IMP: Integrative Multi-species Prediction

Homo sapiens

9 genes annotated in human

mitotic g2 m transition checkpoint

A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "mitotic g2 m transition checkpoint"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "mitotic g2 m transition checkpoint" (in gray)

Name	Description	Probability	Func Analog Organism
PCNA	proliferating cell nuclear antigen	0.892
RB1	retinoblastoma 1	0.693
CUL1	cullin 1	0.489	Fly
BRCA1	breast cancer 1, early onset	0.439
CDK2	cyclin-dependent kinase 2	0.429
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.360
COPS5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.341	Fly
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.294	Mouse Fly
E2F1	E2F transcription factor 1	0.288
COPS6	COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)	0.238	Fly
COPS4	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)	0.231	Fly
NBN	nibrin	0.196
TP53	tumor protein p53	0.179
COPS3	COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)	0.163	Fly
RAD50	RAD50 homolog (S. cerevisiae)	0.153
CUL2	cullin 2	0.126
HDAC1	histone deacetylase 1	0.109
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.102	Zebrafish
PARP1	poly (ADP-ribose) polymerase 1	0.095
RBBP8	retinoblastoma binding protein 8	0.090
ATR	ataxia telangiectasia and Rad3 related	0.090	Fly
CDK8	cyclin-dependent kinase 8	0.080	Fly
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.078
TOPBP1	topoisomerase (DNA) II binding protein 1	0.075	Fly
CNOT6	CCR4-NOT transcription complex, subunit 6	0.067
MDC1	mediator of DNA-damage checkpoint 1	0.066
COPS8	COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)	0.060
MCM7	minichromosome maintenance complex component 7	0.053	Fly
RFWD2	ring finger and WD repeat domain 2	0.052
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.052
UBA1	ubiquitin-like modifier activating enzyme 1	0.047
RBL1	retinoblastoma-like 1 (p107)	0.046	Fly
MCM2	minichromosome maintenance complex component 2	0.041
CUL4A	cullin 4A	0.038
EME1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.036
MSH6	mutS homolog 6 (E. coli)	0.036
DDB1	damage-specific DNA binding protein 1, 127kDa	0.034
PKM2	pyruvate kinase, muscle	0.033
COPS2	COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)	0.030	Fly
MED10	mediator complex subunit 10	0.030
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.026
BTG1	B-cell translocation gene 1, anti-proliferative	0.026
ATM	ataxia telangiectasia mutated	0.024
UBXN7	UBX domain protein 7	0.024
PPP2R5B	protein phosphatase 2, regulatory subunit B', beta	0.023
H2AFX	H2A histone family, member X	0.023
POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	0.022
CCNA2	cyclin A2	0.021
FANCD2	Fanconi anemia, complementation group D2	0.021
FANCA	Fanconi anemia, complementation group A	0.021
SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	0.021
MCM6	minichromosome maintenance complex component 6	0.020
SKP2	S-phase kinase-associated protein 2 (p45)	0.020
RPL39	ribosomal protein L39	0.020
MED13	mediator complex subunit 13	0.020
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.019
CNOT1	CCR4-NOT transcription complex, subunit 1	0.019
CDT1	chromatin licensing and DNA replication factor 1	0.019
GPS1	G protein pathway suppressor 1	0.018	Fly
TFDP1	transcription factor Dp-1	0.017
CAND1	cullin-associated and neddylation-dissociated 1	0.017
COPS7A	COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)	0.017	Fly
CNOT3	CCR4-NOT transcription complex, subunit 3	0.016
UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	0.016
TNRC6B	trinucleotide repeat containing 6B	0.015
RPA2	replication protein A2, 32kDa	0.015
ORC1	origin recognition complex, subunit 1	0.015
CUL3	cullin 3	0.015
GFER	growth factor, augmenter of liver regeneration	0.015
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.013
E2F4	E2F transcription factor 4, p107/p130-binding	0.013
NEDD8	neural precursor cell expressed, developmentally down-regulated 8	0.013
FBXO11	F-box protein 11	0.013
CNOT8	CCR4-NOT transcription complex, subunit 8	0.013	Fly
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.013
TCEB1	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	0.013
C19orf2	chromosome 19 open reading frame 2	0.012
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.012
CLSPN	claspin	0.012
RBX1	ring-box 1, E3 ubiquitin protein ligase	0.012
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.012
ENO1	enolase 1, (alpha)	0.012
MED29	mediator complex subunit 29	0.012
GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa	0.011
RECQL	RecQ protein-like (DNA helicase Q1-like)	0.011
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.011	Fly
MED28	mediator complex subunit 28	0.011
CUL4B	cullin 4B	0.011	Fly
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.010
CNOT6L	CCR4-NOT transcription complex, subunit 6-like	0.010
CCNE1	cyclin E1	0.010