IMP: Integrative Multi-species Prediction

Homo sapiens

4 genes annotated in human

somatic stem cell maintenance

Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "somatic stem cell maintenance"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "somatic stem cell maintenance" (in gray)

Name	Description	Probability	Func Analog Organism
SMAD4	SMAD family member 4	1.000	Fly
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	1.000	Fly
AXIN1	axin 1	1.000	Fly
CSNK1E	casein kinase 1, epsilon	0.999
POU3F2	POU class 3 homeobox 2	0.999	Human
NOTCH1	notch 1	0.999
TAL1	T-cell acute lymphocytic leukemia 1	0.999
SMAD7	SMAD family member 7	0.998
SMAD2	SMAD family member 2	0.991
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.989
JAG1	jagged 1	0.988
SP1	Sp1 transcription factor	0.987
EP300	E1A binding protein p300	0.985
PAX3	paired box 3	0.974
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.967	Fly
CDK2	cyclin-dependent kinase 2	0.967
TRIM33	tripartite motif containing 33	0.964
SMAD3	SMAD family member 3	0.962
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.958	Fly
FOXD3	forkhead box D3	0.956
LMO4	LIM domain only 4	0.952
INSR	insulin receptor	0.947
APLF	aprataxin and PNKP like factor	0.926
RLIM	ring finger protein, LIM domain interacting	0.902
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.879
BMP7	bone morphogenetic protein 7	0.877	Mouse
SOX2	SRY (sex determining region Y)-box 2	0.876
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.876	Fly
NKX2-1	NK2 homeobox 1	0.873
HCFC1	host cell factor C1 (VP16-accessory protein)	0.871
PTCH1	patched 1	0.839
SOX10	SRY (sex determining region Y)-box 10	0.832	Human
RUNX1	runt-related transcription factor 1	0.817
POU5F1	POU class 5 homeobox 1	0.817
SKP1	S-phase kinase-associated protein 1	0.803
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.801
SMAD1	SMAD family member 1	0.790	Fly
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.747
GSK3B	glycogen synthase kinase 3 beta	0.746	Fly
FGF1	fibroblast growth factor 1 (acidic)	0.737
CTNNBIP1	catenin, beta interacting protein 1	0.723
IL4R	interleukin 4 receptor	0.703
APC	adenomatous polyposis coli	0.659	Mouse
CREBBP	CREB binding protein	0.644
FBLN1	fibulin 1	0.626
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.621
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.615
HIC1	hypermethylated in cancer 1	0.613
DDB1	damage-specific DNA binding protein 1, 127kDa	0.598
HNF1A	HNF1 homeobox A	0.596
MYOD1	myogenic differentiation 1	0.583
GATA2	GATA binding protein 2	0.522	Mouse
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.520
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.519
MCC	mutated in colorectal cancers	0.488
WT1	Wilms tumor 1	0.430
C20orf20	chromosome 20 open reading frame 20	0.425
POU3F3	POU class 3 homeobox 3	0.418	Human
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.391	Mouse
BTRC	beta-transducin repeat containing	0.372
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.371	Mouse
MEOX2	mesenchyme homeobox 2	0.369
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.368
XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	0.347
ASCL1	achaete-scute complex homolog 1 (Drosophila)	0.347
SOX11	SRY (sex determining region Y)-box 11	0.343	Human
YAP1	Yes-associated protein 1	0.338	Mouse
CCND1	cyclin D1	0.335
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.334
CDK6	cyclin-dependent kinase 6	0.332
NOG	noggin	0.332
GLIS2	GLIS family zinc finger 2	0.327
JAG2	jagged 2	0.325
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.322
STAP2	signal transducing adaptor family member 2	0.319
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.319
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.314
E2F1	E2F transcription factor 1	0.306
MARCKSL1	MARCKS-like 1	0.306
MAML1	mastermind-like 1 (Drosophila)	0.305
ATXN1L	ataxin 1-like	0.302
DCP1A	DCP1 decapping enzyme homolog A (S. cerevisiae)	0.292
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.292
KITLG	KIT ligand	0.290
FERMT2	fermitin family member 2	0.287
CADM4	cell adhesion molecule 4	0.282
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.264	Mouse
TCF12	transcription factor 12	0.252	Fly
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.252
NCOA2	nuclear receptor coactivator 2	0.248
DMAP1	DNA methyltransferase 1 associated protein 1	0.234
TAOK1	TAO kinase 1	0.229
ATF7IP	activating transcription factor 7 interacting protein	0.224
BBS10	Bardet-Biedl syndrome 10	0.210
KSR1	kinase suppressor of ras 1	0.207
HDAC4	histone deacetylase 4	0.205
SOX1	SRY (sex determining region Y)-box 1	0.205	Human
CXXC5	CXXC finger protein 5	0.201
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.200
CTNND1	catenin (cadherin-associated protein), delta 1	0.199
SMAD5	SMAD family member 5	0.196	Fly
NCOA6	nuclear receptor coactivator 6	0.195
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.192
IL4	interleukin 4	0.186
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.184
SALL2	sal-like 2 (Drosophila)	0.184
SOX21	SRY (sex determining region Y)-box 21	0.182
PRKCE	protein kinase C, epsilon	0.182
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.179
NOTCH2	notch 2	0.176
ZBED5	zinc finger, BED-type containing 5	0.175
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.170
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.170
BMP2	bone morphogenetic protein 2	0.170
SKIL	SKI-like oncogene	0.166
OTP	orthopedia homeobox	0.157
ZIC3	Zic family member 3 (odd-paired homolog, Drosophila)	0.155
DLL1	delta-like 1 (Drosophila)	0.154
FAM110C	family with sequence similarity 110, member C	0.153
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.150
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.150
POU3F1	POU class 3 homeobox 1	0.149	Human
JAK2	Janus kinase 2	0.148
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.146
ATF2	activating transcription factor 2	0.145
CDT1	chromatin licensing and DNA replication factor 1	0.142
PXN	paxillin	0.141
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.138
CCNE1	cyclin E1	0.138	Fly
TNS1	tensin 1	0.135
FOXA2	forkhead box A2	0.133
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.131
IER2	immediate early response 2	0.129
AR	androgen receptor	0.129
DSP	desmoplakin	0.128
FAM110A	family with sequence similarity 110, member A	0.127
HOXA10	homeobox A10	0.127
ARHGEF1	Rho guanine nucleotide exchange factor (GEF) 1	0.125
PML	promyelocytic leukemia	0.124
FOXM1	forkhead box M1	0.124
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.123
POU4F1	POU class 4 homeobox 1	0.121	Human
PAX7	paired box 7	0.120
TBX2	T-box 2	0.119
SOX18	SRY (sex determining region Y)-box 18	0.119	Human
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.118
MPDZ	multiple PDZ domain protein	0.116
OLIG2	oligodendrocyte lineage transcription factor 2	0.115
FOXO1	forkhead box O1	0.115
SOX9	SRY (sex determining region Y)-box 9	0.112	Human Mouse
SMAD6	SMAD family member 6	0.112
CUL2	cullin 2	0.112
FOXG1	forkhead box G1	0.109
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.109
PAX6	paired box 6	0.107
ZNF512B	zinc finger protein 512B	0.107
SSBP2	single-stranded DNA binding protein 2	0.105
MAP2K1	mitogen-activated protein kinase kinase 1	0.105
HES1	hairy and enhancer of split 1, (Drosophila)	0.104	Mouse
PIAS1	protein inhibitor of activated STAT, 1	0.104
TCF4	transcription factor 4	0.104	Fly
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.103
KDM2A	lysine (K)-specific demethylase 2A	0.102
LEF1	lymphoid enhancer-binding factor 1	0.101
LHX1	LIM homeobox 1	0.100
SOX4	SRY (sex determining region Y)-box 4	0.099	Human Mouse
MSX1	msh homeobox 1	0.099
YY1	YY1 transcription factor	0.099
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.096
BBS1	Bardet-Biedl syndrome 1	0.096
JUP	junction plakoglobin	0.096	Fly
DCUN1D2	DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae)	0.095
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.095
INHBB	inhibin, beta B	0.094
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.093
SNIP1	Smad nuclear interacting protein 1	0.093
NLK	nemo-like kinase	0.093
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.091
NEUROG3	neurogenin 3	0.091
JUNB	jun B proto-oncogene	0.091
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.090
CCNB2	cyclin B2	0.089
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.088	Mouse
SIM2	single-minded homolog 2 (Drosophila)	0.086
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	0.086
HOXD9	homeobox D9	0.086
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.086
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.086
FHL1	four and a half LIM domains 1	0.084
WDR5	WD repeat domain 5	0.083
OCLN	occludin	0.083
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.083
TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)	0.082	Mouse
HES2	hairy and enhancer of split 2 (Drosophila)	0.082
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.082
CEP164	centrosomal protein 164kDa	0.082
EPHB4	EPH receptor B4	0.082
NCOA1	nuclear receptor coactivator 1	0.081
LRRK2	leucine-rich repeat kinase 2	0.081
FOXC1	forkhead box C1	0.080
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.080
MAVS	mitochondrial antiviral signaling protein	0.079
SIX3	SIX homeobox 3	0.078
FZD8	frizzled homolog 8 (Drosophila)	0.078
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.078
TP53BP2	tumor protein p53 binding protein, 2	0.077
TP73	tumor protein p73	0.076
CCND2	cyclin D2	0.075
KLHL12	kelch-like 12 (Drosophila)	0.075
ISL1	ISL LIM homeobox 1	0.075
TMEM173	transmembrane protein 173	0.074
HOXB13	homeobox B13	0.074
NFYA	nuclear transcription factor Y, alpha	0.074
ZFPM1	zinc finger protein, multitype 1	0.073
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.072
AMOTL1	angiomotin like 1	0.071
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.070
RARA	retinoic acid receptor, alpha	0.069
FOXO3	forkhead box O3	0.069
DACH1	dachshund homolog 1 (Drosophila)	0.069
NOVA2	neuro-oncological ventral antigen 2	0.069
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.069
ATN1	atrophin 1	0.068
DCP1B	DCP1 decapping enzyme homolog B (S. cerevisiae)	0.068
ATXN1	ataxin 1	0.068
EYA2	eyes absent homolog 2 (Drosophila)	0.068
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.067
EFNB3	ephrin-B3	0.067
LITAF	lipopolysaccharide-induced TNF factor	0.067
SALL3	sal-like 3 (Drosophila)	0.067
CSNK1D	casein kinase 1, delta	0.066
PER1	period homolog 1 (Drosophila)	0.066
CDH5	cadherin 5, type 2 (vascular endothelium)	0.066
BAHD1	bromo adjacent homology domain containing 1	0.065
CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.065
PTK7	PTK7 protein tyrosine kinase 7	0.064
AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.064
BCAM	basal cell adhesion molecule (Lutheran blood group)	0.064
NKX2-2	NK2 homeobox 2	0.064
LTK	leukocyte receptor tyrosine kinase	0.064
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	0.064
CITED1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	0.063
LYL1	lymphoblastic leukemia derived sequence 1	0.063
NHEJ1	nonhomologous end-joining factor 1	0.063
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.063
PEBP4	phosphatidylethanolamine-binding protein 4	0.063
ZNF331	zinc finger protein 331	0.062
GBX2	gastrulation brain homeobox 2	0.062
DSG2	desmoglein 2	0.061
CAPRIN2	caprin family member 2	0.061
SOX5	SRY (sex determining region Y)-box 5	0.061
DPPA2	developmental pluripotency associated 2	0.061
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.060
FOXP1	forkhead box P1	0.060
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.060
AMOTL2	angiomotin like 2	0.060
JAK1	Janus kinase 1	0.059
RAX	retina and anterior neural fold homeobox	0.059
KRT8	keratin 8	0.059
PAX2	paired box 2	0.059	Mouse
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.058
LHX2	LIM homeobox 2	0.058
TCF21	transcription factor 21	0.058
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.058
ZMYM2	zinc finger, MYM-type 2	0.058
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.057
PITX2	paired-like homeodomain 2	0.057
FAM83D	family with sequence similarity 83, member D	0.057
WNT7A	wingless-type MMTV integration site family, member 7A	0.057
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.057
LAMA5	laminin, alpha 5	0.056
PSEN1	presenilin 1	0.056
C1QL1	complement component 1, q subcomponent-like 1	0.056
HOXD1	homeobox D1	0.056
GATA5	GATA binding protein 5	0.055
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.055	Mouse
RAC3	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	0.055
CPSF7	cleavage and polyadenylation specific factor 7, 59kDa	0.055
GPR161	G protein-coupled receptor 161	0.055
KAT2B	K(lysine) acetyltransferase 2B	0.054
BTG1	B-cell translocation gene 1, anti-proliferative	0.054
SIX5	SIX homeobox 5	0.054
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.054
OTX2	orthodenticle homeobox 2	0.053
CCNK	cyclin K	0.053
GLI2	GLI family zinc finger 2	0.053
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.053
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.052
PDX1	pancreatic and duodenal homeobox 1	0.052
HNF1B	HNF1 homeobox B	0.052	Mouse
HCN4	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	0.051
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.051
RBBP8	retinoblastoma binding protein 8	0.051
GSK3A	glycogen synthase kinase 3 alpha	0.051	Fly
TBX5	T-box 5	0.051
DLX4	distal-less homeobox 4	0.050
EGR1	early growth response 1	0.050
HDAC7	histone deacetylase 7	0.050
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.050
FOXH1	forkhead box H1	0.050
NOTCH3	notch 3	0.050	Zebrafish
COL2A1	collagen, type II, alpha 1	0.050
ZNF609	zinc finger protein 609	0.050
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.049
RFWD2	ring finger and WD repeat domain 2	0.049
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.049
JAM2	junctional adhesion molecule 2	0.049
ZBTB7A	zinc finger and BTB domain containing 7A	0.049
KRT18	keratin 18	0.049
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.049
SREBF2	sterol regulatory element binding transcription factor 2	0.048
MPL	myeloproliferative leukemia virus oncogene	0.048
HIPK2	homeodomain interacting protein kinase 2	0.048
EPHB3	EPH receptor B3	0.048
CDK17	cyclin-dependent kinase 17	0.048
NKD1	naked cuticle homolog 1 (Drosophila)	0.048
ACTL6A	actin-like 6A	0.048
SLC6A13	solute carrier family 6 (neurotransmitter transporter, GABA), member 13	0.048
FZD10	frizzled homolog 10 (Drosophila)	0.048
HOXD13	homeobox D13	0.047
EWSR1	Ewing sarcoma breakpoint region 1	0.047
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.047
CALCR	calcitonin receptor	0.047
EMD	emerin	0.047
SKP2	S-phase kinase-associated protein 2 (p45)	0.047
FOXF1	forkhead box F1	0.047
ZHX3	zinc fingers and homeoboxes 3	0.047
CNKSR1	connector enhancer of kinase suppressor of Ras 1	0.047
OVOL1	ovo-like 1(Drosophila)	0.047
AFF1	AF4/FMR2 family, member 1	0.047
LMO2	LIM domain only 2 (rhombotin-like 1)	0.047
WDR76	WD repeat domain 76	0.046
STRN3	striatin, calmodulin binding protein 3	0.046
IRX4	iroquois homeobox 4	0.046
POU4F2	POU class 4 homeobox 2	0.046	Human
PEBP1	phosphatidylethanolamine binding protein 1	0.046
SMAD9	SMAD family member 9	0.046
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.046
TEAD3	TEA domain family member 3	0.046
HMGA2	high mobility group AT-hook 2	0.045
AXIN2	axin 2	0.045	Fly
MTA2	metastasis associated 1 family, member 2	0.045
ZMYND8	zinc finger, MYND-type containing 8	0.045
HNF4A	hepatocyte nuclear factor 4, alpha	0.045
HOXD11	homeobox D11	0.045
EGFL7	EGF-like-domain, multiple 7	0.045
SH3BP2	SH3-domain binding protein 2	0.044
RBBP5	retinoblastoma binding protein 5	0.044
SRCAP	Snf2-related CREBBP activator protein	0.044
PCBD1	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	0.044
MNX1	motor neuron and pancreas homeobox 1	0.044
BCL6	B-cell CLL/lymphoma 6	0.044
POU2F3	POU class 2 homeobox 3	0.044	Human
POU2F2	POU class 2 homeobox 2	0.044	Human
SIK1	salt-inducible kinase 1	0.044
GLI3	GLI family zinc finger 3	0.043
FGD1	FYVE, RhoGEF and PH domain containing 1	0.043
EFNB2	ephrin-B2	0.043
SCNN1G	sodium channel, nonvoltage-gated 1, gamma	0.043
NUMA1	nuclear mitotic apparatus protein 1	0.043
JRK	jerky homolog (mouse)	0.042
SFRP1	secreted frizzled-related protein 1	0.042	Mouse
SETD1A	SET domain containing 1A	0.042
HOXC4	homeobox C4	0.042
AQP5	aquaporin 5	0.042
BAG1	BCL2-associated athanogene	0.042
MLLT1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	0.042
DIO3	deiodinase, iodothyronine, type III	0.042
LRP6	low density lipoprotein receptor-related protein 6	0.042
CRLF1	cytokine receptor-like factor 1	0.041
AMOT	angiomotin	0.041
LDB1	LIM domain binding 1	0.041	Mouse
JUN	jun proto-oncogene	0.041
GFER	growth factor, augmenter of liver regeneration	0.041
TBX1	T-box 1	0.041
MAPT	microtubule-associated protein tau	0.041
PROX1	prospero homeobox 1	0.041
HOXD3	homeobox D3	0.041
EDN3	endothelin 3	0.041
GJB3	gap junction protein, beta 3, 31kDa	0.040
SOX3	SRY (sex determining region Y)-box 3	0.040	Human
MPRIP	myosin phosphatase Rho interacting protein	0.040
MKL2	MKL/myocardin-like 2	0.040
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.040
NKX2-8	NK2 homeobox 8	0.040
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	0.040
SOX17	SRY (sex determining region Y)-box 17	0.039	Human
BRD3	bromodomain containing 3	0.039
DPPA4	developmental pluripotency associated 4	0.039
PUM1	pumilio homolog 1 (Drosophila)	0.039
EN2	engrailed homeobox 2	0.039
KLF11	Kruppel-like factor 11	0.039
POU3F4	POU class 3 homeobox 4	0.039	Human
GFI1	growth factor independent 1 transcription repressor	0.039
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.039
NKD2	naked cuticle homolog 2 (Drosophila)	0.039
SIX2	SIX homeobox 2	0.038	Mouse
RASAL2	RAS protein activator like 2	0.038
KIAA0174	KIAA0174	0.038
ORC1	origin recognition complex, subunit 1	0.038
FOXD2	forkhead box D2	0.038
AMN	amnionless homolog (mouse)	0.038
FBXW7	F-box and WD repeat domain containing 7	0.038
FSCN2	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	0.038
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.038	Fly
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.038
DDIT4	DNA-damage-inducible transcript 4	0.038
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.038
SEMA3F	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.037
FAM46B	family with sequence similarity 46, member B	0.037
SIAH1	seven in absentia homolog 1 (Drosophila)	0.037
IER5	immediate early response 5	0.037
SOX13	SRY (sex determining region Y)-box 13	0.037
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.037
TRAF4	TNF receptor-associated factor 4	0.037
HOXC11	homeobox C11	0.037
CHST3	carbohydrate (chondroitin 6) sulfotransferase 3	0.037
SHH	sonic hedgehog	0.037
SIM1	single-minded homolog 1 (Drosophila)	0.037
ONECUT2	one cut homeobox 2	0.037
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.036
SOX15	SRY (sex determining region Y)-box 15	0.036	Human
MYCL1	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)	0.036
JUND	jun D proto-oncogene	0.036
WNT4	wingless-type MMTV integration site family, member 4	0.036
KIAA2026	KIAA2026	0.036
SFRP5	secreted frizzled-related protein 5	0.036
HOXD12	homeobox D12	0.036
WDYHV1	WDYHV motif containing 1	0.036
KDM5B	lysine (K)-specific demethylase 5B	0.036
GRB7	growth factor receptor-bound protein 7	0.036
SIX6	SIX homeobox 6	0.036
VPRBP	Vpr (HIV-1) binding protein	0.036
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.036
FGF8	fibroblast growth factor 8 (androgen-induced)	0.036
STAT5B	signal transducer and activator of transcription 5B	0.036	Fly
NR2F1	nuclear receptor subfamily 2, group F, member 1	0.036
TRIL	TLR4 interactor with leucine-rich repeats	0.035
STAT5A	signal transducer and activator of transcription 5A	0.035	Fly
OBSL1	obscurin-like 1	0.035
SALL4	sal-like 4 (Drosophila)	0.035
CELSR2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.035
KDM6B	lysine (K)-specific demethylase 6B	0.035
TSC2	tuberous sclerosis 2	0.035
RAI14	retinoic acid induced 14	0.035
WNT6	wingless-type MMTV integration site family, member 6	0.035
HTT	huntingtin	0.035
DCX	doublecortin	0.035
FUT9	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	0.034
EPB41L3	erythrocyte membrane protein band 4.1-like 3	0.034
DLX2	distal-less homeobox 2	0.034
FGFR1	fibroblast growth factor receptor 1	0.034
FAM83H	family with sequence similarity 83, member H	0.034
BTG2	BTG family, member 2	0.034
EN1	engrailed homeobox 1	0.034
ITGB4	integrin, beta 4	0.034
ZBTB17	zinc finger and BTB domain containing 17	0.034
CAPN6	calpain 6	0.034
PROM1	prominin 1	0.034
FAM46A	family with sequence similarity 46, member A	0.034
KRBA1	KRAB-A domain containing 1	0.034
ETV4	ets variant 4	0.033
FOXL1	forkhead box L1	0.033
CIR1	corepressor interacting with RBPJ, 1	0.033
SOX7	SRY (sex determining region Y)-box 7	0.033	Human
TRPS1	trichorhinophalangeal syndrome I	0.033
SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	0.033
VIL1	villin 1	0.033
APC2	adenomatosis polyposis coli 2	0.033
IGFBP2	insulin-like growth factor binding protein 2, 36kDa	0.033
ALX3	ALX homeobox 3	0.033
WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1	0.033
GALR1	galanin receptor 1	0.033
SH3BP4	SH3-domain binding protein 4	0.033
TGIF2	TGFB-induced factor homeobox 2	0.033
CDX2	caudal type homeobox 2	0.033	Mouse
DDB2	damage-specific DNA binding protein 2, 48kDa	0.033
KIF5B	kinesin family member 5B	0.033
FZD7	frizzled homolog 7 (Drosophila)	0.033
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.033
TP53	tumor protein p53	0.032
TGFBR1	transforming growth factor, beta receptor 1	0.032
GRIP1	glutamate receptor interacting protein 1	0.032
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.032
BMP4	bone morphogenetic protein 4	0.032
DLK1	delta-like 1 homolog (Drosophila)	0.032
TLX2	T-cell leukemia homeobox 2	0.032
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.032
FGFR4	fibroblast growth factor receptor 4	0.032
FOXJ1	forkhead box J1	0.032
NR2F2	nuclear receptor subfamily 2, group F, member 2	0.032
RBL1	retinoblastoma-like 1 (p107)	0.032
KLC2	kinesin light chain 2	0.032
GPSM3	G-protein signaling modulator 3	0.032
EFNA3	ephrin-A3	0.032
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.032
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.031
GRIK3	glutamate receptor, ionotropic, kainate 3	0.031
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.031
ONECUT1	one cut homeobox 1	0.031
LFNG	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.031
IRS2	insulin receptor substrate 2	0.031
GPR27	G protein-coupled receptor 27	0.031
BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	0.031
LBX1	ladybird homeobox 1	0.031
BMF	Bcl2 modifying factor	0.031
LMX1B	LIM homeobox transcription factor 1, beta	0.031
NPAS3	neuronal PAS domain protein 3	0.031
TJP2	tight junction protein 2 (zona occludens 2)	0.031
SOCS6	suppressor of cytokine signaling 6	0.031
PITX3	paired-like homeodomain 3	0.031
AFF4	AF4/FMR2 family, member 4	0.031
USP9X	ubiquitin specific peptidase 9, X-linked	0.030
NEUROD1	neurogenic differentiation 1	0.030
LENG1	leukocyte receptor cluster (LRC) member 1	0.030
CALCA	calcitonin-related polypeptide alpha	0.030
CRABP1	cellular retinoic acid binding protein 1	0.030
ELK1	ELK1, member of ETS oncogene family	0.030
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.030
BCOR	BCL6 corepressor	0.030
PRDM13	PR domain containing 13	0.030
VENTX	VENT homeobox homolog (Xenopus laevis)	0.030
NCOR2	nuclear receptor corepressor 2	0.030
WIF1	WNT inhibitory factor 1	0.030
PALM	paralemmin	0.030
TTYH1	tweety homolog 1 (Drosophila)	0.030
TIAM1	T-cell lymphoma invasion and metastasis 1	0.030
MAST4	microtubule associated serine/threonine kinase family member 4	0.030
ZIC2	Zic family member 2 (odd-paired homolog, Drosophila)	0.029
PCDH17	protocadherin 17	0.029
TFCP2L1	transcription factor CP2-like 1	0.029
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.029
NRTN	neurturin	0.029
DAAM1	dishevelled associated activator of morphogenesis 1	0.029
FGFR3	fibroblast growth factor receptor 3	0.029	Mouse
MEF2C	myocyte enhancer factor 2C	0.029
COL9A3	collagen, type IX, alpha 3	0.029
SMO	smoothened homolog (Drosophila)	0.029	Fly
CUX1	cut-like homeobox 1	0.029
ATAD2	ATPase family, AAA domain containing 2	0.029
EMX1	empty spiracles homeobox 1	0.029
VEZF1	vascular endothelial zinc finger 1	0.029
CLDN5	claudin 5	0.029
LPAR4	lysophosphatidic acid receptor 4	0.029
RALGPS2	Ral GEF with PH domain and SH3 binding motif 2	0.029
DAB2IP	DAB2 interacting protein	0.029
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.029
ERBB2IP	erbb2 interacting protein	0.029
BBS7	Bardet-Biedl syndrome 7	0.029
KLF13	Kruppel-like factor 13	0.029
DOCK7	dedicator of cytokinesis 7	0.029
DRD4	dopamine receptor D4	0.028
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.028
FABP7	fatty acid binding protein 7, brain	0.028
GDNF	glial cell derived neurotrophic factor	0.028
NDP	Norrie disease (pseudoglioma)	0.028
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.028
KAT5	K(lysine) acetyltransferase 5	0.028
FOXB1	forkhead box B1	0.028
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.028
ZNF500	zinc finger protein 500	0.028
FGF18	fibroblast growth factor 18	0.028
ELAVL3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.028
PPL	periplakin	0.028
U2AF2	U2 small nuclear RNA auxiliary factor 2	0.028
ENTPD2	ectonucleoside triphosphate diphosphohydrolase 2	0.028
EYA1	eyes absent homolog 1 (Drosophila)	0.028
MSI1	musashi homolog 1 (Drosophila)	0.028
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.028
GAL	galanin prepropeptide	0.028
EPAS1	endothelial PAS domain protein 1	0.028
SPARCL1	SPARC-like 1 (hevin)	0.028
RMND5B	required for meiotic nuclear division 5 homolog B (S. cerevisiae)	0.028
ZFYVE9	zinc finger, FYVE domain containing 9	0.028
HOXB9	homeobox B9	0.028
IRX5	iroquois homeobox 5	0.028
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.028
IRF4	interferon regulatory factor 4	0.028
HMX2	H6 family homeobox 2	0.028
SOX12	SRY (sex determining region Y)-box 12	0.028	Human
KCNQ1	potassium voltage-gated channel, KQT-like subfamily, member 1	0.028
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.028
GRIN2D	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	0.027
FOXF2	forkhead box F2	0.027
FAM82A2	family with sequence similarity 82, member A2	0.027
SLC9A3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.027
NXPH4	neurexophilin 4	0.027
BBS4	Bardet-Biedl syndrome 4	0.027
CIC	capicua homolog (Drosophila)	0.027
ELN	elastin	0.027
PCGF2	polycomb group ring finger 2	0.027
ASCL2	achaete-scute complex homolog 2 (Drosophila)	0.027	Mouse
SAMD4B	sterile alpha motif domain containing 4B	0.027
EPHB1	EPH receptor B1	0.027
EVX1	even-skipped homeobox 1	0.027
TMEM44	transmembrane protein 44	0.027
RBPMS	RNA binding protein with multiple splicing	0.027
JARID2	jumonji, AT rich interactive domain 2	0.027
NDUFA4L2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2	0.027
NFIB	nuclear factor I/B	0.027
FAM19A5	family with sequence similarity 19 (chemokine (C-C motif)-like), member A5	0.027
NEUROD2	neurogenic differentiation 2	0.027
TLX1	T-cell leukemia homeobox 1	0.027
WNT1	wingless-type MMTV integration site family, member 1	0.027
NPAT	nuclear protein, ataxia-telangiectasia locus	0.027
T	T, brachyury homolog (mouse)	0.027
MED12	mediator complex subunit 12	0.027
FOXQ1	forkhead box Q1	0.027
FOXL2	forkhead box L2	0.027
RBMXL2	RNA binding motif protein, X-linked-like 2	0.027
MEIS1	Meis homeobox 1	0.027
TERT	telomerase reverse transcriptase	0.026
KLRG2	killer cell lectin-like receptor subfamily G, member 2	0.026
HOXB5	homeobox B5	0.026
NHLH2	nescient helix loop helix 2	0.026
ZFP28	zinc finger protein 28 homolog (mouse)	0.026
CDH4	cadherin 4, type 1, R-cadherin (retinal)	0.026
HOXB6	homeobox B6	0.026
NKX3-2	NK3 homeobox 2	0.026
NKX6-1	NK6 homeobox 1	0.026
SSBP4	single stranded DNA binding protein 4	0.026
GAS1	growth arrest-specific 1	0.026
DPF2	D4, zinc and double PHD fingers family 2	0.026
CLDN4	claudin 4	0.026
AKAP13	A kinase (PRKA) anchor protein 13	0.026
RASSF8	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8	0.026
MYST2	MYST histone acetyltransferase 2	0.026
HES5	hairy and enhancer of split 5 (Drosophila)	0.026
ADCY8	adenylate cyclase 8 (brain)	0.026
SLC22A2	solute carrier family 22 (organic cation transporter), member 2	0.026
SALL1	sal-like 1 (Drosophila)	0.026	Mouse
IRX1	iroquois homeobox 1	0.026
SLC6A8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	0.026
SOX8	SRY (sex determining region Y)-box 8	0.026	Human
OSBPL3	oxysterol binding protein-like 3	0.026
PRLR	prolactin receptor	0.026
SIX1	SIX homeobox 1	0.025
LRP4	low density lipoprotein receptor-related protein 4	0.025
CDKN2D	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.025
NIN	ninein (GSK3B interacting protein)	0.025
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.025
SAMD4A	sterile alpha motif domain containing 4A	0.025
SP5	Sp5 transcription factor	0.025
TBC1D5	TBC1 domain family, member 5	0.025
MECOM	MDS1 and EVI1 complex locus	0.025
SRSF4	serine/arginine-rich splicing factor 4	0.025
ZNF521	zinc finger protein 521	0.025
ANKRD13A	ankyrin repeat domain 13A	0.025
TLE2	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	0.025
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.025
TMEM151B	transmembrane protein 151B	0.025
PKP4	plakophilin 4	0.025
EPHB2	EPH receptor B2	0.025
RHOB	ras homolog gene family, member B	0.025
INSM1	insulinoma-associated 1	0.025
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.025
PLP1	proteolipid protein 1	0.025
CD70	CD70 molecule	0.025
UTF1	undifferentiated embryonic cell transcription factor 1	0.025
C2orf55	chromosome 2 open reading frame 55	0.025
CCNT1	cyclin T1	0.025
KIF1C	kinesin family member 1C	0.025
RYR3	ryanodine receptor 3	0.025
SRRM2	serine/arginine repetitive matrix 2	0.025
FUS	fused in sarcoma	0.025
PHOX2B	paired-like homeobox 2b	0.025
GATA3	GATA binding protein 3	0.025
LAMA1	laminin, alpha 1	0.025
DLX5	distal-less homeobox 5	0.025
GADD45G	growth arrest and DNA-damage-inducible, gamma	0.025
ZMIZ1	zinc finger, MIZ-type containing 1	0.025
AATK	apoptosis-associated tyrosine kinase	0.025
KIAA0913	KIAA0913	0.025
SRM	spermidine synthase	0.025
TCF15	transcription factor 15 (basic helix-loop-helix)	0.025
NES	nestin	0.025
STOX2	storkhead box 2	0.025
PAX5	paired box 5	0.025
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.025
GPC3	glypican 3	0.025
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.024
ARX	aristaless related homeobox	0.024
TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0.024
SSBP3	single stranded DNA binding protein 3	0.024
NPAS1	neuronal PAS domain protein 1	0.024
VGLL4	vestigial like 4 (Drosophila)	0.024
GPR4	G protein-coupled receptor 4	0.024
ESR2	estrogen receptor 2 (ER beta)	0.024
IL2RB	interleukin 2 receptor, beta	0.024
HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	0.024
HOXA4	homeobox A4	0.024
KCNJ4	potassium inwardly-rectifying channel, subfamily J, member 4	0.024
MDFI	MyoD family inhibitor	0.024
CYTL1	cytokine-like 1	0.024
SORBS3	sorbin and SH3 domain containing 3	0.024
NTN1	netrin 1	0.024
CRTC2	CREB regulated transcription coactivator 2	0.024
IHH	Indian hedgehog	0.024
PGR	progesterone receptor	0.024
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.024
RARG	retinoic acid receptor, gamma	0.024
IRX3	iroquois homeobox 3	0.024
TNFAIP8L1	tumor necrosis factor, alpha-induced protein 8-like 1	0.024
VAX2	ventral anterior homeobox 2	0.024
L1TD1	LINE-1 type transposase domain containing 1	0.024
CDX1	caudal type homeobox 1	0.024
FEV	FEV (ETS oncogene family)	0.024
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.024
ARID5A	AT rich interactive domain 5A (MRF1-like)	0.024
ATXN2L	ataxin 2-like	0.024
PITX1	paired-like homeodomain 1	0.024
EMX2	empty spiracles homeobox 2	0.024
WWTR1	WW domain containing transcription regulator 1	0.024
EDC3	enhancer of mRNA decapping 3 homolog (S. cerevisiae)	0.024
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.024
MTF1	metal-regulatory transcription factor 1	0.024
COL4A6	collagen, type IV, alpha 6	0.024
GHR	growth hormone receptor	0.024
ZC3H10	zinc finger CCCH-type containing 10	0.024
NTN3	netrin 3	0.024
CELA2A	chymotrypsin-like elastase family, member 2A	0.024
DPYSL5	dihydropyrimidinase-like 5	0.024
TH	tyrosine hydroxylase	0.024
SLC6A11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.024
FAM123C	family with sequence similarity 123C	0.023
EFNA1	ephrin-A1	0.023
ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.023
HUNK	hormonally up-regulated Neu-associated kinase	0.023
ITPKB	inositol-trisphosphate 3-kinase B	0.023
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.023
APOBR	apolipoprotein B receptor	0.023
MATN4	matrilin 4	0.023
GMEB1	glucocorticoid modulatory element binding protein 1	0.023
CNTN2	contactin 2 (axonal)	0.023
ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.023
PPFIA3	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	0.023
NELL1	NEL-like 1 (chicken)	0.023
UNC5B	unc-5 homolog B (C. elegans)	0.023
ZFP36L2	zinc finger protein 36, C3H type-like 2	0.023	Mouse
WSCD1	WSC domain containing 1	0.023
EPHA1	EPH receptor A1	0.023
CHSY1	chondroitin sulfate synthase 1	0.023
HOXC10	homeobox C10	0.023
RASIP1	Ras interacting protein 1	0.023
HSPA1B	heat shock 70kDa protein 1B	0.023
CDC42EP4	CDC42 effector protein (Rho GTPase binding) 4	0.023
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.023
MN1	meningioma (disrupted in balanced translocation) 1	0.023
LDOC1	leucine zipper, down-regulated in cancer 1	0.023
C1orf61	chromosome 1 open reading frame 61	0.023