ring finger domain 1	0.014
CRABP2	cellular retinoic acid binding protein 2	0.014
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.013
SERGEF	secretion regulating guanine nucleotide exchange factor	0.013
ZNF576	zinc finger protein 576	0.013
APLF	aprataxin and PNKP like factor	0.013
CKAP5	cytoskeleton associated protein 5	0.013
SLC6A9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	0.013
TBCC	tubulin folding cofactor C	0.013
PIGC	phosphatidylinositol glycan anchor biosynthesis, class C	0.013
CBX5	chromobox homolog 5	0.013
MRI1	methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)	0.013
PLEKHO1	pleckstrin homology domain containing, family O member 1	0.013
PDP1	pyruvate dehyrogenase phosphatase catalytic subunit 1	0.013
PIAS1	protein inhibitor of activated STAT, 1	0.013
TOX4	TOX high mobility group box family member 4	0.013
C5orf41	chromosome 5 open reading frame 41	0.013
MED28	mediator complex subunit 28	0.013
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.013
TTC1	tetratricopeptide repeat domain 1	0.013
RAB9A	RAB9A, member RAS oncogene family	0.012
TOP1	topoisomerase (DNA) I	0.012
CHIC2	cysteine-rich hydrophobic domain 2	0.012
HBP1	HMG-box transcription factor 1	0.012
DLG5	discs, large homolog 5 (Drosophila)	0.012
EMID2	EMI domain containing 2	0.012
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.012
RECQL5	RecQ protein-like 5	0.012
BCL7B	B-cell CLL/lymphoma 7B	0.012
NGRN	neugrin, neurite outgrowth associated	0.012
CENPA	centromere protein A	0.012
CNOT3	CCR4-NOT transcription complex, subunit 3	0.012
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.012
MAF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)	0.012
PSPC1	paraspeckle component 1	0.012
EAPP	E2F-associated phosphoprotein	0.012
E2F4	E2F transcription factor 4, p107/p130-binding	0.012
TRIP4	thyroid hormone receptor interactor 4	0.012
H1FX	H1 histone family, member X	0.012
WASF2	WAS protein family, member 2	0.012
GPS2	G protein pathway suppressor 2	0.012
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.012
ODF2	outer dense fiber of sperm tails 2	0.012
CCNL1	cyclin L1	0.011
DUSP6	dual specificity phosphatase 6	0.011
GPBP1	GC-rich promoter binding protein 1	0.011
ZCCHC10	zinc finger, CCHC domain containing 10	0.011
TAF9B	TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa	0.011
MYCBP	c-myc binding protein	0.011
EFNB1	ephrin-B1	0.011
HNRNPL	heterogeneous nuclear ribonucleoprotein L	0.011
IL24	interleukin 24	0.011
RAD23B	RAD23 homolog B (S. cerevisiae)	0.011
AGPAT1	1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)	0.011
RNF6	ring finger protein (C3H2C3 type) 6	0.011
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.011
ADAP1	ArfGAP with dual PH domains 1	0.011
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.011
DCTN1	dynactin 1	0.011
SSU72	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	0.011
PTPRU	protein tyrosine phosphatase, receptor type, U	0.011
THEM4	thioesterase superfamily member 4	0.011
TNNT1	troponin T type 1 (skeletal, slow)	0.011
BTBD2	BTB (POZ) domain containing 2	0.011
GMEB1	glucocorticoid modulatory element binding protein 1	0.011
SAP18	Sin3A-associated protein, 18kDa	0.011
CTCF	CCCTC-binding factor (zinc finger protein)	0.011
CTSF	cathepsin F	0.011
RNF39	ring finger protein 39	0.011
FHIT	fragile histidine triad gene	0.011
NR1D1	nuclear receptor subfamily 1, group D, member 1	0.011	Human
PAPD7	PAP associated domain containing 7	0.011
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.011
PTPN21	protein tyrosine phosphatase, non-receptor type 21	0.011
PRAF2	PRA1 domain family, member 2	0.011
NPAS2	neuronal PAS domain protein 2	0.011
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.011
GGH	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	0.011
BBX	bobby sox homolog (Drosophila)	0.010
ACTR1A	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	0.010
SNW1	SNW domain containing 1	0.010
SIRT1	sirtuin 1	0.010
ESRRG	estrogen-related receptor gamma	0.010
ANP32A	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	0.010
DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.010
CACNB1	calcium channel, voltage-dependent, beta 1 subunit	0.010
PASK	PAS domain containing serine/threonine kinase	0.010
CEP250	centrosomal protein 250kDa	0.010
TAF1A	TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa	0.010
DACH1	dachshund homolog 1 (Drosophila)	0.010	Mouse
SOCS7	suppressor of cytokine signaling 7	0.010
DNALI1	dynein, axonemal, light intermediate chain 1	0.010
PEF1	penta-EF-hand domain containing 1	0.010
HMGB3	high mobility group box 3	0.010	Human
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.010
ZNF222	zinc finger protein 222	0.010
GTF2H3	general transcription factor IIH, polypeptide 3, 34kDa	0.010