IMP
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epidermal growth factor receptor signaling pathway
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
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Click on a gene's description to view its network relationships with genes known to be involved in "epidermal growth factor receptor signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.982 | ||
| EGFR | epidermal growth factor receptor | 0.962 | ||
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.641 | Human | |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.338 | Human Fly | |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.306 | Mouse Fly | |
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.219 | ||
| DLG1 | discs, large homolog 1 (Drosophila) | 0.175 | Fly | |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.160 | Human | |
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.159 | Mouse | |
| ERBB4 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) | 0.158 | Human | |
| GRB2 | growth factor receptor-bound protein 2 | 0.147 | Fly | |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.104 | ||
| GHR | growth hormone receptor | 0.095 | ||
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.087 | ||
| PTPN23 | protein tyrosine phosphatase, non-receptor type 23 | 0.081 | Fly | |
| ERBB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.078 | Human Rat | |
| RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 0.076 | Fly | |
| PSEN1 | presenilin 1 | 0.074 | Mouse | |
| PTK2 | PTK2 protein tyrosine kinase 2 | 0.073 | Fly | |
| GAB1 | GRB2-associated binding protein 1 | 0.067 | Mouse | |
| ESR1 | estrogen receptor 1 | 0.064 | Rat | |
| SPRR2A | small proline-rich protein 2A | 0.057 | ||
| PAK2 | p21 protein (Cdc42/Rac)-activated kinase 2 | 0.057 | ||
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.054 | ||
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.054 | ||
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.053 | ||
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.052 | ||
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.052 | Mouse Fly | |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.052 | ||
| LAT | linker for activation of T cells | 0.051 | ||
| GDA | guanine deaminase | 0.051 | ||
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.050 | ||
| NCK1 | NCK adaptor protein 1 | 0.046 | ||
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | 0.045 | ||
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 0.043 | Fly | |
| MUC1 | mucin 1, cell surface associated | 0.043 | ||
| APBB1 | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | 0.042 | ||
| APP | amyloid beta (A4) precursor protein | 0.041 | Mouse | |
| SOCS1 | suppressor of cytokine signaling 1 | 0.039 | Human | |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.038 | ||
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.038 | ||
| CRK | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.037 | ||
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.037 | Human | |
| DLG4 | discs, large homolog 4 (Drosophila) | 0.036 | Fly | |
| ABI2 | abl-interactor 2 | 0.035 | ||
| ITCH | itchy E3 ubiquitin protein ligase homolog (mouse) | 0.033 | ||
| PDCD6IP | programmed cell death 6 interacting protein | 0.032 | ||
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.032 | ||
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.031 | ||
| YES1 | v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 | 0.031 | ||
| TFF1 | trefoil factor 1 | 0.031 | ||
| FBLN1 | fibulin 1 | 0.029 | Human | |
| TCEB1 | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) | 0.028 | ||
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.028 | ||
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.028 | ||
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.028 | ||
| ARHGAP1 | Rho GTPase activating protein 1 | 0.027 | ||
| TSG101 | tumor susceptibility gene 101 | 0.027 | ||
| PBK | PDZ binding kinase | 0.026 | ||
| STAMBP | STAM binding protein | 0.026 | ||
| TGM2 | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 0.026 | ||
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.025 | ||
| MPDZ | multiple PDZ domain protein | 0.025 | ||
| PBRM1 | polybromo 1 | 0.025 | ||
| ZAP70 | zeta-chain (TCR) associated protein kinase 70kDa | 0.025 | ||
| PRPF6 | PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) | 0.024 | ||
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 0.024 | ||
| PTPRA | protein tyrosine phosphatase, receptor type, A | 0.023 | ||
| STAM2 | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | 0.023 | Fly | |
| FYB | FYN binding protein | 0.023 | ||
| MED28 | mediator complex subunit 28 | 0.023 | ||
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.023 | ||
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.022 | ||
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | 0.022 | ||
| PXN | paxillin | 0.022 | ||
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.022 | ||
| PLCG1 | phospholipase C, gamma 1 | 0.022 | ||
| TOM1L1 | target of myb1 (chicken)-like 1 | 0.022 | ||
| MAP3K11 | mitogen-activated protein kinase kinase kinase 11 | 0.021 | ||
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.021 | ||
| TNRC6B | trinucleotide repeat containing 6B | 0.021 | ||
| CCDC6 | coiled-coil domain containing 6 | 0.021 | ||
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.021 | ||
| LRRK2 | leucine-rich repeat kinase 2 | 0.020 | ||
| SH2D3A | SH2 domain containing 3A | 0.020 | ||
| PTK2B | PTK2B protein tyrosine kinase 2 beta | 0.020 | Rat Fly | |
| EPOR | erythropoietin receptor | 0.020 | ||
| RASA1 | RAS p21 protein activator (GTPase activating protein) 1 | 0.020 | ||
| ATN1 | atrophin 1 | 0.020 | ||
| DSG2 | desmoglein 2 | 0.020 | ||
| ABL2 | v-abl Abelson murine leukemia viral oncogene homolog 2 | 0.020 | Mouse | |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.020 | ||
| FBN1 | fibrillin 1 | 0.020 | ||
| WAS | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | 0.019 | ||
| SH3BP4 | SH3-domain binding protein 4 | 0.019 | ||
| PTPN21 | protein tyrosine phosphatase, non-receptor type 21 | 0.019 | ||
| SOCS2 | suppressor of cytokine signaling 2 | 0.019 | Human | |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.019 | ||
| FBLN5 | fibulin 5 | 0.019 | Human | |
| KDR | kinase insert domain receptor (a type III receptor tyrosine kinase) | 0.019 | ||
| DAB2 | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | 0.019 | ||
| SOS2 | son of sevenless homolog 2 (Drosophila) | 0.019 | ||
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.019 | Rat | |
| RIN1 | Ras and Rab interactor 1 | 0.018 | ||
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 0.018 | Fly | |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.018 | ||
| CLASP1 | cytoplasmic linker associated protein 1 | 0.018 | ||
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | 0.018 | ||
| UBQLN1 | ubiquilin 1 | 0.018 | ||
| ABI1 | abl-interactor 1 | 0.018 | ||
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.018 | Fly | |
| MET | met proto-oncogene (hepatocyte growth factor receptor) | 0.018 | ||
| HDAC4 | histone deacetylase 4 | 0.018 | ||
| RALB | v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) | 0.018 | Worm | |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 0.018 | ||
| PRKCA | protein kinase C, alpha | 0.017 | ||
| FSTL1 | follistatin-like 1 | 0.017 | ||
| MAP4K1 | mitogen-activated protein kinase kinase kinase kinase 1 | 0.017 | Fly | |
| SH3GL2 | SH3-domain GRB2-like 2 | 0.017 | ||
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.017 | Worm | |
| EFEMP2 | EGF containing fibulin-like extracellular matrix protein 2 | 0.017 | Human | |
| NCOR1 | nuclear receptor corepressor 1 | 0.017 | ||
| ADNP | activity-dependent neuroprotector homeobox | 0.017 | ||
| DNM2 | dynamin 2 | 0.017 | ||
| TCEB2 | transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) | 0.016 | ||
| AHNAK | AHNAK nucleoprotein | 0.016 | ||
| YAP1 | Yes-associated protein 1 | 0.016 | ||
| ADRBK1 | adrenergic, beta, receptor kinase 1 | 0.016 | ||
| PIK3R2 | phosphoinositide-3-kinase, regulatory subunit 2 (beta) | 0.016 | ||
| TLN1 | talin 1 | 0.016 | ||
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 0.016 | ||
| TRIP6 | thyroid hormone receptor interactor 6 | 0.015 | ||
| FYN | FYN oncogene related to SRC, FGR, YES | 0.015 | ||
| BRAF | v-raf murine sarcoma viral oncogene homolog B1 | 0.015 | Fly | |
| CMTM8 | CKLF-like MARVEL transmembrane domain containing 8 | 0.015 | ||
| PPP5C | protein phosphatase 5, catalytic subunit | 0.015 | ||
| CAV2 | caveolin 2 | 0.015 | ||
| IRS4 | insulin receptor substrate 4 | 0.015 | ||
| SGTA | small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha | 0.015 | ||
| ZNF746 | zinc finger protein 746 | 0.015 | ||
| GRAP2 | GRB2-related adaptor protein 2 | 0.015 | Fly | |
| MECP2 | methyl CpG binding protein 2 (Rett syndrome) | 0.015 | ||
| SHC2 | SHC (Src homology 2 domain containing) transforming protein 2 | 0.015 | Fly | |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.015 | ||
| LOXL1 | lysyl oxidase-like 1 | 0.014 | ||
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.014 | ||
| DOK4 | docking protein 4 | 0.014 | ||
| SKIL | SKI-like oncogene | 0.014 | ||
| FLNB | filamin B, beta | 0.014 | ||
| SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | 0.014 | ||
| TNK2 | tyrosine kinase, non-receptor, 2 | 0.014 | ||
| FLT1 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 0.014 | ||
| ADORA2A | adenosine A2a receptor | 0.014 | ||
| JUP | junction plakoglobin | 0.014 | ||
| BLNK | B-cell linker | 0.014 | ||
| WASL | Wiskott-Aldrich syndrome-like | 0.013 | ||
| CISH | cytokine inducible SH2-containing protein | 0.013 | Human | |
| DNM1 | dynamin 1 | 0.013 | ||
| EXOC5 | exocyst complex component 5 | 0.013 | ||
| DPPA4 | developmental pluripotency associated 4 | 0.013 | ||
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.013 | ||
| MAD2L2 | MAD2 mitotic arrest deficient-like 2 (yeast) | 0.013 | ||
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.013 | Rat | |
| SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | 0.013 | ||
| EGF | epidermal growth factor | 0.013 | ||
| S100A4 | S100 calcium binding protein A4 | 0.013 | ||
| CDK8 | cyclin-dependent kinase 8 | 0.013 | ||
| SOCS3 | suppressor of cytokine signaling 3 | 0.013 | Human | |
| EZR | ezrin | 0.013 | ||
| CDC42 | cell division cycle 42 (GTP binding protein, 25kDa) | 0.013 | ||
| MAPK8IP1 | mitogen-activated protein kinase 8 interacting protein 1 | 0.013 | ||
| SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | 0.013 | ||
| VEGFA | vascular endothelial growth factor A | 0.013 | ||
| GRB10 | growth factor receptor-bound protein 10 | 0.013 | ||
| CBLB | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | 0.013 | Human Fly | |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.012 | ||
| ANXA1 | annexin A1 | 0.012 | ||
| RALBP1 | ralA binding protein 1 | 0.012 | ||
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.012 | ||
| LTBP4 | latent transforming growth factor beta binding protein 4 | 0.012 | Human | |
| SNF8 | SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) | 0.012 | ||
| JAK1 | Janus kinase 1 | 0.012 | ||
| SH3RF1 | SH3 domain containing ring finger 1 | 0.012 | ||
| KRAS | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.012 | Worm | |
| RABGGTB | Rab geranylgeranyltransferase, beta subunit | 0.012 | ||
| ZNF512B | zinc finger protein 512B | 0.012 | ||
| ARF6 | ADP-ribosylation factor 6 | 0.012 | ||
| LAMB2 | laminin, beta 2 (laminin S) | 0.012 | ||
| LTBP2 | latent transforming growth factor beta binding protein 2 | 0.012 | Human | |
| CSNK1G3 | casein kinase 1, gamma 3 | 0.012 | ||
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.012 | Fly | |
| ZNF775 | zinc finger protein 775 | 0.012 | ||
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.012 | ||
| RHEB | Ras homolog enriched in brain | 0.012 | ||
| MATK | megakaryocyte-associated tyrosine kinase | 0.012 | ||
| DAZ1 | deleted in azoospermia 1 | 0.012 | ||
| VAV2 | vav 2 guanine nucleotide exchange factor | 0.012 | ||
| ENG | endoglin | 0.012 | ||
| AGRN | agrin | 0.012 | ||
| PUM2 | pumilio homolog 2 (Drosophila) | 0.012 | Fly | |
| MPP5 | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) | 0.012 | ||
| PSMD4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 0.012 | ||
| SORBS3 | sorbin and SH3 domain containing 3 | 0.012 | ||
| INPP5D | inositol polyphosphate-5-phosphatase, 145kDa | 0.012 | ||
| SH3D19 | SH3 domain containing 19 | 0.012 | ||
| CDT1 | chromatin licensing and DNA replication factor 1 | 0.011 | ||
| ARRB1 | arrestin, beta 1 | 0.011 | ||
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 0.011 | ||
| SH3BP2 | SH3-domain binding protein 2 | 0.011 | ||
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 0.011 | ||
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | 0.011 | ||
| CDC73 | cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) | 0.011 | ||
| PDE4DIP | phosphodiesterase 4D interacting protein | 0.011 | ||
| SHC3 | SHC (Src homology 2 domain containing) transforming protein 3 | 0.011 | ||
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.011 | ||
| DEGS1 | degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) | 0.011 | ||
| BLK | B lymphoid tyrosine kinase | 0.011 | ||
| KIF5B | kinesin family member 5B | 0.011 | ||
| EEA1 | early endosome antigen 1 | 0.011 | ||
| CHMP4B | chromatin modifying protein 4B | 0.011 | ||
| ADAM10 | ADAM metallopeptidase domain 10 | 0.011 | ||
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.011 | ||
| FN1 | fibronectin 1 | 0.011 | ||
| UPF3B | UPF3 regulator of nonsense transcripts homolog B (yeast) | 0.011 | ||
| NUP54 | nucleoporin 54kDa | 0.011 | ||
| MAPK8IP2 | mitogen-activated protein kinase 8 interacting protein 2 | 0.011 | ||
| ZNF644 | zinc finger protein 644 | 0.011 | ||
| UPF2 | UPF2 regulator of nonsense transcripts homolog (yeast) | 0.011 | ||
| PLCG2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 0.011 | Human Fly | |
| JAK2 | Janus kinase 2 | 0.011 | ||
| HCK | hemopoietic cell kinase | 0.011 | ||
| LRP1 | low density lipoprotein receptor-related protein 1 | 0.011 | Human | |
| STAM | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | 0.011 | Fly | |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 0.011 | ||
| ANKS1A | ankyrin repeat and sterile alpha motif domain containing 1A | 0.011 | ||
| ELL | elongation factor RNA polymerase II | 0.011 | ||
| PRPF4B | PRP4 pre-mRNA processing factor 4 homolog B (yeast) | 0.011 | ||
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.011 | ||
| SLK | STE20-like kinase | 0.011 | ||
| ARAF | v-raf murine sarcoma 3611 viral oncogene homolog | 0.011 | Fly | |
| TMOD3 | tropomodulin 3 (ubiquitous) | 0.011 | ||
| LMAN1 | lectin, mannose-binding, 1 | 0.011 | ||
| BAIAP2 | BAI1-associated protein 2 | 0.011 | ||
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.011 | ||
| ADRM1 | adhesion regulating molecule 1 | 0.011 | ||
| PCNP | PEST proteolytic signal containing nuclear protein | 0.011 | ||
| TNS4 | tensin 4 | 0.011 | ||
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.011 | Fly | |
| CACNA1C | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.011 | ||
| MAP1S | microtubule-associated protein 1S | 0.010 | ||
| DPYSL4 | dihydropyrimidinase-like 4 | 0.010 | ||
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.010 | ||
| PARD3 | par-3 partitioning defective 3 homolog (C. elegans) | 0.010 | ||
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.010 | Human | |
| TNRC6C | trinucleotide repeat containing 6C | 0.010 | ||
| ENO1 | enolase 1, (alpha) | 0.010 | ||
| MAP2K2 | mitogen-activated protein kinase kinase 2 | 0.010 | ||
| CDCP1 | CUB domain containing protein 1 | 0.010 | ||
| PIK3AP1 | phosphoinositide-3-kinase adaptor protein 1 | 0.010 | ||
| PRKCE | protein kinase C, epsilon | 0.010 | ||
| EIF1AX | eukaryotic translation initiation factor 1A, X-linked | 0.010 | ||
| TGFB3 | transforming growth factor, beta 3 | 0.010 | ||
| RYK | RYK receptor-like tyrosine kinase | 0.010 | ||
| DLG2 | discs, large homolog 2 (Drosophila) | 0.010 | Fly | |
| DKK1 | dickkopf homolog 1 (Xenopus laevis) | 0.010 | ||
| ROD1 | ROD1 regulator of differentiation 1 (S. pombe) | 0.010 |