IMP: Integrative Multi-species Prediction

Homo sapiens

38 genes annotated in human

protein folding

The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein folding"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "protein folding" (in gray)

Name	Description	Probability	Func Analog Organism
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	1.000	Yeast
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	1.000	Yeast
HSPA8	heat shock 70kDa protein 8	1.000
FKBP4	FK506 binding protein 4, 59kDa	1.000
AHSA1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	1.000	Yeast
TCP1	t-complex 1	1.000	Yeast
PDIA4	protein disulfide isomerase family A, member 4	0.999	Yeast Rat
STIP1	stress-induced-phosphoprotein 1	0.999	Yeast
DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.997	Human Yeast
HSPH1	heat shock 105kDa/110kDa protein 1	0.997	Yeast Mouse
P4HB	prolyl 4-hydroxylase, beta polypeptide	0.997	Rat Worm
PPID	peptidylprolyl isomerase D	0.994
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.993	Fly
HSPA4	heat shock 70kDa protein 4	0.990	Yeast
PDIA6	protein disulfide isomerase family A, member 6	0.985
PTGES3	prostaglandin E synthase 3 (cytosolic)	0.984
EPRS	glutamyl-prolyl-tRNA synthetase	0.982
HSPA1B	heat shock 70kDa protein 1B	0.979
CCT3	chaperonin containing TCP1, subunit 3 (gamma)	0.978	Yeast
HSPD1	heat shock 60kDa protein 1 (chaperonin)	0.978
PDIA3	protein disulfide isomerase family A, member 3	0.940	Yeast Worm
CCT5	chaperonin containing TCP1, subunit 5 (epsilon)	0.937	Yeast
CACYBP	calcyclin binding protein	0.926
CCT6A	chaperonin containing TCP1, subunit 6A (zeta 1)	0.898	Yeast
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.878	Yeast
PPP5C	protein phosphatase 5, catalytic subunit	0.875
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.857	Fly
HSPA9	heat shock 70kDa protein 9 (mortalin)	0.815	Yeast
BAG3	BCL2-associated athanogene 3	0.799
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.750
IARS	isoleucyl-tRNA synthetase	0.747
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	0.740
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.706	Fly
CHORDC1	cysteine and histidine-rich domain (CHORD) containing 1	0.656	Mouse
HSPA1A	heat shock 70kDa protein 1A	0.635
CCT2	chaperonin containing TCP1, subunit 2 (beta)	0.634	Yeast
HSPB8	heat shock 22kDa protein 8	0.621
ARL2	ADP-ribosylation factor-like 2	0.612	Yeast
NUB1	negative regulator of ubiquitin-like proteins 1	0.590
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.587	Fly
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.497
BAG1	BCL2-associated athanogene	0.426
CCT7	chaperonin containing TCP1, subunit 7 (eta)	0.425	Yeast
ERO1L	ERO1-like (S. cerevisiae)	0.421
HSPE1	heat shock 10kDa protein 1 (chaperonin 10)	0.420
HSP90B1	heat shock protein 90kDa beta (Grp94), member 1	0.420
BAG2	BCL2-associated athanogene 2	0.420
CALR	calreticulin	0.410	Rat
SUGT1	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)	0.406
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	0.389
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.339
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.323	Yeast
COPS5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.307
NUDC	nuclear distribution gene C homolog (A. nidulans)	0.273	Worm
SOD1	superoxide dismutase 1, soluble	0.267
HLA-DMB	major histocompatibility complex, class II, DM beta	0.235
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.231
MARS	methionyl-tRNA synthetase	0.217
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.199
UBQLN1	ubiquilin 1	0.161
TBCD	tubulin folding cofactor D	0.155
GARS	glycyl-tRNA synthetase	0.141
TOR1A	torsin family 1, member A (torsin A)	0.133
CCDC117	coiled-coil domain containing 117	0.122
KARS	lysyl-tRNA synthetase	0.122
NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	0.120
CANX	calnexin	0.114
PLOD1	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	0.112
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.111
BCL2L1	BCL2-like 1	0.111
SARS	seryl-tRNA synthetase	0.110
TOMM70A	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)	0.110
COPS4	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)	0.108
PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.101
SMAD9	SMAD family member 9	0.101
TBK1	TANK-binding kinase 1	0.100
ASNS	asparagine synthetase (glutamine-hydrolyzing)	0.099
PSEN1	presenilin 1	0.098
CRYAA	crystallin, alpha A	0.095
NARS	asparaginyl-tRNA synthetase	0.094
ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	0.092	Rat
DNAJA2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.087
CHUK	conserved helix-loop-helix ubiquitous kinase	0.082
TOR1AIP2	torsin A interacting protein 2	0.080
PDE6D	phosphodiesterase 6D, cGMP-specific, rod, delta	0.079
TMED5	transmembrane emp24 protein transport domain containing 5	0.076
CRYBB2	crystallin, beta B2	0.075
LDHA	lactate dehydrogenase A	0.074
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.072
HSPA13	heat shock protein 70kDa family, member 13	0.072
TTC4	tetratricopeptide repeat domain 4	0.066
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.063
TOR1B	torsin family 1, member B (torsin B)	0.062	Human
TAPBP	TAP binding protein (tapasin)	0.055
CSNK1A1	casein kinase 1, alpha 1	0.054
SDF2L1	stromal cell-derived factor 2-like 1	0.054
CRYGC	crystallin, gamma C	0.053
HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	0.053
HSPB2	heat shock 27kDa protein 2	0.053
MRPL18	mitochondrial ribosomal protein L18	0.053
TXN	thioredoxin	0.052
HM13	histocompatibility (minor) 13	0.052
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.050
RPAP3	RNA polymerase II associated protein 3	0.047
IPO7	importin 7	0.046
CDK9	cyclin-dependent kinase 9	0.045
OGFOD1	2-oxoglutarate and iron-dependent oxygenase domain containing 1	0.045
HSPB1	heat shock 27kDa protein 1	0.043
ERO1LB	ERO1-like beta (S. cerevisiae)	0.041	Human Yeast
XPOT	exportin, tRNA (nuclear export receptor for tRNAs)	0.041
ABHD16A	abhydrolase domain containing 16A	0.040
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.039
FAM83H	family with sequence similarity 83, member H	0.039
SNX5	sorting nexin 5	0.039
APP	amyloid beta (A4) precursor protein	0.039
DUSP23	dual specificity phosphatase 23	0.039
TOMM34	translocase of outer mitochondrial membrane 34	0.038
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.037
PPIB	peptidylprolyl isomerase B (cyclophilin B)	0.036
VCP	valosin containing protein	0.035
DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	0.033
APOA1	apolipoprotein A-I	0.033
SSBP1	single-stranded DNA binding protein 1	0.033
PSEN2	presenilin 2 (Alzheimer disease 4)	0.032
USP19	ubiquitin specific peptidase 19	0.030
HDAC11	histone deacetylase 11	0.029
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.029
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.028
G3BP2	GTPase activating protein (SH3 domain) binding protein 2	0.028
TLN1	talin 1	0.027
EIF4B	eukaryotic translation initiation factor 4B	0.026
BAG4	BCL2-associated athanogene 4	0.026
CXCR4	chemokine (C-X-C motif) receptor 4	0.025
RARS	arginyl-tRNA synthetase	0.025
FKBP5	FK506 binding protein 5	0.024
DAP3	death associated protein 3	0.024
DCBLD1	discoidin, CUB and LCCL domain containing 1	0.024
TRIM32	tripartite motif containing 32	0.024
LMAN1	lectin, mannose-binding, 1	0.023
CRYBA1	crystallin, beta A1	0.023
ARL3	ADP-ribosylation factor-like 3	0.023
HLA-A	major histocompatibility complex, class I, A	0.023
RPN2	ribophorin II	0.023
GDI2	GDP dissociation inhibitor 2	0.023
PEX14	peroxisomal biogenesis factor 14	0.023
YARS	tyrosyl-tRNA synthetase	0.023
DHPS	deoxyhypusine synthase	0.022
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.022
PRMT1	protein arginine methyltransferase 1	0.022
HYOU1	hypoxia up-regulated 1	0.021
CALU	calumenin	0.021
ACD	adrenocortical dysplasia homolog (mouse)	0.021
ATP6V1E1	ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1	0.020
BAD	BCL2-associated agonist of cell death	0.020
TARS	threonyl-tRNA synthetase	0.020
HFE	hemochromatosis	0.020
IGBP1	immunoglobulin (CD79A) binding protein 1	0.020
SSB	Sjogren syndrome antigen B (autoantigen La)	0.020
CDK5	cyclin-dependent kinase 5	0.020
BAX	BCL2-associated X protein	0.020
TXNDC5	thioredoxin domain containing 5 (endoplasmic reticulum)	0.020
FASN	fatty acid synthase	0.020
DNAJC7	DnaJ (Hsp40) homolog, subfamily C, member 7	0.019
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.019	Fly
GANAB	glucosidase, alpha; neutral AB	0.019
TPT1	tumor protein, translationally-controlled 1	0.019
KPNB1	karyopherin (importin) beta 1	0.019
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.018
CAMKK1	calcium/calmodulin-dependent protein kinase kinase 1, alpha	0.018
LARS	leucyl-tRNA synthetase	0.018
CDC37L1	cell division cycle 37 homolog (S. cerevisiae)-like 1	0.018
LARP4	La ribonucleoprotein domain family, member 4	0.018
PPP4C	protein phosphatase 4, catalytic subunit	0.018
AARS	alanyl-tRNA synthetase	0.018	Mouse
MAP2K1	mitogen-activated protein kinase kinase 1	0.018
SMAD2	SMAD family member 2	0.018
MTHFD1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.018
SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	0.018
NCL	nucleolin	0.018
PDIA5	protein disulfide isomerase family A, member 5	0.017
ATP6V1G1	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1	0.017
PSAT1	phosphoserine aminotransferase 1	0.017
SAFB	scaffold attachment factor B	0.017
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.017
MANF	mesencephalic astrocyte-derived neurotrophic factor	0.017
DARS	aspartyl-tRNA synthetase	0.017
EVC2	Ellis van Creveld syndrome 2	0.017
MEOX2	mesenchyme homeobox 2	0.016
DNM1L	dynamin 1-like	0.016
EGFR	epidermal growth factor receptor	0.016
TRMT112	tRNA methyltransferase 11-2 homolog (S. cerevisiae)	0.016
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.016
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.016
KAT5	K(lysine) acetyltransferase 5	0.016
METTL13	methyltransferase like 13	0.015
DNAJB4	DnaJ (Hsp40) homolog, subfamily B, member 4	0.015	Human Yeast
LAMB2	laminin, beta 2 (laminin S)	0.015
KDELR3	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3	0.015
PAPOLA	poly(A) polymerase alpha	0.015
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.015
NADSYN1	NAD synthetase 1	0.015
RHEB	Ras homolog enriched in brain	0.014
MKKS	McKusick-Kaufman syndrome	0.014
GFPT1	glutamine--fructose-6-phosphate transaminase 1	0.014
ITGB5	integrin, beta 5	0.014
PPP2R2D	protein phosphatase 2, regulatory subunit B, delta	0.014
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.014
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.014
CDK7	cyclin-dependent kinase 7	0.014
HSPA1L	heat shock 70kDa protein 1-like	0.014
MTA2	metastasis associated 1 family, member 2	0.014
LDLR	low density lipoprotein receptor	0.014
MTHFD2	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	0.013
SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	0.013
MARK2	MAP/microtubule affinity-regulating kinase 2	0.013
PPA1	pyrophosphatase (inorganic) 1	0.013
GCLM	glutamate-cysteine ligase, modifier subunit	0.013
TBXA2R	thromboxane A2 receptor	0.013
TMED9	transmembrane emp24 protein transport domain containing 9	0.013
C15orf63	chromosome 15 open reading frame 63	0.013
COG5	component of oligomeric golgi complex 5	0.012
TRIP12	thyroid hormone receptor interactor 12	0.012
UBA6	ubiquitin-like modifier activating enzyme 6	0.012
CSNK1E	casein kinase 1, epsilon	0.012
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.012
CNIH4	cornichon homolog 4 (Drosophila)	0.012
GLRX2	glutaredoxin 2	0.012
TGFBR1	transforming growth factor, beta receptor 1	0.012
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.012
RPN1	ribophorin I	0.012
DYNLL1	dynein, light chain, LC8-type 1	0.012
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.012
DNAJA4	DnaJ (Hsp40) homolog, subfamily A, member 4	0.012
TADA3	transcriptional adaptor 3	0.011
CLTC	clathrin, heavy chain (Hc)	0.011
PFDN2	prefoldin subunit 2	0.011
TOR1AIP1	torsin A interacting protein 1	0.011
ABTB1	ankyrin repeat and BTB (POZ) domain containing 1	0.011
EIF5	eukaryotic translation initiation factor 5	0.011
UNC119	unc-119 homolog (C. elegans)	0.011
MAPK8	mitogen-activated protein kinase 8	0.011
LCAT	lecithin-cholesterol acyltransferase	0.011
FKBP10	FK506 binding protein 10, 65 kDa	0.011
MTFR1	mitochondrial fission regulator 1	0.011
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.011
VPS72	vacuolar protein sorting 72 homolog (S. cerevisiae)	0.011
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.011
CLTA	clathrin, light chain A	0.011
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.011
FKBP2	FK506 binding protein 2, 13kDa	0.011
CDV3	CDV3 homolog (mouse)	0.011
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.011
RIPK3	receptor-interacting serine-threonine kinase 3	0.011
RPS6KC1	ribosomal protein S6 kinase, 52kDa, polypeptide 1	0.011
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.011
C10orf46	chromosome 10 open reading frame 46	0.010
TARS2	threonyl-tRNA synthetase 2, mitochondrial (putative)	0.010
AICDA	activation-induced cytidine deaminase	0.010
SSR4	signal sequence receptor, delta (translocon-associated protein delta)	0.010
SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)	0.010
PHB	prohibitin	0.010
SCARA3	scavenger receptor class A, member 3	0.010
C16orf53	chromosome 16 open reading frame 53	0.010