IMP
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regulation of heart induction by regulation of canonical wnt signaling pathway
Any process that modulates the rate, frequency or extent of canonical Wnt signaling pathway that regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, followed by relaying of the signal via beta-catenin, and ending with a change in transcription of target genes.
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Click on a gene's description to view its network relationships with genes known to be involved in "regulation of heart induction by regulation of canonical wnt signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| FOXD3 | forkhead box D3 | 1.000 | ||
| PAX3 | paired box 3 | 1.000 | ||
| SOX10 | SRY (sex determining region Y)-box 10 | 1.000 | ||
| WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | 1.000 | ||
| SOX2 | SRY (sex determining region Y)-box 2 | 1.000 | ||
| HCFC1 | host cell factor C1 (VP16-accessory protein) | 0.999 | ||
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.986 | ||
| MEOX2 | mesenchyme homeobox 2 | 0.788 | ||
| PDX1 | pancreatic and duodenal homeobox 1 | 0.717 | ||
| SOX1 | SRY (sex determining region Y)-box 1 | 0.688 | ||
| HMGA1 | high mobility group AT-hook 1 | 0.631 | ||
| NOVA2 | neuro-oncological ventral antigen 2 | 0.532 | ||
| SOX11 | SRY (sex determining region Y)-box 11 | 0.520 | ||
| SMAD7 | SMAD family member 7 | 0.517 | ||
| OTP | orthopedia homeobox | 0.497 | ||
| TLX2 | T-cell leukemia homeobox 2 | 0.470 | ||
| NR0B1 | nuclear receptor subfamily 0, group B, member 1 | 0.450 | ||
| POU3F2 | POU class 3 homeobox 2 | 0.412 | Human | |
| GABPA | GA binding protein transcription factor, alpha subunit 60kDa | 0.410 | ||
| FOXE1 | forkhead box E1 (thyroid transcription factor 2) | 0.331 | ||
| TP73 | tumor protein p73 | 0.329 | ||
| NEUROG3 | neurogenin 3 | 0.325 | ||
| POU4F1 | POU class 4 homeobox 1 | 0.304 | Human | |
| ST8SIA2 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 | 0.296 | ||
| LHX1 | LIM homeobox 1 | 0.292 | ||
| HRK | harakiri, BCL2 interacting protein (contains only BH3 domain) | 0.280 | ||
| POU3F3 | POU class 3 homeobox 3 | 0.208 | Human | |
| HOXD12 | homeobox D12 | 0.195 | ||
| POU3F4 | POU class 3 homeobox 4 | 0.185 | Human | |
| NKX2-8 | NK2 homeobox 8 | 0.177 | ||
| HES2 | hairy and enhancer of split 2 (Drosophila) | 0.176 | ||
| NKX2-1 | NK2 homeobox 1 | 0.174 | ||
| ETS2 | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) | 0.172 | ||
| NKX2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.149 | ||
| ZNF281 | zinc finger protein 281 | 0.144 | ||
| NKX6-1 | NK6 homeobox 1 | 0.142 | ||
| BHLHE23 | basic helix-loop-helix family, member e23 | 0.141 | ||
| FGF8 | fibroblast growth factor 8 (androgen-induced) | 0.141 | ||
| SFRP5 | secreted frizzled-related protein 5 | 0.136 | ||
| LHX5 | LIM homeobox 5 | 0.129 | ||
| OLIG2 | oligodendrocyte lineage transcription factor 2 | 0.122 | ||
| HTT | huntingtin | 0.115 | ||
| SIX6 | SIX homeobox 6 | 0.113 | ||
| ASCL1 | achaete-scute complex homolog 1 (Drosophila) | 0.110 | ||
| NFYA | nuclear transcription factor Y, alpha | 0.103 | ||
| BCL6 | B-cell CLL/lymphoma 6 | 0.096 | ||
| SIX2 | SIX homeobox 2 | 0.090 | ||
| LBX1 | ladybird homeobox 1 | 0.088 | ||
| NPAS1 | neuronal PAS domain protein 1 | 0.087 | ||
| ALX3 | ALX homeobox 3 | 0.086 | ||
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.084 | ||
| ZBTB17 | zinc finger and BTB domain containing 17 | 0.082 | ||
| TFAP2B | transcription factor AP-2 beta (activating enhancer binding protein 2 beta) | 0.081 | ||
| FOXB1 | forkhead box B1 | 0.080 | ||
| PYY | peptide YY | 0.079 | ||
| PAX6 | paired box 6 | 0.077 | ||
| GATA5 | GATA binding protein 5 | 0.075 | ||
| VAX2 | ventral anterior homeobox 2 | 0.074 | ||
| FGF3 | fibroblast growth factor 3 | 0.073 | ||
| HTR2C | 5-hydroxytryptamine (serotonin) receptor 2C | 0.072 | ||
| DMRT1 | doublesex and mab-3 related transcription factor 1 | 0.071 | ||
| ZNF157 | zinc finger protein 157 | 0.063 | ||
| PAX2 | paired box 2 | 0.061 | ||
| PAX7 | paired box 7 | 0.061 | ||
| GSC2 | goosecoid homeobox 2 | 0.061 | ||
| FOXA2 | forkhead box A2 | 0.059 | ||
| NHLH2 | nescient helix loop helix 2 | 0.057 | ||
| TLX1 | T-cell leukemia homeobox 1 | 0.056 | ||
| MDFI | MyoD family inhibitor | 0.055 | ||
| CDX2 | caudal type homeobox 2 | 0.054 | ||
| POU4F2 | POU class 4 homeobox 2 | 0.054 | Human | |
| RAX | retina and anterior neural fold homeobox | 0.051 | ||
| NELL1 | NEL-like 1 (chicken) | 0.051 | ||
| HOXB7 | homeobox B7 | 0.049 | ||
| EVX1 | even-skipped homeobox 1 | 0.048 | ||
| CALCA | calcitonin-related polypeptide alpha | 0.048 | ||
| DLX4 | distal-less homeobox 4 | 0.046 | ||
| PRDM13 | PR domain containing 13 | 0.046 | ||
| FOXL1 | forkhead box L1 | 0.045 | ||
| POU4F3 | POU class 4 homeobox 3 | 0.042 | Human | |
| DRD4 | dopamine receptor D4 | 0.041 | ||
| PITX2 | paired-like homeodomain 2 | 0.041 | ||
| VSX1 | visual system homeobox 1 | 0.040 | ||
| HOXD9 | homeobox D9 | 0.040 | ||
| POU3F1 | POU class 3 homeobox 1 | 0.038 | Human | |
| BARX1 | BARX homeobox 1 | 0.038 | ||
| HOXC8 | homeobox C8 | 0.038 | ||
| ZIC1 | Zic family member 1 (odd-paired homolog, Drosophila) | 0.038 | ||
| HOXB9 | homeobox B9 | 0.037 | ||
| FOXC2 | forkhead box C2 (MFH-1, mesenchyme forkhead 1) | 0.037 | ||
| HOXB13 | homeobox B13 | 0.036 | ||
| HOXD11 | homeobox D11 | 0.036 | ||
| DLX2 | distal-less homeobox 2 | 0.036 | ||
| GJD2 | gap junction protein, delta 2, 36kDa | 0.034 | ||
| SIM2 | single-minded homolog 2 (Drosophila) | 0.033 | ||
| HMX2 | H6 family homeobox 2 | 0.033 | ||
| GBX2 | gastrulation brain homeobox 2 | 0.033 | ||
| PAX5 | paired box 5 | 0.032 | ||
| RNF11 | ring finger protein 11 | 0.032 | ||
| MNX1 | motor neuron and pancreas homeobox 1 | 0.032 | ||
| HOXD3 | homeobox D3 | 0.031 | ||
| NKX2-2 | NK2 homeobox 2 | 0.031 | ||
| KRT2 | keratin 2 | 0.030 | ||
| SLC30A3 | solute carrier family 30 (zinc transporter), member 3 | 0.030 | ||
| POMC | proopiomelanocortin | 0.030 | ||
| MYCN | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.030 | ||
| HAND2 | heart and neural crest derivatives expressed 2 | 0.029 | ||
| DCX | doublecortin | 0.029 | ||
| AQP5 | aquaporin 5 | 0.028 | ||
| CRHR2 | corticotropin releasing hormone receptor 2 | 0.028 | ||
| GCM2 | glial cells missing homolog 2 (Drosophila) | 0.028 | ||
| SSTR5 | somatostatin receptor 5 | 0.027 | ||
| HOXC4 | homeobox C4 | 0.027 | ||
| WNT10A | wingless-type MMTV integration site family, member 10A | 0.027 | ||
| SOX3 | SRY (sex determining region Y)-box 3 | 0.027 | ||
| TIGD3 | tigger transposable element derived 3 | 0.026 | ||
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.026 | ||
| SALL3 | sal-like 3 (Drosophila) | 0.026 | ||
| TBX1 | T-box 1 | 0.025 | ||
| ATP2B2 | ATPase, Ca++ transporting, plasma membrane 2 | 0.025 | ||
| TBX5 | T-box 5 | 0.025 | ||
| GATA4 | GATA binding protein 4 | 0.025 | ||
| CRLF1 | cytokine receptor-like factor 1 | 0.025 | ||
| POGZ | pogo transposable element with ZNF domain | 0.025 | ||
| NEUROD2 | neurogenic differentiation 2 | 0.025 | ||
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.025 | ||
| FOXG1 | forkhead box G1 | 0.025 | ||
| SALL4 | sal-like 4 (Drosophila) | 0.024 | ||
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.024 | ||
| POU2F3 | POU class 2 homeobox 3 | 0.024 | Human | |
| KCNS2 | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2 | 0.024 | ||
| UTF1 | undifferentiated embryonic cell transcription factor 1 | 0.023 | ||
| ELAVL2 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) | 0.023 | ||
| MYOD1 | myogenic differentiation 1 | 0.023 | ||
| TTC22 | tetratricopeptide repeat domain 22 | 0.023 | ||
| AMN | amnionless homolog (mouse) | 0.023 | ||
| FCER2 | Fc fragment of IgE, low affinity II, receptor for (CD23) | 0.023 | ||
| SALL2 | sal-like 2 (Drosophila) | 0.023 | ||
| EMX1 | empty spiracles homeobox 1 | 0.022 | ||
| SETD1A | SET domain containing 1A | 0.022 | ||
| PAX8 | paired box 8 | 0.022 | ||
| BCL2L10 | BCL2-like 10 (apoptosis facilitator) | 0.022 | ||
| GSX2 | GS homeobox 2 | 0.022 | ||
| HEYL | hairy/enhancer-of-split related with YRPW motif-like | 0.022 | ||
| IHH | Indian hedgehog | 0.022 | ||
| HOXD10 | homeobox D10 | 0.022 | ||
| FBXL15 | F-box and leucine-rich repeat protein 15 | 0.021 | ||
| HNF1A | HNF1 homeobox A | 0.021 | ||
| BDNF | brain-derived neurotrophic factor | 0.021 | ||
| SLC6A2 | solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 | 0.021 | ||
| HTR7 | 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) | 0.020 | ||
| CDK5R2 | cyclin-dependent kinase 5, regulatory subunit 2 (p39) | 0.020 | ||
| EYA2 | eyes absent homolog 2 (Drosophila) | 0.020 | ||
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | 0.020 | ||
| TCF15 | transcription factor 15 (basic helix-loop-helix) | 0.020 | ||
| ATN1 | atrophin 1 | 0.020 | ||
| HOXD13 | homeobox D13 | 0.019 | ||
| DNMT3B | DNA (cytosine-5-)-methyltransferase 3 beta | 0.019 | ||
| HOXC13 | homeobox C13 | 0.018 | ||
| B4GALNT2 | beta-1,4-N-acetyl-galactosaminyl transferase 2 | 0.018 | ||
| SALL1 | sal-like 1 (Drosophila) | 0.018 | ||
| IRX5 | iroquois homeobox 5 | 0.018 | ||
| ISL1 | ISL LIM homeobox 1 | 0.018 | ||
| KIAA1045 | KIAA1045 | 0.018 | ||
| KLHL35 | kelch-like 35 (Drosophila) | 0.018 | ||
| NR5A1 | nuclear receptor subfamily 5, group A, member 1 | 0.018 | ||
| DLL3 | delta-like 3 (Drosophila) | 0.018 | ||
| AMMECR1 | Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | 0.018 | ||
| HIC1 | hypermethylated in cancer 1 | 0.018 | ||
| NEUROG1 | neurogenin 1 | 0.017 | ||
| FSCN2 | fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) | 0.017 | ||
| SIX1 | SIX homeobox 1 | 0.017 | ||
| RPS24 | ribosomal protein S24 | 0.017 | ||
| MATN4 | matrilin 4 | 0.017 | ||
| HCN2 | hyperpolarization activated cyclic nucleotide-gated potassium channel 2 | 0.017 | ||
| NHLH1 | nescient helix loop helix 1 | 0.017 | ||
| SPTB | spectrin, beta, erythrocytic | 0.017 | ||
| NEUROD1 | neurogenic differentiation 1 | 0.017 | ||
| CD70 | CD70 molecule | 0.016 | ||
| GAD1 | glutamate decarboxylase 1 (brain, 67kDa) | 0.016 | ||
| CD72 | CD72 molecule | 0.016 | ||
| C1orf183 | chromosome 1 open reading frame 183 | 0.016 | ||
| PKP1 | plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) | 0.016 | ||
| NGB | neuroglobin | 0.016 | ||
| IRX4 | iroquois homeobox 4 | 0.016 | ||
| EPHX3 | epoxide hydrolase 3 | 0.016 | ||
| HMBOX1 | homeobox containing 1 | 0.016 | ||
| ONECUT2 | one cut homeobox 2 | 0.016 | ||
| RPS11 | ribosomal protein S11 | 0.016 | ||
| IL26 | interleukin 26 | 0.016 | ||
| DIO3 | deiodinase, iodothyronine, type III | 0.016 | ||
| MYF6 | myogenic factor 6 (herculin) | 0.016 | ||
| ECEL1 | endothelin converting enzyme-like 1 | 0.015 | ||
| LPAR4 | lysophosphatidic acid receptor 4 | 0.015 | ||
| JPH3 | junctophilin 3 | 0.015 | ||
| HES5 | hairy and enhancer of split 5 (Drosophila) | 0.015 | ||
| HOXC5 | homeobox C5 | 0.015 | ||
| NXPH1 | neurexophilin 1 | 0.015 | ||
| PRDM8 | PR domain containing 8 | 0.015 | ||
| TRH | thyrotropin-releasing hormone | 0.015 | ||
| MMD2 | monocyte to macrophage differentiation-associated 2 | 0.015 | ||
| MSX1 | msh homeobox 1 | 0.015 | ||
| INSM1 | insulinoma-associated 1 | 0.014 | ||
| PAQR5 | progestin and adipoQ receptor family member V | 0.014 | ||
| NKX2-3 | NK2 transcription factor related, locus 3 (Drosophila) | 0.014 | ||
| SLC46A2 | solute carrier family 46, member 2 | 0.014 | ||
| SOX18 | SRY (sex determining region Y)-box 18 | 0.014 | ||
| CBX8 | chromobox homolog 8 | 0.014 | ||
| RFX4 | regulatory factor X, 4 (influences HLA class II expression) | 0.014 | ||
| HOXD1 | homeobox D1 | 0.014 | ||
| GRAP | GRB2-related adaptor protein | 0.014 | ||
| FEV | FEV (ETS oncogene family) | 0.014 | ||
| GJA3 | gap junction protein, alpha 3, 46kDa | 0.014 | ||
| PHOX2A | paired-like homeobox 2a | 0.014 | ||
| KCNJ4 | potassium inwardly-rectifying channel, subfamily J, member 4 | 0.013 | ||
| TAL2 | T-cell acute lymphocytic leukemia 2 | 0.013 | ||
| CD79A | CD79a molecule, immunoglobulin-associated alpha | 0.013 | ||
| ICAM4 | intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) | 0.013 | ||
| FOXD2 | forkhead box D2 | 0.013 | ||
| ASCL2 | achaete-scute complex homolog 2 (Drosophila) | 0.013 | ||
| HOXB8 | homeobox B8 | 0.013 | ||
| BNC1 | basonuclin 1 | 0.013 | ||
| SPTBN4 | spectrin, beta, non-erythrocytic 4 | 0.013 | ||
| T | T, brachyury homolog (mouse) | 0.013 | ||
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.013 | ||
| ALX1 | ALX homeobox 1 | 0.013 | ||
| WT1 | Wilms tumor 1 | 0.013 | ||
| SIM1 | single-minded homolog 1 (Drosophila) | 0.013 | ||
| ZIC3 | Zic family member 3 (odd-paired homolog, Drosophila) | 0.013 | ||
| ARHGAP9 | Rho GTPase activating protein 9 | 0.013 | ||
| CD22 | CD22 molecule | 0.013 | ||
| SIX3 | SIX homeobox 3 | 0.013 | ||
| TMEM132E | transmembrane protein 132E | 0.013 | ||
| THAP11 | THAP domain containing 11 | 0.012 | ||
| GHSR | growth hormone secretagogue receptor | 0.012 | ||
| GALR2 | galanin receptor 2 | 0.012 | ||
| HIST1H4B | histone cluster 1, H4b | 0.012 | ||
| HTR6 | 5-hydroxytryptamine (serotonin) receptor 6 | 0.012 | ||
| TLL1 | tolloid-like 1 | 0.012 | ||
| WSCD1 | WSC domain containing 1 | 0.012 | ||
| HOXC11 | homeobox C11 | 0.012 | ||
| NXPH2 | neurexophilin 2 | 0.012 | ||
| SOX15 | SRY (sex determining region Y)-box 15 | 0.012 | ||
| NPTX1 | neuronal pentraxin I | 0.012 | ||
| NRTN | neurturin | 0.012 | ||
| VRTN | vertebrae development homolog (pig) | 0.012 | ||
| RBMXL2 | RNA binding motif protein, X-linked-like 2 | 0.012 | ||
| CADM4 | cell adhesion molecule 4 | 0.012 | ||
| OPHN1 | oligophrenin 1 | 0.012 | ||
| ZNF643 | zinc finger protein 643 | 0.012 | ||
| TSHR | thyroid stimulating hormone receptor | 0.012 | ||
| KRT14 | keratin 14 | 0.012 | ||
| FUT3 | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) | 0.012 | ||
| MYEF2 | myelin expression factor 2 | 0.011 | ||
| NPAS3 | neuronal PAS domain protein 3 | 0.011 | ||
| CA3 | carbonic anhydrase III, muscle specific | 0.011 | ||
| MAP7D3 | MAP7 domain containing 3 | 0.011 | ||
| RORA | RAR-related orphan receptor A | 0.011 | ||
| MYT1 | myelin transcription factor 1 | 0.011 | ||
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.011 | ||
| UNC5D | unc-5 homolog D (C. elegans) | 0.011 | ||
| ADRB1 | adrenergic, beta-1-, receptor | 0.011 | ||
| USF1 | upstream transcription factor 1 | 0.011 | ||
| TMEM151B | transmembrane protein 151B | 0.011 | ||
| CACNA1B | calcium channel, voltage-dependent, N type, alpha 1B subunit | 0.011 | ||
| OVOL1 | ovo-like 1(Drosophila) | 0.011 | ||
| MAFA | v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) | 0.011 | ||
| SHOX2 | short stature homeobox 2 | 0.011 | ||
| RIT2 | Ras-like without CAAX 2 | 0.011 | ||
| PNOC | prepronociceptin | 0.011 | ||
| SLC6A11 | solute carrier family 6 (neurotransmitter transporter, GABA), member 11 | 0.011 | ||
| ABCC8 | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | 0.011 | ||
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | 0.011 | ||
| MAPK4 | mitogen-activated protein kinase 4 | 0.011 | ||
| GPR1 | G protein-coupled receptor 1 | 0.011 | ||
| RPRML | reprimo-like | 0.011 | ||
| CHD8 | chromodomain helicase DNA binding protein 8 | 0.011 | ||
| L1TD1 | LINE-1 type transposase domain containing 1 | 0.011 | ||
| IL11 | interleukin 11 | 0.011 | ||
| FOXL2 | forkhead box L2 | 0.011 | ||
| NEUROG2 | neurogenin 2 | 0.011 | ||
| ESM1 | endothelial cell-specific molecule 1 | 0.011 | ||
| GPRC5A | G protein-coupled receptor, family C, group 5, member A | 0.011 | ||
| HOXC12 | homeobox C12 | 0.010 | ||
| PDK1 | pyruvate dehydrogenase kinase, isozyme 1 | 0.010 | ||
| EFNA1 | ephrin-A1 | 0.010 | ||
| CSPG5 | chondroitin sulfate proteoglycan 5 (neuroglycan C) | 0.010 | ||
| KRT10 | keratin 10 | 0.010 | ||
| KLHDC8A | kelch domain containing 8A | 0.010 | ||
| NKX3-2 | NK3 homeobox 2 | 0.010 | ||
| GRIK3 | glutamate receptor, ionotropic, kainate 3 | 0.010 | ||
| SLC30A2 | solute carrier family 30 (zinc transporter), member 2 | 0.010 | ||
| SLC32A1 | solute carrier family 32 (GABA vesicular transporter), member 1 | 0.010 | ||
| KCNV1 | potassium channel, subfamily V, member 1 | 0.010 | ||
| CIITA | class II, major histocompatibility complex, transactivator | 0.010 | ||
| EN2 | engrailed homeobox 2 | 0.010 | ||
| KRT33A | keratin 33A | 0.010 | ||
| FEZF2 | FEZ family zinc finger 2 | 0.010 | ||
| DMRT3 | doublesex and mab-3 related transcription factor 3 | 0.010 | ||
| PRRG1 | proline rich Gla (G-carboxyglutamic acid) 1 | 0.010 | ||
| ELAVL3 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) | 0.010 | ||
| FAM43B | family with sequence similarity 43, member B | 0.010 | ||
| HES7 | hairy and enhancer of split 7 (Drosophila) | 0.010 | ||
| TLL2 | tolloid-like 2 | 0.010 | ||
| NECAB2 | N-terminal EF-hand calcium binding protein 2 | 0.010 | ||
| HOXC9 | homeobox C9 | 0.010 | ||
| SCT | secretin | 0.010 |